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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 33798

FusionGeneSummary for SHOC2_TMEM178A

check button Fusion gene summary
Fusion gene informationFusion gene name: SHOC2_TMEM178A
Fusion gene ID: 33798
HgeneTgene
Gene symbol

SHOC2

TMEM178A

Gene ID

8036

130733

Gene nameSHOC2, leucine rich repeat scaffold proteintransmembrane protein 178A
SynonymsSIAA0862|SOC2|SUR8TMEM178
Cytomap

10q25.2

2p22.1

Type of geneprotein-codingprotein-coding
Descriptionleucine-rich repeat protein SHOC-2soc-2 suppressor of clear homologtransmembrane protein 178Atransmembrane protein 178
Modification date2018052320180403
UniProtAcc

Q9UQ13

Q8NBL3

Ensembl transtripts involved in fusion geneENST00000265277, ENST00000369452, 
ENST00000489390, 
ENST00000482239, 
ENST00000281961, 
Fusion gene scores* DoF score1 X 1 X 1=12 X 3 X 1=6
# samples 13
** MAII scorelog2(1/1*10)=3.32192809488736log2(3/6*10)=2.32192809488736
Context

PubMed: SHOC2 [Title/Abstract] AND TMEM178A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDPRADTCGA-HC-8262-01ASHOC2chr10

112679415

+TMEM178Achr2

39931221

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3UTRENST00000265277ENST00000482239SHOC2chr10

112679415

+TMEM178Achr2

39931221

+
5UTR-3UTRENST00000265277ENST00000281961SHOC2chr10

112679415

+TMEM178Achr2

39931221

+
5UTR-3UTRENST00000369452ENST00000482239SHOC2chr10

112679415

+TMEM178Achr2

39931221

+
5UTR-3UTRENST00000369452ENST00000281961SHOC2chr10

112679415

+TMEM178Achr2

39931221

+
3UTR-3UTRENST00000489390ENST00000482239SHOC2chr10

112679415

+TMEM178Achr2

39931221

+
3UTR-3UTRENST00000489390ENST00000281961SHOC2chr10

112679415

+TMEM178Achr2

39931221

+

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FusionProtFeatures for SHOC2_TMEM178A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SHOC2

Q9UQ13

TMEM178A

Q8NBL3

Regulatory subunit of protein phosphatase 1 (PP1c) thatacts as a M-Ras/MRAS effector and participates in MAPK pathwayactivation. Upon M-Ras/MRAS activation, targets PP1c tospecifically dephosphorylate the 'Ser-259' inhibitory site of RAF1kinase and stimulate RAF1 activity at specialized signalingcomplexes. {ECO:0000269|PubMed:10783161,ECO:0000269|PubMed:16630891, ECO:0000269|PubMed:25137548}. Acts as a negative regulator of osteoclastdifferentiation in basal and inflammatory conditions by regulatingTNFSF11-induced Ca (2+) fluxes, thereby controlling the inductionof NFATC1. {ECO:0000250|UniProtKB:Q9CZ16}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SHOC2_TMEM178A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SHOC2_TMEM178A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SHOC2KRAS, HRAS, RAF1, MYC, APP, ESR1, HUWE1, MRAS, PPP1CC, PPP1CA, PPP1R3A, SNW1, PSMC5, PPP1CB, NRAS, SLC35F5, PLCL2, TRIM25TMEM178A


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SHOC2_TMEM178A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SHOC2_TMEM178A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSHOC2C1843181NOONAN SYNDROME-LIKE DISORDER WITH LOOSE ANAGEN HAIR2CTD_human;ORPHANET;UNIPROT
HgeneSHOC2C0018500Hair Diseases1CTD_human
HgeneSHOC2C0028326Noonan Syndrome1CTD_human