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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 33811

FusionGeneSummary for SHROOM3_ART3

check button Fusion gene summary
Fusion gene informationFusion gene name: SHROOM3_ART3
Fusion gene ID: 33811
HgeneTgene
Gene symbol

SHROOM3

ART3

Gene ID

57619

419

Gene nameshroom family member 3ADP-ribosyltransferase 3
SynonymsAPXL3|MSTP013|SHRM|ShrmLARTC3
Cytomap

4q21.1

4q21.1|4p15.1-p14

Type of geneprotein-codingprotein-coding
Descriptionprotein Shroom3F-actin-binding proteinshroom-related proteinecto-ADP-ribosyltransferase 3ADP-ribosyltransferase C2 and C3 toxin-like 3NAD(P)(+)--arginine ADP-ribosyltransferase 3mono(ADP-ribosyl)transferase 3mono-ADP-ribosyltransferase
Modification date2018052320180523
UniProtAcc

Q8TF72

Q13508

Ensembl transtripts involved in fusion geneENST00000296043, ENST00000473602, 
ENST00000341029, ENST00000355810, 
ENST00000349321, ENST00000513494, 
Fusion gene scores* DoF score15 X 11 X 9=14853 X 2 X 3=18
# samples 173
** MAII scorelog2(17/1485*10)=-3.12685627955043
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SHROOM3 [Title/Abstract] AND ART3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDTGCTTCGA-YU-AA61-01ASHROOM3chr4

77476916

+ART3chr4

76997034

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000296043ENST00000341029SHROOM3chr4

77476916

+ART3chr4

76997034

+
5CDS-5UTRENST00000296043ENST00000355810SHROOM3chr4

77476916

+ART3chr4

76997034

+
5CDS-5UTRENST00000296043ENST00000349321SHROOM3chr4

77476916

+ART3chr4

76997034

+
5CDS-3UTRENST00000296043ENST00000513494SHROOM3chr4

77476916

+ART3chr4

76997034

+
intron-5UTRENST00000473602ENST00000341029SHROOM3chr4

77476916

+ART3chr4

76997034

+
intron-5UTRENST00000473602ENST00000355810SHROOM3chr4

77476916

+ART3chr4

76997034

+
intron-5UTRENST00000473602ENST00000349321SHROOM3chr4

77476916

+ART3chr4

76997034

+
intron-3UTRENST00000473602ENST00000513494SHROOM3chr4

77476916

+ART3chr4

76997034

+

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FusionProtFeatures for SHROOM3_ART3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SHROOM3

Q8TF72

ART3

Q13508

Controls cell shape changes in the neuroepitheliumduring neural tube closure. Induces apical constriction inepithelial cells by promoting the apical accumulation of F-actinand myosin II, and probably by bundling stress fibers. Inducesapicobasal cell elongation by redistributing gamma-tubulin anddirecting the assembly of robust apicobasal microtubule arrays (Bysimilarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SHROOM3_ART3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SHROOM3_ART3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SHROOM3SFN, SAAL1, YWHAB, UBTD1, CDK2, ILK, RPS6KA2, SIK2, RPS6KB2, MYH9, RAB32, SNW1, CDC5L, CDH1, TRIM25ART3ALCAM, PRKCD, MDN1, ATP12A, PIGO, RAB39B, DDX19B, CHD1L, DYNC2LI1, PAM, NAGLU, ARSK, HSPA12A, GPD1L, ITGA7, MGAT5, CBWD3, POGLUT1, SPG7, PSEN2, MAP2K2, SCAMP2, GALNT7, ITGA8


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SHROOM3_ART3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SHROOM3_ART3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource