FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 340

FusionGeneSummary for ACADVL_ACADVL

check button Fusion gene summary
Fusion gene informationFusion gene name: ACADVL_ACADVL
Fusion gene ID: 340
HgeneTgene
Gene symbol

ACADVL

ACADVL

Gene ID

37

37

Gene nameacyl-CoA dehydrogenase very long chainacyl-CoA dehydrogenase very long chain
SynonymsACAD6|LCACD|VLCADACAD6|LCACD|VLCAD
Cytomap

17p13.1

17p13.1

Type of geneprotein-codingprotein-coding
Descriptionvery long-chain specific acyl-CoA dehydrogenase, mitochondrialacyl-Coenzyme A dehydrogenase, very long chainvery long-chain specific acyl-CoA dehydrogenase, mitochondrialacyl-Coenzyme A dehydrogenase, very long chain
Modification date2018052320180523
UniProtAcc

P49748

P49748

Ensembl transtripts involved in fusion geneENST00000543245, ENST00000356839, 
ENST00000350303, ENST00000581562, 
ENST00000543245, ENST00000356839, 
ENST00000350303, ENST00000581562, 
Fusion gene scores* DoF score3 X 3 X 2=186 X 6 X 4=144
# samples 36
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(6/144*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ACADVL [Title/Abstract] AND ACADVL [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneACADVL

GO:0033539

fatty acid beta-oxidation using acyl-CoA dehydrogenase

7668252

TgeneACADVL

GO:0033539

fatty acid beta-oxidation using acyl-CoA dehydrogenase

7668252


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BI013807ACADVLchr17

7124699

-ACADVLchr17

7124357

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000543245ENST00000543245ACADVLchr17

7124699

-ACADVLchr17

7124357

+
intron-3CDSENST00000543245ENST00000356839ACADVLchr17

7124699

-ACADVLchr17

7124357

+
intron-3CDSENST00000543245ENST00000350303ACADVLchr17

7124699

-ACADVLchr17

7124357

+
intron-3UTRENST00000543245ENST00000581562ACADVLchr17

7124699

-ACADVLchr17

7124357

+
intron-3CDSENST00000356839ENST00000543245ACADVLchr17

7124699

-ACADVLchr17

7124357

+
intron-3CDSENST00000356839ENST00000356839ACADVLchr17

7124699

-ACADVLchr17

7124357

+
intron-3CDSENST00000356839ENST00000350303ACADVLchr17

7124699

-ACADVLchr17

7124357

+
intron-3UTRENST00000356839ENST00000581562ACADVLchr17

7124699

-ACADVLchr17

7124357

+
intron-3CDSENST00000350303ENST00000543245ACADVLchr17

7124699

-ACADVLchr17

7124357

+
intron-3CDSENST00000350303ENST00000356839ACADVLchr17

7124699

-ACADVLchr17

7124357

+
intron-3CDSENST00000350303ENST00000350303ACADVLchr17

7124699

-ACADVLchr17

7124357

+
intron-3UTRENST00000350303ENST00000581562ACADVLchr17

7124699

-ACADVLchr17

7124357

+
intron-3CDSENST00000581562ENST00000543245ACADVLchr17

7124699

-ACADVLchr17

7124357

+
intron-3CDSENST00000581562ENST00000356839ACADVLchr17

7124699

-ACADVLchr17

7124357

+
intron-3CDSENST00000581562ENST00000350303ACADVLchr17

7124699

-ACADVLchr17

7124357

+
intron-3UTRENST00000581562ENST00000581562ACADVLchr17

7124699

-ACADVLchr17

7124357

+

Top

FusionProtFeatures for ACADVL_ACADVL


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ACADVL

P49748

ACADVL

P49748

Active toward esters of long-chain and very long chainfatty acids such as palmitoyl-CoA, myristoyl-CoA and stearoyl-CoA.Can accommodate substrate acyl chain lengths as long as 24carbons, but shows little activity for substrates of less than 12carbons. {ECO:0000269|PubMed:18227065}. Active toward esters of long-chain and very long chainfatty acids such as palmitoyl-CoA, myristoyl-CoA and stearoyl-CoA.Can accommodate substrate acyl chain lengths as long as 24carbons, but shows little activity for substrates of less than 12carbons. {ECO:0000269|PubMed:18227065}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for ACADVL_ACADVL


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for ACADVL_ACADVL


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for ACADVL_ACADVL


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for ACADVL_ACADVL


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneACADVLC3887523Very long chain acyl-CoA dehydrogenase deficiency4CTD_human;ORPHANET;UNIPROT
HgeneACADVLC0242184Hypoxia1CTD_human
TgeneACADVLC3887523Very long chain acyl-CoA dehydrogenase deficiency4CTD_human;ORPHANET;UNIPROT
TgeneACADVLC0242184Hypoxia1CTD_human