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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 34051

FusionGeneSummary for SLC12A8_PARD6G

check button Fusion gene summary
Fusion gene informationFusion gene name: SLC12A8_PARD6G
Fusion gene ID: 34051
HgeneTgene
Gene symbol

SLC12A8

PARD6G

Gene ID

84561

84552

Gene namesolute carrier family 12 member 8par-6 family cell polarity regulator gamma
SynonymsCCC9PAR-6G|PAR6gamma
Cytomap

3q21.2

18q23

Type of geneprotein-codingprotein-coding
Descriptionsolute carrier family 12 member 8cation-chloride cotransporter 9solute carrier family 12 (sodium/potassium/chloride transporters), member 8partitioning defective 6 homolog gammaPAR-6 gamma proteinPAR6Dpar-6 partitioning defective 6 homolog gamma
Modification date2018052320180523
UniProtAcc

A0AV02

Q9BYG4

Ensembl transtripts involved in fusion geneENST00000393469, ENST00000423114, 
ENST00000469902, ENST00000314584, 
ENST00000430155, ENST00000465475, 
ENST00000353265, ENST00000470488, 
Fusion gene scores* DoF score10 X 9 X 5=4507 X 2 X 7=98
# samples 107
** MAII scorelog2(10/450*10)=-2.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/98*10)=-0.485426827170242
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SLC12A8 [Title/Abstract] AND PARD6G [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDUCSTCGA-N8-A4PO-01ASLC12A8chr3

124896587

-PARD6Gchr18

77960815

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000393469ENST00000353265SLC12A8chr3

124896587

-PARD6Gchr18

77960815

-
Frame-shitENST00000393469ENST00000470488SLC12A8chr3

124896587

-PARD6Gchr18

77960815

-
Frame-shitENST00000423114ENST00000353265SLC12A8chr3

124896587

-PARD6Gchr18

77960815

-
Frame-shitENST00000423114ENST00000470488SLC12A8chr3

124896587

-PARD6Gchr18

77960815

-
Frame-shitENST00000469902ENST00000353265SLC12A8chr3

124896587

-PARD6Gchr18

77960815

-
Frame-shitENST00000469902ENST00000470488SLC12A8chr3

124896587

-PARD6Gchr18

77960815

-
5UTR-3CDSENST00000314584ENST00000353265SLC12A8chr3

124896587

-PARD6Gchr18

77960815

-
5UTR-3CDSENST00000314584ENST00000470488SLC12A8chr3

124896587

-PARD6Gchr18

77960815

-
intron-3CDSENST00000430155ENST00000353265SLC12A8chr3

124896587

-PARD6Gchr18

77960815

-
intron-3CDSENST00000430155ENST00000470488SLC12A8chr3

124896587

-PARD6Gchr18

77960815

-
intron-3CDSENST00000465475ENST00000353265SLC12A8chr3

124896587

-PARD6Gchr18

77960815

-
intron-3CDSENST00000465475ENST00000470488SLC12A8chr3

124896587

-PARD6Gchr18

77960815

-

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FusionProtFeatures for SLC12A8_PARD6G


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SLC12A8

A0AV02

PARD6G

Q9BYG4

Adapter protein involved in asymmetrical cell divisionand cell polarization processes. May play a role in the formationof epithelial tight junctions. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (Bysimilarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SLC12A8_PARD6G


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SLC12A8_PARD6G


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SLC12A8NGEFPARD6GPARD3, PRKCZ, RAC1, CDC42, YWHAH, PRKCI, LLGL1, YWHAE, PARD6B, MARK2, LLGL2, BRINP1, HSPA4, PNMA3, PNMA2, PNMAL1, WDR83, RHOJ


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SLC12A8_PARD6G


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SLC12A8_PARD6G


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource