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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 34096

FusionGeneSummary for SLC18A2_IGF2

check button Fusion gene summary
Fusion gene informationFusion gene name: SLC18A2_IGF2
Fusion gene ID: 34096
HgeneTgene
Gene symbol

SLC18A2

IGF2

Gene ID

6571

3481

Gene namesolute carrier family 18 member A2insulin like growth factor 2
SynonymsSVAT|SVMT|VAT2|VMAT2C11orf43|GRDF|IGF-II|PP9974
Cytomap

10q25.3

11p15.5

Type of geneprotein-codingprotein-coding
Descriptionsynaptic vesicular amine transportermonoamine neurotransmitter transportermonoamine transportersolute carrier family 18 (vesicular monoamine transporter), member 2solute carrier family 18 (vesicular monoamine), member 2solute carrier family 18 memberinsulin-like growth factor IIT3M-11-derived growth factorinsulin-like growth factor 2 (somatomedin A)insulin-like growth factor type 2preptin
Modification date2018052320180527
UniProtAcc

Q05940

P01344

Ensembl transtripts involved in fusion geneENST00000497497, ENST00000298472, 
ENST00000381395, ENST00000381406, 
ENST00000416167, ENST00000300632, 
ENST00000434045, ENST00000381392, 
ENST00000381389, ENST00000418738, 
Fusion gene scores* DoF score1 X 1 X 1=123 X 24 X 8=4416
# samples 120
** MAII scorelog2(1/1*10)=3.32192809488736log2(20/4416*10)=-4.46466826700344
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SLC18A2 [Title/Abstract] AND IGF2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneIGF2

GO:0008284

positive regulation of cell proliferation

28873464

TgeneIGF2

GO:0042104

positive regulation of activated T cell proliferation

15694994

TgeneIGF2

GO:0043410

positive regulation of MAPK cascade

11500939

TgeneIGF2

GO:0045840

positive regulation of mitotic nuclear division

11500939

TgeneIGF2

GO:0046628

positive regulation of insulin receptor signaling pathway

11500939

TgeneIGF2

GO:0051897

positive regulation of protein kinase B signaling

11500939


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDPCPGTCGA-SR-A6MS-01ASLC18A2chr10

119003678

+IGF2chr11

2152940

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000497497ENST00000381395SLC18A2chr10

119003678

+IGF2chr11

2152940

-
3UTR-3UTRENST00000497497ENST00000381406SLC18A2chr10

119003678

+IGF2chr11

2152940

-
3UTR-3UTRENST00000497497ENST00000416167SLC18A2chr10

119003678

+IGF2chr11

2152940

-
3UTR-3UTRENST00000497497ENST00000300632SLC18A2chr10

119003678

+IGF2chr11

2152940

-
3UTR-intronENST00000497497ENST00000434045SLC18A2chr10

119003678

+IGF2chr11

2152940

-
3UTR-intronENST00000497497ENST00000381392SLC18A2chr10

119003678

+IGF2chr11

2152940

-
3UTR-intronENST00000497497ENST00000381389SLC18A2chr10

119003678

+IGF2chr11

2152940

-
3UTR-intronENST00000497497ENST00000418738SLC18A2chr10

119003678

+IGF2chr11

2152940

-
5CDS-3UTRENST00000298472ENST00000381395SLC18A2chr10

119003678

+IGF2chr11

2152940

-
5CDS-3UTRENST00000298472ENST00000381406SLC18A2chr10

119003678

+IGF2chr11

2152940

-
5CDS-3UTRENST00000298472ENST00000416167SLC18A2chr10

119003678

+IGF2chr11

2152940

-
5CDS-3UTRENST00000298472ENST00000300632SLC18A2chr10

119003678

+IGF2chr11

2152940

-
5CDS-intronENST00000298472ENST00000434045SLC18A2chr10

119003678

+IGF2chr11

2152940

-
5CDS-intronENST00000298472ENST00000381392SLC18A2chr10

119003678

+IGF2chr11

2152940

-
5CDS-intronENST00000298472ENST00000381389SLC18A2chr10

119003678

+IGF2chr11

2152940

-
5CDS-intronENST00000298472ENST00000418738SLC18A2chr10

119003678

+IGF2chr11

2152940

-

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FusionProtFeatures for SLC18A2_IGF2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SLC18A2

Q05940

IGF2

P01344

Involved in the ATP-dependent vesicular transport ofbiogenic amine neurotransmitters. Pumps cytosolic monoaminesincluding dopamine, norepinephrine, serotonin, and histamine intosynaptic vesicles. Requisite for vesicular amine storage prior tosecretion via exocytosis.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SLC18A2_IGF2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SLC18A2_IGF2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SLC18A2PARK7IGF2NOV, IGFBP7, IGFBP1, TF, IGFBP3, VTN, IDE, IGFBP6, IGFBP4, IGFBP5, BAG6, NMRK2, FAF1, PCSK4, RBPMS


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SLC18A2_IGF2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneSLC18A2Q05940DB00368NorepinephrineSynaptic vesicular amine transportersmall moleculeapproved
HgeneSLC18A2Q05940DB00502HaloperidolSynaptic vesicular amine transportersmall moleculeapproved
HgeneSLC18A2Q05940DB00988DopamineSynaptic vesicular amine transportersmall moleculeapproved
HgeneSLC18A2Q05940DB01089DeserpidineSynaptic vesicular amine transportersmall moleculeapproved
HgeneSLC18A2Q05940DB01364EphedrineSynaptic vesicular amine transportersmall moleculeapproved
HgeneSLC18A2Q05940DB06706IsomethepteneSynaptic vesicular amine transportersmall moleculeapproved
HgeneSLC18A2Q05940DB01576DextroamphetamineSynaptic vesicular amine transportersmall moleculeapproved|illicit
HgeneSLC18A2Q05940DB01577MethamphetamineSynaptic vesicular amine transportersmall moleculeapproved|illicit
HgeneSLC18A2Q05940DB00182AmphetamineSynaptic vesicular amine transportersmall moleculeapproved|illicit|investigational
HgeneSLC18A2Q05940DB00206ReserpineSynaptic vesicular amine transportersmall moleculeapproved|investigational
HgeneSLC18A2Q05940DB00579MazindolSynaptic vesicular amine transportersmall moleculeapproved|investigational
HgeneSLC18A2Q05940DB04844TetrabenazineSynaptic vesicular amine transportersmall moleculeapproved|investigational
HgeneSLC18A2Q05940DB05381HistamineSynaptic vesicular amine transportersmall moleculeapproved|investigational

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RelatedDiseases for SLC18A2_IGF2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSLC18A2C0011570Mental Depression5PSYGENET
HgeneSLC18A2C0011581Depressive disorder5PSYGENET
HgeneSLC18A2C0001973Alcoholic Intoxication, Chronic3PSYGENET
HgeneSLC18A2C0005586Bipolar Disorder3PSYGENET
HgeneSLC18A2C0036341Schizophrenia3PSYGENET
HgeneSLC18A2C0027746Nerve Degeneration1CTD_human
HgeneSLC18A2C0027765nervous system disorder1CTD_human
HgeneSLC18A2C0030567Parkinson Disease1CTD_human
HgeneSLC18A2C0236701Cocaine-induced mood disorder1PSYGENET
HgeneSLC18A2C0242422Parkinsonian Disorders1CTD_human;HPO
HgeneSLC18A2C0270458Severe major depression with psychotic features1PSYGENET
HgeneSLC18A2C0600427Cocaine Dependence1PSYGENET
TgeneIGF2C0004903Beckwith-Wiedemann Syndrome2CTD_human
TgeneIGF2C0015934Fetal Growth Retardation2CTD_human;HPO
TgeneIGF2C0036341Schizophrenia2PSYGENET
TgeneIGF2C0206686Adrenocortical carcinoma2CTD_human;HPO
TgeneIGF2C2239176Liver carcinoma2CTD_human;HPO
TgeneIGF2C0000786Spontaneous abortion1CTD_human
TgeneIGF2C0002395Alzheimer's Disease1CTD_human
TgeneIGF2C0002871Anemia1CTD_human
TgeneIGF2C0004153Atherosclerosis1CTD_human
TgeneIGF2C0004352Autistic Disorder1CTD_human
TgeneIGF2C0005941Bone Diseases, Developmental1CTD_human
TgeneIGF2C0009241Cognition Disorders1CTD_human
TgeneIGF2C0009375Colonic Neoplasms1CTD_human
TgeneIGF2C0009404Colorectal Neoplasms1CTD_human
TgeneIGF2C0018273Growth Disorders1CTD_human
TgeneIGF2C0019284Diaphragmatic Hernia1CTD_human
TgeneIGF2C0020224Polyhydramnios1CTD_human
TgeneIGF2C0020615Hypoglycemia1CTD_human
TgeneIGF2C0023903Liver neoplasms1CTD_human
TgeneIGF2C0025261Memory Disorders1CTD_human
TgeneIGF2C0027708Nephroblastoma1CTD_human;HPO
TgeneIGF2C0027746Nerve Degeneration1CTD_human
TgeneIGF2C0028754Obesity1CTD_human
TgeneIGF2C0030567Parkinson Disease1CTD_human
TgeneIGF2C0032045Placenta Disorders1CTD_human
TgeneIGF2C0032927Precancerous Conditions1CTD_human
TgeneIGF2C0035412Rhabdomyosarcoma1CTD_human
TgeneIGF2C0175693Russell-Silver syndrome1CTD_human
TgeneIGF2C0206624Hepatoblastoma1CTD_human;HPO
TgeneIGF2C0678807prenatal alcohol exposure1PSYGENET
TgeneIGF2C0752347Lewy Body Disease1CTD_human