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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 34003

FusionGeneSummary for SKP1_HSPB1

check button Fusion gene summary
Fusion gene informationFusion gene name: SKP1_HSPB1
Fusion gene ID: 34003
HgeneTgene
Gene symbol

SKP1

HSPB1

Gene ID

6500

3315

Gene nameS-phase kinase associated protein 1heat shock protein family B (small) member 1
SynonymsEMC19|OCP-II|OCP2|SKP1A|TCEB1L|p19ACMT2F|HEL-S-102|HMN2B|HS.76067|HSP27|HSP28|Hsp25|SRP27
Cytomap

5q31.1

7q11.23

Type of geneprotein-codingprotein-coding
DescriptionS-phase kinase-associated protein 1OCP-2RNA polymerase II elongation factor-like protein OCP2SIIIcyclin A/CDK2-associated p19cyclin-A/CDK2-associated protein p19organ of Corti protein 2organ of Corti protein IIp19skp1transcription elongation factheat shock protein beta-128 kDa heat shock proteinepididymis secretory protein Li 102estrogen-regulated 24 kDa proteinheat shock 27 kDa proteinheat shock 27kD protein 1heat shock 27kDa protein 1stress-responsive protein 27
Modification date2018052320180527
UniProtAcc

P63208

P04792

Ensembl transtripts involved in fusion geneENST00000353411, ENST00000522552, 
ENST00000521216, ENST00000517625, 
ENST00000522855, 
ENST00000248553, 
ENST00000429938, 
Fusion gene scores* DoF score5 X 5 X 2=508 X 8 X 3=192
# samples 59
** MAII scorelog2(5/50*10)=0log2(9/192*10)=-1.09310940439148
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SKP1 [Title/Abstract] AND HSPB1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSKP1

GO:0016567

protein ubiquitination

15103331

HgeneSKP1

GO:0031146

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

15103331|20347421

HgeneSKP1

GO:0035518

histone H2A monoubiquitination

16943429


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AJ710478SKP1chr5

133496716

-HSPB1chr7

75932016

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000353411ENST00000248553SKP1chr5

133496716

-HSPB1chr7

75932016

+
intron-intronENST00000353411ENST00000429938SKP1chr5

133496716

-HSPB1chr7

75932016

+
intron-5UTRENST00000522552ENST00000248553SKP1chr5

133496716

-HSPB1chr7

75932016

+
intron-intronENST00000522552ENST00000429938SKP1chr5

133496716

-HSPB1chr7

75932016

+
5CDS-5UTRENST00000521216ENST00000248553SKP1chr5

133496716

-HSPB1chr7

75932016

+
5CDS-intronENST00000521216ENST00000429938SKP1chr5

133496716

-HSPB1chr7

75932016

+
intron-5UTRENST00000517625ENST00000248553SKP1chr5

133496716

-HSPB1chr7

75932016

+
intron-intronENST00000517625ENST00000429938SKP1chr5

133496716

-HSPB1chr7

75932016

+
intron-5UTRENST00000522855ENST00000248553SKP1chr5

133496716

-HSPB1chr7

75932016

+
intron-intronENST00000522855ENST00000429938SKP1chr5

133496716

-HSPB1chr7

75932016

+

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FusionProtFeatures for SKP1_HSPB1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SKP1

P63208

HSPB1

P04792

Essential component of the SCF (SKP1-CUL1-F-box protein)ubiquitin ligase complex, which mediates the ubiquitination ofproteins involved in cell cycle progression, signal transductionand transcription. In the SCF complex, serves as an adapter thatlinks the F-box protein to CUL1. The functional specificity of theSCF complex depends on the F-box protein as substrate recognitioncomponent. SCF(BTRC) and SCF(FBXW11) direct ubiquitination ofCTNNB1 and participate in Wnt signaling. SCF(FBXW11) directsubiquitination of phosphorylated NFKBIA. SCF(BTRC) directsubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A,FBXO5, CEP68 and probably NFKB2 (PubMed:25704143). SCF(SKP2)directs ubiquitination of phosphorylated CDKN1B/p27kip and isinvolved in regulation of G1/S transition. SCF(SKP2) directsubiquitination of ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A,and probably MYC and TAL1. SCF(FBXW7) directs ubiquitination ofcyclin E, NOTCH1 released notch intracellular domain (NICD), andprobably PSEN1. SCF(FBXW2) directs ubiquitination of GCM1.SCF(FBXO32) directs ubiquitination of MYOD1. SCF(FBXO7) directsubiquitination of BIRC2 and DLGAP5. SCF(FBXO33) directsubiquitination of YBX1. SCF(FBXO11) directs ubiquitination of BCL6and DTL but does not seem to direct ubiquitination of TP53.SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and'Lys-22'; the degradation frees the associated NFKB1-RELA dimer totranslocate into the nucleus and to activate transcription.SCF(CCNF) directs ubiquitination of CCP110. SCF(FBXL3) andSCF(FBXL21) direct ubiquitination of CRY1 and CRY2. SCF(FBXO9)directs ubiquitination of TTI1 and TELO2. SCF(FBXO10) directsubiquitination of BCL2. {ECO:0000269|PubMed:16209941,ECO:0000269|PubMed:20181953, ECO:0000269|PubMed:22113614,ECO:0000269|PubMed:23431138, ECO:0000269|PubMed:25704143}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SKP1_HSPB1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SKP1_HSPB1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SKP1_HSPB1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneHSPB1P04792DB11638ArtenimolHeat shock protein beta-1small moleculeapproved|investigational

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RelatedDiseases for SKP1_HSPB1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneHSPB1C2608087NEURONOPATHY, DISTAL HEREDITARY MOTOR, TYPE IIB9CTD_human;UNIPROT
TgeneHSPB1C1847823CHARCOT-MARIE-TOOTH DISEASE, AXONAL, TYPE 2F6CTD_human;ORPHANET;UNIPROT
TgeneHSPB1C0007134Renal Cell Carcinoma1CTD_human
TgeneHSPB1C0007137Squamous cell carcinoma1CTD_human
TgeneHSPB1C0007194Hypertrophic Cardiomyopathy1CTD_human
TgeneHSPB1C0009375Colonic Neoplasms1CTD_human
TgeneHSPB1C0011616Contact Dermatitis1CTD_human
TgeneHSPB1C0018801Heart failure1CTD_human
TgeneHSPB1C0019693HIV Infections1CTD_human
TgeneHSPB1C0020507Hyperplasia1CTD_human
TgeneHSPB1C0023467Leukemia, Myelocytic, Acute1CTD_human
TgeneHSPB1C0026640Mouth Neoplasms1CTD_human
TgeneHSPB1C0026764Multiple Myeloma1CTD_human
TgeneHSPB1C0035126Reperfusion Injury1CTD_human
TgeneHSPB1C0038220Status Epilepticus1CTD_human
TgeneHSPB1C0038356Stomach Neoplasms1CTD_human
TgeneHSPB1C0040411Tongue Neoplasms1CTD_human
TgeneHSPB1C0152013Adenocarcinoma of lung (disorder)1CTD_human
TgeneHSPB1C2239176Liver carcinoma1CTD_human