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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 34168

FusionGeneSummary for SLC24A3_MACROD2

check button Fusion gene summary
Fusion gene informationFusion gene name: SLC24A3_MACROD2
Fusion gene ID: 34168
HgeneTgene
Gene symbol

SLC24A3

MACROD2

Gene ID

57419

140733

Gene namesolute carrier family 24 member 3MACRO domain containing 2
SynonymsNCKX3C20orf133|C2orf133
Cytomap

20p11.23

20p12.1

Type of geneprotein-codingprotein-coding
Descriptionsodium/potassium/calcium exchanger 3Na(+)/K(+)/Ca(2+)-exchange protein 3sodium calcium exchangersolute carrier family 24 (sodium/potassium/calcium exchanger), member 3O-acetyl-ADP-ribose deacetylase MACROD2MACRO domain-containing protein 2[Protein ADP-ribosylglutamate] hydrolase
Modification date2018052320180519
UniProtAcc

Q9HC58

A1Z1Q3

Ensembl transtripts involved in fusion geneENST00000328041, ENST00000217246, 
ENST00000310348, ENST00000464883, 
ENST00000402914, ENST00000378058, 
ENST00000407045, 
Fusion gene scores* DoF score4 X 3 X 4=4819 X 14 X 11=2926
# samples 419
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(19/2926*10)=-3.94485844580754
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SLC24A3 [Title/Abstract] AND MACROD2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMACROD2

GO:0042278

purine nucleoside metabolic process

21257746

TgeneMACROD2

GO:0051725

protein de-ADP-ribosylation

23474712


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUSCTCGA-98-8021-01ASLC24A3chr20

19566188

+MACROD2chr20

15843390

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000328041ENST00000217246SLC24A3chr20

19566188

+MACROD2chr20

15843390

+
In-frameENST00000328041ENST00000310348SLC24A3chr20

19566188

+MACROD2chr20

15843390

+
5CDS-intronENST00000328041ENST00000464883SLC24A3chr20

19566188

+MACROD2chr20

15843390

+
5CDS-5UTRENST00000328041ENST00000402914SLC24A3chr20

19566188

+MACROD2chr20

15843390

+
5CDS-intronENST00000328041ENST00000378058SLC24A3chr20

19566188

+MACROD2chr20

15843390

+
5CDS-intronENST00000328041ENST00000407045SLC24A3chr20

19566188

+MACROD2chr20

15843390

+

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FusionProtFeatures for SLC24A3_MACROD2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SLC24A3

Q9HC58

MACROD2

A1Z1Q3

Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+).{ECO:0000250}. Removes ADP-ribose from glutamate residues in proteinsbearing a single ADP-ribose moiety. Inactive towards proteinsbearing poly-ADP-ribose. Deacetylates O-acetyl-ADP ribose, asignaling molecule generated by the deacetylation of acetylatedlysine residues in histones and other proteins.{ECO:0000269|PubMed:21257746, ECO:0000269|PubMed:23474712}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSLC24A3chr20:19566188chr20:15843390ENST00000328041+617149_189204645RepeatNote=Alpha-1
HgeneSLC24A3chr20:19566188chr20:15843390ENST00000328041+617129_153204645Topological domainCytoplasmic
HgeneSLC24A3chr20:19566188chr20:15843390ENST00000328041+617175_182204645Topological domainExtracellular
HgeneSLC24A3chr20:19566188chr20:15843390ENST00000328041+61745_107204645Topological domainExtracellular
HgeneSLC24A3chr20:19566188chr20:15843390ENST00000328041+617108_128204645TransmembraneHelical
HgeneSLC24A3chr20:19566188chr20:15843390ENST00000328041+617154_174204645TransmembraneHelical
HgeneSLC24A3chr20:19566188chr20:15843390ENST00000328041+617183_203204645TransmembraneHelical
TgeneMACROD2chr20:19566188chr20:15843390ENST00000217246+717247_388215426Compositional biasNote=Glu-rich
TgeneMACROD2chr20:19566188chr20:15843390ENST00000310348+718247_388215449Compositional biasNote=Glu-rich
TgeneMACROD2chr20:19566188chr20:15843390ENST00000378058+010247_3880214Compositional biasNote=Glu-rich
TgeneMACROD2chr20:19566188chr20:15843390ENST00000378058+0106_90214Compositional biasNote=Poly-Lys
TgeneMACROD2chr20:19566188chr20:15843390ENST00000402914+314247_388-20214Compositional biasNote=Glu-rich
TgeneMACROD2chr20:19566188chr20:15843390ENST00000402914+3146_9-20214Compositional biasNote=Poly-Lys
TgeneMACROD2chr20:19566188chr20:15843390ENST00000407045+06247_388-7999Compositional biasNote=Glu-rich
TgeneMACROD2chr20:19566188chr20:15843390ENST00000407045+066_9-7999Compositional biasNote=Poly-Lys
TgeneMACROD2chr20:19566188chr20:15843390ENST00000378058+01059_2400214DomainMacro
TgeneMACROD2chr20:19566188chr20:15843390ENST00000402914+31459_240-20214DomainMacro
TgeneMACROD2chr20:19566188chr20:15843390ENST00000407045+0659_240-7999DomainMacro
TgeneMACROD2chr20:19566188chr20:15843390ENST00000378058+010185_1910214RegionNote=Substrate binding
TgeneMACROD2chr20:19566188chr20:15843390ENST00000378058+01077_790214RegionNote=Substrate binding
TgeneMACROD2chr20:19566188chr20:15843390ENST00000378058+01090_920214RegionNote=Substrate binding
TgeneMACROD2chr20:19566188chr20:15843390ENST00000378058+01097_1020214RegionNote=Substrate binding
TgeneMACROD2chr20:19566188chr20:15843390ENST00000402914+314185_191-20214RegionNote=Substrate binding
TgeneMACROD2chr20:19566188chr20:15843390ENST00000402914+31477_79-20214RegionNote=Substrate binding
TgeneMACROD2chr20:19566188chr20:15843390ENST00000402914+31490_92-20214RegionNote=Substrate binding
TgeneMACROD2chr20:19566188chr20:15843390ENST00000402914+31497_102-20214RegionNote=Substrate binding
TgeneMACROD2chr20:19566188chr20:15843390ENST00000407045+06185_191-7999RegionNote=Substrate binding
TgeneMACROD2chr20:19566188chr20:15843390ENST00000407045+0677_79-7999RegionNote=Substrate binding
TgeneMACROD2chr20:19566188chr20:15843390ENST00000407045+0690_92-7999RegionNote=Substrate binding
TgeneMACROD2chr20:19566188chr20:15843390ENST00000407045+0697_102-7999RegionNote=Substrate binding

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSLC24A3chr20:19566188chr20:15843390ENST00000328041+617422_428204645Compositional biasNote=Poly-Glu
HgeneSLC24A3chr20:19566188chr20:15843390ENST00000328041+617518_549204645RepeatNote=Alpha-2
HgeneSLC24A3chr20:19566188chr20:15843390ENST00000328041+617204_210204645Topological domainCytoplasmic
HgeneSLC24A3chr20:19566188chr20:15843390ENST00000328041+617232_234204645Topological domainExtracellular
HgeneSLC24A3chr20:19566188chr20:15843390ENST00000328041+617256_484204645Topological domainCytoplasmic
HgeneSLC24A3chr20:19566188chr20:15843390ENST00000328041+617506_510204645Topological domainExtracellular
HgeneSLC24A3chr20:19566188chr20:15843390ENST00000328041+617532_549204645Topological domainCytoplasmic
HgeneSLC24A3chr20:19566188chr20:15843390ENST00000328041+617571_580204645Topological domainExtracellular
HgeneSLC24A3chr20:19566188chr20:15843390ENST00000328041+617602_615204645Topological domainCytoplasmic
HgeneSLC24A3chr20:19566188chr20:15843390ENST00000328041+617637_644204645Topological domainExtracellular
HgeneSLC24A3chr20:19566188chr20:15843390ENST00000328041+617211_231204645TransmembraneHelical
HgeneSLC24A3chr20:19566188chr20:15843390ENST00000328041+617235_255204645TransmembraneHelical
HgeneSLC24A3chr20:19566188chr20:15843390ENST00000328041+617485_505204645TransmembraneHelical
HgeneSLC24A3chr20:19566188chr20:15843390ENST00000328041+617511_531204645TransmembraneHelical
HgeneSLC24A3chr20:19566188chr20:15843390ENST00000328041+617550_570204645TransmembraneHelical
HgeneSLC24A3chr20:19566188chr20:15843390ENST00000328041+617581_601204645TransmembraneHelical
HgeneSLC24A3chr20:19566188chr20:15843390ENST00000328041+617616_636204645TransmembraneHelical
TgeneMACROD2chr20:19566188chr20:15843390ENST00000217246+7176_9215426Compositional biasNote=Poly-Lys
TgeneMACROD2chr20:19566188chr20:15843390ENST00000310348+7186_9215449Compositional biasNote=Poly-Lys
TgeneMACROD2chr20:19566188chr20:15843390ENST00000217246+71759_240215426DomainMacro
TgeneMACROD2chr20:19566188chr20:15843390ENST00000310348+71859_240215449DomainMacro
TgeneMACROD2chr20:19566188chr20:15843390ENST00000217246+717185_191215426RegionNote=Substrate binding
TgeneMACROD2chr20:19566188chr20:15843390ENST00000217246+71777_79215426RegionNote=Substrate binding
TgeneMACROD2chr20:19566188chr20:15843390ENST00000217246+71790_92215426RegionNote=Substrate binding
TgeneMACROD2chr20:19566188chr20:15843390ENST00000217246+71797_102215426RegionNote=Substrate binding
TgeneMACROD2chr20:19566188chr20:15843390ENST00000310348+718185_191215449RegionNote=Substrate binding
TgeneMACROD2chr20:19566188chr20:15843390ENST00000310348+71877_79215449RegionNote=Substrate binding
TgeneMACROD2chr20:19566188chr20:15843390ENST00000310348+71890_92215449RegionNote=Substrate binding
TgeneMACROD2chr20:19566188chr20:15843390ENST00000310348+71897_102215449RegionNote=Substrate binding


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FusionGeneSequence for SLC24A3_MACROD2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_SLC24A3_ENST00000328041_chr20_19566188_+_MACROD2_ENST00000217246_chr20_15843390_+_415aa
MRPSGDEDRARRRRRRRRRRDLLLSQLCFLASVALLLWSLSSLREQKELDLMDLVGEDRKWMMARKLMQVNDTLTSEDAGLRNSKNCTEP
ALHEFPNDIFTNEDRRQGAVVLHVLCAIYMFYALAIVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSSAPELFTSVIGVFITKGDVGV
GTIVGSAVFNILCIIGVCGLFAGQVDRIIFCVFLEVDFKIYKKKMNEFFSVDDNNEEEEDVEMKEDSDENGPEEKQSVEEMEEQSQDADG
VNTVTVPGPASEEAVEDCKDEDFAKDENITKGGEVTDHSVRDQDHPDGQENDSTKNEIKIETESQSSYMETEELSSNQEDAVIVEQPEVI

>In-frame_SLC24A3_ENST00000328041_chr20_19566188_+_MACROD2_ENST00000310348_chr20_15843390_+_438aa
MRPSGDEDRARRRRRRRRRRDLLLSQLCFLASVALLLWSLSSLREQKELDLMDLVGEDRKWMMARKLMQVNDTLTSEDAGLRNSKNCTEP
ALHEFPNDIFTNEDRRQGAVVLHVLCAIYMFYALAIVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSSAPELFTSVIGVFITKGDVGV
GTIVGSAVFNILCIIGVCGLFAGQVDRIIFCVFLEVDFKIYKKKMNEFFSVDDNNEEEEDVEMKEDSDENGPEEKQSVEEMEEQSQDADG
VNTVTVPGPASEEAVEDCKDEDFAKDENITKGGEVTDHSVRDQDHPDGQENDSTKNEIKIETESQSSYMETEELSSNQEDAVIVEQPEVI


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_SLC24A3_ENST00000328041_chr20_19566188_+_MACROD2_ENST00000217246_chr20_15843390_+_1245nt
ATGCGGCCGTCCGGCGACGAGGACCGCGCGCGTCGCCGCCGCCGCCGCCGCCGCCGGAGGGACCTTCTGCTGAGCCAGCTCTGCTTCCTG
GCCTCGGTGGCGCTGCTGCTCTGGTCGCTGTCGAGCCTGCGAGAGCAGAAGGAGCTTGACCTCATGGACCTCGTAGGGGAAGACAGAAAG
TGGATGATGGCGAGGAAGCTGATGCAGGTGAACGACACTCTGACTTCCGAAGATGCCGGACTCCGGAACAGCAAGAACTGCACCGAACCA
GCCCTGCATGAATTCCCCAATGACATCTTCACAAACGAGGATAGAAGACAAGGTGCGGTGGTCCTCCATGTGCTCTGTGCCATATACATG
TTCTATGCGCTGGCCATTGTGTGTGATGACTTCTTCGTCCCTTCCTTGGAAAAGATCTGTGAGCGCCTGCACCTCAGTGAAGATGTGGCT
GGGGCCACATTCATGGCAGCGGGAAGTTCGGCCCCAGAGCTGTTCACATCGGTCATAGGGGTCTTCATCACCAAAGGCGATGTGGGAGTT
GGCACCATCGTGGGCTCAGCGGTATTCAACATCCTGTGCATCATTGGTGTCTGTGGGCTCTTTGCTGGGCAGGTGGATCGGATCATTTTC
TGTGTCTTCTTAGAAGTTGACTTCAAAATCTACAAAAAGAAAATGAATGAGTTTTTCTCCGTAGACGATAATAATGAAGAAGAAGAGGAT
GTTGAAATGAAAGAAGATTCAGATGAGAACGGTCCAGAGGAGAAGCAAAGTGTGGAAGAAATGGAAGAGCAGAGCCAAGATGCAGATGGT
GTCAACACTGTCACTGTGCCCGGCCCTGCTTCAGAAGAGGCAGTTGAAGACTGTAAAGATGAAGATTTTGCAAAGGATGAAAATATTACA
AAAGGCGGTGAAGTGACAGATCATTCTGTGCGTGACCAAGATCATCCCGATGGACAAGAGAATGATTCAACGAAGAATGAAATAAAAATT
GAAACAGAATCGCAGAGCTCATATATGGAAACAGAAGAACTTTCATCAAACCAAGAAGATGCCGTGATTGTGGAGCAACCAGAAGTGATT
CCATTAACAGAGGACCAAGAAGAAAAAGAAGGTGAAAAAGCTCCAGGCGAGGACACACCTAGGATGCCTGGGAAAAGTGAAGGCTCCAGT

>In-frame_SLC24A3_ENST00000328041_chr20_19566188_+_MACROD2_ENST00000310348_chr20_15843390_+_1314nt
ATGCGGCCGTCCGGCGACGAGGACCGCGCGCGTCGCCGCCGCCGCCGCCGCCGCCGGAGGGACCTTCTGCTGAGCCAGCTCTGCTTCCTG
GCCTCGGTGGCGCTGCTGCTCTGGTCGCTGTCGAGCCTGCGAGAGCAGAAGGAGCTTGACCTCATGGACCTCGTAGGGGAAGACAGAAAG
TGGATGATGGCGAGGAAGCTGATGCAGGTGAACGACACTCTGACTTCCGAAGATGCCGGACTCCGGAACAGCAAGAACTGCACCGAACCA
GCCCTGCATGAATTCCCCAATGACATCTTCACAAACGAGGATAGAAGACAAGGTGCGGTGGTCCTCCATGTGCTCTGTGCCATATACATG
TTCTATGCGCTGGCCATTGTGTGTGATGACTTCTTCGTCCCTTCCTTGGAAAAGATCTGTGAGCGCCTGCACCTCAGTGAAGATGTGGCT
GGGGCCACATTCATGGCAGCGGGAAGTTCGGCCCCAGAGCTGTTCACATCGGTCATAGGGGTCTTCATCACCAAAGGCGATGTGGGAGTT
GGCACCATCGTGGGCTCAGCGGTATTCAACATCCTGTGCATCATTGGTGTCTGTGGGCTCTTTGCTGGGCAGGTGGATCGGATCATTTTC
TGTGTCTTCTTAGAAGTTGACTTCAAAATCTACAAAAAGAAAATGAATGAGTTTTTCTCCGTAGACGATAATAATGAAGAAGAAGAGGAT
GTTGAAATGAAAGAAGATTCAGATGAGAACGGTCCAGAGGAGAAGCAAAGTGTGGAAGAAATGGAAGAGCAGAGCCAAGATGCAGATGGT
GTCAACACTGTCACTGTGCCCGGCCCTGCTTCAGAAGAGGCAGTTGAAGACTGTAAAGATGAAGATTTTGCAAAGGATGAAAATATTACA
AAAGGCGGTGAAGTGACAGATCATTCTGTGCGTGACCAAGATCATCCCGATGGACAAGAGAATGATTCAACGAAGAATGAAATAAAAATT
GAAACAGAATCGCAGAGCTCATATATGGAAACAGAAGAACTTTCATCAAACCAAGAAGATGCCGTGATTGTGGAGCAACCAGAAGTGATT
CCATTAACAGAGGACCAAGAAGAAAAAGAAGGTGAAAAAGCTCCAGGCGAGGACACACCTAGGATGCCTGGGAAAAGTGAAGGCTCCAGT
GACCTAGAAAATACTCCAGGTCCTGATGTTGAAATGAATAGTCAGGTTGACAAGGTAAATGACCCAACAGAGAGTCAACAAGAAGATCAA


* Fusion transcript sequences (Full-length transcript).
>In-frame_SLC24A3_ENST00000328041_chr20_19566188_+_MACROD2_ENST00000217246_chr20_15843390_+_4763nt
GCGACGAGGAGGGCGACGACGAGGAGACGGGCAGCGGCGAGGAGGAGGAAGAGGAGGCGGAGGCGGCGGCCGGGTGGGAGCGCAGCGAGG
ACGCGCGGCTGCTGCGCGCAGGGCTGCCTCCTGCCGCTGTCCCCGCCGCGGCCGCCCGCGACAGGAGCGGCCGCCGCCCGCCGAGGCCGC
CGCCCGGCCGCCCGAGGATGCGGCCGTCCGGCGACGAGGACCGCGCGCGTCGCCGCCGCCGCCGCCGCCGCCGGAGGGACCTTCTGCTGA
GCCAGCTCTGCTTCCTGGCCTCGGTGGCGCTGCTGCTCTGGTCGCTGTCGAGCCTGCGAGAGCAGAAGGAGCTTGACCTCATGGACCTCG
TAGGGGAAGACAGAAAGTGGATGATGGCGAGGAAGCTGATGCAGGTGAACGACACTCTGACTTCCGAAGATGCCGGACTCCGGAACAGCA
AGAACTGCACCGAACCAGCCCTGCATGAATTCCCCAATGACATCTTCACAAACGAGGATAGAAGACAAGGTGCGGTGGTCCTCCATGTGC
TCTGTGCCATATACATGTTCTATGCGCTGGCCATTGTGTGTGATGACTTCTTCGTCCCTTCCTTGGAAAAGATCTGTGAGCGCCTGCACC
TCAGTGAAGATGTGGCTGGGGCCACATTCATGGCAGCGGGAAGTTCGGCCCCAGAGCTGTTCACATCGGTCATAGGGGTCTTCATCACCA
AAGGCGATGTGGGAGTTGGCACCATCGTGGGCTCAGCGGTATTCAACATCCTGTGCATCATTGGTGTCTGTGGGCTCTTTGCTGGGCAGG
TGGATCGGATCATTTTCTGTGTCTTCTTAGAAGTTGACTTCAAAATCTACAAAAAGAAAATGAATGAGTTTTTCTCCGTAGACGATAATA
ATGAAGAAGAAGAGGATGTTGAAATGAAAGAAGATTCAGATGAGAACGGTCCAGAGGAGAAGCAAAGTGTGGAAGAAATGGAAGAGCAGA
GCCAAGATGCAGATGGTGTCAACACTGTCACTGTGCCCGGCCCTGCTTCAGAAGAGGCAGTTGAAGACTGTAAAGATGAAGATTTTGCAA
AGGATGAAAATATTACAAAAGGCGGTGAAGTGACAGATCATTCTGTGCGTGACCAAGATCATCCCGATGGACAAGAGAATGATTCAACGA
AGAATGAAATAAAAATTGAAACAGAATCGCAGAGCTCATATATGGAAACAGAAGAACTTTCATCAAACCAAGAAGATGCCGTGATTGTGG
AGCAACCAGAAGTGATTCCATTAACAGAGGACCAAGAAGAAAAAGAAGGTGAAAAAGCTCCAGGCGAGGACACACCTAGGATGCCTGGGA
AAAGTGAAGGCTCCAGTGACCTAGAAAATACTCCAGGTCCTGATGCAGGGGCACAAGATGAAGCGAAGGAACAAAGAAATGGAACTAAAT
GACAATCCTCAGCATCGCAAGGCCTCTCCTGGCTCTGGGGGAGCTCGGGAAGATAGCAGCACACGCTGTGGAGGAGGGTGGGGGTGGGGG
GAAGGCAAGTCCCATGGAAGGACGGGGAATCCTTTACTCTAATTTCTCCAGCTGCATTTTGTTCCGTTTATCTGCAGAAAAAGAAAGAAA
AAAAAGAAAAAAAAAGTTTCCTTTAATTTGGTGGAGGGACCCATGTTGACGCATCTTTCAGGCATTATCCTTGTAATTTCTGTCTTTTCT
CTTACAACTTTGCCCCAGGGTCACAGTGGCTTGATTGAACACTCACATGTGTATCCTGGCCCCTGTCTGCTTTCTTGGTTATTTCACAAA
GCTGGTCACACAGTGGTTTATTCAAAGGAAGGGGAGGAAGACAGTGGTTTGATAAGCTGCAGGATAAATTTTAGGAATCAATGAGCCCAG
CAGCAGTATAATCCCCAGACAGAGGAGGCAGGATAGAAAATGGGCAAAAGCCTCGGAAACCACTTGGAAAAGGTCTGGACAATGAGGTGA
AAATATTTTCTTCAGGGTTCCCAAGGCACAATTTGTTCCAAGTGGCTAATGAGAAATATGGAAGCTGAATTTTTTCCAGAGCAGAGTGCA
GAGGCATAACAGAAGGGTGGGCCCTGGCAGCCATCTGGGTCTCTTCCTTCCTAACCATGGTGGCAGGTGCATCCTTCTTTGACACTGACT
TTCAGCAGAGCTTACTTGGTTCATGAGGTCTTCACATGGAGACTACCAGCAAGAGGTGACTCTCTGCTGCATAACTGTAAAGGATGGCCC
TTTGCTAGGTGTTACAGTTAAAAGCTAAGAAAAGGGGCAGTGCATTTAGGACCCAAACATATGCCTATGAATATCAAAAGCTCCTCCTGA
AATTGCTGTGAGTTTTCCATAAAAGAATATCCTGTCTTCACCCAAGGCTTGACAGCCCACAGAGTGGTCTCATTTGAAATTACAGGAAAT
TAGAGCTTTTGCTTGCAGTTCTGCCTTCCTGGCCTGTGTTTAAATGCTGTCACTTGTTTATGCCAAGTTCAAGGCTGATTCAATGGTTGG
TCCCCTCACCCAGAAAACCCTGAAGGGGAGGATACAGCTCTGAAGGGGGGCAGCAGTACTAAAAACCCAAGATGCCAGTGGTATAGTGGG
CACAAGGGATGGCGACCATGAGGATGCCAGGCATCATCACCAATATCTATCCTAGAGCCAGTATAAGGCCAGATGCCTACTTCCCACAGC
CTCCCCGGGTTCCAAAGTCATGTCATTGTTTTCAGTGGAAACATATCGTTTGTTGCATATCTTCTTAAATCCATCTTCCTTGTAAGGGCT
TTAGAACTAAAACTTACTTATATTGTTTTTCCTTAACAGAGGGAGAAAAATAGTGGATTATTATTTCTAAAATAAAAGGATGTTCTGCTT
TCTAAATATCCCATCAAAATCTTCAGTTTTGCACTTTTTTGATGGAAAATTCATCTTATCTTCCTATGACTTTGGTTTTAGCCTTTCTGA
ATTTGTTACCCCTTCTGGATGGCTTATTTGATATACTGGAATAGTTAACAAGCTATACTTCAGCATATGCACTATATTCTAACAAATTTT
TTTTAATAAAATCAAGACATCAGCAAGAATGACATTTACGTGACCTCATAATGTGGGATTATGGCCTTCTGTTGCTATTCCAGTTTGATA
TGGAAGCATCTATATCCTCTATTGCCGTTAGATGTTGTTGCTTTTCAGAAAAGTAACGAAAAGGCTCATTTTAAAGAATCCAAGAAACGA
TGTCATCCAAATATTGACAGTTTCTACATTTCATGCCATCTTTATAACTCAATTGAAAGTTGCCGTCATTCTTGTGAAGTATTTGACAAG
TGCAATCTGCTAGAAGCTCGTTTTTCTTGTGACTCCCAAATGTTAGTGCTACTTAGCCTCAGTAATGAGTTACAGTTGAAAAAAACATGA
GGGAAACAGAGGGACAGAGATTTTCTAATGAACAATGATGGAAGAGACCTAATGTCCTTGCTAGAAACAGCCAGGATGGAAATTATCCAG
CCCTGGCATTCTCCTTATCATCAATGACAGTCATTTTATTCATTTATTTCAAATGTGGGTGGGCTAGAAGTGGAAGGAGGGAATTCTCTC
TGCCTAAAAATTCTAGAAGAATGAAAGTAATCTTTGTATCCAGGAAACTAAGAGAATGAGGAATAAATATCTTCAGCCCGACTCCTGAAT
TTGTTTATTCTTCCATCTATAATTAGATTGTGTTTTCATTTTTGCTTTGTCATGCTTTTTGGTTGTTATTTGGCTATACAGTTTTATGCT
TTAAAACAAATGATAAAGTTAATTTCCAATTCAATAGTGAAATATTAACAATCTAACTATAGCCAGATCAAAGACACCTGAACACAGAAA
ACCTTTATTTGCTGGTGCTGCCATTGCACAGGCTGTACAATGAAATAGATTTGAAAAGCTGATTGATTTTCCCGCACATAAATTCTGGAT
GTCAATTTCCAACCAAACTCCAATACAGCTATGTGGCATGAAGAGTTACAGGAGGGAGGGAGGAAAATAGCCCTATGTTAGTCATGTTTG
CATACAGAGGATCAAAGTAGGCCTTCACCATAATAGTTCTAATTAAAATGGTCCTCGCTGTAGGAGAGACAAAGGGGCTTTTCCTCTAGC
TGGTAACTATTCAGATGATGGACAAGTCTTCTTTCATAAAAGATTACAAAGAAGGCATCCGAATCACTGTCTGTGATACTGGGTCACATA
TTAATCACTGCAGCTAATTGTAAATCTTTCTATGAAACACTGAAAAGCCTCTTTGTGAATTAATACAGTTCTGCTTGATGCACTTGATTT
GAAAAGACATTTCTCTGTATGTGGCGCATGTCGGCTTTGCTTTGAAAAATAACAAAGTTAGCAGAATATGTTCAATATATTTTCTTGGGG
AATAGGGTTTTTATTACATGATTCATTAAGGATTTGCCTTACCCTGACATTTGTGATATAAAGGAAAATCAGAAAAAAAGTAATTTTCTT
GATCAAGATATGTTTTTACTTAATGCAAATAAATGTAGTCTGTTGCTTGCAAGGAAAAAAAAATGGCTTCTGATATCTGGTATAAACTGC
TAAATAGGATAATACGTGCCTCTTTTGTTAAACCGGCATTTAAATGCTGGACTGCTTCTAAATCTGTTTGTTTCTTTTCATCTGTGCCAT

>In-frame_SLC24A3_ENST00000328041_chr20_19566188_+_MACROD2_ENST00000310348_chr20_15843390_+_1511nt
GCGACGAGGAGGGCGACGACGAGGAGACGGGCAGCGGCGAGGAGGAGGAAGAGGAGGCGGAGGCGGCGGCCGGGTGGGAGCGCAGCGAGG
ACGCGCGGCTGCTGCGCGCAGGGCTGCCTCCTGCCGCTGTCCCCGCCGCGGCCGCCCGCGACAGGAGCGGCCGCCGCCCGCCGAGGCCGC
CGCCCGGCCGCCCGAGGATGCGGCCGTCCGGCGACGAGGACCGCGCGCGTCGCCGCCGCCGCCGCCGCCGCCGGAGGGACCTTCTGCTGA
GCCAGCTCTGCTTCCTGGCCTCGGTGGCGCTGCTGCTCTGGTCGCTGTCGAGCCTGCGAGAGCAGAAGGAGCTTGACCTCATGGACCTCG
TAGGGGAAGACAGAAAGTGGATGATGGCGAGGAAGCTGATGCAGGTGAACGACACTCTGACTTCCGAAGATGCCGGACTCCGGAACAGCA
AGAACTGCACCGAACCAGCCCTGCATGAATTCCCCAATGACATCTTCACAAACGAGGATAGAAGACAAGGTGCGGTGGTCCTCCATGTGC
TCTGTGCCATATACATGTTCTATGCGCTGGCCATTGTGTGTGATGACTTCTTCGTCCCTTCCTTGGAAAAGATCTGTGAGCGCCTGCACC
TCAGTGAAGATGTGGCTGGGGCCACATTCATGGCAGCGGGAAGTTCGGCCCCAGAGCTGTTCACATCGGTCATAGGGGTCTTCATCACCA
AAGGCGATGTGGGAGTTGGCACCATCGTGGGCTCAGCGGTATTCAACATCCTGTGCATCATTGGTGTCTGTGGGCTCTTTGCTGGGCAGG
TGGATCGGATCATTTTCTGTGTCTTCTTAGAAGTTGACTTCAAAATCTACAAAAAGAAAATGAATGAGTTTTTCTCCGTAGACGATAATA
ATGAAGAAGAAGAGGATGTTGAAATGAAAGAAGATTCAGATGAGAACGGTCCAGAGGAGAAGCAAAGTGTGGAAGAAATGGAAGAGCAGA
GCCAAGATGCAGATGGTGTCAACACTGTCACTGTGCCCGGCCCTGCTTCAGAAGAGGCAGTTGAAGACTGTAAAGATGAAGATTTTGCAA
AGGATGAAAATATTACAAAAGGCGGTGAAGTGACAGATCATTCTGTGCGTGACCAAGATCATCCCGATGGACAAGAGAATGATTCAACGA
AGAATGAAATAAAAATTGAAACAGAATCGCAGAGCTCATATATGGAAACAGAAGAACTTTCATCAAACCAAGAAGATGCCGTGATTGTGG
AGCAACCAGAAGTGATTCCATTAACAGAGGACCAAGAAGAAAAAGAAGGTGAAAAAGCTCCAGGCGAGGACACACCTAGGATGCCTGGGA
AAAGTGAAGGCTCCAGTGACCTAGAAAATACTCCAGGTCCTGATGTTGAAATGAATAGTCAGGTTGACAAGGTAAATGACCCAACAGAGA


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FusionGenePPI for SLC24A3_MACROD2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SLC24A3MACROD2TERF1, TERF2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SLC24A3_MACROD2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SLC24A3_MACROD2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSLC24A3C0010606Adenoid Cystic Carcinoma1CTD_human
HgeneSLC24A3C0036095Salivary Gland Neoplasms1CTD_human
TgeneMACROD2C0004352Autistic Disorder1CTD_human
TgeneMACROD2C0023903Liver neoplasms1CTD_human
TgeneMACROD2C0236969Substance-Related Disorders1CTD_human