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Fusion gene ID: 33830 |
FusionGeneSummary for SIAE_GRIK4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SIAE_GRIK4 | Fusion gene ID: 33830 | Hgene | Tgene | Gene symbol | SIAE | GRIK4 | Gene ID | 54414 | 2900 |
| Gene name | sialic acid acetylesterase | glutamate ionotropic receptor kainate type subunit 4 | |
| Synonyms | AIS6|CSE-C|CSEC|LSE|YSG2 | EAA1|GRIK|GluK4|KA1 | |
| Cytomap | 11q24.2 | 11q23.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | sialate O-acetylesteraseH-Lsecytosolic sialic acid 9-O-acetylesterase homologsialic acid-specific acetylesterase II | glutamate receptor ionotropic, kainate 4excitatory amino acid receptor 1glutamate receptor KA1glutamate receptor, ionotropic, kainate 4 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q9HAT2 | Q16099 | |
| Ensembl transtripts involved in fusion gene | ENST00000263593, ENST00000545756, ENST00000525730, | ENST00000527524, ENST00000438375, ENST00000527130, | |
| Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 5 X 5 X 6=150 |
| # samples | 4 | 6 | |
| ** MAII score | log2(4/27*10)=0.567040592723894 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(6/150*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SIAE [Title/Abstract] AND GRIK4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | SIAE | GO:0005975 | carbohydrate metabolic process | 23308225 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | UCEC | TCGA-A5-A1OH-01A | SIAE | chr11 | 124530524 | - | GRIK4 | chr11 | 120823564 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000263593 | ENST00000527524 | SIAE | chr11 | 124530524 | - | GRIK4 | chr11 | 120823564 | + |
| In-frame | ENST00000263593 | ENST00000438375 | SIAE | chr11 | 124530524 | - | GRIK4 | chr11 | 120823564 | + |
| 5CDS-intron | ENST00000263593 | ENST00000527130 | SIAE | chr11 | 124530524 | - | GRIK4 | chr11 | 120823564 | + |
| Frame-shift | ENST00000545756 | ENST00000527524 | SIAE | chr11 | 124530524 | - | GRIK4 | chr11 | 120823564 | + |
| Frame-shift | ENST00000545756 | ENST00000438375 | SIAE | chr11 | 124530524 | - | GRIK4 | chr11 | 120823564 | + |
| 5CDS-intron | ENST00000545756 | ENST00000527130 | SIAE | chr11 | 124530524 | - | GRIK4 | chr11 | 120823564 | + |
| intron-3CDS | ENST00000525730 | ENST00000527524 | SIAE | chr11 | 124530524 | - | GRIK4 | chr11 | 120823564 | + |
| intron-3CDS | ENST00000525730 | ENST00000438375 | SIAE | chr11 | 124530524 | - | GRIK4 | chr11 | 120823564 | + |
| intron-intron | ENST00000525730 | ENST00000527130 | SIAE | chr11 | 124530524 | - | GRIK4 | chr11 | 120823564 | + |
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FusionProtFeatures for SIAE_GRIK4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SIAE | GRIK4 |
| Catalyzes the removal of O-acetyl ester groups fromposition 9 of the parent sialic acid, N-acetylneuraminic acid. | Receptor for glutamate. L-glutamate acts as anexcitatory neurotransmitter at many synapses in the centralnervous system. The postsynaptic actions of Glu are mediated by avariety of receptors that are named according to their selectiveagonists. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >GRIK4 | chr11:124530524 | chr11:120823564 | ENST00000438375 | + | 12 | 20 | 862_865 | 530 | 957 | Compositional bias | Note=Poly-Arg |
| Tgene | >GRIK4 | chr11:124530524 | chr11:120823564 | ENST00000527524 | + | 13 | 21 | 862_865 | 530 | 957 | Compositional bias | Note=Poly-Arg |
| Tgene | >GRIK4 | chr11:124530524 | chr11:120823564 | ENST00000438375 | + | 12 | 20 | 567_623 | 530 | 957 | Topological domain | Cytoplasmic |
| Tgene | >GRIK4 | chr11:124530524 | chr11:120823564 | ENST00000438375 | + | 12 | 20 | 645_804 | 530 | 957 | Topological domain | Extracellular |
| Tgene | >GRIK4 | chr11:124530524 | chr11:120823564 | ENST00000438375 | + | 12 | 20 | 826_956 | 530 | 957 | Topological domain | Cytoplasmic |
| Tgene | >GRIK4 | chr11:124530524 | chr11:120823564 | ENST00000527524 | + | 13 | 21 | 567_623 | 530 | 957 | Topological domain | Cytoplasmic |
| Tgene | >GRIK4 | chr11:124530524 | chr11:120823564 | ENST00000527524 | + | 13 | 21 | 645_804 | 530 | 957 | Topological domain | Extracellular |
| Tgene | >GRIK4 | chr11:124530524 | chr11:120823564 | ENST00000527524 | + | 13 | 21 | 826_956 | 530 | 957 | Topological domain | Cytoplasmic |
| Tgene | >GRIK4 | chr11:124530524 | chr11:120823564 | ENST00000438375 | + | 12 | 20 | 546_566 | 530 | 957 | Transmembrane | Helical |
| Tgene | >GRIK4 | chr11:124530524 | chr11:120823564 | ENST00000438375 | + | 12 | 20 | 624_644 | 530 | 957 | Transmembrane | Helical |
| Tgene | >GRIK4 | chr11:124530524 | chr11:120823564 | ENST00000438375 | + | 12 | 20 | 805_825 | 530 | 957 | Transmembrane | Helical |
| Tgene | >GRIK4 | chr11:124530524 | chr11:120823564 | ENST00000527524 | + | 13 | 21 | 546_566 | 530 | 957 | Transmembrane | Helical |
| Tgene | >GRIK4 | chr11:124530524 | chr11:120823564 | ENST00000527524 | + | 13 | 21 | 624_644 | 530 | 957 | Transmembrane | Helical |
| Tgene | >GRIK4 | chr11:124530524 | chr11:120823564 | ENST00000527524 | + | 13 | 21 | 805_825 | 530 | 957 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | GRIK4 | chr11:124530524 | chr11:120823564 | ENST00000438375 | + | 12 | 20 | 21_545 | 530 | 957 | Topological domain | Extracellular |
| Tgene | GRIK4 | chr11:124530524 | chr11:120823564 | ENST00000527524 | + | 13 | 21 | 21_545 | 530 | 957 | Topological domain | Extracellular |
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FusionGeneSequence for SIAE_GRIK4 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_SIAE_ENST00000263593_chr11_124530524_-_GRIK4_ENST00000527524_chr11_120823564_+_562aa MVAPGLVLGLVLPLILWADRSAGIGFRFASYINNDMVLQKEPAGAVIWGFGTPGATVTVTLRQGQETIMKKVTSVKAHSDTWMVVLDPMK PGGPFEVMAQQTLEKINFTLRVHDVLFGDVWLCSGQSNMQMTVLQGRKPGYFSFLDPFSPGVWLFMLLAYLAVSCVLFLVARLTPYEWYS PHPCAQGRCNLLVNQYSLGNSLWFPVGGFMQQGSTIAPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMDVPIESVDDLADQTAI EYGTIHGGSSMTFFQNSRYQTYQRMWNYMYSKQPSVFVKSTEEGIARVLNSNYAFLLESTMNEYYRQRNCNLTQIGGLLDTKGYGIGMPV GSVFRDEFDLAILQLQENNRLEILKRKWWEGGKCPKEEDHRAKGLGMENIGGIFVVLICGLIVAIFMAMLEFLWTLRHSEATEVSVCQEM VTELRSIILCQDSIHPRRRRAAVPPPRPPIPEERRPRGTATLSNGKLCGAGEPDQLAQRLAQEAALVARGCTHIRVCPECRRFQGLRARP >In-frame_SIAE_ENST00000263593_chr11_124530524_-_GRIK4_ENST00000438375_chr11_120823564_+_562aa MVAPGLVLGLVLPLILWADRSAGIGFRFASYINNDMVLQKEPAGAVIWGFGTPGATVTVTLRQGQETIMKKVTSVKAHSDTWMVVLDPMK PGGPFEVMAQQTLEKINFTLRVHDVLFGDVWLCSGQSNMQMTVLQGRKPGYFSFLDPFSPGVWLFMLLAYLAVSCVLFLVARLTPYEWYS PHPCAQGRCNLLVNQYSLGNSLWFPVGGFMQQGSTIAPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMDVPIESVDDLADQTAI EYGTIHGGSSMTFFQNSRYQTYQRMWNYMYSKQPSVFVKSTEEGIARVLNSNYAFLLESTMNEYYRQRNCNLTQIGGLLDTKGYGIGMPV GSVFRDEFDLAILQLQENNRLEILKRKWWEGGKCPKEEDHRAKGLGMENIGGIFVVLICGLIVAIFMAMLEFLWTLRHSEATEVSVCQEM VTELRSIILCQDSIHPRRRRAAVPPPRPPIPEERRPRGTATLSNGKLCGAGEPDQLAQRLAQEAALVARGCTHIRVCPECRRFQGLRARP |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_SIAE_ENST00000263593_chr11_124530524_-_GRIK4_ENST00000527524_chr11_120823564_+_1686nt ATGGTCGCGCCGGGGCTTGTACTCGGGCTGGTGCTGCCATTAATCCTGTGGGCCGACAGAAGTGCAGGTATTGGTTTTCGCTTTGCTTCA TACATCAATAATGATATGGTGCTGCAGAAGGAGCCTGCTGGGGCAGTGATATGGGGCTTCGGTACACCTGGAGCCACAGTGACCGTGACC CTGCGCCAAGGTCAGGAAACCATCATGAAGAAAGTGACCAGTGTGAAAGCTCACTCTGATACGTGGATGGTGGTACTGGATCCTATGAAG CCTGGAGGACCTTTCGAAGTGATGGCACAACAGACTTTGGAGAAAATAAACTTCACCCTGAGAGTTCATGACGTCCTGTTTGGAGATGTC TGGCTCTGTAGTGGGCAGAGTAACATGCAGATGACTGTGTTACAGGGACGCAAACCCGGCTATTTCTCCTTCCTGGACCCATTTTCTCCG GGCGTCTGGCTCTTCATGCTTCTAGCCTATCTGGCCGTCAGCTGTGTCCTCTTCCTGGTGGCTCGGTTGACGCCCTACGAGTGGTACAGC CCACACCCATGTGCCCAGGGCCGGTGCAACCTCCTGGTGAACCAGTACTCCCTGGGCAACAGCCTCTGGTTTCCGGTCGGGGGGTTCATG CAGCAAGGCTCCACCATCGCCCCTCGCGCCTTATCCACCCGCTGTGTCAGTGGCGTCTGGTGGGCATTCACGCTGATCATCATCTCATCC TACACGGCCAACCTGGCAGCCTTCCTGACCGTGCAGCGCATGGATGTGCCCATTGAGTCAGTGGATGACCTGGCTGACCAGACCGCCATT GAATATGGCACAATTCACGGAGGCTCCAGCATGACCTTCTTCCAAAATTCCCGCTACCAGACCTACCAACGCATGTGGAATTACATGTAT TCCAAGCAGCCCAGCGTGTTCGTGAAGAGCACAGAGGAGGGAATCGCCAGGGTGTTGAATTCCAACTACGCCTTCCTCCTGGAATCCACC ATGAACGAGTACTATCGGCAGCGAAACTGCAACCTCACTCAGATTGGGGGCCTGCTGGACACCAAGGGCTATGGGATTGGCATGCCAGTC GGCTCGGTTTTCCGGGACGAGTTTGATCTGGCCATTCTCCAGCTGCAGGAGAACAACCGCCTGGAGATCCTGAAGCGCAAATGGTGGGAA GGAGGGAAGTGCCCCAAGGAGGAAGATCACAGAGCTAAAGGCCTGGGAATGGAGAATATTGGTGGAATCTTTGTGGTTCTTATTTGTGGC TTAATCGTGGCCATTTTTATGGCTATGTTGGAGTTTTTATGGACTCTCAGACACTCAGAAGCAACTGAGGTGTCCGTCTGCCAGGAGATG GTGACCGAGCTGCGCAGCATTATCCTGTGTCAGGACAGTATCCACCCCCGCCGGCGGCGCGCCGCAGTCCCGCCGCCCCGGCCCCCCATC CCCGAGGAGCGCCGACCGCGGGGCACGGCGACGCTCAGCAACGGGAAGCTGTGCGGGGCAGGGGAGCCCGACCAGCTCGCGCAGAGACTG GCGCAGGAGGCCGCCCTGGTGGCCCGCGGCTGCACGCACATCCGCGTCTGCCCCGAGTGCCGCCGCTTCCAGGGCCTGCGGGCACGGCCG >In-frame_SIAE_ENST00000263593_chr11_124530524_-_GRIK4_ENST00000438375_chr11_120823564_+_1686nt ATGGTCGCGCCGGGGCTTGTACTCGGGCTGGTGCTGCCATTAATCCTGTGGGCCGACAGAAGTGCAGGTATTGGTTTTCGCTTTGCTTCA TACATCAATAATGATATGGTGCTGCAGAAGGAGCCTGCTGGGGCAGTGATATGGGGCTTCGGTACACCTGGAGCCACAGTGACCGTGACC CTGCGCCAAGGTCAGGAAACCATCATGAAGAAAGTGACCAGTGTGAAAGCTCACTCTGATACGTGGATGGTGGTACTGGATCCTATGAAG CCTGGAGGACCTTTCGAAGTGATGGCACAACAGACTTTGGAGAAAATAAACTTCACCCTGAGAGTTCATGACGTCCTGTTTGGAGATGTC TGGCTCTGTAGTGGGCAGAGTAACATGCAGATGACTGTGTTACAGGGACGCAAACCCGGCTATTTCTCCTTCCTGGACCCATTTTCTCCG GGCGTCTGGCTCTTCATGCTTCTAGCCTATCTGGCCGTCAGCTGTGTCCTCTTCCTGGTGGCTCGGTTGACGCCCTACGAGTGGTACAGC CCACACCCATGTGCCCAGGGCCGGTGCAACCTCCTGGTGAACCAGTACTCCCTGGGCAACAGCCTCTGGTTTCCGGTCGGGGGGTTCATG CAGCAAGGCTCCACCATCGCCCCTCGCGCCTTATCCACCCGCTGTGTCAGTGGCGTCTGGTGGGCATTCACGCTGATCATCATCTCATCC TACACGGCCAACCTGGCAGCCTTCCTGACCGTGCAGCGCATGGATGTGCCCATTGAGTCAGTGGATGACCTGGCTGACCAGACCGCCATT GAATATGGCACAATTCACGGAGGCTCCAGCATGACCTTCTTCCAAAATTCCCGCTACCAGACCTACCAACGCATGTGGAATTACATGTAT TCCAAGCAGCCCAGCGTGTTCGTGAAGAGCACAGAGGAGGGAATCGCCAGGGTGTTGAATTCCAACTACGCCTTCCTCCTGGAATCCACC ATGAACGAGTACTATCGGCAGCGAAACTGCAACCTCACTCAGATTGGGGGCCTGCTGGACACCAAGGGCTATGGGATTGGCATGCCAGTC GGCTCGGTTTTCCGGGACGAGTTTGATCTGGCCATTCTCCAGCTGCAGGAGAACAACCGCCTGGAGATCCTGAAGCGCAAATGGTGGGAA GGAGGGAAGTGCCCCAAGGAGGAAGATCACAGAGCTAAAGGCCTGGGAATGGAGAATATTGGTGGAATCTTTGTGGTTCTTATTTGTGGC TTAATCGTGGCCATTTTTATGGCTATGTTGGAGTTTTTATGGACTCTCAGACACTCAGAAGCAACTGAGGTGTCCGTCTGCCAGGAGATG GTGACCGAGCTGCGCAGCATTATCCTGTGTCAGGACAGTATCCACCCCCGCCGGCGGCGCGCCGCAGTCCCGCCGCCCCGGCCCCCCATC CCCGAGGAGCGCCGACCGCGGGGCACGGCGACGCTCAGCAACGGGAAGCTGTGCGGGGCAGGGGAGCCCGACCAGCTCGCGCAGAGACTG GCGCAGGAGGCCGCCCTGGTGGCCCGCGGCTGCACGCACATCCGCGTCTGCCCCGAGTGCCGCCGCTTCCAGGGCCTGCGGGCACGGCCG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_SIAE_ENST00000263593_chr11_124530524_-_GRIK4_ENST00000527524_chr11_120823564_+_4503nt AAAAAAAAAAAAAAACTACGGCGGCCGAGAAGGGGCGAGTACAGCCCAGTCCTGAGGTCGCGGGAGGCTGCGAGGACTGCAAAAGGGTGG AGTCGGCCTCGCCCCCGCCCAGGCCCCGCCCCTGCCGGGAACCCACTTTCCCAGTCCTAGGCGGCGGTCAGATCCTTGCAAGCATGGTCG CGCCGGGGCTTGTACTCGGGCTGGTGCTGCCATTAATCCTGTGGGCCGACAGAAGTGCAGGTATTGGTTTTCGCTTTGCTTCATACATCA ATAATGATATGGTGCTGCAGAAGGAGCCTGCTGGGGCAGTGATATGGGGCTTCGGTACACCTGGAGCCACAGTGACCGTGACCCTGCGCC AAGGTCAGGAAACCATCATGAAGAAAGTGACCAGTGTGAAAGCTCACTCTGATACGTGGATGGTGGTACTGGATCCTATGAAGCCTGGAG GACCTTTCGAAGTGATGGCACAACAGACTTTGGAGAAAATAAACTTCACCCTGAGAGTTCATGACGTCCTGTTTGGAGATGTCTGGCTCT GTAGTGGGCAGAGTAACATGCAGATGACTGTGTTACAGGGACGCAAACCCGGCTATTTCTCCTTCCTGGACCCATTTTCTCCGGGCGTCT GGCTCTTCATGCTTCTAGCCTATCTGGCCGTCAGCTGTGTCCTCTTCCTGGTGGCTCGGTTGACGCCCTACGAGTGGTACAGCCCACACC CATGTGCCCAGGGCCGGTGCAACCTCCTGGTGAACCAGTACTCCCTGGGCAACAGCCTCTGGTTTCCGGTCGGGGGGTTCATGCAGCAAG GCTCCACCATCGCCCCTCGCGCCTTATCCACCCGCTGTGTCAGTGGCGTCTGGTGGGCATTCACGCTGATCATCATCTCATCCTACACGG CCAACCTGGCAGCCTTCCTGACCGTGCAGCGCATGGATGTGCCCATTGAGTCAGTGGATGACCTGGCTGACCAGACCGCCATTGAATATG GCACAATTCACGGAGGCTCCAGCATGACCTTCTTCCAAAATTCCCGCTACCAGACCTACCAACGCATGTGGAATTACATGTATTCCAAGC AGCCCAGCGTGTTCGTGAAGAGCACAGAGGAGGGAATCGCCAGGGTGTTGAATTCCAACTACGCCTTCCTCCTGGAATCCACCATGAACG AGTACTATCGGCAGCGAAACTGCAACCTCACTCAGATTGGGGGCCTGCTGGACACCAAGGGCTATGGGATTGGCATGCCAGTCGGCTCGG TTTTCCGGGACGAGTTTGATCTGGCCATTCTCCAGCTGCAGGAGAACAACCGCCTGGAGATCCTGAAGCGCAAATGGTGGGAAGGAGGGA AGTGCCCCAAGGAGGAAGATCACAGAGCTAAAGGCCTGGGAATGGAGAATATTGGTGGAATCTTTGTGGTTCTTATTTGTGGCTTAATCG TGGCCATTTTTATGGCTATGTTGGAGTTTTTATGGACTCTCAGACACTCAGAAGCAACTGAGGTGTCCGTCTGCCAGGAGATGGTGACCG AGCTGCGCAGCATTATCCTGTGTCAGGACAGTATCCACCCCCGCCGGCGGCGCGCCGCAGTCCCGCCGCCCCGGCCCCCCATCCCCGAGG AGCGCCGACCGCGGGGCACGGCGACGCTCAGCAACGGGAAGCTGTGCGGGGCAGGGGAGCCCGACCAGCTCGCGCAGAGACTGGCGCAGG AGGCCGCCCTGGTGGCCCGCGGCTGCACGCACATCCGCGTCTGCCCCGAGTGCCGCCGCTTCCAGGGCCTGCGGGCACGGCCGTCGCCCG CCCGCAGCGAGGAGAGCCTGGAGTGGGAGAAAACCACCAACAGCAGCGAGCCCGAGTAGTCCCGGAGGCCACAGGACGCGCAGAGGCCGG GCGGGGCGGGAGGGGAGGGGCGGGGCGGGCGCTGCTGTCAGCCGCCAGCCGGAACTTGTACAGCGTCGACACCTCTCCAGATTTCGGATC CAGTCACTTTTCAAAAAGATCAAGGAGCCTGACGCCCCAGCCAGAGACCGCGCCCGGTCAGGGAGCAGGGTCCACCCGGAAACGTTGCAC CCAAAGGGCAAAGGACGGCCCTCCCTCCTGGGCACAAGGACCCATCTTCTCCCAGTGGGTCTTTCCCTCTCGCCAAAATAACAAGAGTAT AGGGTGGGGGGTCCCTACCCAGACCAGTCCAATGAATTGGTGGAATCATCAGTTGAATTTCCCCCTAGTCAGGGGCCAATGTACCCTCCG TCTAGTTCTTACAGAAAAAAAAAAAATTAAACAGGGAAGTTTTTCTTTTCTGGATTTGTATATTTTTGTTAATGTTCTTTTCCCTTTTCT TTCCTCCTCTCCTTTTCTTCTTTGTCATCTTCTCAGTCCTGTTAATTTGTTTTGTGTTTTTTGGAGGGGGAGGCTGGGTTAGGGAATGGA AGCCTAAATAATCCCTATTTCTTCTTTTTCCTGAATTTTGGAATATTGCGTTACCAGTGCATCCGATTTCAGGTGCTTAACTCTCTGTAT GGTGACTGAGGGGCCTGCAGGAGCACAGGAGAAGGAGTCTTGGGAAGAATCAGATGGAGAGTCTCAAAAGTCCATTGCAGTAAACTTTGA GATGCCAAAAAGCAATTAACTCATCCTATACTCAGACCTTGAAACGCCTGGAATGTCAAGGGTTAATCTGTCTTTTCTTTCCCTTTCTCT TTCTGACTGTCACTATTACTGGGTTTGATTTGATCTTTTTGTGAATGTAGTCTCTGAAGACAGACAGGGGAGGAGAACAGAATGCACAAA GTATCCTAGGACTTTGTTTAAGGAGCGGAAAGAGCAGATAGAATTTTCCCATACCATGGCCTTGGCTTCCGGTGGAACGTGCCGTTCACA GAGGCGGAAGGACTGGGCCACCCCGTTGGTATGGTGCATACTTTGTCAACTGCATCTCTTTTCAACCAAACTCAAATGAGTGGCTGCCTA TGAAGCCAGACCCCCAAGACTATCATGGATTGGGTGGTTTCTTGCTACTTAGACGTGAGACCTGGGTGCAAGTGTATGTGTGTGTATGTG TGCGCGCGTGTGCGTGTGTGTATTTATTCAACAGAAAGACCTTAAGTATTCAAGAATTTGCTAGGTTCCTGGGAGAGAGGTGGAGTCTCC TAGTCAATACACGGGCCTGGGAACCAGGAACTCTTGAGTCGTAACCTCAGCTTGAGCAGTAGCCCTCCCACCTTGTATGACTTTAGGTAA AGCATTTAACTTCTCTTCCATCTACCAAATAGGAGTTACTGATGCTGTCCAGGTTACCAGGTGACTGCTAGTGACTGCTCTCCATGTGAG AAGTTTGCAGAGTCCAGAGCACACATCTGATGGGAGGGGCGAGGCTTTCTACAGCTGCTTGACCTTTGCTTGGCTTCACTAATTGGGAGT TTCACGCAGAGTTCTCATTGGCTGATGGAAAACAAATTCTATGCAATTTCTGATTGTAAACTTAGAAAATTCAGAGAGAAACAAACAGCC GCTACCAACCACCTCCACCTCCACCACCGCTGCCACCACCTTGAATGGAATTGTCCTCACTTTTGTTGCTGTTGCAAATGTACTAAAATA AAGACATCTTTGGAAGATGACGAGCTTAATTCATGTTTTTGCCATTTGGGTTGGTCGGCATCCTCTTTATGCCAGGACAATCAGTTAGGG CTGCCGTCCTGGGGGCCAAATGGTACCCTGATTATTCCTGTGAGGGATACTCGTTTTGTCCTCACCTGACCTCACTCATGAATTTGAATC CTTTATCTTTTTTCTCTTTAACCATCAAATGACAACAAGCTGTGCAAGACACTTGTGTCTTTTTTTAAACCTTGCCTTGATCCTCGTGGA GAAACGTGGATTTGGTGGGAAGGGCACCCGAAGGCCAGCTGACAACAAACCCCAATGGTGCCACTCTGCTCCAACCTGCAGCTCCATCCT ATGCTTCTCACAGACAACGTGGTTCCTACTGTCAGATCACATTTGGGGCGGGAAGGGTGGTTTTTTAAAAAAACTCGTTTTTATGAGCAG GCTATCTTGATCAATAGCAAACTTTTTTTAATGGATTAGTGAAATAAATGTCCCCATGCATCATTTATAGTCTGTTTCTTTCTCCGTGTG GAATCAAGATAAGACTGCCAGCACTAGACGGTTTCTGTTAGCTGCTGAGACCAGGGCCTCACCTTGCTCAAGCTAGTGGGTGAATTTGCA ACCAGCTAATACTCTTCCTTGGTTTGTTTCCACTTTTTATCTGTTGGTTGTTGGCTTTCTTTTCCATTCTGTATTTTCTATCTGACTCTG TATACTGTATAAAGCAGTTTTTTCTTGTCTGTTTATCTTTCTTCAACTGGAATATTTACAATAAAACAGAAACAAATCCTGAAATGTTAG TGATGGATGACAGCTGTTTGGGTTTAGAAAGTATGGTTCAGTGTGTCTAATATCCAGGTACTAGACTTGAAAAGCAAATAAAATCATAAA >In-frame_SIAE_ENST00000263593_chr11_124530524_-_GRIK4_ENST00000438375_chr11_120823564_+_2860nt AAAAAAAAAAAAAAACTACGGCGGCCGAGAAGGGGCGAGTACAGCCCAGTCCTGAGGTCGCGGGAGGCTGCGAGGACTGCAAAAGGGTGG AGTCGGCCTCGCCCCCGCCCAGGCCCCGCCCCTGCCGGGAACCCACTTTCCCAGTCCTAGGCGGCGGTCAGATCCTTGCAAGCATGGTCG CGCCGGGGCTTGTACTCGGGCTGGTGCTGCCATTAATCCTGTGGGCCGACAGAAGTGCAGGTATTGGTTTTCGCTTTGCTTCATACATCA ATAATGATATGGTGCTGCAGAAGGAGCCTGCTGGGGCAGTGATATGGGGCTTCGGTACACCTGGAGCCACAGTGACCGTGACCCTGCGCC AAGGTCAGGAAACCATCATGAAGAAAGTGACCAGTGTGAAAGCTCACTCTGATACGTGGATGGTGGTACTGGATCCTATGAAGCCTGGAG GACCTTTCGAAGTGATGGCACAACAGACTTTGGAGAAAATAAACTTCACCCTGAGAGTTCATGACGTCCTGTTTGGAGATGTCTGGCTCT GTAGTGGGCAGAGTAACATGCAGATGACTGTGTTACAGGGACGCAAACCCGGCTATTTCTCCTTCCTGGACCCATTTTCTCCGGGCGTCT GGCTCTTCATGCTTCTAGCCTATCTGGCCGTCAGCTGTGTCCTCTTCCTGGTGGCTCGGTTGACGCCCTACGAGTGGTACAGCCCACACC CATGTGCCCAGGGCCGGTGCAACCTCCTGGTGAACCAGTACTCCCTGGGCAACAGCCTCTGGTTTCCGGTCGGGGGGTTCATGCAGCAAG GCTCCACCATCGCCCCTCGCGCCTTATCCACCCGCTGTGTCAGTGGCGTCTGGTGGGCATTCACGCTGATCATCATCTCATCCTACACGG CCAACCTGGCAGCCTTCCTGACCGTGCAGCGCATGGATGTGCCCATTGAGTCAGTGGATGACCTGGCTGACCAGACCGCCATTGAATATG GCACAATTCACGGAGGCTCCAGCATGACCTTCTTCCAAAATTCCCGCTACCAGACCTACCAACGCATGTGGAATTACATGTATTCCAAGC AGCCCAGCGTGTTCGTGAAGAGCACAGAGGAGGGAATCGCCAGGGTGTTGAATTCCAACTACGCCTTCCTCCTGGAATCCACCATGAACG AGTACTATCGGCAGCGAAACTGCAACCTCACTCAGATTGGGGGCCTGCTGGACACCAAGGGCTATGGGATTGGCATGCCAGTCGGCTCGG TTTTCCGGGACGAGTTTGATCTGGCCATTCTCCAGCTGCAGGAGAACAACCGCCTGGAGATCCTGAAGCGCAAATGGTGGGAAGGAGGGA AGTGCCCCAAGGAGGAAGATCACAGAGCTAAAGGCCTGGGAATGGAGAATATTGGTGGAATCTTTGTGGTTCTTATTTGTGGCTTAATCG TGGCCATTTTTATGGCTATGTTGGAGTTTTTATGGACTCTCAGACACTCAGAAGCAACTGAGGTGTCCGTCTGCCAGGAGATGGTGACCG AGCTGCGCAGCATTATCCTGTGTCAGGACAGTATCCACCCCCGCCGGCGGCGCGCCGCAGTCCCGCCGCCCCGGCCCCCCATCCCCGAGG AGCGCCGACCGCGGGGCACGGCGACGCTCAGCAACGGGAAGCTGTGCGGGGCAGGGGAGCCCGACCAGCTCGCGCAGAGACTGGCGCAGG AGGCCGCCCTGGTGGCCCGCGGCTGCACGCACATCCGCGTCTGCCCCGAGTGCCGCCGCTTCCAGGGCCTGCGGGCACGGCCGTCGCCCG CCCGCAGCGAGGAGAGCCTGGAGTGGGAGAAAACCACCAACAGCAGCGAGCCCGAGTAGTCCCGGAGGCCACAGGACGCGCAGAGGCCGG GCGGGGCGGGAGGGGAGGGGCGGGGCGGGCGCTGCTGTCAGCCGCCAGCCGGAACTTGTACAGCGTCGACACCTCTCCAGATTTCGGATC CAGTCACTTTTCAAAAAGATCAAGGAGCCTGACGCCCCAGCCAGAGACCGCGCCCGGTCAGGGAGCAGGGTCCACCCGGAAACGTTGCAC CCAAAGGGCAAAGGACGGCCCTCCCTCCTGGGCACAAGGACCCATCTTCTCCCAGTGGGTCTTTCCCTCTCGCCAAAATAACAAGAGTAT AGGGTGGGGGGTCCCTACCCAGACCAGTCCAATGAATTGGTGGAATCATCAGTTGAATTTCCCCCTAGTCAGGGGCCAATGTACCCTCCG TCTAGTTCTTACAGAAAAAAAAAAAATTAAACAGGGAAGTTTTTCTTTTCTGGATTTGTATATTTTTGTTAATGTTCTTTTCCCTTTTCT TTCCTCCTCTCCTTTTCTTCTTTGTCATCTTCTCAGTCCTGTTAATTTGTTTTGTGTTTTTTGGAGGGGGAGGCTGGGTTAGGGAATGGA AGCCTAAATAATCCCTATTTCTTCTTTTTCCTGAATTTTGGAATATTGCGTTACCAGTGCATCCGATTTCAGGTGCTTAACTCTCTGTAT GGTGACTGAGGGGCCTGCAGGAGCACAGGAGAAGGAGTCTTGGGAAGAATCAGATGGAGAGTCTCAAAAGTCCATTGCAGTAAACTTTGA GATGCCAAAAAGCAATTAACTCATCCTATACTCAGACCTTGAAACGCCTGGAATGTCAAGGGTTAATCTGTCTTTTCTTTCCCTTTCTCT TTCTGACTGTCACTATTACTGGGTTTGATTTGATCTTTTTGTGAATGTAGTCTCTGAAGACAGACAGGGGAGGAGAACAGAATGCACAAA |
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FusionGenePPI for SIAE_GRIK4 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| SIAE | FBXO6, PTPRK, CPE, HLA-B, ENTPD6, NPTX1, CNTNAP3, MANEAL, OAF, TMEM30A, MR1, COCH, FAM162A, GPR98, GFPT2, MOXD1, LNPEP, PLXNB2, TCTN1, POC1A, NDST2, SGSH, TENM3, ERAP1, MANBA, ITGA8, TMEM2, LAMB2, FASTKD3, CHSY3, GDF11, DDX47, TMEM131, ARSK, ARSB, MBTPS1, COL18A1, MANEA, NAAA, RPP38, NRP2, PTGFRN, PLTP, KIAA1161, DCBLD2, SEPN1, GALNT7, TGFBR3, MAN2B2, TMEM132A, GALNS, NAGLU, CTSF, TRIM25 | GRIK4 | RAB5A, RUFY1, EGFR |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SIAE_GRIK4 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | GRIK4 | Q16099 | DB00142 | Glutamic Acid | Glutamate receptor ionotropic, kainate 4 | small molecule | approved|nutraceutical |
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RelatedDiseases for SIAE_GRIK4 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | SIAE | C3150797 | AUTOIMMUNE DISEASE, SUSCEPTIBILITY TO, 6 | 1 | UNIPROT |
| Tgene | GRIK4 | C0005586 | Bipolar Disorder | 5 | PSYGENET |
| Tgene | GRIK4 | C0036341 | Schizophrenia | 4 | PSYGENET |
| Tgene | GRIK4 | C0005587 | Depression, Bipolar | 1 | PSYGENET |
| Tgene | GRIK4 | C0033975 | Psychotic Disorders | 1 | PSYGENET |
| Tgene | GRIK4 | C0041696 | Unipolar Depression | 1 | PSYGENET |
| Tgene | GRIK4 | C0349204 | Nonorganic psychosis | 1 | PSYGENET |
| Tgene | GRIK4 | C1269683 | Major Depressive Disorder | 1 | PSYGENET |
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