|
Fusion gene ID: 33763 |
FusionGeneSummary for SHC2_CREB3L3 |
Fusion gene summary |
Fusion gene information | Fusion gene name: SHC2_CREB3L3 | Fusion gene ID: 33763 | Hgene | Tgene | Gene symbol | SHC2 | CREB3L3 | Gene ID | 25759 | 84699 |
Gene name | SHC adaptor protein 2 | cAMP responsive element binding protein 3 like 3 | |
Synonyms | SCK|SHCB|SLI | CREB-H|CREBH|HYST1481 | |
Cytomap | 19p13.3 | 19p13.3 | |
Type of gene | protein-coding | protein-coding | |
Description | SHC-transforming protein 2SH2 domain protein C2SHC (Src homology 2 domain containing) transforming protein 2SHC-transforming protein Bneuronal Shc adaptor homologprotein Scksrc homology 2 domain-containing-transforming protein C2 | cyclic AMP-responsive element-binding protein 3-like protein 3CREB/ATF family transcription factor | |
Modification date | 20180523 | 20180522 | |
UniProtAcc | P98077 | Q68CJ9 | |
Ensembl transtripts involved in fusion gene | ENST00000264554, | ENST00000078445, ENST00000252587, ENST00000595923, ENST00000602257, ENST00000602147, | |
Fusion gene scores | * DoF score | 6 X 4 X 4=96 | 4 X 4 X 4=64 |
# samples | 6 | 4 | |
** MAII score | log2(6/96*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: SHC2 [Title/Abstract] AND CREB3L3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation | Transcription factor involved fusion gene, inframe and retained DNA-binding domain. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | CREB3L3 | GO:1990440 | positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress | 16469704 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | LUAD | TCGA-44-8119-01A | SHC2 | chr19 | 460529 | - | CREB3L3 | chr19 | 4164500 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000264554 | ENST00000078445 | SHC2 | chr19 | 460529 | - | CREB3L3 | chr19 | 4164500 | + |
In-frame | ENST00000264554 | ENST00000252587 | SHC2 | chr19 | 460529 | - | CREB3L3 | chr19 | 4164500 | + |
In-frame | ENST00000264554 | ENST00000595923 | SHC2 | chr19 | 460529 | - | CREB3L3 | chr19 | 4164500 | + |
In-frame | ENST00000264554 | ENST00000602257 | SHC2 | chr19 | 460529 | - | CREB3L3 | chr19 | 4164500 | + |
In-frame | ENST00000264554 | ENST00000602147 | SHC2 | chr19 | 460529 | - | CREB3L3 | chr19 | 4164500 | + |
Top |
FusionProtFeatures for SHC2_CREB3L3 |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
SHC2 | CREB3L3 |
Signaling adapter that couples activated growth factorreceptors to signaling pathway in neurons. Involved in the signaltransduction pathways of neurotrophin-activated Trk receptors incortical neurons (By similarity). {ECO:0000250}. | Transcription factor that may act during endoplasmicreticulum stress by activating unfolded protein response targetgenes. Activated in response to cAMP stimulation. In vitro, bindsto the cAMP response element (CRE) and box-B element. Activatestranscription through box-B element. Activates transcriptionthrough CRE (By similarity). Seems to function synergisticallywith ATF6. In acute inflammatory response, may activate expressionof acute phase response (APR) genes. May be involved in growthsuppression. {ECO:0000250, ECO:0000269|PubMed:11353085,ECO:0000269|PubMed:15800215, ECO:0000269|PubMed:16469704}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | >CREB3L3 | chr19:460529 | chr19:4164500 | ENST00000078445 | + | 3 | 10 | 243_306 | 192 | 462 | Domain | bZIP |
Tgene | >CREB3L3 | chr19:460529 | chr19:4164500 | ENST00000595923 | + | 3 | 10 | 243_306 | 191 | 461 | Domain | bZIP |
Tgene | >CREB3L3 | chr19:460529 | chr19:4164500 | ENST00000078445 | + | 3 | 10 | 245_274 | 192 | 462 | Region | Basic motif |
Tgene | >CREB3L3 | chr19:460529 | chr19:4164500 | ENST00000078445 | + | 3 | 10 | 285_306 | 192 | 462 | Region | Leucine-zipper |
Tgene | >CREB3L3 | chr19:460529 | chr19:4164500 | ENST00000595923 | + | 3 | 10 | 245_274 | 191 | 461 | Region | Basic motif |
Tgene | >CREB3L3 | chr19:460529 | chr19:4164500 | ENST00000595923 | + | 3 | 10 | 285_306 | 191 | 461 | Region | Leucine-zipper |
Tgene | >CREB3L3 | chr19:460529 | chr19:4164500 | ENST00000078445 | + | 3 | 10 | 344_461 | 192 | 462 | Topological domain | Lumenal |
Tgene | >CREB3L3 | chr19:460529 | chr19:4164500 | ENST00000595923 | + | 3 | 10 | 344_461 | 191 | 461 | Topological domain | Lumenal |
Tgene | >CREB3L3 | chr19:460529 | chr19:4164500 | ENST00000078445 | + | 3 | 10 | 323_343 | 192 | 462 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
Tgene | >CREB3L3 | chr19:460529 | chr19:4164500 | ENST00000595923 | + | 3 | 10 | 323_343 | 191 | 461 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >SHC2 | chr19:460529 | chr19:4164500 | ENST00000264554 | - | 1 | 13 | 147_329 | 156 | 694 | Domain | PID |
Hgene | >SHC2 | chr19:460529 | chr19:4164500 | ENST00000264554 | - | 1 | 13 | 487_578 | 156 | 694 | Domain | SH2 |
Hgene | >SHC2 | chr19:460529 | chr19:4164500 | ENST00000264554 | - | 1 | 13 | 330_486 | 156 | 694 | Region | Note=CH1 |
Tgene | CREB3L3 | chr19:460529 | chr19:4164500 | ENST00000078445 | + | 3 | 10 | 1_322 | 192 | 462 | Topological domain | Cytoplasmic |
Tgene | CREB3L3 | chr19:460529 | chr19:4164500 | ENST00000595923 | + | 3 | 10 | 1_322 | 191 | 461 | Topological domain | Cytoplasmic |
Top |
FusionGeneSequence for SHC2_CREB3L3 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_SHC2_ENST00000264554_chr19_460529_-_CREB3L3_ENST00000078445_chr19_4164500_+_426aa MTQGPGGRAPPAPPAPPEPEAPTTFCALLPRMPQWKFAAPGGFLGRGPAAARAAGASGGADPQPEPAGPGGVPALAAAVLGACEPRCAAP CPLPALSRCRGAGSRGSRGGRGAAGSGDAAAAAEWIRKGSFIHKPAHGWLHPDARVLGPGVSYVVRQQHHLGASYLLRPGAGHCQELVLT EDEKKLLAKEGITLPTQLPLTKYEERVLKKIRRKIRNKQSAQESRKKKKEYIDGLETRMSACTAQNQELQRKVLHLEKQNLSLLEQLKKL QAIVVQSTSKSAQTGTCVAVLLLSFALIILPSISPFGPNKTESPGDFAPVRVFSRTLHNDAASRVAADAVPGSEAPGPRPEADTTREESP >In-frame_SHC2_ENST00000264554_chr19_460529_-_CREB3L3_ENST00000252587_chr19_4164500_+_324aa MTQGPGGRAPPAPPAPPEPEAPTTFCALLPRMPQWKFAAPGGFLGRGPAAARAAGASGGADPQPEPAGPGGVPALAAAVLGACEPRCAAP CPLPALSRCRGAGSRGSRGGRGAAGSGDAAAAAEWIRKGSFIHKPAHGWLHPDARVLGPGVSYVVRQQHHLGASYLLRPGAGHCQELVLT EDEKKLLAKEGITLPTQLPLTKYEERVLKKIRRKIRNKQSAQESRKKKKEYIDGLETRSCCCPLPSSSSPPSALLAPTKPRALGTLRLYE >In-frame_SHC2_ENST00000264554_chr19_460529_-_CREB3L3_ENST00000595923_chr19_4164500_+_426aa MTQGPGGRAPPAPPAPPEPEAPTTFCALLPRMPQWKFAAPGGFLGRGPAAARAAGASGGADPQPEPAGPGGVPALAAAVLGACEPRCAAP CPLPALSRCRGAGSRGSRGGRGAAGSGDAAAAAEWIRKGSFIHKPAHGWLHPDARVLGPGVSYVVRQQHHLGASYLLRPGAGHCQELVLT EDEKKLLAKEGITLPTQLPLTKYEERVLKKIRRKIRNKQSAQESRKKKKEYIDGLETRMSACTAQNQELQRKVLHLEKQNLSLLEQLKKL QAIVVQSTSKSAQTGTCVAVLLLSFALIILPSISPFGPNKTESPGDFAPVRVFSRTLHNDAASRVAADAVPGSEAPGPRPEADTTREESP >In-frame_SHC2_ENST00000264554_chr19_460529_-_CREB3L3_ENST00000602257_chr19_4164500_+_424aa MTQGPGGRAPPAPPAPPEPEAPTTFCALLPRMPQWKFAAPGGFLGRGPAAARAAGASGGADPQPEPAGPGGVPALAAAVLGACEPRCAAP CPLPALSRCRGAGSRGSRGGRGAAGSGDAAAAAEWIRKGSFIHKPAHGWLHPDARVLGPGVSYVVRHHLGASYLLRPGAGHCQELVLTED EKKLLAKEGITLPTQLPLTKYEERVLKKIRRKIRNKQSAQESRKKKKEYIDGLETRMSACTAQNQELQRKVLHLEKQNLSLLEQLKKLQA IVVQSTSKSAQTGTCVAVLLLSFALIILPSISPFGPNKTESPGDFAPVRVFSRTLHNDAASRVAADAVPGSEAPGPRPEADTTREESPGS >In-frame_SHC2_ENST00000264554_chr19_460529_-_CREB3L3_ENST00000602147_chr19_4164500_+_302aa MTQGPGGRAPPAPPAPPEPEAPTTFCALLPRMPQWKFAAPGGFLGRGPAAARAAGASGGADPQPEPAGPGGVPALAAAVLGACEPRCAAP CPLPALSRCRGAGSRGSRGGRGAAGSGDAAAAAEWIRKGSFIHKPAHGWLHPDARVLGPGVSYVVRQQHHLGASYLLRPGAGHCQELVLT EDEKKLLAKEGITLPTQLPLTKDVSLHCSESGVTEESLASREAKPVPLGATEETPGHCGAVHQQVSPDRHLCRSPVAVLCPHHPPLHQPF |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_SHC2_ENST00000264554_chr19_460529_-_CREB3L3_ENST00000078445_chr19_4164500_+_1278nt ATGACGCAGGGTCCGGGCGGGCGCGCGCCCCCGGCGCCCCCCGCGCCCCCCGAGCCCGAGGCGCCCACCACCTTCTGCGCGTTGCTGCCC CGAATGCCGCAGTGGAAGTTCGCGGCCCCGGGCGGCTTCCTGGGCCGCGGCCCGGCGGCGGCGCGGGCGGCTGGGGCCTCGGGGGGCGCG GACCCCCAACCCGAGCCGGCGGGCCCGGGGGGCGTCCCGGCGCTGGCGGCCGCCGTCCTGGGCGCCTGCGAGCCCCGCTGCGCCGCGCCC TGTCCCCTGCCCGCGCTCAGCCGCTGTCGGGGCGCGGGGTCGCGGGGGTCGCGGGGCGGGCGGGGGGCGGCGGGGTCCGGGGACGCCGCC GCCGCCGCCGAGTGGATCCGGAAGGGCAGCTTCATCCACAAACCCGCGCACGGCTGGCTACACCCCGACGCCAGGGTCCTGGGGCCCGGG GTCTCCTACGTCGTGCGGCAACAGCATCACCTGGGGGCCTCCTACCTCCTGCGACCTGGGGCTGGGCACTGTCAGGAGCTGGTGCTCACC GAGGATGAGAAGAAGCTGCTGGCTAAAGAAGGCATCACCCTGCCCACTCAGCTGCCCCTCACTAAGTACGAGGAGCGAGTGCTGAAAAAA ATCCGCCGGAAAATCCGGAACAAGCAGTCGGCGCAAGAAAGCAGGAAGAAGAAGAAGGAATATATCGATGGCCTGGAGACTCGGATGTCA GCTTGCACTGCTCAGAATCAGGAGTTACAGAGGAAAGTCTTGCATCTCGAGAAGCAAAACCTGTCCCTCTTGGAGCAACTGAAGAAACTC CAGGCCATTGTGGTGCAGTCCACCAGCAAGTCAGCCCAGACAGGCACCTGTGTCGCAGTCCTGTTGCTGTCCTTTGCCCTCATCATCCTC CCCTCCATCAGCCCTTTTGGCCCCAACAAAACCGAGAGCCCTGGGGACTTTGCGCCTGTACGAGTGTTCTCCAGAACTTTGCACAACGAT GCTGCCTCCCGCGTGGCTGCTGATGCTGTGCCAGGCTCCGAGGCCCCAGGACCCCGACCCGAGGCTGACACAACCCGAGAAGAGTCTCCA GGAAGCCCCGGGGCAGACTGGGGCTTCCAGGACACCGCGAACCTGACCAATTCGACGGAGGAGCTGGACAACGCCACCCTGGTCCTGAGG AATGCAACAGAGGGGCTGGGCCAGGTCGCCCTGCTGGACTGGGTGGCGCCTGGGCCGAGCACTGGCTCAGGACGTGCAGGGCTGGAGGCG >In-frame_SHC2_ENST00000264554_chr19_460529_-_CREB3L3_ENST00000252587_chr19_4164500_+_972nt ATGACGCAGGGTCCGGGCGGGCGCGCGCCCCCGGCGCCCCCCGCGCCCCCCGAGCCCGAGGCGCCCACCACCTTCTGCGCGTTGCTGCCC CGAATGCCGCAGTGGAAGTTCGCGGCCCCGGGCGGCTTCCTGGGCCGCGGCCCGGCGGCGGCGCGGGCGGCTGGGGCCTCGGGGGGCGCG GACCCCCAACCCGAGCCGGCGGGCCCGGGGGGCGTCCCGGCGCTGGCGGCCGCCGTCCTGGGCGCCTGCGAGCCCCGCTGCGCCGCGCCC TGTCCCCTGCCCGCGCTCAGCCGCTGTCGGGGCGCGGGGTCGCGGGGGTCGCGGGGCGGGCGGGGGGCGGCGGGGTCCGGGGACGCCGCC GCCGCCGCCGAGTGGATCCGGAAGGGCAGCTTCATCCACAAACCCGCGCACGGCTGGCTACACCCCGACGCCAGGGTCCTGGGGCCCGGG GTCTCCTACGTCGTGCGGCAACAGCATCACCTGGGGGCCTCCTACCTCCTGCGACCTGGGGCTGGGCACTGTCAGGAGCTGGTGCTCACC GAGGATGAGAAGAAGCTGCTGGCTAAAGAAGGCATCACCCTGCCCACTCAGCTGCCCCTCACTAAGTACGAGGAGCGAGTGCTGAAAAAA ATCCGCCGGAAAATCCGGAACAAGCAGTCGGCGCAAGAAAGCAGGAAGAAGAAGAAGGAATATATCGATGGCCTGGAGACTCGGTCCTGT TGCTGTCCTTTGCCCTCATCATCCTCCCCTCCATCAGCCCTTTTGGCCCCAACAAAACCGAGAGCCCTGGGGACTTTGCGCCTGTACGAG TGTTCTCCAGAACTTTGCACAACGATGCTGCCTCCCGCGTGGCTGCTGATGCTGTGCCAGGCTCCGAGGCCCCAGGACCCCGACCCGAGG >In-frame_SHC2_ENST00000264554_chr19_460529_-_CREB3L3_ENST00000595923_chr19_4164500_+_1278nt ATGACGCAGGGTCCGGGCGGGCGCGCGCCCCCGGCGCCCCCCGCGCCCCCCGAGCCCGAGGCGCCCACCACCTTCTGCGCGTTGCTGCCC CGAATGCCGCAGTGGAAGTTCGCGGCCCCGGGCGGCTTCCTGGGCCGCGGCCCGGCGGCGGCGCGGGCGGCTGGGGCCTCGGGGGGCGCG GACCCCCAACCCGAGCCGGCGGGCCCGGGGGGCGTCCCGGCGCTGGCGGCCGCCGTCCTGGGCGCCTGCGAGCCCCGCTGCGCCGCGCCC TGTCCCCTGCCCGCGCTCAGCCGCTGTCGGGGCGCGGGGTCGCGGGGGTCGCGGGGCGGGCGGGGGGCGGCGGGGTCCGGGGACGCCGCC GCCGCCGCCGAGTGGATCCGGAAGGGCAGCTTCATCCACAAACCCGCGCACGGCTGGCTACACCCCGACGCCAGGGTCCTGGGGCCCGGG GTCTCCTACGTCGTGCGGCAACAGCATCACCTGGGGGCCTCCTACCTCCTGCGACCTGGGGCTGGGCACTGTCAGGAGCTGGTGCTCACC GAGGATGAGAAGAAGCTGCTGGCTAAAGAAGGCATCACCCTGCCCACTCAGCTGCCCCTCACTAAGTACGAGGAGCGAGTGCTGAAAAAA ATCCGCCGGAAAATCCGGAACAAGCAGTCGGCGCAAGAAAGCAGGAAGAAGAAGAAGGAATATATCGATGGCCTGGAGACTCGGATGTCA GCTTGCACTGCTCAGAATCAGGAGTTACAGAGGAAAGTCTTGCATCTCGAGAAGCAAAACCTGTCCCTCTTGGAGCAACTGAAGAAACTC CAGGCCATTGTGGTGCAGTCCACCAGCAAGTCAGCCCAGACAGGCACCTGTGTCGCAGTCCTGTTGCTGTCCTTTGCCCTCATCATCCTC CCCTCCATCAGCCCTTTTGGCCCCAACAAAACCGAGAGCCCTGGGGACTTTGCGCCTGTACGAGTGTTCTCCAGAACTTTGCACAACGAT GCTGCCTCCCGCGTGGCTGCTGATGCTGTGCCAGGCTCCGAGGCCCCAGGACCCCGACCCGAGGCTGACACAACCCGAGAAGAGTCTCCA GGAAGCCCCGGGGCAGACTGGGGCTTCCAGGACACCGCGAACCTGACCAATTCGACGGAGGAGCTGGACAACGCCACCCTGGTCCTGAGG AATGCAACAGAGGGGCTGGGCCAGGTCGCCCTGCTGGACTGGGTGGCGCCTGGGCCGAGCACTGGCTCAGGACGTGCAGGGCTGGAGGCG >In-frame_SHC2_ENST00000264554_chr19_460529_-_CREB3L3_ENST00000602257_chr19_4164500_+_1272nt ATGACGCAGGGTCCGGGCGGGCGCGCGCCCCCGGCGCCCCCCGCGCCCCCCGAGCCCGAGGCGCCCACCACCTTCTGCGCGTTGCTGCCC CGAATGCCGCAGTGGAAGTTCGCGGCCCCGGGCGGCTTCCTGGGCCGCGGCCCGGCGGCGGCGCGGGCGGCTGGGGCCTCGGGGGGCGCG GACCCCCAACCCGAGCCGGCGGGCCCGGGGGGCGTCCCGGCGCTGGCGGCCGCCGTCCTGGGCGCCTGCGAGCCCCGCTGCGCCGCGCCC TGTCCCCTGCCCGCGCTCAGCCGCTGTCGGGGCGCGGGGTCGCGGGGGTCGCGGGGCGGGCGGGGGGCGGCGGGGTCCGGGGACGCCGCC GCCGCCGCCGAGTGGATCCGGAAGGGCAGCTTCATCCACAAACCCGCGCACGGCTGGCTACACCCCGACGCCAGGGTCCTGGGGCCCGGG GTCTCCTACGTCGTGCGGCATCACCTGGGGGCCTCCTACCTCCTGCGACCTGGGGCTGGGCACTGTCAGGAGCTGGTGCTCACCGAGGAT GAGAAGAAGCTGCTGGCTAAAGAAGGCATCACCCTGCCCACTCAGCTGCCCCTCACTAAGTACGAGGAGCGAGTGCTGAAAAAAATCCGC CGGAAAATCCGGAACAAGCAGTCGGCGCAAGAAAGCAGGAAGAAGAAGAAGGAATATATCGATGGCCTGGAGACTCGGATGTCAGCTTGC ACTGCTCAGAATCAGGAGTTACAGAGGAAAGTCTTGCATCTCGAGAAGCAAAACCTGTCCCTCTTGGAGCAACTGAAGAAACTCCAGGCC ATTGTGGTGCAGTCCACCAGCAAGTCAGCCCAGACAGGCACCTGTGTCGCAGTCCTGTTGCTGTCCTTTGCCCTCATCATCCTCCCCTCC ATCAGCCCTTTTGGCCCCAACAAAACCGAGAGCCCTGGGGACTTTGCGCCTGTACGAGTGTTCTCCAGAACTTTGCACAACGATGCTGCC TCCCGCGTGGCTGCTGATGCTGTGCCAGGCTCCGAGGCCCCAGGACCCCGACCCGAGGCTGACACAACCCGAGAAGAGTCTCCAGGAAGC CCCGGGGCAGACTGGGGCTTCCAGGACACCGCGAACCTGACCAATTCGACGGAGGAGCTGGACAACGCCACCCTGGTCCTGAGGAATGCA ACAGAGGGGCTGGGCCAGGTCGCCCTGCTGGACTGGGTGGCGCCTGGGCCGAGCACTGGCTCAGGACGTGCAGGGCTGGAGGCGGCGGGA >In-frame_SHC2_ENST00000264554_chr19_460529_-_CREB3L3_ENST00000602147_chr19_4164500_+_906nt ATGACGCAGGGTCCGGGCGGGCGCGCGCCCCCGGCGCCCCCCGCGCCCCCCGAGCCCGAGGCGCCCACCACCTTCTGCGCGTTGCTGCCC CGAATGCCGCAGTGGAAGTTCGCGGCCCCGGGCGGCTTCCTGGGCCGCGGCCCGGCGGCGGCGCGGGCGGCTGGGGCCTCGGGGGGCGCG GACCCCCAACCCGAGCCGGCGGGCCCGGGGGGCGTCCCGGCGCTGGCGGCCGCCGTCCTGGGCGCCTGCGAGCCCCGCTGCGCCGCGCCC TGTCCCCTGCCCGCGCTCAGCCGCTGTCGGGGCGCGGGGTCGCGGGGGTCGCGGGGCGGGCGGGGGGCGGCGGGGTCCGGGGACGCCGCC GCCGCCGCCGAGTGGATCCGGAAGGGCAGCTTCATCCACAAACCCGCGCACGGCTGGCTACACCCCGACGCCAGGGTCCTGGGGCCCGGG GTCTCCTACGTCGTGCGGCAACAGCATCACCTGGGGGCCTCCTACCTCCTGCGACCTGGGGCTGGGCACTGTCAGGAGCTGGTGCTCACC GAGGATGAGAAGAAGCTGCTGGCTAAAGAAGGCATCACCCTGCCCACTCAGCTGCCCCTCACTAAGGATGTCAGCTTGCACTGCTCAGAA TCAGGAGTTACAGAGGAAAGTCTTGCATCTCGAGAAGCAAAACCTGTCCCTCTTGGAGCAACTGAAGAAACTCCAGGCCATTGTGGTGCA GTCCACCAGCAAGTCAGCCCAGACAGGCACCTGTGTCGCAGTCCTGTTGCTGTCCTTTGCCCTCATCATCCTCCCCTCCATCAGCCCTTT TGGCCCCAACAAAACCGAGAGCCCTGGGGACTTTGCGCCTGTACGAGTGTTCTCCAGAACTTTGCACAACGATGCTGCCTCCCGCGTGGC |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_SHC2_ENST00000264554_chr19_460529_-_CREB3L3_ENST00000078445_chr19_4164500_+_2363nt ATGACGCAGGGTCCGGGCGGGCGCGCGCCCCCGGCGCCCCCCGCGCCCCCCGAGCCCGAGGCGCCCACCACCTTCTGCGCGTTGCTGCCC CGAATGCCGCAGTGGAAGTTCGCGGCCCCGGGCGGCTTCCTGGGCCGCGGCCCGGCGGCGGCGCGGGCGGCTGGGGCCTCGGGGGGCGCG GACCCCCAACCCGAGCCGGCGGGCCCGGGGGGCGTCCCGGCGCTGGCGGCCGCCGTCCTGGGCGCCTGCGAGCCCCGCTGCGCCGCGCCC TGTCCCCTGCCCGCGCTCAGCCGCTGTCGGGGCGCGGGGTCGCGGGGGTCGCGGGGCGGGCGGGGGGCGGCGGGGTCCGGGGACGCCGCC GCCGCCGCCGAGTGGATCCGGAAGGGCAGCTTCATCCACAAACCCGCGCACGGCTGGCTACACCCCGACGCCAGGGTCCTGGGGCCCGGG GTCTCCTACGTCGTGCGGCAACAGCATCACCTGGGGGCCTCCTACCTCCTGCGACCTGGGGCTGGGCACTGTCAGGAGCTGGTGCTCACC GAGGATGAGAAGAAGCTGCTGGCTAAAGAAGGCATCACCCTGCCCACTCAGCTGCCCCTCACTAAGTACGAGGAGCGAGTGCTGAAAAAA ATCCGCCGGAAAATCCGGAACAAGCAGTCGGCGCAAGAAAGCAGGAAGAAGAAGAAGGAATATATCGATGGCCTGGAGACTCGGATGTCA GCTTGCACTGCTCAGAATCAGGAGTTACAGAGGAAAGTCTTGCATCTCGAGAAGCAAAACCTGTCCCTCTTGGAGCAACTGAAGAAACTC CAGGCCATTGTGGTGCAGTCCACCAGCAAGTCAGCCCAGACAGGCACCTGTGTCGCAGTCCTGTTGCTGTCCTTTGCCCTCATCATCCTC CCCTCCATCAGCCCTTTTGGCCCCAACAAAACCGAGAGCCCTGGGGACTTTGCGCCTGTACGAGTGTTCTCCAGAACTTTGCACAACGAT GCTGCCTCCCGCGTGGCTGCTGATGCTGTGCCAGGCTCCGAGGCCCCAGGACCCCGACCCGAGGCTGACACAACCCGAGAAGAGTCTCCA GGAAGCCCCGGGGCAGACTGGGGCTTCCAGGACACCGCGAACCTGACCAATTCGACGGAGGAGCTGGACAACGCCACCCTGGTCCTGAGG AATGCAACAGAGGGGCTGGGCCAGGTCGCCCTGCTGGACTGGGTGGCGCCTGGGCCGAGCACTGGCTCAGGACGTGCAGGGCTGGAGGCG GCGGGAGACGAGCTGTGAGCCCCGCCAGGACTATGCTCCCAGGCCCCTCTGCCCAGGGGTGCCTTGGGGATGCTGCACTGGGCAGCTACC CACCTGGGGATGGGACGTGAGGCCAAGACCCCAGCAGAGATGCCAGAATGGGGGAGGCACAGCTCATAGCCACACACCCAGGGCCTGACT GAGGCCCACGCAGGAACCGACACTCAGACACAAGGCAAAGAGGGCCACAGGACCCGGGAAATACACACAGAGCCAGGAGCAGAAGCAAAG AGCAGACACACATACAGCCTGAAACAGACCTGGACAGACAGACACAGCCTGAAACAGACCCGGACAGACAGACACAGCCTGAAACAGACC CAGACAAACAGACAGACAGACACAGCCTGAAACAGACCCAGACAGACAGACAGACAGCCTGAAACAGACCCAGACACAGCCTGAAACAGA TCCGGACAGACAGACAGAAACAGCCTGAAACAGACCCAGACAGACAGACAGACACAGCCTGAAACAGACCCGGACAGACAGACAGACACA GCCTGAAACAGACCCGGACAGACAGACAGACACAGCCTGAAACAGACCCGGACAGACAGACAGACACAGCCTGAAACAGACCTAGACAGA CAGACACAGATTGAAACAGACCCAGACAAACAGACAGACACAGCCTGAAACAGACCCAGACACAGCCTGAAACAGACCCGGACAGACAGA CAGACACAGCCTGAAACAGACCCAGACAGACAGACAGACACAGCCTGAAACAGACCCAGACAGACAGACCGACGCAGCCTGAAAGAGACC CAGACAGAGAGACAGGCAGACACAGCCTAAAACAGACCTGGACAGACAGGCAGACGTAGTCTGAAACAGACCTGAACAGACAGACAGACG CACACACACAACAGATGCGCAGCAACTCCCCGCCCAGGGACCCCTCCCGGCCTCCCTCGCACACTGGGAGGAGGAAGCCGCCGAGACTGC AGGGAGCCTGGCCCCGGAGCCCCGGGTGCGCCCTGGTCTTTGGAGCAGCCACGGCCCACAATCACCCCCCTTTTCTAAGACTGCCTGATC >In-frame_SHC2_ENST00000264554_chr19_460529_-_CREB3L3_ENST00000252587_chr19_4164500_+_2208nt ATGACGCAGGGTCCGGGCGGGCGCGCGCCCCCGGCGCCCCCCGCGCCCCCCGAGCCCGAGGCGCCCACCACCTTCTGCGCGTTGCTGCCC CGAATGCCGCAGTGGAAGTTCGCGGCCCCGGGCGGCTTCCTGGGCCGCGGCCCGGCGGCGGCGCGGGCGGCTGGGGCCTCGGGGGGCGCG GACCCCCAACCCGAGCCGGCGGGCCCGGGGGGCGTCCCGGCGCTGGCGGCCGCCGTCCTGGGCGCCTGCGAGCCCCGCTGCGCCGCGCCC TGTCCCCTGCCCGCGCTCAGCCGCTGTCGGGGCGCGGGGTCGCGGGGGTCGCGGGGCGGGCGGGGGGCGGCGGGGTCCGGGGACGCCGCC GCCGCCGCCGAGTGGATCCGGAAGGGCAGCTTCATCCACAAACCCGCGCACGGCTGGCTACACCCCGACGCCAGGGTCCTGGGGCCCGGG GTCTCCTACGTCGTGCGGCAACAGCATCACCTGGGGGCCTCCTACCTCCTGCGACCTGGGGCTGGGCACTGTCAGGAGCTGGTGCTCACC GAGGATGAGAAGAAGCTGCTGGCTAAAGAAGGCATCACCCTGCCCACTCAGCTGCCCCTCACTAAGTACGAGGAGCGAGTGCTGAAAAAA ATCCGCCGGAAAATCCGGAACAAGCAGTCGGCGCAAGAAAGCAGGAAGAAGAAGAAGGAATATATCGATGGCCTGGAGACTCGGTCCTGT TGCTGTCCTTTGCCCTCATCATCCTCCCCTCCATCAGCCCTTTTGGCCCCAACAAAACCGAGAGCCCTGGGGACTTTGCGCCTGTACGAG TGTTCTCCAGAACTTTGCACAACGATGCTGCCTCCCGCGTGGCTGCTGATGCTGTGCCAGGCTCCGAGGCCCCAGGACCCCGACCCGAGG CTGACACAACCCGAGAAGAGTCTCCAGGAAGCCCCGGGGCAGACTGGGGCTTCCAGGACACCGCGAACCTGACCAATTCGACGGAGGAGC TGGACAACGCCACCCTGGTCCTGAGGAATGCAACAGAGGGGCTGGGCCAGGTCGCCCTGCTGGACTGGGTGGCGCCTGGGCCGAGCACTG GCTCAGGACGTGCAGGGCTGGAGGCGGCGGGAGACGAGCTGTGAGCCCCGCCAGGACTATGCTCCCAGGCCCCTCTGCCCAGGGGTGCCT TGGGGATGCTGCACTGGGCAGCTACCCACCTGGGGATGGGACGTGAGGCCAAGACCCCAGCAGAGATGCCAGAATGGGGGAGGCACAGCT CATAGCCACACACCCAGGGCCTGACTGAGGCCCACGCAGGAACCGACACTCAGACACAAGGCAAAGAGGGCCACAGGACCCGGGAAATAC ACACAGAGCCAGGAGCAGAAGCAAAGAGCAGACACACATACAGCCTGAAACAGACCTGGACAGACAGACACAGCCTGAAACAGACCCGGA CAGACAGACACAGCCTGAAACAGACCCAGACAAACAGACAGACAGACACAGCCTGAAACAGACCCAGACAGACAGACAGACAGCCTGAAA CAGACCCAGACACAGCCTGAAACAGATCCGGACAGACAGACAGAAACAGCCTGAAACAGACCCAGACAGACAGACAGACACAGCCTGAAA CAGACCCGGACAGACAGACAGACACAGCCTGAAACAGACCCGGACAGACAGACAGACACAGCCTGAAACAGACCCGGACAGACAGACAGA CACAGCCTGAAACAGACCTAGACAGACAGACACAGATTGAAACAGACCCAGACAAACAGACAGACACAGCCTGAAACAGACCCAGACACA GCCTGAAACAGACCCGGACAGACAGACAGACACAGCCTGAAACAGACCCAGACAGACAGACAGACACAGCCTGAAACAGACCCAGACAGA CAGACCGACGCAGCCTGAAAGAGACCCAGACAGAGAGACAGGCAGACACAGCCTAAAACAGACCTGGACAGACAGGCAGACGTAGTCTGA AACAGACCTGAACAGACAGACAGACGCACACACACAACAGATGCGCAGCAACTCCCCGCCCAGGGACCCCTCCCGGCCTCCCTCGCACAC TGGGAGGAGGAAGCCGCCGAGACTGCAGGGAGCCTGGCCCCGGAGCCCCGGGTGCGCCCTGGTCTTTGGAGCAGCCACGGCCCACAATCA >In-frame_SHC2_ENST00000264554_chr19_460529_-_CREB3L3_ENST00000595923_chr19_4164500_+_1278nt ATGACGCAGGGTCCGGGCGGGCGCGCGCCCCCGGCGCCCCCCGCGCCCCCCGAGCCCGAGGCGCCCACCACCTTCTGCGCGTTGCTGCCC CGAATGCCGCAGTGGAAGTTCGCGGCCCCGGGCGGCTTCCTGGGCCGCGGCCCGGCGGCGGCGCGGGCGGCTGGGGCCTCGGGGGGCGCG GACCCCCAACCCGAGCCGGCGGGCCCGGGGGGCGTCCCGGCGCTGGCGGCCGCCGTCCTGGGCGCCTGCGAGCCCCGCTGCGCCGCGCCC TGTCCCCTGCCCGCGCTCAGCCGCTGTCGGGGCGCGGGGTCGCGGGGGTCGCGGGGCGGGCGGGGGGCGGCGGGGTCCGGGGACGCCGCC GCCGCCGCCGAGTGGATCCGGAAGGGCAGCTTCATCCACAAACCCGCGCACGGCTGGCTACACCCCGACGCCAGGGTCCTGGGGCCCGGG GTCTCCTACGTCGTGCGGCAACAGCATCACCTGGGGGCCTCCTACCTCCTGCGACCTGGGGCTGGGCACTGTCAGGAGCTGGTGCTCACC GAGGATGAGAAGAAGCTGCTGGCTAAAGAAGGCATCACCCTGCCCACTCAGCTGCCCCTCACTAAGTACGAGGAGCGAGTGCTGAAAAAA ATCCGCCGGAAAATCCGGAACAAGCAGTCGGCGCAAGAAAGCAGGAAGAAGAAGAAGGAATATATCGATGGCCTGGAGACTCGGATGTCA GCTTGCACTGCTCAGAATCAGGAGTTACAGAGGAAAGTCTTGCATCTCGAGAAGCAAAACCTGTCCCTCTTGGAGCAACTGAAGAAACTC CAGGCCATTGTGGTGCAGTCCACCAGCAAGTCAGCCCAGACAGGCACCTGTGTCGCAGTCCTGTTGCTGTCCTTTGCCCTCATCATCCTC CCCTCCATCAGCCCTTTTGGCCCCAACAAAACCGAGAGCCCTGGGGACTTTGCGCCTGTACGAGTGTTCTCCAGAACTTTGCACAACGAT GCTGCCTCCCGCGTGGCTGCTGATGCTGTGCCAGGCTCCGAGGCCCCAGGACCCCGACCCGAGGCTGACACAACCCGAGAAGAGTCTCCA GGAAGCCCCGGGGCAGACTGGGGCTTCCAGGACACCGCGAACCTGACCAATTCGACGGAGGAGCTGGACAACGCCACCCTGGTCCTGAGG AATGCAACAGAGGGGCTGGGCCAGGTCGCCCTGCTGGACTGGGTGGCGCCTGGGCCGAGCACTGGCTCAGGACGTGCAGGGCTGGAGGCG >In-frame_SHC2_ENST00000264554_chr19_460529_-_CREB3L3_ENST00000602257_chr19_4164500_+_1287nt ATGACGCAGGGTCCGGGCGGGCGCGCGCCCCCGGCGCCCCCCGCGCCCCCCGAGCCCGAGGCGCCCACCACCTTCTGCGCGTTGCTGCCC CGAATGCCGCAGTGGAAGTTCGCGGCCCCGGGCGGCTTCCTGGGCCGCGGCCCGGCGGCGGCGCGGGCGGCTGGGGCCTCGGGGGGCGCG GACCCCCAACCCGAGCCGGCGGGCCCGGGGGGCGTCCCGGCGCTGGCGGCCGCCGTCCTGGGCGCCTGCGAGCCCCGCTGCGCCGCGCCC TGTCCCCTGCCCGCGCTCAGCCGCTGTCGGGGCGCGGGGTCGCGGGGGTCGCGGGGCGGGCGGGGGGCGGCGGGGTCCGGGGACGCCGCC GCCGCCGCCGAGTGGATCCGGAAGGGCAGCTTCATCCACAAACCCGCGCACGGCTGGCTACACCCCGACGCCAGGGTCCTGGGGCCCGGG GTCTCCTACGTCGTGCGGCATCACCTGGGGGCCTCCTACCTCCTGCGACCTGGGGCTGGGCACTGTCAGGAGCTGGTGCTCACCGAGGAT GAGAAGAAGCTGCTGGCTAAAGAAGGCATCACCCTGCCCACTCAGCTGCCCCTCACTAAGTACGAGGAGCGAGTGCTGAAAAAAATCCGC CGGAAAATCCGGAACAAGCAGTCGGCGCAAGAAAGCAGGAAGAAGAAGAAGGAATATATCGATGGCCTGGAGACTCGGATGTCAGCTTGC ACTGCTCAGAATCAGGAGTTACAGAGGAAAGTCTTGCATCTCGAGAAGCAAAACCTGTCCCTCTTGGAGCAACTGAAGAAACTCCAGGCC ATTGTGGTGCAGTCCACCAGCAAGTCAGCCCAGACAGGCACCTGTGTCGCAGTCCTGTTGCTGTCCTTTGCCCTCATCATCCTCCCCTCC ATCAGCCCTTTTGGCCCCAACAAAACCGAGAGCCCTGGGGACTTTGCGCCTGTACGAGTGTTCTCCAGAACTTTGCACAACGATGCTGCC TCCCGCGTGGCTGCTGATGCTGTGCCAGGCTCCGAGGCCCCAGGACCCCGACCCGAGGCTGACACAACCCGAGAAGAGTCTCCAGGAAGC CCCGGGGCAGACTGGGGCTTCCAGGACACCGCGAACCTGACCAATTCGACGGAGGAGCTGGACAACGCCACCCTGGTCCTGAGGAATGCA ACAGAGGGGCTGGGCCAGGTCGCCCTGCTGGACTGGGTGGCGCCTGGGCCGAGCACTGGCTCAGGACGTGCAGGGCTGGAGGCGGCGGGA >In-frame_SHC2_ENST00000264554_chr19_460529_-_CREB3L3_ENST00000602147_chr19_4164500_+_1194nt ATGACGCAGGGTCCGGGCGGGCGCGCGCCCCCGGCGCCCCCCGCGCCCCCCGAGCCCGAGGCGCCCACCACCTTCTGCGCGTTGCTGCCC CGAATGCCGCAGTGGAAGTTCGCGGCCCCGGGCGGCTTCCTGGGCCGCGGCCCGGCGGCGGCGCGGGCGGCTGGGGCCTCGGGGGGCGCG GACCCCCAACCCGAGCCGGCGGGCCCGGGGGGCGTCCCGGCGCTGGCGGCCGCCGTCCTGGGCGCCTGCGAGCCCCGCTGCGCCGCGCCC TGTCCCCTGCCCGCGCTCAGCCGCTGTCGGGGCGCGGGGTCGCGGGGGTCGCGGGGCGGGCGGGGGGCGGCGGGGTCCGGGGACGCCGCC GCCGCCGCCGAGTGGATCCGGAAGGGCAGCTTCATCCACAAACCCGCGCACGGCTGGCTACACCCCGACGCCAGGGTCCTGGGGCCCGGG GTCTCCTACGTCGTGCGGCAACAGCATCACCTGGGGGCCTCCTACCTCCTGCGACCTGGGGCTGGGCACTGTCAGGAGCTGGTGCTCACC GAGGATGAGAAGAAGCTGCTGGCTAAAGAAGGCATCACCCTGCCCACTCAGCTGCCCCTCACTAAGGATGTCAGCTTGCACTGCTCAGAA TCAGGAGTTACAGAGGAAAGTCTTGCATCTCGAGAAGCAAAACCTGTCCCTCTTGGAGCAACTGAAGAAACTCCAGGCCATTGTGGTGCA GTCCACCAGCAAGTCAGCCCAGACAGGCACCTGTGTCGCAGTCCTGTTGCTGTCCTTTGCCCTCATCATCCTCCCCTCCATCAGCCCTTT TGGCCCCAACAAAACCGAGAGCCCTGGGGACTTTGCGCCTGTACGAGTGTTCTCCAGAACTTTGCACAACGATGCTGCCTCCCGCGTGGC TGCTGATGCTGTGCCAGGCTCCGAGGCCCCAGGACCCCGACCCGAGGCTGACACAACCCGAGAAGAGTCTCCAGGAAGCCCCGGGGCAGA CTGGGGCTTCCAGGACACCGCGAACCTGACCAATTCGACGGAGGAGCTGGACAACGCCACCCTGGTCCTGAGGAATGCAACAGAGGGGCT GGGCCAGGTCGCCCTGCTGGACTGGGTGGCGCCTGGGCCGAGCACTGGCTCAGGACGTGCAGGGCTGGAGGCGGCGGGAGACGAGCTGTG |
Top |
FusionGenePPI for SHC2_CREB3L3 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
SHC2 | KDR, ARHGAP32, FLT1, EGFR, ERBB2, ERRFI1, GRB2, SHC1 | CREB3L3 | CREBZF, USP7, CREB3L1, CREB3L3, CREB3, KPNA2, RIOK3, KHDRBS1, PELI2, BAD, PPARGC1A, GSK3B, CSNK2A1, BTRC, CUL1, RBX1 |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for SHC2_CREB3L3 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for SHC2_CREB3L3 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |