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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 33774

FusionGeneSummary for SHC4_STAG3L1

check button Fusion gene summary
Fusion gene informationFusion gene name: SHC4_STAG3L1
Fusion gene ID: 33774
HgeneTgene
Gene symbol

SHC4

STAG3L1

Gene ID

399694

442578

Gene nameSHC adaptor protein 4stromal antigen 3-like 3 (pseudogene)
SynonymsRaLP|SHCDSTAG3L1|STAG3L2|STAG3L3P
Cytomap

15q21.1

7q11.23

Type of geneprotein-codingpseudo
DescriptionSHC-transforming protein 4SH2 domain protein C4SHC (Src homology 2 domain containing) family, member 4SHC-transforming protein DhShcDrai-like proteinsrc homology 2 domain-containing-transforming protein C4STAG3-like protein 3stromal antigen 3 pseudogene
Modification date2018052320180329
UniProtAcc

Q6S5L8

Ensembl transtripts involved in fusion geneENST00000332408, ENST00000396535, 
ENST00000537958, 
ENST00000402225, 
Fusion gene scores* DoF score4 X 4 X 1=161 X 1 X 1=1
# samples 41
** MAII scorelog2(4/16*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(1/1*10)=3.32192809488736
Context

PubMed: SHC4 [Title/Abstract] AND STAG3L1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BU625857SHC4chr15

49171511

-STAG3L1chr7

74993983

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000332408ENST00000402225SHC4chr15

49171511

-STAG3L1chr7

74993983

-
intron-3UTRENST00000396535ENST00000402225SHC4chr15

49171511

-STAG3L1chr7

74993983

-
intron-3UTRENST00000537958ENST00000402225SHC4chr15

49171511

-STAG3L1chr7

74993983

-

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FusionProtFeatures for SHC4_STAG3L1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SHC4

Q6S5L8

STAG3L1

Activates both Ras-dependent and Ras-independentmigratory pathways in melanomas. Contributes to the early phasesof agrin-induced tyrosine phosphorylation of CHRNB1.{ECO:0000269|PubMed:17409413}. Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SHC4_STAG3L1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SHC4_STAG3L1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SHC4_STAG3L1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SHC4_STAG3L1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneSTAG3L1C0010606Adenoid Cystic Carcinoma1CTD_human
TgeneSTAG3L1C0036095Salivary Gland Neoplasms1CTD_human