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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 33805

FusionGeneSummary for SHQ1_PSMB7

check button Fusion gene summary
Fusion gene informationFusion gene name: SHQ1_PSMB7
Fusion gene ID: 33805
HgeneTgene
Gene symbol

SHQ1

PSMB7

Gene ID

55164

5695

Gene nameSHQ1, H/ACA ribonucleoprotein assembly factorproteasome subunit beta 7
SynonymsGRIM-1|Shq1pZ
Cytomap

3p13

9q33.3

Type of geneprotein-codingprotein-coding
Descriptionprotein SHQ1 homologSHQ1 homologgene associated with retinoid and interferon-induced mortality 1proteasome subunit beta type-7macropain chain Zmulticatalytic endopeptidase complex chain Zproteasome (prosome, macropain) subunit, beta type, 7proteasome catalytic subunit 2proteasome subunit Zproteasome subunit alphaprotein serine kinase c17
Modification date2018052320180523
UniProtAcc

Q6PI26

Q99436

Ensembl transtripts involved in fusion geneENST00000325599, ENST00000463369, 
ENST00000468371, 
ENST00000498485, 
ENST00000259457, ENST00000536392, 
Fusion gene scores* DoF score1 X 2 X 1=210 X 9 X 6=540
# samples 113
** MAII scorelog2(1/2*10)=2.32192809488736log2(13/540*10)=-2.05444778402238
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SHQ1 [Title/Abstract] AND PSMB7 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSHQ1

GO:0022618

ribonucleoprotein complex assembly

19383767

HgeneSHQ1

GO:0043065

positive regulation of apoptotic process

20663920

HgeneSHQ1

GO:2000233

negative regulation of rRNA processing

20663920


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-ZG-A9LZ-01ASHQ1chr3

72897349

-PSMB7chr9

127146935

-
TCGALDPRADTCGA-ZG-A9LZ-01ASHQ1chr3

72897348

-PSMB7chr9

127167710

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000325599ENST00000498485SHQ1chr3

72897349

-PSMB7chr9

127146935

-
5CDS-5UTRENST00000325599ENST00000259457SHQ1chr3

72897349

-PSMB7chr9

127146935

-
5CDS-5UTRENST00000325599ENST00000536392SHQ1chr3

72897349

-PSMB7chr9

127146935

-
intron-5UTRENST00000463369ENST00000498485SHQ1chr3

72897349

-PSMB7chr9

127146935

-
intron-5UTRENST00000463369ENST00000259457SHQ1chr3

72897349

-PSMB7chr9

127146935

-
intron-5UTRENST00000463369ENST00000536392SHQ1chr3

72897349

-PSMB7chr9

127146935

-
intron-5UTRENST00000468371ENST00000498485SHQ1chr3

72897349

-PSMB7chr9

127146935

-
intron-5UTRENST00000468371ENST00000259457SHQ1chr3

72897349

-PSMB7chr9

127146935

-
intron-5UTRENST00000468371ENST00000536392SHQ1chr3

72897349

-PSMB7chr9

127146935

-
5CDS-intronENST00000325599ENST00000498485SHQ1chr3

72897348

-PSMB7chr9

127167710

-
5CDS-intronENST00000325599ENST00000259457SHQ1chr3

72897348

-PSMB7chr9

127167710

-
5CDS-intronENST00000325599ENST00000536392SHQ1chr3

72897348

-PSMB7chr9

127167710

-
intron-intronENST00000463369ENST00000498485SHQ1chr3

72897348

-PSMB7chr9

127167710

-
intron-intronENST00000463369ENST00000259457SHQ1chr3

72897348

-PSMB7chr9

127167710

-
intron-intronENST00000463369ENST00000536392SHQ1chr3

72897348

-PSMB7chr9

127167710

-
intron-intronENST00000468371ENST00000498485SHQ1chr3

72897348

-PSMB7chr9

127167710

-
intron-intronENST00000468371ENST00000259457SHQ1chr3

72897348

-PSMB7chr9

127167710

-
intron-intronENST00000468371ENST00000536392SHQ1chr3

72897348

-PSMB7chr9

127167710

-

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FusionProtFeatures for SHQ1_PSMB7


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SHQ1

Q6PI26

PSMB7

Q99436

Required for the quantitative accumulation of H/ACAribonucleoproteins (RNPs), including telomerase, probably throughthe stabilization of DKC1, from the time of its synthesis untilits association with NOP10, NHP2, and NAF1 at the nascent H/ACARNA. {ECO:0000269|PubMed:19383767}. Component of the 20S core proteasome complex involved inthe proteolytic degradation of most intracellular proteins. Thiscomplex plays numerous essential roles within the cell byassociating with different regulatory particles. Associated withtwo 19S regulatory particles, forms the 26S proteasome and thusparticipates in the ATP-dependent degradation of ubiquitinatedproteins. The 26S proteasome plays a key role in the maintenanceof protein homeostasis by removing misfolded or damaged proteinsthat could impair cellular functions, and by removing proteinswhose functions are no longer required. Associated with the PA200or PA28, the 20S proteasome mediates ubiquitin-independent proteindegradation. This type of proteolysis is required in severalpathways including spermatogenesis (20S-PA200 complex) orgeneration of a subset of MHC class I-presented antigenic peptides(20S-PA28 complex). Within the 20S core complex, PSMB7 displays atrypsin-like activity. {ECO:0000269|PubMed:15244466,ECO:0000269|PubMed:27176742, ECO:0000269|PubMed:8610016}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SHQ1_PSMB7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SHQ1_PSMB7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SHQ1WDR48, DKC1, ELAVL1, NAF1, SHQ1, GMCL1, GMCL1P1, GAR1, XPO1, EXOSC4, RUVBL1, GPR156, DGCR8, KNOP1, RUVBL2, ZNHIT2PSMB7PLK1, UBC, PSMA2, PCK1, PSMB1, PSMB5, PSMB6, PSMB3, POMP, PSMA4, SERPINA10, FKBP8, UCHL5, PSMB4, PSMB7, PSMA8, PSMB9, PSMB8, PSME1, PSME2, PSMA1, PSMB2, PSMA3, PSMA5, PSMA6, PSMA7, PSMD6, PSMD1, PSMC3, PSMC4, PSMC2, PSMD13, PSMD2, PSMC5, PSMD3, PSMC1, PSMD12, PSMD11, PSMD8, PSMD4, PSMD7, PSMD14, UBE2D1, RAD23B, SYAP1, C11orf58, PCMT1, S100A9, NUDCD2, TMOD3, IQCB1, NOS2, PARK2, AFP, FUS, HTT, HECW2, CAST, ACACA, EPB41L1, KIF5B, AURKA, HUWE1, AMFR, SYVN1, PSMG2, PSME4, PSMC6, NAA25, FBXO7, PSMG1, PSMG3, PSMF1, ADRM1, CLIC4, POLR1C, PSMD5, PYGL, RAD23A, CBX8, DERL1, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SHQ1_PSMB7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SHQ1_PSMB7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource