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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 33923

FusionGeneSummary for SIRPB2_HSPA1A

check button Fusion gene summary
Fusion gene informationFusion gene name: SIRPB2_HSPA1A
Fusion gene ID: 33923
HgeneTgene
Gene symbol

SIRPB2

HSPA1A

Gene ID

284759

3303

Gene namesignal regulatory protein beta 2heat shock protein family A (Hsp70) member 1A
SynonymsPTPN1L|PTPNS1L3|dJ776F14.2HEL-S-103|HSP70-1|HSP70-1A|HSP70.1|HSP70I|HSP72|HSPA1
Cytomap

20p13

6p21.33

Type of geneprotein-codingprotein-coding
Descriptionsignal-regulatory protein beta-2SIRP-beta-2protein tyrosine phosphatase non-receptor type substrate proteinprotein tyrosine phosphatase, non-receptor type substrate 1-like 3heat shock 70 kDa protein 1AHSP70-1/HSP70-2HSP70.1/HSP70.2dnaK-type molecular chaperone HSP70-1epididymis secretory protein Li 103heat shock 70 kDa protein 1heat shock 70 kDa protein 1/2heat shock 70 kDa protein 1A/1Bheat shock 70kD protein 1Ahea
Modification date2018052320180523
UniProtAcc

Q5JXA9

Ensembl transtripts involved in fusion geneENST00000359801, ENST00000444444, 
ENST00000537284, ENST00000608747, 
ENST00000375651, ENST00000458062, 
ENST00000608703, ENST00000430065, 
ENST00000422919, ENST00000441618, 
ENST00000449876, ENST00000433487, 
ENST00000452298, ENST00000400040, 
ENST00000383389, 
Fusion gene scores* DoF score1 X 1 X 1=13 X 3 X 1=9
# samples 15
** MAII scorelog2(1/1*10)=3.32192809488736log2(5/9*10)=2.47393118833241
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SIRPB2 [Title/Abstract] AND HSPA1A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneHSPA1A

GO:0006402

mRNA catabolic process

10205060

TgeneHSPA1A

GO:0006986

response to unfolded protein

10859165

TgeneHSPA1A

GO:0031396

regulation of protein ubiquitination

16809764

TgeneHSPA1A

GO:0031397

negative regulation of protein ubiquitination

12150907

TgeneHSPA1A

GO:0032436

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

24613385

TgeneHSPA1A

GO:0034605

cellular response to heat

24061851

TgeneHSPA1A

GO:0042026

protein refolding

15603737|21231916

TgeneHSPA1A

GO:0046034

ATP metabolic process

23921388

TgeneHSPA1A

GO:0050821

protein stabilization

21909508

TgeneHSPA1A

GO:0051131

chaperone-mediated protein complex assembly

10811660

TgeneHSPA1A

GO:0090084

negative regulation of inclusion body assembly

15603737|21231916

TgeneHSPA1A

GO:0097201

negative regulation of transcription from RNA polymerase II promoter in response to stress

9499401

TgeneHSPA1A

GO:1901029

negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

20625543

TgeneHSPA1A

GO:1902236

negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

12150907|20625543

TgeneHSPA1A

GO:1902380

positive regulation of endoribonuclease activity

20625543


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AK097113SIRPB2chr20

1470878

-HSPA1Achr6

3078464

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000359801ENST00000375651SIRPB2chr20

