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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 34216

FusionGeneSummary for SLC25A26_LGMN

check button Fusion gene summary
Fusion gene informationFusion gene name: SLC25A26_LGMN
Fusion gene ID: 34216
HgeneTgene
Gene symbol

SLC25A26

LGMN

Gene ID

115286

5641

Gene namesolute carrier family 25 member 26legumain
SynonymsCOXPD28|SAMCAEP|LGMN1|PRSC1
Cytomap

3p14.1

14q32.12

Type of geneprotein-codingprotein-coding
DescriptionS-adenosylmethionine mitochondrial carrier proteinmitochondrial S-adenosylmethionine transportersolute carrier family 25 (S-adenosylmethionine carrier), member 26solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 26legumainasparaginyl endopeptidasecysteine protease 1protease, cysteine 1protease, cysteine, 1 (legumain)
Modification date2018052320180525
UniProtAcc

Q70HW3

Q99538

Ensembl transtripts involved in fusion geneENST00000354883, ENST00000336733, 
ENST00000536651, ENST00000413054, 
ENST00000484768, 		ENST00000555699, 
ENST00000334869, ENST00000557434, 
ENST00000393218, ENST00000557034, 
Fusion gene scores* DoF score6 X 5 X 4=1206 X 5 X 3=90
# samples 66
** MAII scorelog2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/90*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SLC25A26 [Title/Abstract] AND LGMN [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneLGMN

GO:0010447

response to acidic pH

18374643

TgeneLGMN

GO:0035729

cellular response to hepatocyte growth factor stimulus

21237226

TgeneLGMN

GO:0071277

cellular response to calcium ion

21237226

TgeneLGMN

GO:0090026

positive regulation of monocyte chemotaxis

18377911

TgeneLGMN

GO:0097202

activation of cysteine-type endopeptidase activity

9821970|18374643

TgeneLGMN

GO:0097264

self proteolysis

9821970|18374643

TgeneLGMN

GO:1904646

cellular response to amyloid-beta

25326800

TgeneLGMN

GO:2001028

positive regulation of endothelial cell chemotaxis

18377911


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLIHCTCGA-DD-A4NG-01ASLC25A26chr3

66313803

+LGMNchr14

93199160

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000354883ENST00000555699SLC25A26chr3

66313803

+LGMNchr14

93199160

-
5CDS-5UTRENST00000354883ENST00000334869SLC25A26chr3

66313803

+LGMNchr14

93199160

-
5CDS-5UTRENST00000354883ENST00000557434SLC25A26chr3

66313803

+LGMNchr14

93199160

-
5CDS-5UTRENST00000354883ENST00000393218SLC25A26chr3

66313803

+LGMNchr14

93199160

-
5CDS-intronENST00000354883ENST00000557034SLC25A26chr3

66313803

+LGMNchr14

93199160

-
5CDS-5UTRENST00000336733ENST00000555699SLC25A26chr3

66313803

+LGMNchr14

93199160

-
5CDS-5UTRENST00000336733ENST00000334869SLC25A26chr3

66313803

+LGMNchr14

93199160

-
5CDS-5UTRENST00000336733ENST00000557434SLC25A26chr3

66313803

+LGMNchr14

93199160

-
5CDS-5UTRENST00000336733ENST00000393218SLC25A26chr3

66313803

+LGMNchr14

93199160

-
5CDS-intronENST00000336733ENST00000557034SLC25A26chr3

66313803

+LGMNchr14

93199160

-
3UTR-5UTRENST00000536651ENST00000555699SLC25A26chr3

66313803

+LGMNchr14

93199160

-
3UTR-5UTRENST00000536651ENST00000334869SLC25A26chr3

66313803

+LGMNchr14

93199160

-
3UTR-5UTRENST00000536651ENST00000557434SLC25A26chr3

66313803

+LGMNchr14

93199160

-
3UTR-5UTRENST00000536651ENST00000393218SLC25A26chr3

66313803

+LGMNchr14

93199160

-
3UTR-intronENST00000536651ENST00000557034SLC25A26chr3

66313803

+LGMNchr14

93199160

-
5CDS-5UTRENST00000413054ENST00000555699SLC25A26chr3

66313803

+LGMNchr14

93199160

-
5CDS-5UTRENST00000413054ENST00000334869SLC25A26chr3

66313803

+LGMNchr14

93199160

-
5CDS-5UTRENST00000413054ENST00000557434SLC25A26chr3

66313803

+LGMNchr14

93199160

-
5CDS-5UTRENST00000413054ENST00000393218SLC25A26chr3

66313803

+LGMNchr14

93199160

-
5CDS-intronENST00000413054ENST00000557034SLC25A26chr3

66313803

+LGMNchr14

93199160

-
3UTR-5UTRENST00000484768ENST00000555699SLC25A26chr3

66313803

+LGMNchr14

93199160

-
3UTR-5UTRENST00000484768ENST00000334869SLC25A26chr3

66313803

+LGMNchr14

93199160

-
3UTR-5UTRENST00000484768ENST00000557434SLC25A26chr3

66313803

+LGMNchr14

93199160

-
3UTR-5UTRENST00000484768ENST00000393218SLC25A26chr3

66313803

+LGMNchr14

93199160

-
3UTR-intronENST00000484768ENST00000557034SLC25A26chr3

66313803

+LGMNchr14

93199160

-

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FusionProtFeatures for SLC25A26_LGMN


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SLC25A26

Q70HW3

LGMN

Q99538

Mitochondrial solute carriers shuttle metabolites,nucleotides, and cofactors through the mitochondrial innermembrane. Specifically mediates the transport of S-adenosylmethionine (SAM) into the mitochondria.{ECO:0000269|PubMed:14674884, ECO:0000269|PubMed:26522469}. Has a strict specificity for hydrolysis of asparaginylbonds. Can also cleave aspartyl bonds slowly, especially underacidic conditions. Required for normal lysosomal proteindegradation in renal proximal tubules. Required for normaldegradation of internalized EGFR. Plays a role in the regulationof cell proliferation via its role in EGFR degradation (Bysimilarity). May be involved in the processing of proteins for MHCclass II antigen presentation in the lysosomal/endosomal system.{ECO:0000250, ECO:0000269|PubMed:23776206}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SLC25A26_LGMN


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SLC25A26_LGMN


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SLC25A26MYC, SPACA1, MARCH5, DUSP23LGMNUSP17L9P, ISG15, FBXO6, IGF2BP3, ACIN1, HNRNPR, LAMC3, TRAF6, USP17L2, PDIA5, ATG7, HNRNPH2, SOD1, YWHAH, RNASEH2A, PPP2R3C, DEFA1, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SLC25A26_LGMN


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SLC25A26_LGMN


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSLC25A26C4225206COMBINED OXIDATIVE PHOSPHORYLATION DEFICIENCY 281ORPHANET;UNIPROT
TgeneLGMNC0023893Liver Cirrhosis, Experimental1CTD_human