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Fusion gene ID: 34017 |
FusionGeneSummary for SLC11A1_SLC11A1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SLC11A1_SLC11A1 | Fusion gene ID: 34017 | Hgene | Tgene | Gene symbol | SLC11A1 | SLC11A1 | Gene ID | 6556 | 6556 |
| Gene name | solute carrier family 11 member 1 | solute carrier family 11 member 1 | |
| Synonyms | LSH|NRAMP|NRAMP1 | LSH|NRAMP|NRAMP1 | |
| Cytomap | 2q35 | 2q35 | |
| Type of gene | protein-coding | protein-coding | |
| Description | natural resistance-associated macrophage protein 1NRAMP 1solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1solute carrier family 11 (sod | natural resistance-associated macrophage protein 1NRAMP 1solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1solute carrier family 11 (sod | |
| Modification date | 20180403 | 20180403 | |
| UniProtAcc | P49279 | P49279 | |
| Ensembl transtripts involved in fusion gene | ENST00000233202, ENST00000473367, ENST00000539932, | ENST00000233202, ENST00000473367, ENST00000539932, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 2 X 2 X 2=8 |
| # samples | 1 | 2 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: SLC11A1 [Title/Abstract] AND SLC11A1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | SLC11A1 | GO:0009617 | response to bacterium | 7717395 |
| Tgene | SLC11A1 | GO:0009617 | response to bacterium | 7717395 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BC037550 | SLC11A1 | chr2 | 219259358 | + | SLC11A1 | chr2 | 219248410 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000233202 | ENST00000233202 | SLC11A1 | chr2 | 219259358 | + | SLC11A1 | chr2 | 219248410 | + |
| intron-intron | ENST00000233202 | ENST00000473367 | SLC11A1 | chr2 | 219259358 | + | SLC11A1 | chr2 | 219248410 | + |
| intron-intron | ENST00000233202 | ENST00000539932 | SLC11A1 | chr2 | 219259358 | + | SLC11A1 | chr2 | 219248410 | + |
| intron-intron | ENST00000473367 | ENST00000233202 | SLC11A1 | chr2 | 219259358 | + | SLC11A1 | chr2 | 219248410 | + |
| intron-intron | ENST00000473367 | ENST00000473367 | SLC11A1 | chr2 | 219259358 | + | SLC11A1 | chr2 | 219248410 | + |
| intron-intron | ENST00000473367 | ENST00000539932 | SLC11A1 | chr2 | 219259358 | + | SLC11A1 | chr2 | 219248410 | + |
| intron-intron | ENST00000539932 | ENST00000233202 | SLC11A1 | chr2 | 219259358 | + | SLC11A1 | chr2 | 219248410 | + |
| intron-intron | ENST00000539932 | ENST00000473367 | SLC11A1 | chr2 | 219259358 | + | SLC11A1 | chr2 | 219248410 | + |
| intron-intron | ENST00000539932 | ENST00000539932 | SLC11A1 | chr2 | 219259358 | + | SLC11A1 | chr2 | 219248410 | + |
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FusionProtFeatures for SLC11A1_SLC11A1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SLC11A1 | SLC11A1 |
| Divalent transition metal (iron and manganese)transporter involved in iron metabolism and host resistance tocertain pathogens. Macrophage-specific membrane transportfunction. Controls natural resistance to infection withintracellular parasites. Pathogen resistance involvessequestration of Fe(2+) and Mn(2+), cofactors of both prokaryoticand eukaryotic catalases and superoxide dismutases, not only toprotect the macrophage against its own generation of reactiveoxygen species, but to deny the cations to the pathogen forsynthesis of its protective enzymes. | Divalent transition metal (iron and manganese)transporter involved in iron metabolism and host resistance tocertain pathogens. Macrophage-specific membrane transportfunction. Controls natural resistance to infection withintracellular parasites. Pathogen resistance involvessequestration of Fe(2+) and Mn(2+), cofactors of both prokaryoticand eukaryotic catalases and superoxide dismutases, not only toprotect the macrophage against its own generation of reactiveoxygen species, but to deny the cations to the pathogen forsynthesis of its protective enzymes. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SLC11A1_SLC11A1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SLC11A1_SLC11A1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SLC11A1_SLC11A1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SLC11A1_SLC11A1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | SLC11A1 | C0003873 | Rheumatoid Arthritis | 1 | CTD_human |
| Hgene | SLC11A1 | C0009324 | Ulcerative Colitis | 1 | CTD_human |
| Hgene | SLC11A1 | C0010346 | Crohn Disease | 1 | CTD_human |
| Hgene | SLC11A1 | C0011615 | Dermatitis, Atopic | 1 | CTD_human |
| Hgene | SLC11A1 | C0011854 | Diabetes Mellitus, Insulin-Dependent | 1 | CTD_human |
| Hgene | SLC11A1 | C0016470 | Food Allergy | 1 | CTD_human |
| Hgene | SLC11A1 | C0019693 | HIV Infections | 1 | CTD_human |
| Hgene | SLC11A1 | C0021390 | Inflammatory Bowel Diseases | 1 | CTD_human |
| Hgene | SLC11A1 | C0023290 | Leishmaniasis, Visceral | 1 | CTD_human |
| Hgene | SLC11A1 | C0023343 | Leprosy | 1 | CTD_human |
| Hgene | SLC11A1 | C0025294 | Meningococcal meningitis | 1 | CTD_human |
| Hgene | SLC11A1 | C0026769 | Multiple Sclerosis | 1 | CTD_human |
| Hgene | SLC11A1 | C0036202 | Sarcoidosis | 1 | CTD_human |
| Hgene | SLC11A1 | C0041296 | Tuberculosis | 1 | CTD_human;ORPHANET |
| Hgene | SLC11A1 | C2609414 | Acute kidney injury | 1 | CTD_human |
| Hgene | SLC11A1 | C3495559 | Juvenile arthritis | 1 | CTD_human |
| Tgene | SLC11A1 | C0003873 | Rheumatoid Arthritis | 1 | CTD_human |
| Tgene | SLC11A1 | C0009324 | Ulcerative Colitis | 1 | CTD_human |
| Tgene | SLC11A1 | C0010346 | Crohn Disease | 1 | CTD_human |
| Tgene | SLC11A1 | C0011615 | Dermatitis, Atopic | 1 | CTD_human |
| Tgene | SLC11A1 | C0011854 | Diabetes Mellitus, Insulin-Dependent | 1 | CTD_human |
| Tgene | SLC11A1 | C0016470 | Food Allergy | 1 | CTD_human |
| Tgene | SLC11A1 | C0019693 | HIV Infections | 1 | CTD_human |
| Tgene | SLC11A1 | C0021390 | Inflammatory Bowel Diseases | 1 | CTD_human |
| Tgene | SLC11A1 | C0023290 | Leishmaniasis, Visceral | 1 | CTD_human |
| Tgene | SLC11A1 | C0023343 | Leprosy | 1 | CTD_human |
| Tgene | SLC11A1 | C0025294 | Meningococcal meningitis | 1 | CTD_human |
| Tgene | SLC11A1 | C0026769 | Multiple Sclerosis | 1 | CTD_human |
| Tgene | SLC11A1 | C0036202 | Sarcoidosis | 1 | CTD_human |
| Tgene | SLC11A1 | C0041296 | Tuberculosis | 1 | CTD_human;ORPHANET |
| Tgene | SLC11A1 | C2609414 | Acute kidney injury | 1 | CTD_human |
| Tgene | SLC11A1 | C3495559 | Juvenile arthritis | 1 | CTD_human |
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