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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 34135

FusionGeneSummary for SLC20A2_SLC20A2

check button Fusion gene summary
Fusion gene informationFusion gene name: SLC20A2_SLC20A2
Fusion gene ID: 34135
HgeneTgene
Gene symbol

SLC20A2

SLC20A2

Gene ID

6575

6575

Gene namesolute carrier family 20 member 2solute carrier family 20 member 2
SynonymsGLVR-2|GLVR2|IBGC1|IBGC3|MLVAR|PIT-2|PIT2|RAM1|Ram-1GLVR-2|GLVR2|IBGC1|IBGC3|MLVAR|PIT-2|PIT2|RAM1|Ram-1
Cytomap

8p11.21

8p11.21

Type of geneprotein-codingprotein-coding
Descriptionsodium-dependent phosphate transporter 2gibbon ape leukemia virus receptor 2murine leukemia virus, amphotropic, receptor formurine leukemia virus, amphotropic; receptorsolute carrier family 20 (phosphate transporter), member 2sodium-dependent phosphate transporter 2gibbon ape leukemia virus receptor 2murine leukemia virus, amphotropic, receptor formurine leukemia virus, amphotropic; receptorsolute carrier family 20 (phosphate transporter), member 2
Modification date2018052320180523
UniProtAcc

Q08357

Q08357

Ensembl transtripts involved in fusion geneENST00000342228, ENST00000520262, 
ENST00000520179, ENST00000523340, 
ENST00000342228, ENST00000520262, 
ENST00000520179, ENST00000523340, 
Fusion gene scores* DoF score12 X 9 X 6=6489 X 9 X 4=324
# samples 1512
** MAII scorelog2(15/648*10)=-2.11103131238874
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/324*10)=-1.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SLC20A2 [Title/Abstract] AND SLC20A2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE162973SLC20A2chr8

42274617

-SLC20A2chr8

42274664

+
ChiTaRS3.1AA665033SLC20A2chr8

42384498

-SLC20A2chr8

42384640

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000342228ENST00000342228SLC20A2chr8

42274617

-SLC20A2chr8

42274664

+
intron-intronENST00000342228ENST00000520262SLC20A2chr8

42274617

-SLC20A2chr8

42274664

+
intron-intronENST00000342228ENST00000520179SLC20A2chr8

42274617

-SLC20A2chr8

42274664

+
intron-intronENST00000342228ENST00000523340SLC20A2chr8

42274617

-SLC20A2chr8

42274664

+
intron-3UTRENST00000520262ENST00000342228SLC20A2chr8

42274617

-SLC20A2chr8

42274664

+
intron-intronENST00000520262ENST00000520262SLC20A2chr8

42274617

-SLC20A2chr8

42274664

+
intron-intronENST00000520262ENST00000520179SLC20A2chr8

42274617

-SLC20A2chr8

42274664

+
intron-intronENST00000520262ENST00000523340SLC20A2chr8

42274617

-SLC20A2chr8

42274664

+
intron-3UTRENST00000520179ENST00000342228SLC20A2chr8

42274617

-SLC20A2chr8

42274664

+
intron-intronENST00000520179ENST00000520262SLC20A2chr8

42274617

-SLC20A2chr8

42274664

+
intron-intronENST00000520179ENST00000520179SLC20A2chr8

42274617

-SLC20A2chr8

42274664

+
intron-intronENST00000520179ENST00000523340SLC20A2chr8

42274617

-SLC20A2chr8

42274664

+
intron-3UTRENST00000523340ENST00000342228SLC20A2chr8

42274617

-SLC20A2chr8

42274664

+
intron-intronENST00000523340ENST00000520262SLC20A2chr8

42274617

-SLC20A2chr8

42274664

+
intron-intronENST00000523340ENST00000520179SLC20A2chr8

42274617

-SLC20A2chr8

42274664

+
intron-intronENST00000523340ENST00000523340SLC20A2chr8

42274617

-SLC20A2chr8

42274664

+
intron-intronENST00000342228ENST00000342228SLC20A2chr8

42384498

-SLC20A2chr8

42384640

+
intron-intronENST00000342228ENST00000520262SLC20A2chr8

42384498

-SLC20A2chr8

42384640

+
intron-intronENST00000342228ENST00000520179SLC20A2chr8

42384498

-SLC20A2chr8

42384640

+
intron-intronENST00000342228ENST00000523340SLC20A2chr8

42384498

-SLC20A2chr8

42384640

+
intron-intronENST00000520262ENST00000342228SLC20A2chr8

42384498

-SLC20A2chr8

42384640

+
intron-intronENST00000520262ENST00000520262SLC20A2chr8

42384498

-SLC20A2chr8

42384640

+
intron-intronENST00000520262ENST00000520179SLC20A2chr8

42384498

-SLC20A2chr8

42384640

+
intron-intronENST00000520262ENST00000523340SLC20A2chr8

42384498

-SLC20A2chr8

42384640

+
intron-intronENST00000520179ENST00000342228SLC20A2chr8

42384498

-SLC20A2chr8

42384640

+
intron-intronENST00000520179ENST00000520262SLC20A2chr8

42384498

-SLC20A2chr8

42384640

+
intron-intronENST00000520179ENST00000520179SLC20A2chr8

42384498

-SLC20A2chr8

42384640

+
intron-intronENST00000520179ENST00000523340SLC20A2chr8

42384498

-SLC20A2chr8

42384640

+
intron-intronENST00000523340ENST00000342228SLC20A2chr8

42384498

-SLC20A2chr8

42384640

+
intron-intronENST00000523340ENST00000520262SLC20A2chr8

42384498

-SLC20A2chr8

42384640

+
intron-intronENST00000523340ENST00000520179SLC20A2chr8

42384498

-SLC20A2chr8

42384640

+
intron-intronENST00000523340ENST00000523340SLC20A2chr8

42384498

-SLC20A2chr8

42384640

+

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FusionProtFeatures for SLC20A2_SLC20A2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SLC20A2

Q08357

SLC20A2

Q08357

Sodium-phosphate symporter which seems to play afundamental housekeeping role in phosphate transport by absorbingphosphate from interstitial fluid for normal cellular functionssuch as cellular metabolism, signal transduction, and nucleic acidand lipid synthesis. In vitro, sodium-dependent phosphate uptakeis not siginificantly affected by acidic and alkaline conditions,however sodium-independent phosphate uptake occurs at acidicconditions. May play a role in extracellular matrix, cartilage andvascular calcification. Functions as a retroviral receptor andconfers human cells susceptibility to infection to amphotropicmurine leukemia virus (A-MuLV), 10A1 murine leukemia virus (10A1MLV) and some feline leukemia virus subgroup B (FeLV-B) variants.{ECO:0000269|PubMed:11435563, ECO:0000269|PubMed:12205090,ECO:0000269|PubMed:15955065, ECO:0000269|PubMed:16790504,ECO:0000269|PubMed:8302848}. Sodium-phosphate symporter which seems to play afundamental housekeeping role in phosphate transport by absorbingphosphate from interstitial fluid for normal cellular functionssuch as cellular metabolism, signal transduction, and nucleic acidand lipid synthesis. In vitro, sodium-dependent phosphate uptakeis not siginificantly affected by acidic and alkaline conditions,however sodium-independent phosphate uptake occurs at acidicconditions. May play a role in extracellular matrix, cartilage andvascular calcification. Functions as a retroviral receptor andconfers human cells susceptibility to infection to amphotropicmurine leukemia virus (A-MuLV), 10A1 murine leukemia virus (10A1MLV) and some feline leukemia virus subgroup B (FeLV-B) variants.{ECO:0000269|PubMed:11435563, ECO:0000269|PubMed:12205090,ECO:0000269|PubMed:15955065, ECO:0000269|PubMed:16790504,ECO:0000269|PubMed:8302848}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SLC20A2_SLC20A2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SLC20A2_SLC20A2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SLC20A2_SLC20A2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SLC20A2_SLC20A2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSLC20A2C0393590Fahr's syndrome (disorder)6CTD_human;ORPHANET;UNIPROT
HgeneSLC20A2C0004782Basal Ganglia Diseases1CTD_human
HgeneSLC20A2C0006663Calcinosis1CTD_human
TgeneSLC20A2C0393590Fahr's syndrome (disorder)6CTD_human;ORPHANET;UNIPROT
TgeneSLC20A2C0004782Basal Ganglia Diseases1CTD_human
TgeneSLC20A2C0006663Calcinosis1CTD_human