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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 34257

FusionGeneSummary for SLC25A44_SEMA4A

check button Fusion gene summary
Fusion gene informationFusion gene name: SLC25A44_SEMA4A
Fusion gene ID: 34257
HgeneTgene
Gene symbol

SLC25A44

SEMA4A

Gene ID

9673

64218

Gene namesolute carrier family 25 member 44semaphorin 4A
Synonyms-CORD10|RP35|SEMAB|SEMB
Cytomap

1q22

1q22

Type of geneprotein-codingprotein-coding
Descriptionsolute carrier family 25 member 44semaphorin-4Asema Bsema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4Asemaphorin-B
Modification date2018052220180523
UniProtAcc

Q96H78

Q9H3S1

Ensembl transtripts involved in fusion geneENST00000359511, ENST00000423538, 
ENST00000469537, 
ENST00000355014, 
ENST00000368285, ENST00000368284, 
ENST00000368286, ENST00000368282, 
ENST00000487358, 
Fusion gene scores* DoF score10 X 5 X 5=2503 X 2 X 3=18
# samples 104
** MAII scorelog2(10/250*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/18*10)=1.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SLC25A44 [Title/Abstract] AND SEMA4A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUSCTCGA-O2-A52Q-01ASLC25A44chr1

156164038

+SEMA4Achr1

156142617

+
TCGARVUCECTCGA-B5-A0JN-01ASLC25A44chr1

156164038

+SEMA4Achr1

156142617

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000359511ENST00000355014SLC25A44chr1

156164038

+SEMA4Achr1

156142617

+
5UTR-3CDSENST00000359511ENST00000368285SLC25A44chr1

156164038

+SEMA4Achr1

156142617

+
5UTR-3CDSENST00000359511ENST00000368284SLC25A44chr1

156164038

+SEMA4Achr1

156142617

+
5UTR-3CDSENST00000359511ENST00000368286SLC25A44chr1

156164038

+SEMA4Achr1

156142617

+
5UTR-3CDSENST00000359511ENST00000368282SLC25A44chr1

156164038

+SEMA4Achr1

156142617

+
5UTR-3UTRENST00000359511ENST00000487358SLC25A44chr1

156164038

+SEMA4Achr1

156142617

+
5UTR-3CDSENST00000423538ENST00000355014SLC25A44chr1

156164038

+SEMA4Achr1

156142617

+
5UTR-3CDSENST00000423538ENST00000368285SLC25A44chr1

156164038

+SEMA4Achr1

156142617

+
5UTR-3CDSENST00000423538ENST00000368284SLC25A44chr1

156164038

+SEMA4Achr1

156142617

+
5UTR-3CDSENST00000423538ENST00000368286SLC25A44chr1

156164038

+SEMA4Achr1

156142617

+
5UTR-3CDSENST00000423538ENST00000368282SLC25A44chr1

156164038

+SEMA4Achr1

156142617

+
5UTR-3UTRENST00000423538ENST00000487358SLC25A44chr1

156164038

+SEMA4Achr1

156142617

+
intron-3CDSENST00000469537ENST00000355014SLC25A44chr1

156164038

+SEMA4Achr1

156142617

+
intron-3CDSENST00000469537ENST00000368285SLC25A44chr1

156164038

+SEMA4Achr1

156142617

+
intron-3CDSENST00000469537ENST00000368284SLC25A44chr1

156164038

+SEMA4Achr1

156142617

+
intron-3CDSENST00000469537ENST00000368286SLC25A44chr1

156164038

+SEMA4Achr1

156142617

+
intron-3CDSENST00000469537ENST00000368282SLC25A44chr1

156164038

+SEMA4Achr1

156142617

+
intron-3UTRENST00000469537ENST00000487358SLC25A44chr1

156164038

+SEMA4Achr1

156142617

+

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FusionProtFeatures for SLC25A44_SEMA4A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SLC25A44

Q96H78

SEMA4A

Q9H3S1

Cell surface receptor for PLXNB1, PLXNB2, PLXNB3 andPLXND1 that plays an important role in cell-cell signaling. Playsa role in priming antigen-specific T-cells, promotesdifferentiation of Th1 T-helper cells, and thereby contributes toadaptive immunity. Promotes phosphorylation of TIMD2. Inhibitsangiogenesis. Promotes axon growth cone collapse. Inhibits axonalextension by providing local signals to specify territoriesinaccessible for growing axons (By similarity).{ECO:0000250|UniProtKB:Q62178}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SLC25A44_SEMA4A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SLC25A44_SEMA4A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SLC25A44ELAVL1, JUP, NME2P1, IMPDH2, LASP1, IMPDH1SEMA4ADDX54


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SLC25A44_SEMA4A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SLC25A44_SEMA4A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneSEMA4AC1853214RETINITIS PIGMENTOSA 351CTD_human;UNIPROT