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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 33878

FusionGeneSummary for SIMC1_MCM4

check button Fusion gene summary
Fusion gene informationFusion gene name: SIMC1_MCM4
Fusion gene ID: 33878
HgeneTgene
Gene symbol

SIMC1

MCM4

Gene ID

375484

4173

Gene nameSUMO interacting motifs containing 1minichromosome maintenance complex component 4
SynonymsC5orf25|OOMA1|PLEIADCDC21|CDC54|IMD54|NKCD|NKGCD|P1-CDC21|hCdc21
Cytomap

5q35.2

8q11.21

Type of geneprotein-codingprotein-coding
DescriptionSUMO-interacting motif-containing protein 1oocyte maturation associated 1platform element for inhibition of autolytic degradationDNA replication licensing factor MCM4CDC21 homologhomolog of S. pombe cell devision cycle 21minichromosome maintenance deficient 4
Modification date2018052320180522
UniProtAcc

Q8NDZ2

P33991

Ensembl transtripts involved in fusion geneENST00000341199, ENST00000430704, 
ENST00000443967, ENST00000332772, 
ENST00000429602, ENST00000503595, 
ENST00000523944, ENST00000262105, 
ENST00000518680, 
Fusion gene scores* DoF score1 X 1 X 1=13 X 3 X 2=18
# samples 13
** MAII scorelog2(1/1*10)=3.32192809488736log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SIMC1 [Title/Abstract] AND MCM4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BP430816SIMC1chr5

175772514

+MCM4chr8

48889332

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000341199ENST00000523944SIMC1chr5

175772514

+MCM4chr8

48889332

+
3UTR-3CDSENST00000341199ENST00000262105SIMC1chr5

175772514

+MCM4chr8

48889332

+
3UTR-intronENST00000341199ENST00000518680SIMC1chr5

175772514

+MCM4chr8

48889332

+
3UTR-3CDSENST00000430704ENST00000523944SIMC1chr5

175772514

+MCM4chr8

48889332

+
3UTR-3CDSENST00000430704ENST00000262105SIMC1chr5

175772514

+MCM4chr8

48889332

+
3UTR-intronENST00000430704ENST00000518680SIMC1chr5

175772514

+MCM4chr8

48889332

+
3UTR-3CDSENST00000443967ENST00000523944SIMC1chr5

175772514

+MCM4chr8

48889332

+
3UTR-3CDSENST00000443967ENST00000262105SIMC1chr5

175772514

+MCM4chr8

48889332

+
3UTR-intronENST00000443967ENST00000518680SIMC1chr5

175772514

+MCM4chr8

48889332

+
3UTR-3CDSENST00000332772ENST00000523944SIMC1chr5

175772514

+MCM4chr8

48889332

+
3UTR-3CDSENST00000332772ENST00000262105SIMC1chr5

175772514

+MCM4chr8

48889332

+
3UTR-intronENST00000332772ENST00000518680SIMC1chr5

175772514

+MCM4chr8

48889332

+
intron-3CDSENST00000429602ENST00000523944SIMC1chr5

175772514

+MCM4chr8

48889332

+
intron-3CDSENST00000429602ENST00000262105SIMC1chr5

175772514

+MCM4chr8

48889332

+
intron-intronENST00000429602ENST00000518680SIMC1chr5

175772514

+MCM4chr8

48889332

+
intron-3CDSENST00000503595ENST00000523944SIMC1chr5

175772514

+MCM4chr8

48889332

+
intron-3CDSENST00000503595ENST00000262105SIMC1chr5

175772514

+MCM4chr8

48889332

+
intron-intronENST00000503595ENST00000518680SIMC1chr5

175772514

+MCM4chr8

48889332

+

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FusionProtFeatures for SIMC1_MCM4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SIMC1

Q8NDZ2

MCM4

P33991

Acts as component of the MCM2-7 complex (MCM complex)which is the putative replicative helicase essential for 'once percell cycle' DNA replication initiation and elongation ineukaryotic cells. The active ATPase sites in the MCM2-7 ring areformed through the interaction surfaces of two neighboringsubunits such that a critical structure of a conserved argininefinger motif is provided in trans relative to the ATP-binding siteof the Walker A box of the adjacent subunit. The six ATPase activesites, however, are likely to contribute differentially to thecomplex helicase activity. {ECO:0000269|PubMed:16899510,ECO:0000269|PubMed:9305914}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SIMC1_MCM4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SIMC1_MCM4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SIMC1_MCM4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SIMC1_MCM4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource