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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 33772

FusionGeneSummary for SHC4_RANGAP1

check button Fusion gene summary
Fusion gene informationFusion gene name: SHC4_RANGAP1
Fusion gene ID: 33772
HgeneTgene
Gene symbol

SHC4

RANGAP1

Gene ID

399694

5905

Gene nameSHC adaptor protein 4Ran GTPase activating protein 1
SynonymsRaLP|SHCDFug1|RANGAP|SD
Cytomap

15q21.1

22q13.2

Type of geneprotein-codingprotein-coding
DescriptionSHC-transforming protein 4SH2 domain protein C4SHC (Src homology 2 domain containing) family, member 4SHC-transforming protein DhShcDrai-like proteinsrc homology 2 domain-containing-transforming protein C4ran GTPase-activating protein 1segregation distorter homologsegregation distortion
Modification date2018052320180522
UniProtAcc

Q6S5L8

P46060

Ensembl transtripts involved in fusion geneENST00000332408, ENST00000396535, 
ENST00000537958, 
ENST00000405486, 
ENST00000356244, ENST00000455915, 
ENST00000407260, 
Fusion gene scores* DoF score4 X 4 X 1=168 X 8 X 5=320
# samples 49
** MAII scorelog2(4/16*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(9/320*10)=-1.83007499855769
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SHC4 [Title/Abstract] AND RANGAP1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneRANGAP1

GO:0046826

negative regulation of protein export from nucleus

16449645

TgeneRANGAP1

GO:0090630

activation of GTPase activity

16428860


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE925437SHC4chr15

49170450

+RANGAP1chr22

41641876

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000332408ENST00000405486SHC4chr15

49170450

+RANGAP1chr22

41641876

-
intron-3UTRENST00000332408ENST00000356244SHC4chr15

49170450

+RANGAP1chr22

41641876

-
intron-3UTRENST00000332408ENST00000455915SHC4chr15

49170450

+RANGAP1chr22

41641876

-
intron-intronENST00000332408ENST00000407260SHC4chr15

49170450

+RANGAP1chr22

41641876

-
intron-3UTRENST00000396535ENST00000405486SHC4chr15

49170450

+RANGAP1chr22

41641876

-
intron-3UTRENST00000396535ENST00000356244SHC4chr15

49170450

+RANGAP1chr22

41641876

-
intron-3UTRENST00000396535ENST00000455915SHC4chr15

49170450

+RANGAP1chr22

41641876

-
intron-intronENST00000396535ENST00000407260SHC4chr15

49170450

+RANGAP1chr22

41641876

-
intron-3UTRENST00000537958ENST00000405486SHC4chr15

49170450

+RANGAP1chr22

41641876

-
intron-3UTRENST00000537958ENST00000356244SHC4chr15

49170450

+RANGAP1chr22

41641876

-
intron-3UTRENST00000537958ENST00000455915SHC4chr15

49170450

+RANGAP1chr22

41641876

-
intron-intronENST00000537958ENST00000407260SHC4chr15

49170450

+RANGAP1chr22

41641876

-

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FusionProtFeatures for SHC4_RANGAP1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SHC4

Q6S5L8

RANGAP1

P46060

Activates both Ras-dependent and Ras-independentmigratory pathways in melanomas. Contributes to the early phasesof agrin-induced tyrosine phosphorylation of CHRNB1.{ECO:0000269|PubMed:17409413}. GTPase activator for RAN (PubMed:8146159,PubMed:8896452, PubMed:16428860). Converts cytoplasmic GTP-boundRAN to GDP-bound RAN, which is essential for RAN-mediated nuclearimport and export (PubMed:8896452, PubMed:27160050). Mediatesdissociation of cargo from nuclear export complexes containingXPO1, RAN and RANBP2 after nuclear export (PubMed:27160050).{ECO:0000269|PubMed:16428860, ECO:0000269|PubMed:27160050,ECO:0000269|PubMed:8146159, ECO:0000269|PubMed:8896452}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SHC4_RANGAP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SHC4_RANGAP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SHC4_RANGAP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SHC4_RANGAP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneRANGAP1C0079744Diffuse Large B-Cell Lymphoma1CTD_human