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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 34067

FusionGeneSummary for SLC16A13_JOSD1

check button Fusion gene summary
Fusion gene informationFusion gene name: SLC16A13_JOSD1
Fusion gene ID: 34067
HgeneTgene
Gene symbol

SLC16A13

JOSD1

Gene ID

201232

9929

Gene namesolute carrier family 16 member 13Josephin domain containing 1
SynonymsMCT13dJ508I15.2
Cytomap

17p13.1

22q13.1

Type of geneprotein-codingprotein-coding
Descriptionmonocarboxylate transporter 13MCT 13monocarboxylic acid transporter 13solute carrier family 16 (monocarboxylic acid transporters), member 13josephin-1josephin domain-containing 1josephin domain-containing protein 1
Modification date2018052320180523
UniProtAcc

Q7RTY0

Q15040

Ensembl transtripts involved in fusion geneENST00000308027, ENST00000216039, 
ENST00000462610, 
Fusion gene scores* DoF score1 X 1 X 1=12 X 2 X 1=4
# samples 12
** MAII scorelog2(1/1*10)=3.32192809488736log2(2/4*10)=2.32192809488736
Context

PubMed: SLC16A13 [Title/Abstract] AND JOSD1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BX538323SLC16A13chr17

6940383

+JOSD1chr22

39083072

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000308027ENST00000216039SLC16A13chr17

6940383

+JOSD1chr22

39083072

-
intron-intronENST00000308027ENST00000462610SLC16A13chr17

6940383

+JOSD1chr22

39083072

-

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FusionProtFeatures for SLC16A13_JOSD1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SLC16A13

Q7RTY0

JOSD1

Q15040

Proton-linked monocarboxylate transporter. May catalyzethe transport of monocarboxylates across the plasma membrane.{ECO:0000305|PubMed:12739169}. Deubiquitinates monoubiquitinated probes (in vitro).When ubiquitinated, cleaves 'Lys-63'-linked and 'Lys-48'-linkedpoly-ubiquitin chains (in vitro), hence may act as adeubiquitinating enzyme. May increase macropinocytosis andsuppress clathrin- and caveolae-mediated endocytosis. May enhancemembrane dynamics and cell motility independently of its catalyticactivity. {ECO:0000269|PubMed:21118805,ECO:0000269|PubMed:23625928}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SLC16A13_JOSD1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SLC16A13_JOSD1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SLC16A13_JOSD1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SLC16A13_JOSD1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource