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Fusion gene ID: 3386 |
FusionGeneSummary for ATP5B_CALCA |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ATP5B_CALCA | Fusion gene ID: 3386 | Hgene | Tgene | Gene symbol | ATP5B | CALCA | Gene ID | 796 |
| Gene name | calcitonin related polypeptide alpha | ||
| Synonyms | CALC1|CGRP|CGRP-I|CGRP1|CT|KC|PCT | ||
| Cytomap | 11p15.2 | ||
| Type of gene | protein-coding | ||
| Description | calcitonincalcitonin gene-related peptide 1alpha-type CGRPcalcitonin 1calcitonin gene-related peptide Icalcitonin/calcitonin-related polypeptide, alphakatacalcin | ||
| Modification date | 20180519 | ||
| UniProtAcc | P06881 | ||
| Ensembl transtripts involved in fusion gene | ENST00000262030, ENST00000552919, ENST00000550162, | ENST00000486207, ENST00000361010, ENST00000359642, ENST00000331587, ENST00000396372, | |
| Fusion gene scores | * DoF score | 8 X 9 X 4=288 | 1 X 1 X 1=1 |
| # samples | 10 | 1 | |
| ** MAII score | log2(10/288*10)=-1.52606881166759 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: ATP5B [Title/Abstract] AND CALCA [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | CALCA | GO:0002548 | monocyte chemotaxis | 15248232 |
| Tgene | CALCA | GO:0007189 | adenylate cyclase-activating G-protein coupled receptor signaling pathway | 8078488|11014233 |
| Tgene | CALCA | GO:0007204 | positive regulation of cytosolic calcium ion concentration | 17983652 |
| Tgene | CALCA | GO:0007566 | embryo implantation | 17983652 |
| Tgene | CALCA | GO:0032147 | activation of protein kinase activity | 17983652 |
| Tgene | CALCA | GO:0045779 | negative regulation of bone resorption | 17241109 |
| Tgene | CALCA | GO:0045892 | negative regulation of transcription, DNA-templated | 11014233 |
| Tgene | CALCA | GO:0051482 | positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway | 8078488 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LUAD | TCGA-80-5608-01A | ATP5B | chr12 | 57039621 | - | CALCA | chr11 | 14992747 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000262030 | ENST00000486207 | ATP5B | chr12 | 57039621 | - | CALCA | chr11 | 14992747 | - |
| 5CDS-5UTR | ENST00000262030 | ENST00000361010 | ATP5B | chr12 | 57039621 | - | CALCA | chr11 | 14992747 | - |
| 5CDS-5UTR | ENST00000262030 | ENST00000359642 | ATP5B | chr12 | 57039621 | - | CALCA | chr11 | 14992747 | - |
| 5CDS-5UTR | ENST00000262030 | ENST00000331587 | ATP5B | chr12 | 57039621 | - | CALCA | chr11 | 14992747 | - |
| 5CDS-5UTR | ENST00000262030 | ENST00000396372 | ATP5B | chr12 | 57039621 | - | CALCA | chr11 | 14992747 | - |
| In-frame | ENST00000552919 | ENST00000486207 | ATP5B | chr12 | 57039621 | - | CALCA | chr11 | 14992747 | - |
| 5CDS-5UTR | ENST00000552919 | ENST00000361010 | ATP5B | chr12 | 57039621 | - | CALCA | chr11 | 14992747 | - |
| 5CDS-5UTR | ENST00000552919 | ENST00000359642 | ATP5B | chr12 | 57039621 | - | CALCA | chr11 | 14992747 | - |
| 5CDS-5UTR | ENST00000552919 | ENST00000331587 | ATP5B | chr12 | 57039621 | - | CALCA | chr11 | 14992747 | - |
| 5CDS-5UTR | ENST00000552919 | ENST00000396372 | ATP5B | chr12 | 57039621 | - | CALCA | chr11 | 14992747 | - |
| intron-3CDS | ENST00000550162 | ENST00000486207 | ATP5B | chr12 | 57039621 | - | CALCA | chr11 | 14992747 | - |
| intron-5UTR | ENST00000550162 | ENST00000361010 | ATP5B | chr12 | 57039621 | - | CALCA | chr11 | 14992747 | - |
| intron-5UTR | ENST00000550162 | ENST00000359642 | ATP5B | chr12 | 57039621 | - | CALCA | chr11 | 14992747 | - |
| intron-5UTR | ENST00000550162 | ENST00000331587 | ATP5B | chr12 | 57039621 | - | CALCA | chr11 | 14992747 | - |
| intron-5UTR | ENST00000550162 | ENST00000396372 | ATP5B | chr12 | 57039621 | - | CALCA | chr11 | 14992747 | - |
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FusionProtFeatures for ATP5B_CALCA |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ATP5B | CALCA |
| Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. | CGRP induces vasodilation. It dilates a variety ofvessels including the coronary, cerebral and systemic vasculature.Its abundance in the CNS also points toward a neurotransmitter orneuromodulator role. It also elevates platelet cAMP.{ECO:0000269|PubMed:1318039}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >ATP5B | chr12:57039621 | chr11:14992747 | ENST00000262030 | - | 1 | 10 | 207_214 | 42 | 530 | Nucleotide binding | ATP |
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FusionGeneSequence for ATP5B_CALCA |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_ATP5B_ENST00000262030_chr12_57039621_-_CALCA_ENST00000486207_chr11_14992747_-_42aa >In-frame_ATP5B_ENST00000552919_chr12_57039621_-_CALCA_ENST00000486207_chr11_14992747_-_42aa |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_ATP5B_ENST00000262030_chr12_57039621_-_CALCA_ENST00000486207_chr11_14992747_-_127nt ATGTTGGGGTTTGTGGGTCGGGTGGCCGCTGCTCCGGCCTCCGGGGCCTTGCGGAGACTCACCCCTTCAGCGTCGCTGCCCCCAGCTCAG >In-frame_ATP5B_ENST00000552919_chr12_57039621_-_CALCA_ENST00000486207_chr11_14992747_-_127nt ATGTTGGGGTTTGTGGGTCGGGTGGCCGCTGCTCCGGCCTCCGGGGCCTTGCGGAGACTCACCCCTTCAGCGTCGCTGCCCCCAGCTCAG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_ATP5B_ENST00000262030_chr12_57039621_-_CALCA_ENST00000486207_chr11_14992747_-_1029nt GAGCAGGCGGCTGCGGTTGCTGCAGCCTTCAGTCTCCACCCGGACTACGCCATGTTGGGGTTTGTGGGTCGGGTGGCCGCTGCTCCGGCC TCCGGGGCCTTGCGGAGACTCACCCCTTCAGCGTCGCTGCCCCCAGCTCAGCTCTTACTGCGGGCCGCTCCGACGGCGGTCCATCCTGAG AGGTGTCATGGGCTTCCAAAAGTTCTCCCCCTTCCTGGCTCTCAGCATCTTGGTCCTGTTGCAGGCAGGCAGCCTCCATGCAGCACCATT CAGGTCTGCCCTGGAGAGCAGCCCAGCAGACCCGGCCACGCTCAGTGAGGACGAAGCGCGCCTCCTGCTGGCTGCACTGGTGCAGAACTA TGTGCAGATGAAGGCCAGTGAGCTGGAGCAGGAGCAAGAGAGAGAGGGCTCCAGAATCATTGCCCAGAAGAGAGCCTGTGACACTGCCAC CTGTGTGACTCATCGGCTGGCAGGCTTGCTGAGCAGATCAGGGGGTGTGGTGAAGAACAACTTTGTGCCCACCAATGTGGGTTCCAAAGC CTTTGGCAGGCGCCGCAGGGACCTTCAAGCCTGAGCAGCTGAATGACTCAAGAAGGTCACAATAAAGCTGAACTCCTTTTAATGTGTAAT GAAAGCAATTTGTAGGAAAGGCTCCATGGAAGACATACATATAGGCATCCTTCTTGATACTGAAAACTATCTTCTTTGTTTGAAAGGAAC TATTGCTAAATGCAGAACAAGCTCATTGCAGTTACCTATTGTGCATCTTTTTAAATACTTGATTATGTAACCATAAATCTGACAGCATGT CTCATTGGCTTATCTGGTAGCAAATCTAGGCCCCGTCAGCCACCCTATTGACATTGGTGGCTCTGCTAAACCTCAGGGGGACATGAAATC ACTGCCTCTTGGGCATCTGGGGACACATGGTAATGCTGTGCCTTGACAGAAGTATTTGTTTAAAGAAATGTCAATGCTGTCATTTGTGAA >In-frame_ATP5B_ENST00000552919_chr12_57039621_-_CALCA_ENST00000486207_chr11_14992747_-_988nt GGACTACGCCATGTTGGGGTTTGTGGGTCGGGTGGCCGCTGCTCCGGCCTCCGGGGCCTTGCGGAGACTCACCCCTTCAGCGTCGCTGCC CCCAGCTCAGCTCTTACTGCGGGCCGCTCCGACGGCGGTCCATCCTGAGAGGTGTCATGGGCTTCCAAAAGTTCTCCCCCTTCCTGGCTC TCAGCATCTTGGTCCTGTTGCAGGCAGGCAGCCTCCATGCAGCACCATTCAGGTCTGCCCTGGAGAGCAGCCCAGCAGACCCGGCCACGC TCAGTGAGGACGAAGCGCGCCTCCTGCTGGCTGCACTGGTGCAGAACTATGTGCAGATGAAGGCCAGTGAGCTGGAGCAGGAGCAAGAGA GAGAGGGCTCCAGAATCATTGCCCAGAAGAGAGCCTGTGACACTGCCACCTGTGTGACTCATCGGCTGGCAGGCTTGCTGAGCAGATCAG GGGGTGTGGTGAAGAACAACTTTGTGCCCACCAATGTGGGTTCCAAAGCCTTTGGCAGGCGCCGCAGGGACCTTCAAGCCTGAGCAGCTG AATGACTCAAGAAGGTCACAATAAAGCTGAACTCCTTTTAATGTGTAATGAAAGCAATTTGTAGGAAAGGCTCCATGGAAGACATACATA TAGGCATCCTTCTTGATACTGAAAACTATCTTCTTTGTTTGAAAGGAACTATTGCTAAATGCAGAACAAGCTCATTGCAGTTACCTATTG TGCATCTTTTTAAATACTTGATTATGTAACCATAAATCTGACAGCATGTCTCATTGGCTTATCTGGTAGCAAATCTAGGCCCCGTCAGCC ACCCTATTGACATTGGTGGCTCTGCTAAACCTCAGGGGGACATGAAATCACTGCCTCTTGGGCATCTGGGGACACATGGTAATGCTGTGC |
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FusionGenePPI for ATP5B_CALCA |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ATP5B | FANCA, PSME3, ATPAF1, PSMD4, HAX1, ICT1, YWHAQ, HDAC5, SIRT3, PSMA3, HMOX2, GRB7, RPP14, TK1, CDKN1A, CDK4, SMN1, PIN1, ANXA7, MAPK3, ARRB1, ISG15, FBXO25, CUL3, CDK2, CAND1, FBXO6, ATP5A1, ATP5C1, ATP5D, ATP5O, NDUFA2, NDUFS1, NDUFB9, UQCRC2, UQCRC1, NDUFA12, ATP6V1B2, P4HB, RPL18, CHCHD4, SDHB, RPS2, EIF5A, RPS3A, MDH2, RPL4, HNRNPA3, TOMM22, PA2G4, OXA1L, DLST, NNT, MYL6, HNRNPA2B1, TUBA1A, ESR1, CA9, YWHAE, FMNL1, PPP1CC, BTK, VCAM1, FN1, ATF2, UBL4A, ITGA4, TERT, ADRB2, GBP1, ASB5, ASB11, GRSF1, STAU1, SPRTN, TRIM63, TRIM55, HUWE1, FUS, FDX1, ATPAF2, CUL7, OBSL1, CCDC8, EZH2, SUZ12, RNF2, BMI1, FAF2, ARAF, BLK, ILK, IRAK1, MAST3, PPT1, HTR1E, ACKR3, ATP5F1, P2RY12, B4GALT3, HNRNPA1, FBXW11, IPO4, NPM3, PTBP1, VDAC1, VDAC2, VDAC3, ATP5H, ATP5I, ATP5J2, ATP5L, ATP6V0D1, CALR, EEF1A1, GFPT1, GFPT2, HSP90AA1, HSP90AB1, MTCH2, PHB, TAGLN2, TUBB, NTRK1, SCARNA22, LNX2, FZD1, GOLT1B, TMEM63B, YIPF5, TUBA1C, MBOAT1, SKI, MCM2, ATP5J, CDC73, CRBN, ZNF746, DNAJC28, ZFYVE27, ATP5G3, ATP8, GPR21, SLC27A3, TMEM120A, CERS2, ALG10B, RELL1, VIPR2, S1PR2, SLC35F1, ATP6V0C, HTR2C, CHRM4, CCR1, TACR1, SLC19A2, SGCZ, VIPR1, GPR35, GPAA1, FPR2, TAS2R41, GPRC5B, FAM134C, CTNNA3, SLC6A5, ATPIF1, C3AR1, LHFPL4, SLC22A12, GPR141, CYLD, NCDN, CCND2, TES, HDAC6 | CALCA | BBS1, BBS4, ECE1, CALCRL, RBM3 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ATP5B_CALCA |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ATP5B_CALCA |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | CALCA | C0020429 | Hyperalgesia | 4 | CTD_human |
| Tgene | CALCA | C0007370 | Catalepsy | 3 | CTD_human |
| Tgene | CALCA | C0020437 | Hypercalcemia | 2 | CTD_human |
| Tgene | CALCA | C0020538 | Hypertensive disease | 2 | CTD_human |
| Tgene | CALCA | C0085129 | Bronchial Hyperreactivity | 2 | CTD_human |
| Tgene | CALCA | C0149931 | Migraine Disorders | 2 | CTD_human |
| Tgene | CALCA | C0338480 | Common Migraine | 2 | CTD_human |
| Tgene | CALCA | C0424295 | Hyperactive behavior | 2 | CTD_human |
| Tgene | CALCA | C0001973 | Alcoholic Intoxication, Chronic | 1 | PSYGENET |
| Tgene | CALCA | C0004352 | Autistic Disorder | 1 | CTD_human |
| Tgene | CALCA | C0005586 | Bipolar Disorder | 1 | PSYGENET |
| Tgene | CALCA | C0013080 | Down Syndrome | 1 | CTD_human |
| Tgene | CALCA | C0013604 | Edema | 1 | CTD_human |
| Tgene | CALCA | C0020542 | Pulmonary Hypertension | 1 | CTD_human |
| Tgene | CALCA | C0021368 | Inflammation | 1 | CTD_human |
| Tgene | CALCA | C0029408 | Degenerative polyarthritis | 1 | CTD_human |
| Tgene | CALCA | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| Tgene | CALCA | C0034069 | Pulmonary Fibrosis | 1 | CTD_human |
| Tgene | CALCA | C0040997 | Trigeminal Neuralgia | 1 | CTD_human |
| Tgene | CALCA | C0149940 | Sciatic Neuropathy | 1 | CTD_human |
| Tgene | CALCA | C0344315 | Depressed mood | 1 | PSYGENET |
| Tgene | CALCA | C0600467 | Neurogenic Inflammation | 1 | CTD_human |
| Tgene | CALCA | C0993582 | Arthritis, Experimental | 1 | CTD_human |
| Tgene | CALCA | C3714756 | Intellectual Disability | 1 | CTD_human |
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