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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 33771

FusionGeneSummary for SHC4_B3GAT3

check button Fusion gene summary
Fusion gene informationFusion gene name: SHC4_B3GAT3
Fusion gene ID: 33771
HgeneTgene
Gene symbol

SHC4

B3GAT3

Gene ID

399694

26229

Gene nameSHC adaptor protein 4beta-1,3-glucuronyltransferase 3
SynonymsRaLP|SHCDGLCATI|JDSCD|glcUAT-I
Cytomap

15q21.1

11q12.3

Type of geneprotein-codingprotein-coding
DescriptionSHC-transforming protein 4SH2 domain protein C4SHC (Src homology 2 domain containing) family, member 4SHC-transforming protein DhShcDrai-like proteinsrc homology 2 domain-containing-transforming protein C4galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3Sqv-8-like proteinUDP-GlcUA:Gal beta-1,3-Gal-R glucuronyltransferasebeta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I)
Modification date2018052320180523
UniProtAcc

Q6S5L8

O94766

Ensembl transtripts involved in fusion geneENST00000332408, ENST00000396535, 
ENST00000537958, 
ENST00000265471, 
ENST00000531383, ENST00000534026, 
Fusion gene scores* DoF score4 X 4 X 1=161 X 1 X 1=1
# samples 41
** MAII scorelog2(4/16*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(1/1*10)=3.32192809488736
Context

PubMed: SHC4 [Title/Abstract] AND B3GAT3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneB3GAT3

GO:0006024

glycosaminoglycan biosynthetic process

24425863

TgeneB3GAT3

GO:0015012

heparan sulfate proteoglycan biosynthetic process

21763480

TgeneB3GAT3

GO:0043085

positive regulation of catalytic activity

24425863

TgeneB3GAT3

GO:0050650

chondroitin sulfate proteoglycan biosynthetic process

21763480

TgeneB3GAT3

GO:0050651

dermatan sulfate proteoglycan biosynthetic process

21763480


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BP227858SHC4chr15

49170723

+B3GAT3chr11

62388102

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000332408ENST00000265471SHC4chr15

49170723

+B3GAT3chr11

62388102

-
intron-3CDSENST00000332408ENST00000531383SHC4chr15

49170723

+B3GAT3chr11

62388102

-
intron-3CDSENST00000332408ENST00000534026SHC4chr15

49170723

+B3GAT3chr11

62388102

-
intron-3CDSENST00000396535ENST00000265471SHC4chr15

49170723

+B3GAT3chr11

62388102

-
intron-3CDSENST00000396535ENST00000531383SHC4chr15

49170723

+B3GAT3chr11

62388102

-
intron-3CDSENST00000396535ENST00000534026SHC4chr15

49170723

+B3GAT3chr11

62388102

-
intron-3CDSENST00000537958ENST00000265471SHC4chr15

49170723

+B3GAT3chr11

62388102

-
intron-3CDSENST00000537958ENST00000531383SHC4chr15

49170723

+B3GAT3chr11

62388102

-
intron-3CDSENST00000537958ENST00000534026SHC4chr15

49170723

+B3GAT3chr11

62388102

-

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FusionProtFeatures for SHC4_B3GAT3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SHC4

Q6S5L8

B3GAT3

O94766

Activates both Ras-dependent and Ras-independentmigratory pathways in melanomas. Contributes to the early phasesof agrin-induced tyrosine phosphorylation of CHRNB1.{ECO:0000269|PubMed:17409413}. Glycosaminoglycans biosynthesis (PubMed:25893793).Involved in forming the linkage tetrasaccharide present in heparansulfate and chondroitin sulfate. Transfers a glucuronic acidmoiety from the uridine diphosphate-glucuronic acid (UDP-GlcUA) tothe common linkage region trisaccharide Gal-beta-1,3-Gal-beta-1,4-Xyl covalently bound to a Ser residue at the glycosaminylglycanattachment site of proteoglycans. Can also play a role in thebiosynthesis of l2/HNK-1 carbohydrate epitope on glycoproteins.Shows strict specificity for Gal-beta-1,3-Gal-beta-1,4-Xyl,exhibiting negligible incorporation into other galactosidesubstrates including Galbeta1-3Gal beta1-O-benzyl, Galbeta1-4GlcNAc and Galbeta1-4Glc. Stimulates 2-phosphoxylose phosphataseactivity of PXYLP1 in presence of uridine diphosphate-glucuronicacid (UDP-GlcUA) during completion of linkage region formation(PubMed:24425863). {ECO:0000269|PubMed:24425863,ECO:0000269|PubMed:25893793}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SHC4_B3GAT3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SHC4_B3GAT3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SHC4_B3GAT3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SHC4_B3GAT3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneB3GAT3C3278404MULTIPLE JOINT DISLOCATIONS, SHORT STATURE, CRANIOFACIAL DYSMORPHISM, AND CONGENITAL HEART DEFECTS2ORPHANET;UNIPROT
TgeneB3GAT3C0376634Craniofacial Abnormalities1CTD_human