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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 3390

FusionGeneSummary for ATP5B_PTMA

check button Fusion gene summary
Fusion gene informationFusion gene name: ATP5B_PTMA
Fusion gene ID: 3390
HgeneTgene
Gene symbol

ATP5B

PTMA

Gene ID

5757

Gene nameprothymosin alpha
SynonymsTMSA
Cytomap

2q37.1

Type of geneprotein-coding
Descriptionprothymosin alphagene sequence 28prothymosin alpha proteinprothymosin-I+/-
Modification date20180522
UniProtAcc

P06454

Ensembl transtripts involved in fusion geneENST00000262030, ENST00000552919, 
ENST00000550162, 
ENST00000466801, 
ENST00000409321, ENST00000409115, 
ENST00000341369, ENST00000409683, 
ENST00000410064, 
Fusion gene scores* DoF score8 X 9 X 4=28817 X 17 X 2=578
# samples 1018
** MAII scorelog2(10/288*10)=-1.52606881166759
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(18/578*10)=-1.683072586171
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ATP5B [Title/Abstract] AND PTMA [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CV344647ATP5Bchr12

57037273

-PTMAchr2

232573417

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000262030ENST00000466801ATP5Bchr12

57037273

-PTMAchr2

232573417

-
intron-intronENST00000262030ENST00000409321ATP5Bchr12

57037273

-PTMAchr2

232573417

-
intron-intronENST00000262030ENST00000409115ATP5Bchr12

57037273

-PTMAchr2

232573417

-
intron-intronENST00000262030ENST00000341369ATP5Bchr12

57037273

-PTMAchr2

232573417

-
intron-intronENST00000262030ENST00000409683ATP5Bchr12

57037273

-PTMAchr2

232573417

-
intron-intronENST00000262030ENST00000410064ATP5Bchr12

57037273

-PTMAchr2

232573417

-
intron-intronENST00000552919ENST00000466801ATP5Bchr12

57037273

-PTMAchr2

232573417

-
intron-intronENST00000552919ENST00000409321ATP5Bchr12

57037273

-PTMAchr2

232573417

-
intron-intronENST00000552919ENST00000409115ATP5Bchr12

57037273

-PTMAchr2

232573417

-
intron-intronENST00000552919ENST00000341369ATP5Bchr12

57037273

-PTMAchr2

232573417

-
intron-intronENST00000552919ENST00000409683ATP5Bchr12

57037273

-PTMAchr2

232573417

-
intron-intronENST00000552919ENST00000410064ATP5Bchr12

57037273

-PTMAchr2

232573417

-
intron-intronENST00000550162ENST00000466801ATP5Bchr12

57037273

-PTMAchr2

232573417

-
intron-intronENST00000550162ENST00000409321ATP5Bchr12

57037273

-PTMAchr2

232573417

-
intron-intronENST00000550162ENST00000409115ATP5Bchr12

57037273

-PTMAchr2

232573417

-
intron-intronENST00000550162ENST00000341369ATP5Bchr12

57037273

-PTMAchr2

232573417

-
intron-intronENST00000550162ENST00000409683ATP5Bchr12

57037273

-PTMAchr2

232573417

-
intron-intronENST00000550162ENST00000410064ATP5Bchr12

57037273

-PTMAchr2

232573417

-

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FusionProtFeatures for ATP5B_PTMA


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ATP5B

PTMA

P06454

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. Prothymosin alpha may mediate immune function byconferring resistance to certain opportunistic infections.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ATP5B_PTMA


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ATP5B_PTMA


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ATP5B_PTMA


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ATP5B_PTMA


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePTMAC0001430Adenoma1CTD_human
TgenePTMAC0015695Fatty Liver1CTD_human
TgenePTMAC0024121Lung Neoplasms1CTD_human
TgenePTMAC0035412Rhabdomyosarcoma1CTD_human