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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 33770

FusionGeneSummary for SHC3_PTPLAD2

check button Fusion gene summary
Fusion gene informationFusion gene name: SHC3_PTPLAD2
Fusion gene ID: 33770
HgeneTgene
Gene symbol

SHC3

PTPLAD2

Gene ID

53358

401494

Gene nameSHC adaptor protein 33-hydroxyacyl-CoA dehydratase 4
SynonymsN-Shc|NSHC|RAI|SHCCPTPLAD2
Cytomap

9q22.1

9p21.3

Type of geneprotein-codingprotein-coding
DescriptionSHC-transforming protein 3SH2 domain protein C3SHC (Src homology 2 domain containing) transforming protein 3SHC-transforming protein CShc3 p51neuronal Shcprotein Raisrc homology 2 domain-containing transforming protein C3very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 4protein tyrosine phosphatase-like A domain containing 2protein tyrosine phosphatase-like protein PTPLAD2protein-tyrosine phosphatase-like A domain-containing protein 2very-long-chain (3R)-3-hydroxyac
Modification date2018052320180523
UniProtAcc

Q92529

Ensembl transtripts involved in fusion geneENST00000375835, ENST00000375830, 
ENST00000375831, 		ENST00000513293, 
ENST00000495827, ENST00000488436, 
Fusion gene scores* DoF score2 X 2 X 2=83 X 1 X 2=6
# samples 23
** MAII scorelog2(2/8*10)=1.32192809488736log2(3/6*10)=2.32192809488736
Context

PubMed: SHC3 [Title/Abstract] AND PTPLAD2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePTPLAD2

GO:0030497

fatty acid elongation

18554506

TgenePTPLAD2

GO:0042761

very long-chain fatty acid biosynthetic process

18554506


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLGGTCGA-E1-A7YI-01ASHC3chr9

91792902

-PTPLAD2chr9

21029397

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000375835ENST00000513293SHC3chr9

91792902

-PTPLAD2chr9

21029397

-
Frame-shiftENST00000375835ENST00000495827SHC3chr9

91792902

-PTPLAD2chr9

21029397

-
5CDS-intronENST00000375835ENST00000488436SHC3chr9

91792902

-PTPLAD2chr9

21029397

-
5UTR-3CDSENST00000375830ENST00000513293SHC3chr9

91792902

-PTPLAD2chr9

21029397

-
5UTR-3CDSENST00000375830ENST00000495827SHC3chr9

91792902

-PTPLAD2chr9

21029397

-
5UTR-intronENST00000375830ENST00000488436SHC3chr9

91792902

-PTPLAD2chr9

21029397

-
intron-3CDSENST00000375831ENST00000513293SHC3chr9

91792902

-PTPLAD2chr9

21029397

-
intron-3CDSENST00000375831ENST00000495827SHC3chr9

91792902

-PTPLAD2chr9

21029397

-
intron-intronENST00000375831ENST00000488436SHC3chr9

91792902

-PTPLAD2chr9

21029397

-

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FusionProtFeatures for SHC3_PTPLAD2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SHC3

Q92529

PTPLAD2

Signaling adapter that couples activated growth factorreceptors to signaling pathway in neurons. Involved in the signaltransduction pathways of neurotrophin-activated Trk receptors incortical neurons. Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePTPLAD2chr9:91792902chr9:21029397ENST00000495827-07228_23112233Compositional biasNote=Poly-Lys
TgenePTPLAD2chr9:91792902chr9:21029397ENST00000513293-09228_23112635Compositional biasNote=Poly-Lys
TgenePTPLAD2chr9:91792902chr9:21029397ENST00000495827-07134_13512233Topological domainLumenal
TgenePTPLAD2chr9:91792902chr9:21029397ENST00000495827-07157_15712233Topological domainCytoplasmic
TgenePTPLAD2chr9:91792902chr9:21029397ENST00000495827-07179_18912233Topological domainLumenal
TgenePTPLAD2chr9:91792902chr9:21029397ENST00000495827-07211_23212233Topological domainCytoplasmic
TgenePTPLAD2chr9:91792902chr9:21029397ENST00000495827-0741_5612233Topological domainLumenal
TgenePTPLAD2chr9:91792902chr9:21029397ENST00000495827-0778_11212233Topological domainCytoplasmic
TgenePTPLAD2chr9:91792902chr9:21029397ENST00000513293-09134_13512635Topological domainLumenal
TgenePTPLAD2chr9:91792902chr9:21029397ENST00000513293-09157_15712635Topological domainCytoplasmic
TgenePTPLAD2chr9:91792902chr9:21029397ENST00000513293-09179_18912635Topological domainLumenal
TgenePTPLAD2chr9:91792902chr9:21029397ENST00000513293-09211_23212635Topological domainCytoplasmic
TgenePTPLAD2chr9:91792902chr9:21029397ENST00000513293-0941_5612635Topological domainLumenal
TgenePTPLAD2chr9:91792902chr9:21029397ENST00000513293-0978_11212635Topological domainCytoplasmic
TgenePTPLAD2chr9:91792902chr9:21029397ENST00000495827-07113_13312233TransmembraneHelical
TgenePTPLAD2chr9:91792902chr9:21029397ENST00000495827-07136_15612233TransmembraneHelical
TgenePTPLAD2chr9:91792902chr9:21029397ENST00000495827-07158_17812233TransmembraneHelical
TgenePTPLAD2chr9:91792902chr9:21029397ENST00000495827-07190_21012233TransmembraneHelical
TgenePTPLAD2chr9:91792902chr9:21029397ENST00000495827-0720_4012233TransmembraneHelical
TgenePTPLAD2chr9:91792902chr9:21029397ENST00000495827-0757_7712233TransmembraneHelical
TgenePTPLAD2chr9:91792902chr9:21029397ENST00000513293-09113_13312635TransmembraneHelical
TgenePTPLAD2chr9:91792902chr9:21029397ENST00000513293-09136_15612635TransmembraneHelical
TgenePTPLAD2chr9:91792902chr9:21029397ENST00000513293-09158_17812635TransmembraneHelical
TgenePTPLAD2chr9:91792902chr9:21029397ENST00000513293-09190_21012635TransmembraneHelical
TgenePTPLAD2chr9:91792902chr9:21029397ENST00000513293-0920_4012635TransmembraneHelical
TgenePTPLAD2chr9:91792902chr9:21029397ENST00000513293-0957_7712635TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSHC3chr9:91792902chr9:21029397ENST00000375835-112149_334158595DomainPID
HgeneSHC3chr9:91792902chr9:21029397ENST00000375835-112499_590158595DomainSH2
HgeneSHC3chr9:91792902chr9:21029397ENST00000375835-112335_498158595RegionNote=CH1
TgenePTPLAD2chr9:91792902chr9:21029397ENST00000495827-071_1912233Topological domainCytoplasmic
TgenePTPLAD2chr9:91792902chr9:21029397ENST00000513293-091_1912635Topological domainCytoplasmic


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FusionGeneSequence for SHC3_PTPLAD2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_SHC3_ENST00000375835_chr9_91792902_-_PTPLAD2_ENST00000513293_chr9_21029397_-_158aa
MLPRTKYNRFRNDSVTSVDDLLHSLSVSGGGGKVSAARATPAAAPYLVSGEALRKAPDDGPGSLGHLLHKVSHLKLSSSGLRGLSSAARE


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_SHC3_ENST00000375835_chr9_91792902_-_PTPLAD2_ENST00000513293_chr9_21029397_-_474nt
ATGCTTCCACGCACCAAGTATAACCGCTTCAGGAATGACTCGGTGACATCGGTCGATGACCTTCTCCACAGCCTGTCGGTGAGCGGCGGC
GGAGGCAAGGTTTCGGCGGCGCGCGCGACCCCGGCGGCGGCTCCCTACTTGGTGTCCGGCGAGGCGCTGCGCAAGGCGCCCGACGATGGG
CCCGGCAGCCTGGGCCACCTGCTCCACAAGGTGTCCCACCTGAAACTCTCCAGCTCGGGCCTCCGCGGCCTGTCGTCGGCCGCCCGGGAG
CGGGCGGGCGCGCGGCTCTCGGGCAGCTGCAGCGCGCCCAGCCTGGCCGCCCCGGACGGCAGTGCGCCCTCGGCGCCCCGCGCCCCGGCC
ATGAGCGCCGCCAGGAAGGGCCGGCCCGGCGACGAGCCGCTGCCCAGGCCCCCTCGGGGGGCGCCGCACGCCAGCGACCAGGTGCTGGGG


* Fusion transcript sequences (Full-length transcript).
>In-frame_SHC3_ENST00000375835_chr9_91792902_-_PTPLAD2_ENST00000513293_chr9_21029397_-_2855nt
TGCTTTTGCTGTGAGCAGCCCCAAGCAGCTGGGCGCTCCATCAGAGGCAACTATGACTTTTGCAAAGCAAACGTGCAACCCCAAGCAGCG
GTCTCCCGGGCCGGGGCTGCGCGGCCGCCGCTGTGCTGGCTTTTAACGGTGGGAGGGCACCATCCTCTTGCTCTGCTCTCGTTCTCCAGA
AGGCTGTCCCGGGGCCCCCACTCTCCGTCCCGCTCCGGGGACAGTGGCTCGCCTGCTATGCGCGGCAGCCCGCGCCGGGGCCGGCACCAG
CAGCGCCCGGGCGGATGCAGCGAGCCCACGGAGGGGCATGCTTCCACGCACCAAGTATAACCGCTTCAGGAATGACTCGGTGACATCGGT
CGATGACCTTCTCCACAGCCTGTCGGTGAGCGGCGGCGGAGGCAAGGTTTCGGCGGCGCGCGCGACCCCGGCGGCGGCTCCCTACTTGGT
GTCCGGCGAGGCGCTGCGCAAGGCGCCCGACGATGGGCCCGGCAGCCTGGGCCACCTGCTCCACAAGGTGTCCCACCTGAAACTCTCCAG
CTCGGGCCTCCGCGGCCTGTCGTCGGCCGCCCGGGAGCGGGCGGGCGCGCGGCTCTCGGGCAGCTGCAGCGCGCCCAGCCTGGCCGCCCC
GGACGGCAGTGCGCCCTCGGCGCCCCGCGCCCCGGCCATGAGCGCCGCCAGGAAGGGCCGGCCCGGCGACGAGCCGCTGCCCAGGCCCCC
TCGGGGGGCGCCGCACGCCAGCGACCAGGTGCTGGGGCCCGGAGTCACCTACGTGGTCAAGGTATAGGAAGAATGCGTATCTTTTCATCT
ATTACTTAATCCAGTTCTGTGGCCACTCTTGGATATTTACAAATATGACAGTCAGATTCTTTTCATTTGGAAAAGATTCAATGGTTGACA
CTTTTTATGCTATTGGACTTGTGATGCGACTTTGCCAATCCGTATCTCTCCTGGAACTGCTGCACATATATGTTGGCATTGAGTCAAACC
ATCTTCTCCCAAGGTTTTTGCAGCTCACAGAAAGAATAATCATCCTTTTTGTGGTGATCACCAGTCAAGAGGAAGTCCAAGAGAAATATG
TGGTGTGTGTTTTATTCGTCTTTTGGAATCTATTGGATATGGTTAGGTACACTTATAGCATGTTATCAGTCATAGGAATATCCTATGCTG
TCTTGACATGGCTCAGTCAAACACTATGGATGCCAATTTATCCTTTGTGTGTTCTTGCTGAAGCATTTGCCATCTATCAATCGCTGCCTT
