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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 33959

FusionGeneSummary for SKAP2_SCIN

check button Fusion gene summary
Fusion gene informationFusion gene name: SKAP2_SCIN
Fusion gene ID: 33959
HgeneTgene
Gene symbol

SKAP2

SCIN

Gene ID

8935

85477

Gene namesrc kinase associated phosphoprotein 2scinderin
SynonymsPRAP|RA70|SAPS|SCAP2|SKAP-HOM|SKAP55R-
Cytomap

7p15.2

7p21.3

Type of geneprotein-codingprotein-coding
Descriptionsrc kinase-associated phosphoprotein 2Fyn-associated phosphoprotein SKAP55 homologuePyk2/RAFTK-associated proteinSKAP-55HOMSKAP55 homologretinoic acid-induced protein 70src family-associated phosphoprotein 2src kinase-associated phosphoprotein of 5adseverin
Modification date2018052320180519
UniProtAcc

O75563

Q9Y6U3

Ensembl transtripts involved in fusion geneENST00000345317, ENST00000539623, 
ENST00000489977, 		ENST00000297029, 
ENST00000519209, ENST00000445618, 
ENST00000473722, 
Fusion gene scores* DoF score2 X 2 X 2=85 X 5 X 4=100
# samples 25
** MAII scorelog2(2/8*10)=1.32192809488736log2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SKAP2 [Title/Abstract] AND SCIN [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-AN-A0FZ-01ASKAP2chr7

26883649

-SCINchr7

12617689

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000345317ENST00000297029SKAP2chr7

26883649

-SCINchr7

12617689

+
5CDS-intronENST00000345317ENST00000519209SKAP2chr7

26883649

-SCINchr7

12617689

+
5CDS-intronENST00000345317ENST00000445618SKAP2chr7

26883649

-SCINchr7

12617689

+
5CDS-intronENST00000345317ENST00000473722SKAP2chr7

26883649

-SCINchr7

12617689

+
5UTR-3CDSENST00000539623ENST00000297029SKAP2chr7

26883649

-SCINchr7

12617689

+
5UTR-intronENST00000539623ENST00000519209SKAP2chr7

26883649

-SCINchr7

12617689

+
5UTR-intronENST00000539623ENST00000445618SKAP2chr7

26883649

-SCINchr7

12617689

+
5UTR-intronENST00000539623ENST00000473722SKAP2chr7

26883649

-SCINchr7

12617689

+
intron-3CDSENST00000489977ENST00000297029SKAP2chr7

26883649

-SCINchr7

12617689

+
intron-intronENST00000489977ENST00000519209SKAP2chr7

26883649

-SCINchr7

12617689

+
intron-intronENST00000489977ENST00000445618SKAP2chr7

26883649

-SCINchr7

12617689

+
intron-intronENST00000489977ENST00000473722SKAP2chr7

26883649

-SCINchr7

12617689

+

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FusionProtFeatures for SKAP2_SCIN


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SKAP2

O75563

SCIN

Q9Y6U3

May be involved in B-cell and macrophage adhesionprocesses. In B-cells, may act by coupling the B-cell receptor(BCR) to integrin activation. May play a role in src signalingpathway. {ECO:0000269|PubMed:12893833,ECO:0000269|PubMed:9837776}. Ca(2+)-dependent actin filament-severing protein thathas a regulatory function in exocytosis by affecting theorganization of the microfilament network underneath the plasmamembrane (PubMed:8547642, PubMed:26365202). Severing activity isinhibited by phosphatidylinositol 4,5-bis-phosphate (PIP2) (Bysimilarity). In vitro, also has barbed end capping and nucleatingactivities in the presence of Ca(2+). Required for megakaryocytedifferentiation, maturation, polyploidization and apoptosis withthe release of platelet-like particles (PubMed:11568009). Plays arole in osteoclastogenesis (OCG) and actin cytoskeletalorganization in osteoclasts (By similarity). Regulates chondrocyteproliferation and differentiation (By similarity). Inhibits cellproliferation and tumorigenesis. Signaling is mediated by MAPK,p38 and JNK pathways (PubMed:11568009).{ECO:0000250|UniProtKB:Q28046, ECO:0000250|UniProtKB:Q5ZIV9,ECO:0000250|UniProtKB:Q60604, ECO:0000269|PubMed:11568009,ECO:0000269|PubMed:26365202, ECO:0000269|PubMed:8547642}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSKAP2chr7:26883649chr7:12617689ENST00000345317-41314_641021096RegionHomodimerization
TgeneSCINchr7:26883649chr7:12617689ENST00000297029+016112_11966716RegionPolyphosphoinositide binding
TgeneSCINchr7:26883649chr7:12617689ENST00000297029+016138_14666716RegionPolyphosphoinositide binding
TgeneSCINchr7:26883649chr7:12617689ENST00000297029+016364_71566716RegionNote=Ca(2+)-dependent actin binding
TgeneSCINchr7:26883649chr7:12617689ENST00000445618+013112_119-76469RegionPolyphosphoinositide binding
TgeneSCINchr7:26883649chr7:12617689ENST00000445618+013138_146-76469RegionPolyphosphoinositide binding
TgeneSCINchr7:26883649chr7:12617689ENST00000445618+0131_363-76469RegionActin-severing
TgeneSCINchr7:26883649chr7:12617689ENST00000445618+013364_715-76469RegionNote=Ca(2+)-dependent actin binding
TgeneSCINchr7:26883649chr7:12617689ENST00000519209+014112_119-122469RegionPolyphosphoinositide binding
TgeneSCINchr7:26883649chr7:12617689ENST00000519209+014138_146-122469RegionPolyphosphoinositide binding
TgeneSCINchr7:26883649chr7:12617689ENST00000519209+0141_363-122469RegionActin-severing
TgeneSCINchr7:26883649chr7:12617689ENST00000519209+014364_715-122469RegionNote=Ca(2+)-dependent actin binding
TgeneSCINchr7:26883649chr7:12617689ENST00000297029+016148_18866716RepeatNote=Gelsolin-like 2
TgeneSCINchr7:26883649chr7:12617689ENST00000297029+016265_30766716RepeatNote=Gelsolin-like 3
TgeneSCINchr7:26883649chr7:12617689ENST00000297029+016398_45166716RepeatNote=Gelsolin-like 4
TgeneSCINchr7:26883649chr7:12617689ENST00000297029+016523_56466716RepeatNote=Gelsolin-like 5
TgeneSCINchr7:26883649chr7:12617689ENST00000297029+016626_66866716RepeatNote=Gelsolin-like 6
TgeneSCINchr7:26883649chr7:12617689ENST00000445618+013148_188-76469RepeatNote=Gelsolin-like 2
TgeneSCINchr7:26883649chr7:12617689ENST00000445618+013265_307-76469RepeatNote=Gelsolin-like 3
TgeneSCINchr7:26883649chr7:12617689ENST00000445618+01327_76-76469RepeatNote=Gelsolin-like 1
TgeneSCINchr7:26883649chr7:12617689ENST00000445618+013398_451-76469RepeatNote=Gelsolin-like 4
TgeneSCINchr7:26883649chr7:12617689ENST00000445618+013523_564-76469RepeatNote=Gelsolin-like 5
TgeneSCINchr7:26883649chr7:12617689ENST00000445618+013626_668-76469RepeatNote=Gelsolin-like 6
TgeneSCINchr7:26883649chr7:12617689ENST00000519209+014148_188-122469RepeatNote=Gelsolin-like 2
TgeneSCINchr7:26883649chr7:12617689ENST00000519209+014265_307-122469RepeatNote=Gelsolin-like 3
TgeneSCINchr7:26883649chr7:12617689ENST00000519209+01427_76-122469RepeatNote=Gelsolin-like 1
TgeneSCINchr7:26883649chr7:12617689ENST00000519209+014398_451-122469RepeatNote=Gelsolin-like 4
TgeneSCINchr7:26883649chr7:12617689ENST00000519209+014523_564-122469RepeatNote=Gelsolin-like 5
TgeneSCINchr7:26883649chr7:12617689ENST00000519209+014626_668-122469RepeatNote=Gelsolin-like 6

- In-frame and not-retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSKAP2chr7:26883649chr7:12617689ENST00000345317-413116_2191021096DomainPH
HgeneSKAP2chr7:26883649chr7:12617689ENST00000345317-413297_3581021096DomainSH3
TgeneSCINchr7:26883649chr7:12617689ENST00000297029+0161_36366716RegionActin-severing
TgeneSCINchr7:26883649chr7:12617689ENST00000297029+01627_7666716RepeatNote=Gelsolin-like 1


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FusionGeneSequence for SKAP2_SCIN


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_SKAP2_ENST00000345317_chr7_26883649_-_SCIN_ENST00000297029_chr7_12617689_+_752aa
MPNPSSTSSPYPLPEEIRNLLADVETFVADILKGENLSKKAKEKRESLIKKIKDVKSIYLQEFQDKGDAEDGEEYDDPFAGPPDTISLAS
ERYDKDDEAPSDGKECSQDESTAAAIFTVQMDDYLGGKPVQNRELQGYESNDFVSYFKGGLKYKAGGVASGLNHVLTNDLTAKRLLHVKG
RRVVRATEVPLSWDSFNKGDCFIIDLGTEIYQWCGSSCNKYERLKANQVATGIRYNERKGRSELIVVEEGSEPSELIKVLGEKPELPDGG
DDDDIIADISNRKMAKLYMVSDASGSMRVTVVAEENPFSMAMLLSEECFILDHGAAKQIFVWKGKDANPQERKAAMKTAEEFLQQMNYSK
NTQIQVLPEGGETPIFKQFFKDWRDKDQSDGFGKVYVTEKVAQIKQIPFDASKLHSSPQMAAQHNMVDDGSGKVEIWRVENNGRIQVDQN
SYGEFYGGDCYIILYTYPRGQIIYTWQGANATRDELTTSAFLTVQLDRSLGGQAVQIRVSQGKEPVHLLSLFKDKPLIIYKNGTSKKGGQ
APAPPTRLFQVRRNLASITRIVEVDVDANSLNSNDVFVLKLPQNSGYIWVGKGASQEEEKGAEYVASVLKCKTLRIQEGEEPEEFWNSLG
GKKDYQTSPLLETQAEDHPPRLYGCSNKTGRFVIEEIPGEFTQDDLAEDDVMLLDAWEQIFIWIGKDANEVEKKESLKSAKMYLETDPSG


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_SKAP2_ENST00000345317_chr7_26883649_-_SCIN_ENST00000297029_chr7_12617689_+_2256nt
ATGCCCAACCCCAGCAGCACCTCCTCTCCCTACCCCCTCCCTGAGGAAATTAGGAACCTGTTGGCAGATGTTGAAACATTTGTAGCAGAT
ATACTGAAAGGAGAAAATTTATCCAAGAAAGCAAAGGAAAAGAGAGAATCCCTTATTAAGAAGATAAAAGATGTAAAGTCTATCTATCTT
CAGGAATTTCAAGACAAAGGTGATGCAGAAGATGGGGAAGAATATGATGACCCTTTTGCTGGGCCTCCAGACACTATTTCATTAGCCTCA
GAACGATATGATAAAGACGATGAAGCCCCCTCTGATGGAAAGGAGTGTTCCCAGGATGAAAGCACAGCTGCTGCCATCTTCACTGTTCAG
ATGGATGACTATTTGGGTGGCAAGCCAGTGCAGAATAGAGAACTTCAAGGATATGAGTCTAATGACTTTGTTAGCTATTTCAAAGGCGGT
CTGAAATACAAGGCTGGAGGCGTGGCATCTGGATTAAATCATGTTCTTACGAACGACCTGACAGCCAAGAGGCTCCTACATGTGAAGGGT
CGTAGAGTGGTGAGAGCCACAGAAGTTCCCCTTAGCTGGGACAGTTTCAACAAGGGTGACTGCTTCATCATTGACCTTGGCACCGAAATT
TATCAGTGGTGTGGTTCCTCGTGCAACAAATATGAACGTCTGAAGGCAAACCAGGTAGCTACTGGCATTCGGTACAATGAAAGGAAAGGA
AGGTCTGAACTAATTGTCGTGGAAGAAGGAAGTGAACCCTCAGAACTTATAAAGGTCTTAGGGGAAAAGCCAGAGCTTCCAGATGGAGGT
GATGATGATGACATTATAGCAGACATAAGTAACAGGAAAATGGCTAAACTATACATGGTTTCAGATGCAAGTGGCTCCATGAGAGTGACT
GTGGTGGCAGAAGAAAACCCCTTCTCAATGGCAATGCTGCTGTCTGAAGAATGCTTTATTTTGGACCACGGGGCTGCCAAACAAATTTTC
GTATGGAAAGGTAAAGATGCTAATCCCCAAGAGAGGAAGGCTGCAATGAAGACAGCTGAAGAATTTCTACAGCAAATGAATTATTCCAAG
AATACCCAAATTCAAGTTCTTCCAGAAGGAGGTGAAACACCAATCTTCAAACAGTTTTTTAAGGACTGGAGAGATAAAGATCAGAGTGAT
GGCTTCGGGAAAGTTTATGTCACAGAGAAAGTGGCTCAAATAAAACAAATTCCCTTTGATGCCTCAAAATTACACAGTTCTCCGCAGATG
GCAGCCCAGCACAATATGGTGGATGATGGTTCTGGCAAAGTGGAGATTTGGCGTGTAGAAAACAATGGTAGGATCCAAGTTGACCAAAAC
TCATATGGTGAATTCTATGGTGGTGACTGCTACATCATACTCTACACCTATCCCAGAGGACAGATTATCTACACGTGGCAAGGAGCAAAT
GCCACACGAGATGAGCTGACAACATCTGCGTTCCTGACTGTTCAGTTGGATCGGTCCCTTGGAGGACAGGCTGTGCAGATCCGAGTCTCC
CAAGGCAAAGAGCCTGTTCACCTACTGAGTTTGTTCAAAGACAAACCGCTCATTATTTACAAGAATGGAACATCAAAGAAAGGAGGTCAG
GCACCTGCTCCCCCTACACGCCTCTTTCAAGTCCGGAGAAACCTGGCATCTATCACCAGAATTGTGGAGGTTGATGTTGATGCAAATTCA
CTGAATTCTAACGATGTTTTTGTCCTGAAACTGCCACAAAATAGTGGCTACATCTGGGTAGGAAAAGGTGCTAGCCAGGAGGAGGAGAAA
GGAGCAGAGTATGTAGCAAGTGTCCTAAAGTGCAAAACCTTAAGGATCCAAGAAGGCGAGGAGCCAGAGGAGTTCTGGAATTCCCTTGGA
GGGAAAAAAGACTACCAGACCTCACCACTACTGGAAACCCAGGCTGAAGACCATCCACCTCGGCTTTACGGCTGCTCTAACAAAACTGGA
AGATTTGTTATTGAAGAGATTCCAGGAGAGTTCACCCAGGATGATTTAGCTGAAGATGATGTCATGTTACTAGATGCTTGGGAACAGATA
TTTATTTGGATTGGCAAAGATGCTAATGAAGTTGAGAAAAAAGAATCTCTGAAGTCTGCCAAAATGTACCTTGAGACAGACCCTTCTGGA
AGAGACAAGAGGACACCAATTGTCATCATAAAACAGGGCCATGAGCCACCCACATTCACAGGCTGGTTCCTGGGCTGGGATTCCAGCAAG


* Fusion transcript sequences (Full-length transcript).
>In-frame_SKAP2_ENST00000345317_chr7_26883649_-_SCIN_ENST00000297029_chr7_12617689_+_3458nt
AGGCTCTTTCTTCTGGGGCCGGGAAAACCGAGGAATACACATGCGCAGTTGGACCCCTCAGGCCCTTCGTGTCCCTTCCCACCCATCTCC
CCGCCCCGGCCCTCTGGGCGGGGCTGGGCCGACAGTCCAGCTGCAGCTCGCTGGAGATTCAGTGACTTCCTTGTTGTGAGCCCCGGCCCG
GCAGTGTCCCGACTCGTAGCCCCGCTGTTCTTAATCCGGGCCGCTAGCCTGAGTCTAGGTCGCAGCCGCAGCCCCACCCCGTCGGTCACC
TTTTCAGCGCAGGTCCTTTCCCCGCACGCCCTGCGCTCCCTAACATGCCCAACCCCAGCAGCACCTCCTCTCCCTACCCCCTCCCTGAGG
AAATTAGGAACCTGTTGGCAGATGTTGAAACATTTGTAGCAGATATACTGAAAGGAGAAAATTTATCCAAGAAAGCAAAGGAAAAGAGAG
AATCCCTTATTAAGAAGATAAAAGATGTAAAGTCTATCTATCTTCAGGAATTTCAAGACAAAGGTGATGCAGAAGATGGGGAAGAATATG
ATGACCCTTTTGCTGGGCCTCCAGACACTATTTCATTAGCCTCAGAACGATATGATAAAGACGATGAAGCCCCCTCTGATGGAAAGGAGT
GTTCCCAGGATGAAAGCACAGCTGCTGCCATCTTCACTGTTCAGATGGATGACTATTTGGGTGGCAAGCCAGTGCAGAATAGAGAACTTC
AAGGATATGAGTCTAATGACTTTGTTAGCTATTTCAAAGGCGGTCTGAAATACAAGGCTGGAGGCGTGGCATCTGGATTAAATCATGTTC
TTACGAACGACCTGACAGCCAAGAGGCTCCTACATGTGAAGGGTCGTAGAGTGGTGAGAGCCACAGAAGTTCCCCTTAGCTGGGACAGTT
TCAACAAGGGTGACTGCTTCATCATTGACCTTGGCACCGAAATTTATCAGTGGTGTGGTTCCTCGTGCAACAAATATGAACGTCTGAAGG
CAAACCAGGTAGCTACTGGCATTCGGTACAATGAAAGGAAAGGAAGGTCTGAACTAATTGTCGTGGAAGAAGGAAGTGAACCCTCAGAAC
TTATAAAGGTCTTAGGGGAAAAGCCAGAGCTTCCAGATGGAGGTGATGATGATGACATTATAGCAGACATAAGTAACAGGAAAATGGCTA
AACTATACATGGTTTCAGATGCAAGTGGCTCCATGAGAGTGACTGTGGTGGCAGAAGAAAACCCCTTCTCAATGGCAATGCTGCTGTCTG
AAGAATGCTTTATTTTGGACCACGGGGCTGCCAAACAAATTTTCGTATGGAAAGGTAAAGATGCTAATCCCCAAGAGAGGAAGGCTGCAA
TGAAGACAGCTGAAGAATTTCTACAGCAAATGAATTATTCCAAGAATACCCAAATTCAAGTTCTTCCAGAAGGAGGTGAAACACCAATCT
TCAAACAGTTTTTTAAGGACTGGAGAGATAAAGATCAGAGTGATGGCTTCGGGAAAGTTTATGTCACAGAGAAAGTGGCTCAAATAAAAC
AAATTCCCTTTGATGCCTCAAAATTACACAGTTCTCCGCAGATGGCAGCCCAGCACAATATGGTGGATGATGGTTCTGGCAAAGTGGAGA
TTTGGCGTGTAGAAAACAATGGTAGGATCCAAGTTGACCAAAACTCATATGGTGAATTCTATGGTGGTGACTGCTACATCATACTCTACA
CCTATCCCAGAGGACAGATTATCTACACGTGGCAAGGAGCAAATGCCACACGAGATGAGCTGACAACATCTGCGTTCCTGACTGTTCAGT
TGGATCGGTCCCTTGGAGGACAGGCTGTGCAGATCCGAGTCTCCCAAGGCAAAGAGCCTGTTCACCTACTGAGTTTGTTCAAAGACAAAC
CGCTCATTATTTACAAGAATGGAACATCAAAGAAAGGAGGTCAGGCACCTGCTCCCCCTACACGCCTCTTTCAAGTCCGGAGAAACCTGG
CATCTATCACCAGAATTGTGGAGGTTGATGTTGATGCAAATTCACTGAATTCTAACGATGTTTTTGTCCTGAAACTGCCACAAAATAGTG
GCTACATCTGGGTAGGAAAAGGTGCTAGCCAGGAGGAGGAGAAAGGAGCAGAGTATGTAGCAAGTGTCCTAAAGTGCAAAACCTTAAGGA
TCCAAGAAGGCGAGGAGCCAGAGGAGTTCTGGAATTCCCTTGGAGGGAAAAAAGACTACCAGACCTCACCACTACTGGAAACCCAGGCTG
AAGACCATCCACCTCGGCTTTACGGCTGCTCTAACAAAACTGGAAGATTTGTTATTGAAGAGATTCCAGGAGAGTTCACCCAGGATGATT
TAGCTGAAGATGATGTCATGTTACTAGATGCTTGGGAACAGATATTTATTTGGATTGGCAAAGATGCTAATGAAGTTGAGAAAAAAGAAT
CTCTGAAGTCTGCCAAAATGTACCTTGAGACAGACCCTTCTGGAAGAGACAAGAGGACACCAATTGTCATCATAAAACAGGGCCATGAGC
CACCCACATTCACAGGCTGGTTCCTGGGCTGGGATTCCAGCAAGTGGTAAATTGGTATTTGTAAAAAGCAAACAAACATTACAAGGCAGT
TATCTCATTGCTGTTTTGGGAGAGGAACGGGAAAAGCTTTTTGCTTATTTGTCTTTTGAAAATTAAGGCTGGGCGCGGTGGCTCACACCT
GTAATCCCAGCACTTTGAGAGGATGAGGTAGGCGGATCACTGGGGTCAGGATTTCGAGACCAGCCTGGCCAACATGGCGAAACCTCGCCT
CTACTAAAAATACAAAAAAATTAGCTGCGCGTGGTGGTGCACGCCTGTAGTCCCTGCTACTTGGAAGGCTGAGACAGGAAAATTGCTTGA
ACCCAGGAGGCTGAGGTTGCAGTGAGCCAGGATTGCGCCACCACACTCCAGCCTGGGCAACAGAGACTCTGTCTCAAAAAAAAAAAAAAA
AAAAATTAACCTCAACCAAACGCCTATTTTTTAATGCTTAGTTTTGGCTTGAAATTCTTCTTCACCTGGAGTTTTCTTACGTTAATACAT
TAAAATAACCTGAAGGAAACTTTCGTTATGGGCCAATATTAGCTCTTATGGAAACTGATTTATATCTTTTTTATGACCTTTCAAAAGTAA
AATACTATGCATAATCTAGAAAGATTTGTCAGATAGGAAATTTTATAATGCATTAGCCATTAGTCAGAGTTGTTTTTTAACATGCCAGAG
AAAAAGTTGTAATGCCTTGGAAGTTATTCTCTTTTCTATAGATTGTGTTCAAAAGATGTGTATACTTGCAATAAGGTTTATGTTAAGGTG
GCTTTAACAATTGGTTGCTATTTTCCTTCTTTAGTCAATATGACTTTGATGTCATTAACTGCTAAGTGTTATTTTCTAAGAGGAATTTTA


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FusionGenePPI for SKAP2_SCIN


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SKAP2PRAM1, FYN, LYN, HCK, KHDRBS1, FASLG, PTK2B, SRC, GRB2, APP, SKAP1, RGS3, ABHD5, FRMD1, SNRPNSCINACTA1, BAG3, OBSL1, CCDC8, TMOD1, TMOD2, ACTR1B, SSH1, TMOD3, BCL7C, BCL7A, LSP1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SKAP2_SCIN


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SKAP2_SCIN


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSKAP2C0023893Liver Cirrhosis, Experimental1CTD_human