FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 33810

FusionGeneSummary for SHROOM2_TOP1

check button Fusion gene summary
Fusion gene informationFusion gene name: SHROOM2_TOP1
Fusion gene ID: 33810
HgeneTgene
Gene symbol

SHROOM2

TOP1

Gene ID

357

7150

Gene nameshroom family member 2DNA topoisomerase I
SynonymsAPXL|HSAPXLTOPI
Cytomap

Xp22.2

20q12

Type of geneprotein-codingprotein-coding
Descriptionprotein Shroom2APX homolog of Xenopusapical-like proteinDNA topoisomerase 1topoisomerase (DNA) Itype I DNA topoisomerase
Modification date2018052320180523
UniProtAcc

Q13796

P11387

Ensembl transtripts involved in fusion geneENST00000380913, ENST00000493668, 
ENST00000418909, 
ENST00000361337, 
Fusion gene scores* DoF score5 X 6 X 3=906 X 5 X 3=90
# samples 56
** MAII scorelog2(5/90*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/90*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SHROOM2 [Title/Abstract] AND TOP1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSHROOM2

GO:0000902

cell morphogenesis

16684770

TgeneTOP1

GO:0006265

DNA topological change

14594810


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BG008680SHROOM2chrX

9765010

-TOP1chr20

39750756

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000380913ENST00000361337SHROOM2chrX

9765010

-TOP1chr20

39750756

+
intron-3CDSENST00000493668ENST00000361337SHROOM2chrX

9765010

-TOP1chr20

39750756

+
intron-3CDSENST00000418909ENST00000361337SHROOM2chrX

9765010

-TOP1chr20

39750756

+

Top

FusionProtFeatures for SHROOM2_TOP1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SHROOM2

Q13796

TOP1

P11387

May be involved in endothelial cell morphology changesduring cell spreading. In the retinal pigment epithelium, mayregulate the biogenesis of melanosomes and promote theirassociation with the apical cell surface by inducing gamma-tubulinredistribution (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for SHROOM2_TOP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for SHROOM2_TOP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for SHROOM2_TOP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneTOP1P11387DB00762IrinotecanDNA topoisomerase 1small moleculeapproved|investigational
TgeneTOP1P11387DB01030TopotecanDNA topoisomerase 1small moleculeapproved|investigational
TgeneTOP1P11387DB05630Sodium stibogluconateDNA topoisomerase 1small moleculeapproved|investigational

Top

RelatedDiseases for SHROOM2_TOP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneTOP1C0041755Adverse reaction to drug1CTD_human