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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 34186

FusionGeneSummary for SLC25A14_BCORL1

check button Fusion gene summary
Fusion gene informationFusion gene name: SLC25A14_BCORL1
Fusion gene ID: 34186
HgeneTgene
Gene symbol

SLC25A14

BCORL1

Gene ID

9016

63035

Gene namesolute carrier family 25 member 14BCL6 corepressor like 1
SynonymsBMCP1|UCP5BCoR-L1|CXorf10
Cytomap

Xq26.1

Xq26.1

Type of geneprotein-codingprotein-coding
Descriptionbrain mitochondrial carrier protein 1mitochondrial uncoupling protein 5BCL-6 corepressor-like protein 1BCoR-like protein 1
Modification date2018052320180519
UniProtAcc

O95258

Q5H9F3

Ensembl transtripts involved in fusion geneENST00000543953, ENST00000218197, 
ENST00000467496, ENST00000339231, 
ENST00000361980, ENST00000545805, 
ENST00000607874, ENST00000218147, 
ENST00000359304, ENST00000303743, 
ENST00000540052, 
Fusion gene scores* DoF score1 X 1 X 1=13 X 3 X 2=18
# samples 13
** MAII scorelog2(1/1*10)=3.32192809488736log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SLC25A14 [Title/Abstract] AND BCORL1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVUCECTCGA-PG-A915-01ASLC25A14chrX

129484705

+BCORL1chrX

129184692

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000543953ENST00000607874SLC25A14chrX

129484705

+BCORL1chrX

129184692

+
5CDS-intronENST00000543953ENST00000218147SLC25A14chrX

129484705

+BCORL1chrX

129184692

+
5CDS-intronENST00000543953ENST00000359304SLC25A14chrX

129484705

+BCORL1chrX

129184692

+
5CDS-intronENST00000543953ENST00000303743SLC25A14chrX

129484705

+BCORL1chrX

129184692

+
5CDS-intronENST00000543953ENST00000540052SLC25A14chrX

129484705

+BCORL1chrX

129184692

+
5CDS-intronENST00000218197ENST00000607874SLC25A14chrX

129484705

+BCORL1chrX

129184692

+
5CDS-intronENST00000218197ENST00000218147SLC25A14chrX

129484705

+BCORL1chrX

129184692

+
5CDS-intronENST00000218197ENST00000359304SLC25A14chrX

129484705

+BCORL1chrX

129184692

+
5CDS-intronENST00000218197ENST00000303743SLC25A14chrX

129484705

+BCORL1chrX

129184692

+
5CDS-intronENST00000218197ENST00000540052SLC25A14chrX

129484705

+BCORL1chrX

129184692

+
3UTR-intronENST00000467496ENST00000607874SLC25A14chrX

129484705

+BCORL1chrX

129184692

+
3UTR-intronENST00000467496ENST00000218147SLC25A14chrX

129484705

+BCORL1chrX

129184692

+
3UTR-intronENST00000467496ENST00000359304SLC25A14chrX

129484705

+BCORL1chrX

129184692

+
3UTR-intronENST00000467496ENST00000303743SLC25A14chrX

129484705

+BCORL1chrX

129184692

+
3UTR-intronENST00000467496ENST00000540052SLC25A14chrX

129484705

+BCORL1chrX

129184692

+
5CDS-intronENST00000339231ENST00000607874SLC25A14chrX

129484705

+BCORL1chrX

129184692

+
5CDS-intronENST00000339231ENST00000218147SLC25A14chrX

129484705

+BCORL1chrX

129184692

+
5CDS-intronENST00000339231ENST00000359304SLC25A14chrX

129484705

+BCORL1chrX

129184692

+
5CDS-intronENST00000339231ENST00000303743SLC25A14chrX

129484705

+BCORL1chrX

129184692

+
5CDS-intronENST00000339231ENST00000540052SLC25A14chrX

129484705

+BCORL1chrX

129184692

+
5CDS-intronENST00000361980ENST00000607874SLC25A14chrX

129484705

+BCORL1chrX

129184692

+
5CDS-intronENST00000361980ENST00000218147SLC25A14chrX

129484705

+BCORL1chrX

129184692

+
5CDS-intronENST00000361980ENST00000359304SLC25A14chrX

129484705

+BCORL1chrX

129184692

+
5CDS-intronENST00000361980ENST00000303743SLC25A14chrX

129484705

+BCORL1chrX

129184692

+
5CDS-intronENST00000361980ENST00000540052SLC25A14chrX

129484705

+BCORL1chrX

129184692

+
5CDS-intronENST00000545805ENST00000607874SLC25A14chrX

129484705

+BCORL1chrX

129184692

+
5CDS-intronENST00000545805ENST00000218147SLC25A14chrX

129484705

+BCORL1chrX

129184692

+
5CDS-intronENST00000545805ENST00000359304SLC25A14chrX

129484705

+BCORL1chrX

129184692

+
5CDS-intronENST00000545805ENST00000303743SLC25A14chrX

129484705

+BCORL1chrX

129184692

+
5CDS-intronENST00000545805ENST00000540052SLC25A14chrX

129484705

+BCORL1chrX

129184692

+

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FusionProtFeatures for SLC25A14_BCORL1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SLC25A14

O95258

BCORL1

Q5H9F3

Participates in the mitochondrial proton leak measuredin brain mitochondria. Transcriptional corepressor. May specifically inhibitgene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6. This repression may bemediated at least in part by histone deacetylase activities whichcan associate with this corepressor.{ECO:0000269|PubMed:17379597}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SLC25A14_BCORL1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SLC25A14_BCORL1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SLC25A14BTN2A1, VSIG4, CD79B, IMPDH1, POLR3E, LAMP3, MUC20, TOR1AIP2BCORL1CTBP1, HDAC4, HDAC5, HDAC7, PCGF1, PCGF3, RNF2, RYBP, YAF2, FBL, KRAS, HIST1H2BG, EWSR1, USP7, LDHD, PCGF6, PCGF2, BAG4


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SLC25A14_BCORL1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SLC25A14_BCORL1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneBCORL1C0010606Adenoid Cystic Carcinoma1CTD_human