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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 3416

FusionGeneSummary for ATP5J2-PTCD1_NMT2

check button Fusion gene summary
Fusion gene informationFusion gene name: ATP5J2-PTCD1_NMT2
Fusion gene ID: 3416
HgeneTgene
Gene symbol

ATP5J2-PTCD1

NMT2

Gene ID

9397

Gene nameN-myristoyltransferase 2
Synonyms-
Cytomap

10p13

Type of geneprotein-coding
Descriptionglycylpeptide N-tetradecanoyltransferase 2NMT 2glycylpeptide N-tetradecanoyltransferase 2 variant 3glycylpeptide N-tetradecanoyltransferase 2 variant 4myristoyl-CoA:protein N-myristoyltransferase 2peptide N-myristoyltransferase 2type II N-myristoylt
Modification date20180523
UniProtAcc

O60551

Ensembl transtripts involved in fusion geneENST00000413834, ENST00000437572, 
ENST00000378165, ENST00000378150, 
ENST00000535341, ENST00000466201, 
ENST00000540259, 
Fusion gene scores* DoF score2 X 2 X 1=43 X 3 X 3=27
# samples 23
** MAII scorelog2(2/4*10)=2.32192809488736log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ATP5J2-PTCD1 [Title/Abstract] AND NMT2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneNMT2

GO:0018008

N-terminal peptidyl-glycine N-myristoylation

25255805


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA085790ATP5J2-PTCD1chr7

99057774

+NMT2chr10

15154874

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000413834ENST00000378165ATP5J2-PTCD1chr7

99057774

+NMT2chr10

15154874

+
intron-3CDSENST00000413834ENST00000378150ATP5J2-PTCD1chr7

99057774

+NMT2chr10

15154874

+
intron-3CDSENST00000413834ENST00000535341ATP5J2-PTCD1chr7

99057774

+NMT2chr10

15154874

+
intron-intronENST00000413834ENST00000466201ATP5J2-PTCD1chr7

99057774

+NMT2chr10

15154874

+
intron-intronENST00000413834ENST00000540259ATP5J2-PTCD1chr7

99057774

+NMT2chr10

15154874

+
intron-3CDSENST00000437572ENST00000378165ATP5J2-PTCD1chr7

99057774

+NMT2chr10

15154874

+
intron-3CDSENST00000437572ENST00000378150ATP5J2-PTCD1chr7

99057774

+NMT2chr10

15154874

+
intron-3CDSENST00000437572ENST00000535341ATP5J2-PTCD1chr7

99057774

+NMT2chr10

15154874

+
intron-intronENST00000437572ENST00000466201ATP5J2-PTCD1chr7

99057774

+NMT2chr10

15154874

+
intron-intronENST00000437572ENST00000540259ATP5J2-PTCD1chr7

99057774

+NMT2chr10

15154874

+

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FusionProtFeatures for ATP5J2-PTCD1_NMT2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ATP5J2-PTCD1

NMT2

O60551

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. Adds a myristoyl group to the N-terminal glycine residueof certain cellular and viral proteins.{ECO:0000269|PubMed:25255805, ECO:0000269|PubMed:9506952}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ATP5J2-PTCD1_NMT2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ATP5J2-PTCD1_NMT2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ATP5J2-PTCD1_NMT2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ATP5J2-PTCD1_NMT2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneNMT2C0029927Ovarian Cysts1CTD_human