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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 34210

FusionGeneSummary for SLC25A25_LYPLAL1

check button Fusion gene summary
Fusion gene informationFusion gene name: SLC25A25_LYPLAL1
Fusion gene ID: 34210
HgeneTgene
Gene symbol

SLC25A25

LYPLAL1

Gene ID

114789

127018

Gene namesolute carrier family 25 member 25lysophospholipase like 1
SynonymsMCSC|PCSCL|SCAMC-2Q96AV0
Cytomap

9q34.11

1q41

Type of geneprotein-codingprotein-coding
Descriptioncalcium-binding mitochondrial carrier protein SCaMC-2mitochondrial ATP-Mg/Pi carrier protein 3mitochondrial Ca(2+)-dependent solute carrier protein 3short calcium-binding mitochondrial carrier 2small calcium-binding mitochondrial carrier 2solute carrlysophospholipase-like protein 1
Modification date2018052320180523
UniProtAcc

Q6KCM7

Q5VWZ2

Ensembl transtripts involved in fusion geneENST00000373068, ENST00000373069, 
ENST00000432073, ENST00000373066, 
ENST00000373064, ENST00000433501, 
ENST00000366928, ENST00000366927, 
ENST00000483635, 
Fusion gene scores* DoF score5 X 3 X 4=602 X 2 X 2=8
# samples 52
** MAII scorelog2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: SLC25A25 [Title/Abstract] AND LYPLAL1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW854013SLC25A25chr9

130831777

-LYPLAL1chr1

219378854

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000373068ENST00000366928SLC25A25chr9

130831777

-LYPLAL1chr1

219378854

-
intron-intronENST00000373068ENST00000366927SLC25A25chr9

130831777

-LYPLAL1chr1

219378854

-
intron-intronENST00000373068ENST00000483635SLC25A25chr9

130831777

-LYPLAL1chr1

219378854

-
intron-intronENST00000373069ENST00000366928SLC25A25chr9

130831777

-LYPLAL1chr1

219378854

-
intron-intronENST00000373069ENST00000366927SLC25A25chr9

130831777

-LYPLAL1chr1

219378854

-
intron-intronENST00000373069ENST00000483635SLC25A25chr9

130831777

-LYPLAL1chr1

219378854

-
intron-intronENST00000432073ENST00000366928SLC25A25chr9

130831777

-LYPLAL1chr1

219378854

-
intron-intronENST00000432073ENST00000366927SLC25A25chr9

130831777

-LYPLAL1chr1

219378854

-
intron-intronENST00000432073ENST00000483635SLC25A25chr9

130831777

-LYPLAL1chr1

219378854

-
intron-intronENST00000373066ENST00000366928SLC25A25chr9

130831777

-LYPLAL1chr1

219378854

-
intron-intronENST00000373066ENST00000366927SLC25A25chr9

130831777

-LYPLAL1chr1

219378854

-
intron-intronENST00000373066ENST00000483635SLC25A25chr9

130831777

-LYPLAL1chr1

219378854

-
intron-intronENST00000373064ENST00000366928SLC25A25chr9

130831777

-LYPLAL1chr1

219378854

-
intron-intronENST00000373064ENST00000366927SLC25A25chr9

130831777

-LYPLAL1chr1

219378854

-
intron-intronENST00000373064ENST00000483635SLC25A25chr9

130831777

-LYPLAL1chr1

219378854

-
intron-intronENST00000433501ENST00000366928SLC25A25chr9

130831777

-LYPLAL1chr1

219378854

-
intron-intronENST00000433501ENST00000366927SLC25A25chr9

130831777

-LYPLAL1chr1

219378854

-
intron-intronENST00000433501ENST00000483635SLC25A25chr9

130831777

-LYPLAL1chr1

219378854

-

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FusionProtFeatures for SLC25A25_LYPLAL1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SLC25A25

Q6KCM7

LYPLAL1

Q5VWZ2

Has depalmitoylating activity toward KCNMA1. Does notexhibit phospholipase nor triacylglycerol lipase activity, able tohydrolyze only short chain substrates due to its shallow activesite. {ECO:0000269|PubMed:22052940, ECO:0000269|PubMed:22399288}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SLC25A25_LYPLAL1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SLC25A25_LYPLAL1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SLC25A25_LYPLAL1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SLC25A25_LYPLAL1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource