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Fusion gene ID: 33877 |
FusionGeneSummary for SIM2_MORC3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SIM2_MORC3 | Fusion gene ID: 33877 | Hgene | Tgene | Gene symbol | SIM2 | MORC3 | Gene ID | 6493 | 23515 |
| Gene name | SIM bHLH transcription factor 2 | MORC family CW-type zinc finger 3 | |
| Synonyms | HMC13F06|HMC29C01|SIM|bHLHe15 | NXP2|ZCW5|ZCWCC3 | |
| Cytomap | 21q22.13 | 21q22.12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | single-minded homolog 2class E basic helix-loop-helix protein 15single-minded family bHLH transcription factor 2transcription factor SIM2 | MORC family CW-type zinc finger protein 3nuclear matrix protein 2nuclear matrix protein NXP2zinc finger CW-type coiled-coil domain protein 3zinc finger, CW type with coiled-coil domain 3 | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | Q14190 | Q14149 | |
| Ensembl transtripts involved in fusion gene | ENST00000460783, ENST00000290399, ENST00000430056, | ENST00000400485, ENST00000487909, | |
| Fusion gene scores | * DoF score | 3 X 2 X 3=18 | 5 X 5 X 3=75 |
| # samples | 3 | 5 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SIM2 [Title/Abstract] AND MORC3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | MORC3 | GO:0006468 | protein phosphorylation | 17332504 |
| Tgene | MORC3 | GO:0007569 | cell aging | 17332504 |
| Tgene | MORC3 | GO:0018105 | peptidyl-serine phosphorylation | 17332504 |
| Tgene | MORC3 | GO:0048147 | negative regulation of fibroblast proliferation | 17332504 |
| Tgene | MORC3 | GO:0050821 | protein stabilization | 17332504 |
| Tgene | MORC3 | GO:0051457 | maintenance of protein location in nucleus | 17332504 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | ESCA | TCGA-L5-A891-01A | SIM2 | chr21 | 38103452 | + | MORC3 | chr21 | 37721609 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000460783 | ENST00000400485 | SIM2 | chr21 | 38103452 | + | MORC3 | chr21 | 37721609 | + |
| intron-3UTR | ENST00000460783 | ENST00000487909 | SIM2 | chr21 | 38103452 | + | MORC3 | chr21 | 37721609 | + |
| Frame-shift | ENST00000290399 | ENST00000400485 | SIM2 | chr21 | 38103452 | + | MORC3 | chr21 | 37721609 | + |
| 5CDS-3UTR | ENST00000290399 | ENST00000487909 | SIM2 | chr21 | 38103452 | + | MORC3 | chr21 | 37721609 | + |
| Frame-shift | ENST00000430056 | ENST00000400485 | SIM2 | chr21 | 38103452 | + | MORC3 | chr21 | 37721609 | + |
| 5CDS-3UTR | ENST00000430056 | ENST00000487909 | SIM2 | chr21 | 38103452 | + | MORC3 | chr21 | 37721609 | + |
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FusionProtFeatures for SIM2_MORC3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SIM2 | MORC3 |
| Transcription factor that may be a master gene of CNSdevelopment in cooperation with Arnt. It may have pleiotropiceffects in the tissues expressed during development. | Nuclear factor which forms MORC3-NBs (nuclear bodies)via an ATP-dependent mechanism (PubMed:20501696). SumoylatedMORC3-NBs can also associate with PML-NBs (PubMed:20501696).Recruits TP53 and SP100 to PML-NBs, thus regulating TP53 activity(PubMed:17332504). Binds RNA in vitro (PubMed:11927593). May berequired for influenza A transcription during viral infection(PubMed:26202233). {ECO:0000269|PubMed:11927593,ECO:0000269|PubMed:17332504, ECO:0000269|PubMed:20501696,ECO:0000269|PubMed:26202233}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SIM2_MORC3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SIM2_MORC3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| SIM2 | ARNT, ARNT2, PARK2, ARIH1, HSP90AA1, FOXR2, FOXN1 | MORC3 | RAD23A, ROR1, KPNA2, HIST1H2BG, HIST1H3A, HTT, SNTB1, MOGS, DYNLL1, CRIPT, TRIB1, SYNE2, DEPDC1, DOCK8, RDH10, C6orf141, UBC, DYNLL2, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SIM2_MORC3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SIM2_MORC3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | SIM2 | C0008925 | Cleft Palate | 1 | CTD_human |
| Hgene | SIM2 | C0376634 | Craniofacial Abnormalities | 1 | CTD_human |
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