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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 34213

FusionGeneSummary for SLC25A26_BGN

check button Fusion gene summary
Fusion gene informationFusion gene name: SLC25A26_BGN
Fusion gene ID: 34213
HgeneTgene
Gene symbol

SLC25A26

BGN

Gene ID

115286

633

Gene namesolute carrier family 25 member 26biglycan
SynonymsCOXPD28|SAMCDSPG1|MRLS|PG-S1|PGI|SEMDX|SLRR1A
Cytomap

3p14.1

Xq28

Type of geneprotein-codingprotein-coding
DescriptionS-adenosylmethionine mitochondrial carrier proteinmitochondrial S-adenosylmethionine transportersolute carrier family 25 (S-adenosylmethionine carrier), member 26solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 26biglycanbone/cartilage proteoglycan-Idermatan sulphate proteoglycan Ismall leucine-rich protein 1A
Modification date2018052320180522
UniProtAcc

Q70HW3

P21810

Ensembl transtripts involved in fusion geneENST00000354883, ENST00000336733, 
ENST00000536651, ENST00000413054, 
ENST00000484768, 
ENST00000331595, 
ENST00000480756, 
Fusion gene scores* DoF score6 X 5 X 4=1207 X 7 X 2=98
# samples 67
** MAII scorelog2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/98*10)=-0.485426827170242
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SLC25A26 [Title/Abstract] AND BGN [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF930412SLC25A26chr3

66436618

-BGNchrX

152771406

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000354883ENST00000331595SLC25A26chr3

66436618

-BGNchrX

152771406

+
intron-3UTRENST00000354883ENST00000480756SLC25A26chr3

66436618

-BGNchrX

152771406

+
intron-3CDSENST00000336733ENST00000331595SLC25A26chr3

66436618

-BGNchrX

152771406

+
intron-3UTRENST00000336733ENST00000480756SLC25A26chr3

66436618

-BGNchrX

152771406

+
3UTR-3CDSENST00000536651ENST00000331595SLC25A26chr3

66436618

-BGNchrX

152771406

+
3UTR-3UTRENST00000536651ENST00000480756SLC25A26chr3

66436618

-BGNchrX

152771406

+
intron-3CDSENST00000413054ENST00000331595SLC25A26chr3

66436618

-BGNchrX

152771406

+
intron-3UTRENST00000413054ENST00000480756SLC25A26chr3

66436618

-BGNchrX

152771406

+
intron-3CDSENST00000484768ENST00000331595SLC25A26chr3

66436618

-BGNchrX

152771406

+
intron-3UTRENST00000484768ENST00000480756SLC25A26chr3

66436618

-BGNchrX

152771406

+

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FusionProtFeatures for SLC25A26_BGN


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SLC25A26

Q70HW3

BGN

P21810

Mitochondrial solute carriers shuttle metabolites,nucleotides, and cofactors through the mitochondrial innermembrane. Specifically mediates the transport of S-adenosylmethionine (SAM) into the mitochondria.{ECO:0000269|PubMed:14674884, ECO:0000269|PubMed:26522469}. May be involved in collagen fiber assembly.{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SLC25A26_BGN


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SLC25A26_BGN


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SLC25A26_BGN


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SLC25A26_BGN


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSLC25A26C4225206COMBINED OXIDATIVE PHOSPHORYLATION DEFICIENCY 281ORPHANET;UNIPROT
TgeneBGNC0003873Rheumatoid Arthritis1CTD_human
TgeneBGNC0023893Liver Cirrhosis, Experimental1CTD_human
TgeneBGNC1848097Spondyloepimetaphyseal Dysplasia, X-Linked1ORPHANET;UNIPROT