FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 3421

FusionGeneSummary for ATP5S_TNS3

check button Fusion gene summary
Fusion gene informationFusion gene name: ATP5S_TNS3
Fusion gene ID: 3421
HgeneTgene
Gene symbol

ATP5S

TNS3

Gene ID

27109

64759

Gene nameATP synthase, H+ transporting, mitochondrial Fo complex subunit s (factor B)tensin 3
SynonymsATPW|FB|HSU79253TEM6|TENS1
Cytomap

14q21.3

7p12.3

Type of geneprotein-codingprotein-coding
DescriptionATP synthase subunit s, mitochondrialATP synthase coupling factor B, mitochondrialATP synthase coupling factor B-like 1ATP synthase, H+ transporting, mitochondrial F0 complex, subunit s (factor B)ATP synthase-coupling factor Bmitochondrial ATP synthatensin-3tensin-like SH2 domain containing 1tensin-like SH2 domain-containing protein 1thyroid specific PTB domain proteintumor endothelial marker 6
Modification date2018052220180519
UniProtAcc

Q99766

Q68CZ2

Ensembl transtripts involved in fusion geneENST00000554438, ENST00000245448, 
ENST00000426751, ENST00000311459, 
ENST00000358473, 
ENST00000311160, 
ENST00000355730, ENST00000398879, 
ENST00000442536, ENST00000458317, 
ENST00000474346, 
Fusion gene scores* DoF score2 X 2 X 1=43 X 3 X 2=18
# samples 24
** MAII scorelog2(2/4*10)=2.32192809488736log2(4/18*10)=1.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ATP5S [Title/Abstract] AND TNS3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW840281ATP5Schr14

50801121

-TNS3chr7

47314978

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000554438ENST00000311160ATP5Schr14

50801121

-TNS3chr7

47314978

+
intron-3UTRENST00000554438ENST00000355730ATP5Schr14

50801121

-TNS3chr7

47314978

+
intron-3UTRENST00000554438ENST00000398879ATP5Schr14

50801121

-TNS3chr7

47314978

+
intron-intronENST00000554438ENST00000442536ATP5Schr14

50801121

-TNS3chr7

47314978

+
intron-intronENST00000554438ENST00000458317ATP5Schr14

50801121

-TNS3chr7

47314978

+
intron-intronENST00000554438ENST00000474346ATP5Schr14

50801121

-TNS3chr7

47314978

+
intron-3UTRENST00000245448ENST00000311160ATP5Schr14

50801121

-TNS3chr7

47314978

+
intron-3UTRENST00000245448ENST00000355730ATP5Schr14

50801121

-TNS3chr7

47314978

+
intron-3UTRENST00000245448ENST00000398879ATP5Schr14

50801121

-TNS3chr7

47314978

+
intron-intronENST00000245448ENST00000442536ATP5Schr14

50801121

-TNS3chr7

47314978

+
intron-intronENST00000245448ENST00000458317ATP5Schr14

50801121

-TNS3chr7

47314978

+
intron-intronENST00000245448ENST00000474346ATP5Schr14

50801121

-TNS3chr7

47314978

+
intron-3UTRENST00000426751ENST00000311160ATP5Schr14

50801121

-TNS3chr7

47314978

+
intron-3UTRENST00000426751ENST00000355730ATP5Schr14

50801121

-TNS3chr7

47314978

+
intron-3UTRENST00000426751ENST00000398879ATP5Schr14

50801121

-TNS3chr7

47314978

+
intron-intronENST00000426751ENST00000442536ATP5Schr14

50801121

-TNS3chr7

47314978

+
intron-intronENST00000426751ENST00000458317ATP5Schr14

50801121

-TNS3chr7

47314978

+
intron-intronENST00000426751ENST00000474346ATP5Schr14

50801121

-TNS3chr7

47314978

+
intron-3UTRENST00000311459ENST00000311160ATP5Schr14

50801121

-TNS3chr7

47314978

+
intron-3UTRENST00000311459ENST00000355730ATP5Schr14

50801121

-TNS3chr7

47314978

+
intron-3UTRENST00000311459ENST00000398879ATP5Schr14

50801121

-TNS3chr7

47314978

+
intron-intronENST00000311459ENST00000442536ATP5Schr14

50801121

-TNS3chr7

47314978

+
intron-intronENST00000311459ENST00000458317ATP5Schr14

50801121

-TNS3chr7

47314978

+
intron-intronENST00000311459ENST00000474346ATP5Schr14

50801121

-TNS3chr7

47314978

+
intron-3UTRENST00000358473ENST00000311160ATP5Schr14

50801121

-TNS3chr7

47314978

+
intron-3UTRENST00000358473ENST00000355730ATP5Schr14

50801121

-TNS3chr7

47314978

+
intron-3UTRENST00000358473ENST00000398879ATP5Schr14

50801121

-TNS3chr7

47314978

+
intron-intronENST00000358473ENST00000442536ATP5Schr14

50801121

-TNS3chr7

47314978

+
intron-intronENST00000358473ENST00000458317ATP5Schr14

50801121

-TNS3chr7

47314978

+
intron-intronENST00000358473ENST00000474346ATP5Schr14

50801121

-TNS3chr7

47314978

+

Top

FusionProtFeatures for ATP5S_TNS3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ATP5S

Q99766

TNS3

Q68CZ2

Involved in regulation of mitochondrial membrane ATPsynthase. Necessary for H(+) conduction of ATP synthase.Facilitates energy-driven catalysis of ATP synthesis by blocking aproton leak through an alternative proton exit pathway (Bysimilarity). {ECO:0000250}. May play a role in actin remodeling. Involved in thedissociation of the integrin-tensin-actin complex. EGF activatesTNS4 and down-regulates TNS3 which results in capping the tail ofITGB1. Seems to be involved in mammary cell migration. May beinvolved in cell migration and bone development (By similarity).{ECO:0000250, ECO:0000269|PubMed:17643115}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for ATP5S_TNS3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for ATP5S_TNS3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for ATP5S_TNS3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for ATP5S_TNS3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource