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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 34055

FusionGeneSummary for SLC12A8_ZFP36

check button Fusion gene summary
Fusion gene informationFusion gene name: SLC12A8_ZFP36
Fusion gene ID: 34055
HgeneTgene
Gene symbol

SLC12A8

ZFP36

Gene ID

84561

7538

Gene namesolute carrier family 12 member 8ZFP36 ring finger protein
SynonymsCCC9G0S24|GOS24|NUP475|RNF162A|TIS11|TTP|zfp-36
Cytomap

3q21.2

19q13.2

Type of geneprotein-codingprotein-coding
Descriptionsolute carrier family 12 member 8cation-chloride cotransporter 9solute carrier family 12 (sodium/potassium/chloride transporters), member 8mRNA decay activator protein ZFP36G0/G1 switch regulatory protein 24growth factor-inducible nuclear protein NUP475tristetraprolintristetraprolinezinc finger protein 36 homologzinc finger protein 36, C3H type, homologzinc finger protein, C3H type, 3
Modification date2018052320180523
UniProtAcc

A0AV02

P26651

Ensembl transtripts involved in fusion geneENST00000393469, ENST00000423114, 
ENST00000469902, ENST00000314584, 
ENST00000430155, ENST00000465475, 
ENST00000597629, ENST00000248673, 
ENST00000594045, 
Fusion gene scores* DoF score10 X 9 X 5=4506 X 6 X 1=36
# samples 106
** MAII scorelog2(10/450*10)=-2.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/36*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SLC12A8 [Title/Abstract] AND ZFP36 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneZFP36

GO:0000288

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

23644599

TgeneZFP36

GO:0006402

mRNA catabolic process

10330172|10751406|11782475|20221403

TgeneZFP36

GO:0009611

response to wounding

27182009

TgeneZFP36

GO:0031086

nuclear-transcribed mRNA catabolic process, deadenylation-independent decay

11279239

TgeneZFP36

GO:0032680

regulation of tumor necrosis factor production

15014438

TgeneZFP36

GO:0042594

response to starvation

15014438

TgeneZFP36

GO:0043488

regulation of mRNA stability

9703499|11719186|15687258|20702587

TgeneZFP36

GO:0044344

cellular response to fibroblast growth factor stimulus

20166898

TgeneZFP36

GO:0045647

negative regulation of erythrocyte differentiation

20702587

TgeneZFP36

GO:0060213

positive regulation of nuclear-transcribed mRNA poly(A) tail shortening

10330172

TgeneZFP36

GO:0061158

3'-UTR-mediated mRNA destabilization

9703499|11719186|15687258|20221403|27193233

TgeneZFP36

GO:0070935

3'-UTR-mediated mRNA stabilization

15014438

TgeneZFP36

GO:0071222

cellular response to lipopolysaccharide

14766228

TgeneZFP36

GO:0071356

cellular response to tumor necrosis factor

20166898

TgeneZFP36

GO:0071364

cellular response to epidermal growth factor stimulus

20166898

TgeneZFP36

GO:0071385

cellular response to glucocorticoid stimulus

20166898

TgeneZFP36

GO:0097011

cellular response to granulocyte macrophage colony-stimulating factor stimulus

20166898

TgeneZFP36

GO:1900153

positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

12748283

TgeneZFP36

GO:1901835

positive regulation of deadenylation-independent decapping of nuclear-transcribed mRNA

16364915


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF094229SLC12A8chr3

124991033

+ZFP36chr19

39899709

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000393469ENST00000597629SLC12A8chr3

124991033

+ZFP36chr19

39899709

-
intron-3UTRENST00000393469ENST00000248673SLC12A8chr3

124991033

+ZFP36chr19

39899709

-
intron-intronENST00000393469ENST00000594045SLC12A8chr3

124991033

+ZFP36chr19

39899709

-
intron-3UTRENST00000423114ENST00000597629SLC12A8chr3

124991033

+ZFP36chr19

39899709

-
intron-3UTRENST00000423114ENST00000248673SLC12A8chr3

124991033

+ZFP36chr19

39899709

-
intron-intronENST00000423114ENST00000594045SLC12A8chr3

124991033

+ZFP36chr19

39899709

-
intron-3UTRENST00000469902ENST00000597629SLC12A8chr3

124991033

+ZFP36chr19

39899709

-
intron-3UTRENST00000469902ENST00000248673SLC12A8chr3

124991033

+ZFP36chr19

39899709

-
intron-intronENST00000469902ENST00000594045SLC12A8chr3

124991033

+ZFP36chr19

39899709

-
intron-3UTRENST00000314584ENST00000597629SLC12A8chr3

124991033

+ZFP36chr19

39899709

-
intron-3UTRENST00000314584ENST00000248673SLC12A8chr3

124991033

+ZFP36chr19

39899709

-
intron-intronENST00000314584ENST00000594045SLC12A8chr3

124991033

+ZFP36chr19

39899709

-
intron-3UTRENST00000430155ENST00000597629SLC12A8chr3

124991033

+ZFP36chr19

39899709

-
intron-3UTRENST00000430155ENST00000248673SLC12A8chr3

124991033

+ZFP36chr19

39899709

-
intron-intronENST00000430155ENST00000594045SLC12A8chr3

124991033

+ZFP36chr19

39899709

-
intron-3UTRENST00000465475ENST00000597629SLC12A8chr3

124991033

+ZFP36chr19

39899709

-
intron-3UTRENST00000465475ENST00000248673SLC12A8chr3

124991033

+ZFP36chr19

39899709

-
intron-intronENST00000465475ENST00000594045SLC12A8chr3

124991033

+ZFP36chr19

39899709

-

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FusionProtFeatures for SLC12A8_ZFP36


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SLC12A8

A0AV02

ZFP36

P26651

Zinc-finger RNA-binding protein that destabilizesseveral cytoplasmic AU-rich element (ARE)-containing mRNAtranscripts by promoting their poly(A) tail removal ordeadenylation, and hence provide a mechanism for attenuatingprotein synthesis (PubMed:9703499, PubMed:10330172,PubMed:10751406, PubMed:11279239, PubMed:12115244,PubMed:12748283, PubMed:15187101, PubMed:15634918,PubMed:17030620, PubMed:16702957, PubMed:20702587,PubMed:20221403, PubMed:21775632, PubMed:27193233,PubMed:23644599, PubMed:25815583). Acts as an 3'-untranslatedregion (UTR) ARE mRNA-binding adapter protein to communicatesignaling events to the mRNA decay machinery (PubMed:15687258,PubMed:23644599). Recruits deadenylase CNOT7 (and probably theCCR4-NOT complex) via association with CNOT1, and hence promotesARE-mediated mRNA deadenylation (PubMed:23644599). Functions alsoby recruiting components of the cytoplasmic RNA decay machinery tothe bound ARE-containing mRNAs (PubMed:11719186, PubMed:12748283,PubMed:15687258, PubMed:16364915). Self regulates by destabilizingits own mRNA (PubMed:15187101). Binds to 3'-UTR ARE of numerousmRNAs and of its own mRNA (PubMed:10330172, PubMed:10751406,PubMed:12115244, PubMed:15187101, PubMed:15634918,PubMed:17030620, PubMed:16702957, PubMed:19188452,PubMed:20702587, PubMed:20221403, PubMed:21775632,PubMed:25815583). Plays a role in anti-inflammatory responses;suppresses tumor necrosis factor (TNF)-alpha production bystimulating ARE-mediated TNF-alpha mRNA decay and several otherinflammatory ARE-containing mRNAs in interferon (IFN)- and/orlipopolysaccharide (LPS)-induced macrophages (By similarity).Plays also a role in the regulation of dendritic cell maturationat the post-transcriptional level, and hence operates as part of anegative feedback loop to limit the inflammatory response(PubMed:18367721). Promotes ARE-mediated mRNA decay of hypoxia-inducible factor HIF1A mRNA during the response of endothelialcells to hypoxia (PubMed:21775632). Positively regulates earlyadipogenesis of preadipocytes by promoting ARE-mediated mRNA decayof immediate early genes (IEGs) (By similarity). Negativelyregulates hematopoietic/erythroid cell differentiation bypromoting ARE-mediated mRNA decay of the transcription factorSTAT5B mRNA (PubMed:20702587). Plays a role in maintainingskeletal muscle satellite cell quiescence by promoting ARE-mediated mRNA decay of the myogenic determination factor MYOD1mRNA (By similarity). Associates also with and regulates theexpression of non-ARE-containing target mRNAs at the post-transcriptional level, such as MHC class I mRNAs(PubMed:18367721). Participates in association with argonaute RISCcatalytic components in the ARE-mediated mRNA decay mechanism;assists microRNA (miRNA) targeting ARE-containing mRNAs(PubMed:15766526). May also play a role in the regulation ofcytoplasmic mRNA decapping; enhances decapping of ARE-containingRNAs, in vitro (PubMed:16364915). Involved in the delivery oftarget ARE-mRNAs to processing bodies (PBs) (PubMed:17369404). Inaddition to its cytosolic mRNA-decay function, affects nuclearpre-mRNA processing (By similarity). Negatively regulates nuclearpoly(A)-binding protein PABPN1-stimulated polyadenylation activityon ARE-containing pre-mRNA during LPS-stimulated macrophages (Bysimilarity). Also involved in the regulation of stress granule(SG) and P-body (PB) formation and fusion (By similarity). Plays arole in the regulation of keratinocyte proliferation,differentiation and apoptosis (PubMed:27182009). Plays a role as atumor suppressor by inhibiting cell proliferation in breast cancercells (PubMed:26926077). {ECO:0000250|UniProtKB:P22893,ECO:0000269|PubMed:10330172, ECO:0000269|PubMed:10751406,ECO:0000269|PubMed:11279239, ECO:0000269|PubMed:11719186,ECO:0000269|PubMed:12115244, ECO:0000269|PubMed:12748283,ECO:0000269|PubMed:15187101, ECO:0000269|PubMed:15634918,ECO:0000269|PubMed:15687258, ECO:0000269|PubMed:15766526,ECO:0000269|PubMed:16364915, ECO:0000269|PubMed:16702957,ECO:0000269|PubMed:17030620, ECO:0000269|PubMed:17369404,ECO:0000269|PubMed:18367721, ECO:0000269|PubMed:19188452,ECO:0000269|PubMed:20221403, ECO:0000269|PubMed:20702587,ECO:0000269|PubMed:21775632, ECO:0000269|PubMed:23644599,ECO:0000269|PubMed:25815583, ECO:0000269|PubMed:26926077,ECO:0000269|PubMed:27182009, ECO:0000269|PubMed:27193233,ECO:0000269|PubMed:9703499}. (Microbial infection) Negatively regulates HTLV-1 TAX-dependent transactivation of viral long terminal repeat (LTR)promoter. {ECO:0000269|PubMed:14679154}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SLC12A8_ZFP36


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SLC12A8_ZFP36


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SLC12A8_ZFP36


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SLC12A8_ZFP36


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneZFP36C0006625Cachexia2CTD_human
TgeneZFP36C0002170Alopecia1CTD_human
TgeneZFP36C0003864Arthritis1CTD_human
TgeneZFP36C0011603Dermatitis1CTD_human
TgeneZFP36C0020507Hyperplasia1CTD_human
TgeneZFP36C0021368Inflammation1CTD_human
TgeneZFP36C0027626Neoplasm Invasiveness1CTD_human
TgeneZFP36C0151744Myocardial Ischemia1CTD_human