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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 34076

FusionGeneSummary for SLC16A3_RNF213

check button Fusion gene summary
Fusion gene informationFusion gene name: SLC16A3_RNF213
Fusion gene ID: 34076
HgeneTgene
Gene symbol

SLC16A3

RNF213

Gene ID

9123

57674

Gene namesolute carrier family 16 member 3ring finger protein 213
SynonymsMCT 3|MCT 4|MCT-3|MCT-4|MCT3|MCT4ALO17|C17orf27|KIAA1618|MYMY2|MYSTR|NET57
Cytomap

17q25.3

17q25.3

Type of geneprotein-codingprotein-coding
Descriptionmonocarboxylate transporter 4monocarboxylate transporter 3solute carrier family 16 (monocarboxylate transporter), member 3solute carrier family 16 (monocarboxylic acid transporters), member 3solute carrier family 16, member 3 (monocarboxylic acid tranE3 ubiquitin-protein ligase RNF213ALK lymphoma oligomerization partner on chromosome 17RING-type E3 ubiquitin transferase RNF213mysterin
Modification date2018052320180527
UniProtAcc

O15427

Q63HN8

Ensembl transtripts involved in fusion geneENST00000392341, ENST00000582743, 
ENST00000584781, ENST00000392339, 
ENST00000581287, 
ENST00000508628, 
ENST00000456466, ENST00000582970, 
ENST00000319921, ENST00000336301, 
ENST00000427003, 
Fusion gene scores* DoF score4 X 5 X 2=4012 X 13 X 6=936
# samples 515
** MAII scorelog2(5/40*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(15/936*10)=-2.64154602908752
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SLC16A3 [Title/Abstract] AND RNF213 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneRNF213

GO:0016567

protein ubiquitination

21799892

TgeneRNF213

GO:0051260

protein homooligomerization

24658080|26126547

TgeneRNF213

GO:0051865

protein autoubiquitination

21799892


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA373754SLC16A3chr17

80186983

+RNF213chr17

78237458

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000392341ENST00000508628SLC16A3chr17

80186983

+RNF213chr17

78237458

+
intron-5UTRENST00000392341ENST00000456466SLC16A3chr17

80186983

+RNF213chr17

78237458

+
intron-5UTRENST00000392341ENST00000582970SLC16A3chr17

80186983

+RNF213chr17

78237458

+
intron-5UTRENST00000392341ENST00000319921SLC16A3chr17

80186983

+RNF213chr17

78237458

+
intron-intronENST00000392341ENST00000336301SLC16A3chr17

80186983

+RNF213chr17

78237458

+
intron-intronENST00000392341ENST00000427003SLC16A3chr17

80186983

+RNF213chr17

78237458

+
5UTR-5UTRENST00000582743ENST00000508628SLC16A3chr17

80186983

+RNF213chr17

78237458

+
5UTR-5UTRENST00000582743ENST00000456466SLC16A3chr17

80186983

+RNF213chr17

78237458

+
5UTR-5UTRENST00000582743ENST00000582970SLC16A3chr17

80186983

+RNF213chr17

78237458

+
5UTR-5UTRENST00000582743ENST00000319921SLC16A3chr17

80186983

+RNF213chr17

78237458

+
5UTR-intronENST00000582743ENST00000336301SLC16A3chr17

80186983

+RNF213chr17

78237458

+
5UTR-intronENST00000582743ENST00000427003SLC16A3chr17

80186983

+RNF213chr17

78237458

+
3UTR-5UTRENST00000584781ENST00000508628SLC16A3chr17

80186983

+RNF213chr17

78237458

+
3UTR-5UTRENST00000584781ENST00000456466SLC16A3chr17

80186983

+RNF213chr17

78237458

+
3UTR-5UTRENST00000584781ENST00000582970SLC16A3chr17

80186983

+RNF213chr17

78237458

+
3UTR-5UTRENST00000584781ENST00000319921SLC16A3chr17

80186983

+RNF213chr17

78237458

+
3UTR-intronENST00000584781ENST00000336301SLC16A3chr17

80186983

+RNF213chr17

78237458

+
3UTR-intronENST00000584781ENST00000427003SLC16A3chr17

80186983

+RNF213chr17

78237458

+
intron-5UTRENST00000392339ENST00000508628SLC16A3chr17

80186983

+RNF213chr17

78237458

+
intron-5UTRENST00000392339ENST00000456466SLC16A3chr17

80186983

+RNF213chr17

78237458

+
intron-5UTRENST00000392339ENST00000582970SLC16A3chr17

80186983

+RNF213chr17

78237458

+
intron-5UTRENST00000392339ENST00000319921SLC16A3chr17

80186983

+RNF213chr17

78237458

+
intron-intronENST00000392339ENST00000336301SLC16A3chr17

80186983

+RNF213chr17

78237458

+
intron-intronENST00000392339ENST00000427003SLC16A3chr17

80186983

+RNF213chr17

78237458

+
intron-5UTRENST00000581287ENST00000508628SLC16A3chr17

80186983

+RNF213chr17

78237458

+
intron-5UTRENST00000581287ENST00000456466SLC16A3chr17

80186983

+RNF213chr17

78237458

+
intron-5UTRENST00000581287ENST00000582970SLC16A3chr17

80186983

+RNF213chr17

78237458

+
intron-5UTRENST00000581287ENST00000319921SLC16A3chr17

80186983

+RNF213chr17

78237458

+
intron-intronENST00000581287ENST00000336301SLC16A3chr17

80186983

+RNF213chr17

78237458

+
intron-intronENST00000581287ENST00000427003SLC16A3chr17

80186983

+RNF213chr17

78237458

+

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FusionProtFeatures for SLC16A3_RNF213


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SLC16A3

O15427

RNF213

Q63HN8

Proton-linked monocarboxylate transporter. Catalyzes therapid transport across the plasma membrane of manymonocarboxylates such as lactate, pyruvate, branched-chain oxoacids derived from leucine, valine and isoleucine, and the ketonebodies acetoacetate, beta-hydroxybutyrate and acetate (Bysimilarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SLC16A3_RNF213


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SLC16A3_RNF213


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SLC16A3_RNF213


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SLC16A3_RNF213


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneRNF213C1846689MOYAMOYA DISEASE 23UNIPROT