1470878

-HSPA1Achr6

3078464

+
intron-intronENST00000359801ENST00000458062SIRPB2chr20

1470878

-HSPA1Achr6

3078464

+
intron-intronENST00000359801ENST00000608703SIRPB2chr20

1470878

-HSPA1Achr6

3078464

+
intron-intronENST00000359801ENST00000430065SIRPB2chr20

1470878

-HSPA1Achr6

3078464

+
intron-intronENST00000359801ENST00000422919SIRPB2chr20

1470878

-HSPA1Achr6

3078464

+
intron-intronENST00000359801ENST00000441618SIRPB2chr20

1470878

-HSPA1Achr6

3078464

+
intron-intronENST00000359801ENST00000449876SIRPB2chr20

1470878

-HSPA1Achr6

3078464

+
intron-intronENST00000359801ENST00000433487SIRPB2chr20

1470878

-HSPA1Achr6

3078464

+
intron-intronENST00000359801ENST00000452298SIRPB2chr20

1470878

-HSPA1Achr6

3078464

+
intron-intronENST00000359801ENST00000400040SIRPB2chr20

1470878

-HSPA1Achr6

3078464

+
intron-intronENST00000359801ENST00000383389SIRPB2chr20

1470878

-HSPA1Achr6

3078464

+
intron-intronENST00000444444ENST00000375651SIRPB2chr20

1470878

-HSPA1Achr6

3078464

+
intron-intronENST00000444444ENST00000458062SIRPB2chr20

1470878

-HSPA1Achr6

3078464

+
intron-intronENST00000444444ENST00000608703SIRPB2chr20

1470878

-HSPA1Achr6

3078464

+
intron-intronENST00000444444ENST00000430065SIRPB2chr20

1470878

-HSPA1Achr6

3078464

+
intron-intronENST00000444444ENST00000422919SIRPB2chr20

1470878

-HSPA1Achr6

3078464

+
intron-intronENST00000444444ENST00000441618SIRPB2chr20

1470878

-HSPA1Achr6

3078464

+
intron-intronENST00000444444ENST00000449876SIRPB2chr20

1470878

-HSPA1Achr6

3078464

+
intron-intronENST00000444444ENST00000433487SIRPB2chr20

1470878

-HSPA1Achr6

3078464

+
intron-intronENST00000444444ENST00000452298SIRPB2chr20

1470878

-HSPA1Achr6

3078464

+
intron-intronENST00000444444ENST00000400040SIRPB2chr20

1470878

-HSPA1Achr6

3078464

+
intron-intronENST00000444444ENST00000383389SIRPB2chr20

1470878

-HSPA1Achr6

3078464

+
intron-intronENST00000537284ENST00000375651SIRPB2chr20

1470878

-HSPA1Achr6

3078464

+
intron-intronENST00000537284ENST00000458062SIRPB2chr20

1470878

-HSPA1Achr6

3078464

+
intron-intronENST00000537284ENST00000608703SIRPB2chr20

1470878

-HSPA1Achr6

3078464

+
intron-intronENST00000537284ENST00000430065SIRPB2chr20

1470878

-HSPA1Achr6

3078464

+
intron-intronENST00000537284ENST00000422919SIRPB2chr20

1470878

-HSPA1Achr6

3078464

+
intron-intronENST00000537284ENST00000441618SIRPB2chr20

1470878

-HSPA1Achr6

3078464

+
intron-intronENST00000537284ENST00000449876SIRPB2chr20

1470878

-HSPA1Achr6

3078464

+
intron-intronENST00000537284ENST00000433487SIRPB2chr20

1470878

-HSPA1Achr6

3078464

+
intron-intronENST00000537284ENST00000452298SIRPB2chr20

1470878

-HSPA1Achr6

3078464

+
intron-intronENST00000537284ENST00000400040SIRPB2chr20

1470878

-HSPA1Achr6

3078464

+
intron-intronENST00000537284ENST00000383389SIRPB2chr20

1470878

-HSPA1Achr6

3078464

+
intron-intronENST00000608747ENST00000375651SIRPB2chr20

1470878

-HSPA1Achr6

3078464

+
intron-intronENST00000608747ENST00000458062SIRPB2chr20

1470878

-HSPA1Achr6

3078464

+
intron-intronENST00000608747ENST00000608703SIRPB2chr20

1470878

-HSPA1Achr6

3078464

+
intron-intronENST00000608747ENST00000430065SIRPB2chr20

1470878

-HSPA1Achr6

3078464

+
intron-intronENST00000608747ENST00000422919SIRPB2chr20

1470878

-HSPA1Achr6

3078464

+
intron-intronENST00000608747ENST00000441618SIRPB2chr20

1470878

-HSPA1Achr6

3078464

+
intron-intronENST00000608747ENST00000449876SIRPB2chr20

1470878

-HSPA1Achr6

3078464

+
intron-intronENST00000608747ENST00000433487SIRPB2chr20

1470878

-HSPA1Achr6

3078464

+
intron-intronENST00000608747ENST00000452298SIRPB2chr20

1470878

-HSPA1Achr6

3078464

+
intron-intronENST00000608747ENST00000400040SIRPB2chr20

1470878

-HSPA1Achr6

3078464

+
intron-intronENST00000608747ENST00000383389SIRPB2chr20

1470878

-HSPA1Achr6

3078464

+

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FusionProtFeatures for SIRPB2_HSPA1A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SIRPB2

Q5JXA9

HSPA1A

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SIRPB2_HSPA1A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SIRPB2_HSPA1A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SIRPB2_HSPA1A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SIRPB2_HSPA1A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneHSPA1AC0036341Schizophrenia5PSYGENET
TgeneHSPA1AC0041696Unipolar Depression3PSYGENET
TgeneHSPA1AC1269683Major Depressive Disorder3PSYGENET
TgeneHSPA1AC2609414Acute kidney injury2CTD_human
TgeneHSPA1AC0013182Drug Allergy1CTD_human
TgeneHSPA1AC0023895Liver diseases1CTD_human
TgeneHSPA1AC0024517Single major depressive episode1PSYGENET
TgeneHSPA1AC0025202melanoma1CTD_human
TgeneHSPA1AC0027627Neoplasm Metastasis1CTD_human
TgeneHSPA1AC0030567Parkinson Disease1CTD_human
TgeneHSPA1AC0033578Prostatic Neoplasms1CTD_human
TgeneHSPA1AC0035126Reperfusion Injury1CTD_human
TgeneHSPA1AC0036349Paranoid Schizophrenia1PSYGENET
TgeneHSPA1AC0151744Myocardial Ischemia1CTD_human
TgeneHSPA1AC0282507Heat Stress Disorders1CTD_human
TgeneHSPA1AC0887833Carcinoma, Pancreatic Ductal1CTD_human