ATTTTGAATCATTTGGCACTTATTCCACCAAGCTGCCCTTTGACTTATCCATCTATTTCCCATATGTGCTGAAAATATATCTCATGATGC
TCTTTATAGGTATGTATTTTACCTACAGTCATCTATACTCAGAAAGAAGAGACATCCTCGGAATCTTTCCCATTAAAAAAAAGAAGATGT
GAAGTACAGCATTCCAGTGTGACACGAGAAAAGACAGGCTGTGGATTCAGTGCAGTAAATAAAACACAGGAAGTATTCTGGTGGAAAAAT
ACCTTGTATTTGATAAAAATCCATTACATGAAATAACTGCACATACCCCCAAAACTCTAGACATAACAGGCTATGTTTTTCACACATTGT
ATTTTTAAGACATATATATTCTCCATACCCTGCTTCACCAAAATTCCTGCTTCATTTGGATTTTATACAAGTTATACTTACATTGTATGA
AGTCTGATTATTTTCCTGTAAGTTTAATGAGAAATAGGAGATTAGCTGCAATAGATTCAATTAAATTAAGAAACCAAACTTGATAACCTA
AATTACATGTATTCTTTTTCACTTCCAAGTTCCCAAATAGATCTGTAGGAGAAGAGGGATGGAAAATATATTCCACAGTTGCCTAGAATA
ACATATTTCATAGACAGATGTCTGTCTTCAGATCTAATAATACTCACCCTAAACATTAGATATGTTTAGAAAATTAAATATCTTTCCAAG
CCCTATGTCTTAGCTCAGGTTGCTATAATAGAACACCATAAACCGAATGGCTTAAACAACAGCAAACGCTTCTCACAGTTCTGGAGGCTG
GGAATTCCGCTCAGGATCAAGGCATCAGCTAATGCAGTTTCTGGACCCAGTGAGGCAGAGGTATTGCCCCCAGGACTATGTTGGAGGAGG
ATGACCCCCATATCACCAGGCGGAAGCTGTCAGGCCTGTTGAAACCAAGGCAATGACTGCCCCTTTTGAAACTGAGAAGCAGGGAGAAGA
TAATATCTTCAAGCTTTCACAAAGAAAATCTCCACATTGAACTCAAGCCAAATAAAGAAAATCCAAGTTCCTGTTTCAGTCTCAACTGGC
CCGGGTACTAAAGCAATGCACTCCTCTCTTAGGAGGCATGTGTCAAGCTGTCAGTGATGTGGCCATCTTTTCATGACCCTTAACTCTCTG
CATCATGTCTCAGCAATACCAGGCATGAATTCTGAAAAACTTCTTCCACTTATATGGTTTTCCTCATCCAGCTGAGAATGCTGCTGGTTA
CTGCAAAACTGTTCACCAACCATATGCTCTGGTCCATACAGCTTTCTTCTTAAACTCTGGGAGAACTCTCAAGGACAGCAGGGTGGCTAA
GGGGACAAAATATAGGTATGGCTGCATTTGAAAAGGTCATTTTGATCAAAAAGGTGTCAGAACAGAATTTGTCTTTTTCTCACTTGGCTA
ATGTTCAAGACTAGGGAGTTCCATCGATATTTTGGCAGGATTTTAATGGCAGAAAACCATTTATAAATGTTGGGGGGAAAGTTGTTTTTT


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FusionGenePPI for SHC3_PTPLAD2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SHC3ARHGAP32, ALK, EGFR, NTRK1, NTRK2, SH3GL3, ERBB2, ERBB3, GOLGA2, KRT31, KRT40, SHC4PTPLAD2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SHC3_PTPLAD2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SHC3_PTPLAD2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource