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Fusion gene ID: 34189 |
FusionGeneSummary for SLC25A16_NDUFA9 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SLC25A16_NDUFA9 | Fusion gene ID: 34189 | Hgene | Tgene | Gene symbol | SLC25A16 | NDUFA9 | Gene ID | 8034 | 4704 |
| Gene name | solute carrier family 25 member 16 | NADH:ubiquinone oxidoreductase subunit A9 | |
| Synonyms | D10S105E|GDA|GDC|HGT.1|ML7|hML7 | CC6|CI-39k|CI39k|NDUFS2L|SDR22E1 | |
| Cytomap | 10q21.3 | 12p13.32 | |
| Type of gene | protein-coding | protein-coding | |
| Description | graves disease carrier proteinmitochondrial solute carrier protein homologsolute carrier family 25 (mitochondrial carrier; Graves disease autoantigen), member 16 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrialCI-39kDNADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDaNADH dehydrogenase (ubiquinone) Fe-S protein 2-like (NADH-coenzyme Q reductase)NADH-ubiquinone oxidoreductase | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | P16260 | Q16795 | |
| Ensembl transtripts involved in fusion gene | ENST00000609923, ENST00000539557, ENST00000265870, | ENST00000266544, ENST00000542369, ENST00000540688, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 2 X 2 X 2=8 |
| # samples | 2 | 2 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: SLC25A16 [Title/Abstract] AND NDUFA9 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | NDUFA9 | GO:0007623 | circadian rhythm | 28985504 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUSC | TCGA-94-A4VJ-01A | SLC25A16 | chr10 | 70246901 | - | NDUFA9 | chr12 | 4791371 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000609923 | ENST00000266544 | SLC25A16 | chr10 | 70246901 | - | NDUFA9 | chr12 | 4791371 | + |
| 5CDS-intron | ENST00000609923 | ENST00000542369 | SLC25A16 | chr10 | 70246901 | - | NDUFA9 | chr12 | 4791371 | + |
| 5CDS-intron | ENST00000609923 | ENST00000540688 | SLC25A16 | chr10 | 70246901 | - | NDUFA9 | chr12 | 4791371 | + |
| Frame-shift | ENST00000539557 | ENST00000266544 | SLC25A16 | chr10 | 70246901 | - | NDUFA9 | chr12 | 4791371 | + |
| 5CDS-intron | ENST00000539557 | ENST00000542369 | SLC25A16 | chr10 | 70246901 | - | NDUFA9 | chr12 | 4791371 | + |
| 5CDS-intron | ENST00000539557 | ENST00000540688 | SLC25A16 | chr10 | 70246901 | - | NDUFA9 | chr12 | 4791371 | + |
| 5UTR-3CDS | ENST00000265870 | ENST00000266544 | SLC25A16 | chr10 | 70246901 | - | NDUFA9 | chr12 | 4791371 | + |
| 5UTR-intron | ENST00000265870 | ENST00000542369 | SLC25A16 | chr10 | 70246901 | - | NDUFA9 | chr12 | 4791371 | + |
| 5UTR-intron | ENST00000265870 | ENST00000540688 | SLC25A16 | chr10 | 70246901 | - | NDUFA9 | chr12 | 4791371 | + |
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FusionProtFeatures for SLC25A16_NDUFA9 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SLC25A16 | NDUFA9 |
| Required for the accumulation of coenzyme A in themitochondrial matrix. {ECO:0000269|PubMed:11158296}. | Accessory subunit of the mitochondrial membranerespiratory chain NADH dehydrogenase (Complex I), that is believednot to be involved in catalysis. Complex I functions in thetransfer of electrons from NADH to the respiratory chain. Theimmediate electron acceptor for the enzyme is believed to beubiquinone. {ECO:0000269|PubMed:22114105,ECO:0000269|PubMed:27626371}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | SLC25A16 | chr10:70246901 | chr12:4791371 | ENST00000609923 | - | 8 | 9 | 128_216 | 280 | 333 | Repeat | Note=Solcar 2 |
| Hgene | SLC25A16 | chr10:70246901 | chr12:4791371 | ENST00000609923 | - | 8 | 9 | 34_120 | 280 | 333 | Repeat | Note=Solcar 1 |
| Hgene | SLC25A16 | chr10:70246901 | chr12:4791371 | ENST00000609923 | - | 8 | 9 | 134_154 | 280 | 333 | Transmembrane | Helical%3B Name%3D3 |
| Hgene | SLC25A16 | chr10:70246901 | chr12:4791371 | ENST00000609923 | - | 8 | 9 | 191_211 | 280 | 333 | Transmembrane | Helical%3B Name%3D4 |
| Hgene | SLC25A16 | chr10:70246901 | chr12:4791371 | ENST00000609923 | - | 8 | 9 | 244_264 | 280 | 333 | Transmembrane | Helical%3B Name%3D5 |
| Hgene | SLC25A16 | chr10:70246901 | chr12:4791371 | ENST00000609923 | - | 8 | 9 | 37_57 | 280 | 333 | Transmembrane | Helical%3B Name%3D1 |
| Hgene | SLC25A16 | chr10:70246901 | chr12:4791371 | ENST00000609923 | - | 8 | 9 | 88_108 | 280 | 333 | Transmembrane | Helical%3B Name%3D2 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >SLC25A16 | chr10:70246901 | chr12:4791371 | ENST00000609923 | - | 8 | 9 | 238_328 | 280 | 333 | Repeat | Note=Solcar 3 |
| Hgene | >SLC25A16 | chr10:70246901 | chr12:4791371 | ENST00000609923 | - | 8 | 9 | 299_319 | 280 | 333 | Transmembrane | Helical%3B Name%3D6 |
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FusionGeneSequence for SLC25A16_NDUFA9 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_SLC25A16_ENST00000609923_chr10_70246901_-_NDUFA9_ENST00000266544_chr12_4791371_+_392aa MAAATAAAALAAADPPPAMPQAAGAGGPTTRRDFYWLRSFLAGGIAGCCAKTTVAPLDRVKVLLQAHNHHYKHLGVFSALRAVPQKEGFL GLYKGNGAMMIRIFPYGAIQFMAFEHYKTLITTKLGISGHVHRLMAGSMAGMTAVICTYPLDMVRVRLAFQVKGEHSYTGIIHAFKTIYA KEGGFFGFYRGLMPTILGMAPYAGVSFFTFGTLKSVGLSHAPTLLGRPSSDNPNVLVLKTHVNLLCGGVAGAIAQTISYPFDVTRRRMQL GTVLPEFEKCLPSRYLLFHLVKYIFAVAHRLFLPFPLPLFAYRWVARVFEISPFEPWITRDKVERMHITDMKLPHLPGLEDLGIQATPLE |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_SLC25A16_ENST00000609923_chr10_70246901_-_NDUFA9_ENST00000266544_chr12_4791371_+_1176nt ATGGCGGCGGCGACGGCCGCGGCAGCCCTGGCGGCGGCCGATCCCCCTCCCGCAATGCCGCAGGCGGCAGGGGCCGGAGGGCCCACAACC CGCAGAGACTTCTACTGGCTGCGCTCCTTTCTGGCCGGAGGTATTGCTGGATGCTGTGCCAAAACAACAGTTGCTCCATTGGATCGAGTA AAGGTTTTATTACAAGCTCACAATCACCATTACAAGCATTTAGGAGTATTTTCTGCATTGCGTGCTGTTCCTCAAAAAGAAGGATTCCTT GGATTGTATAAAGGAAATGGTGCAATGATGATTCGAATCTTTCCCTATGGTGCAATCCAGTTTATGGCATTTGAGCATTATAAAACGTTA ATTACTACGAAGCTGGGAATTTCAGGTCATGTGCACAGATTAATGGCTGGATCCATGGCAGGTATGACAGCAGTTATCTGTACTTACCCT CTTGACATGGTTAGGGTCCGCCTAGCATTCCAGGTGAAAGGGGAACACAGCTATACAGGAATTATTCATGCTTTCAAAACAATTTATGCA AAGGAAGGTGGTTTCTTTGGATTTTACAGAGGTCTGATGCCTACTATTTTAGGAATGGCTCCATATGCAGGTGTTTCATTTTTTACTTTT GGTACCTTGAAGAGTGTTGGGCTTTCCCATGCTCCTACCCTTCTTGGCAGACCTTCATCAGACAATCCTAATGTCTTAGTTTTGAAAACT CATGTAAACTTACTTTGTGGTGGTGTTGCTGGAGCAATAGCGCAGACAATATCCTACCCATTTGATGTGACTCGTCGGCGAATGCAATTA GGAACTGTTCTGCCGGAATTTGAAAAGTGCCTTCCCAGTCGGTACCTCCTTTTCCACCTGGTGAAGTACATCTTTGCTGTGGCTCACAGA TTGTTCCTCCCATTCCCCTTGCCGCTTTTTGCCTATCGATGGGTAGCAAGAGTCTTTGAAATAAGCCCATTTGAGCCCTGGATAACAAGG GATAAAGTGGAGCGGATGCACATCACAGACATGAAATTGCCTCACCTGCCTGGCTTAGAAGACCTTGGTATTCAGGCAACACCACTGGAA CTCAAGGCCATTGAGGTGCTGCGGCGTCATCGCACTTACCGCTGGCTGTCTGCTGAAATTGAGGATGTGAAGCCGGCCAAGACCGTCAAC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_SLC25A16_ENST00000609923_chr10_70246901_-_NDUFA9_ENST00000266544_chr12_4791371_+_3455nt GCGGGGCGGTCAGCCTCCTGTCACCGCCTGTTCCGGCTATGGTCCCGTCCGGTGTTCTGTAAGTTGGCAACCTAGGCTCCTGACGCGACC CTGGTCCTGATGGCGGCGGCGACGGCCGCGGCAGCCCTGGCGGCGGCCGATCCCCCTCCCGCAATGCCGCAGGCGGCAGGGGCCGGAGGG CCCACAACCCGCAGAGACTTCTACTGGCTGCGCTCCTTTCTGGCCGGAGGTATTGCTGGATGCTGTGCCAAAACAACAGTTGCTCCATTG GATCGAGTAAAGGTTTTATTACAAGCTCACAATCACCATTACAAGCATTTAGGAGTATTTTCTGCATTGCGTGCTGTTCCTCAAAAAGAA GGATTCCTTGGATTGTATAAAGGAAATGGTGCAATGATGATTCGAATCTTTCCCTATGGTGCAATCCAGTTTATGGCATTTGAGCATTAT AAAACGTTAATTACTACGAAGCTGGGAATTTCAGGTCATGTGCACAGATTAATGGCTGGATCCATGGCAGGTATGACAGCAGTTATCTGT ACTTACCCTCTTGACATGGTTAGGGTCCGCCTAGCATTCCAGGTGAAAGGGGAACACAGCTATACAGGAATTATTCATGCTTTCAAAACA ATTTATGCAAAGGAAGGTGGTTTCTTTGGATTTTACAGAGGTCTGATGCCTACTATTTTAGGAATGGCTCCATATGCAGGTGTTTCATTT TTTACTTTTGGTACCTTGAAGAGTGTTGGGCTTTCCCATGCTCCTACCCTTCTTGGCAGACCTTCATCAGACAATCCTAATGTCTTAGTT TTGAAAACTCATGTAAACTTACTTTGTGGTGGTGTTGCTGGAGCAATAGCGCAGACAATATCCTACCCATTTGATGTGACTCGTCGGCGA ATGCAATTAGGAACTGTTCTGCCGGAATTTGAAAAGTGCCTTCCCAGTCGGTACCTCCTTTTCCACCTGGTGAAGTACATCTTTGCTGTG GCTCACAGATTGTTCCTCCCATTCCCCTTGCCGCTTTTTGCCTATCGATGGGTAGCAAGAGTCTTTGAAATAAGCCCATTTGAGCCCTGG ATAACAAGGGATAAAGTGGAGCGGATGCACATCACAGACATGAAATTGCCTCACCTGCCTGGCTTAGAAGACCTTGGTATTCAGGCAACA CCACTGGAACTCAAGGCCATTGAGGTGCTGCGGCGTCATCGCACTTACCGCTGGCTGTCTGCTGAAATTGAGGATGTGAAGCCGGCCAAG ACCGTCAACATTTAGTGCCTCCTGAGCAGCTCTTGGTTTTGGCGTCTTTTGGGTCGGCCCATGTGGTTTGAGCACCCAGCCAGGCGGTCT CTTTAGAGGATCCTGTACACAGTTCCACTATTAAAACATTTCAGGTTGAATTCTGCAGTATTTTCTTCCTTGATTTACAAAATGAGAAAT GTAGTCACTTAGAACTTGAGCATGATTTTTGTTAAACATATTTAATAATGATATATATACTATTTATTCTCTGAAATGCCAGAGAGTTTG AATTTTCCTATGACAAACCACTTCTAGCATACGTTCTAGAAGACAAGGACCCTTTTTAATGTCAAAGTATTGTAAAGACCCCAAGTGATA TGTGATTGTTTTTTAATTTCCATTAAATGAGAGAGCATACAGTATCCCCTAACCTGAATGTGTTTACACTGAAGGTGTTTTTAAAATTTA TTTTAATAATGTCCATATGCCTTTTAAAAATAGTAGTACATATATAGAAAAACATTGTCCATAGATTCTCAAACCCCTTGCAGTAATTCC ACAGTCTTCTTGGATCTGAGCTATCTGAGGCCAGCCCGATGCCCTTAGTACCACATCTGGATTATTTCAGACACATAGGTGGAGATAGAT TCTCTTCACATGCAAAGGAGATGCTTCAGCTTCTATGCCAGCAGTGCCAGCACTTAGGAATTATGACCTTCTAATGAAGTTCTTAAAATT GCAGCCAAGACCCAGATGAACATTTGGTTTAGTGTTGGCAAATCCCACCAGTACAGTGTGATTTAAAACTCCCACAATTTGTGGTGAAGC CAACATACCACCATCCTAGGTGACCCAGGGTTGGTCATTGTGTTTCACTGGACTTCAGCCTCCTGATCTATATTTGGGACAGGGATGTCA GTAAAAACGCTGTTTGATGAGGGAATGCCCGTCTCCTTACAGAGAGAAAGGTATATCAGTGTTGAAGGTAAGTTCTCCACCTGCCCTTTC TGCCTGCATCAGAATCTTTTTATCCCAAAACGGTCAACAGTGAGCTACTCCAAGTGTGGTCCATAGATCACCAGCATTGGGATCATCTTG GGGCTTGTTAGAAATGCAGAACCCGGGCTGGGCACAGTGGCTCACACCTGTAATCCCAACGCTTTTGAGTTGCTGTGGTGGGACGGTCGC TTGAGGCCAGGAGTTTGAGACCAGCCTAGGCAATATGGCAAGACCTTGTCTCTACAGAAAAATTTCAAAAAGTTAGTAGGGCATGGTGGC ACGCACCTGTAGTCTCAGTTATTCGGGAGGCTAAGGTATGATGATTGCTTGAGCCTGGGAGTTCAAGGTTACAGTGAGCTATGATAGTGC CACTGCACTTCAGCTTGGACTGAAGATCCTGTCTCAGAAAAAAAAAAAAAAAAAGGCAGAATCCTAGGTTTTGTCCTGTCCCAGGCGTGT TGAATCAGAATCTGCATTTTAGCAAGGTCTCCAGGAGATTTGTATGCACATTACAGTATGAGAAGCACTGCCATACAGAAGAGCTGTATC AGAGTTCAGTGTGATCCCTGTTATTAATCCAGGTTGCTGACCCCACCCCAGACCTACTGAATCAGAGTCTCAGGAAGGAGGGCCCAGGAA TTTTAGTTTTATTAAACATTCTAGTTTATTCTCCTGTACACTAGTATGTCAGAATCAGCGTACTAGGGAAAGGAACACAAACCCAACTTC ACGTTTTTTCTTCAGATGCTGTCTGTTATTTTGGATGACACCCCTCCTGGCCATAAGCCAGCCATTAGGCACAGAGATGGGTGGATTTAA TTTGAAAAGGAACTATAATTCTATAATGCACAGTGTCCTCTCTTAGAATATCTACACTTTCTTTCCTTTTTTTGATTCTTAAAAAAAAAC TTATTGATACATAATAGATGTAAATATTGTCAGGGTATATGTGGTAATTTGATATATTCATATAATCAATCAGTGTAATTGGGATATCCA TCACCTTAAACATTTACCTTTATGCTAGTAACATTCAAATTACTCTCTTCTAGCTATTTTGAAATGTACAGTAGATTAGTATTAACTCTA GTTACCCTACTGATCTATTGAACACCAGGTCTTACTTCTTCTGTCTTAACTGTAATTATCTTCATTTTCTAGCAATGCTATTTCTCATCT |
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FusionGenePPI for SLC25A16_NDUFA9 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| SLC25A16 | HLA-DRA, C4BPB, HLA-DPA1, NRG1, RNF126, TXNDC15, SDF4, DTNBP1, ITGB8, FAF2, CNDP1, DKK3, SYP, TOR1AIP2, PDCD1, CD79B, FAM131B, TPP1, EDEM2, PPP6R2 | NDUFA9 | TSC22D1, ICT1, MME, NDUFS3, NDUFS1, NDUFV1, NDUFA12, NDUFB8, DLD, ELAVL1, HLA-B, SDHB, NNT, OPA1, IMMT, ABCC2, COX15, FN1, FBXO6, RNF2, EGFR, NDUFA8, NTRK1, AFG3L2, ATP6V1C1, IQGAP1, NDUFA6, ATP1B3, ATP5F1, GMDS, NDUFB9, UQCRC2, UQCRFS1, VDAC1, VDAC2, VDAC3, YBX1, YBX3, NDUFB10, SSR1, KRAS, TCTN3, NDUFS4, NDUFS7, NDUFS5, NDUFA11, EMC8, NDUFS6, ND5, NDUFV3, NDUFV2, CYTB, NDUFB4, NDUFA2, NDUFS2, NDUFB3, UQCR10, NDUFA5, NDUFB5, NDUFB11, NDUFA7, NDUFA10, MCU, NDUFAB1, NDUFB7, NDUFS8, NDUFB1, NDUFA13, TIMMDC1, CLTC, VAPA, GOLT1B, GTSE1, NDUFA4, C15orf48, COX6B1, OCIAD1, COA3, EYA2, MTM1, PTPN21, PTPN22, SOAT1, ACAP2, PIGS |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SLC25A16_NDUFA9 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SLC25A16_NDUFA9 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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