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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDiseases

Fusion gene ID: 33763

FusionGeneSummary for SHC2_CREB3L3

check button Fusion gene summary
Fusion gene informationFusion gene name: SHC2_CREB3L3
Fusion gene ID: 33763
HgeneTgene
Gene symbol

SHC2

CREB3L3

Gene ID

25759

84699

Gene nameSHC adaptor protein 2cAMP responsive element binding protein 3 like 3
SynonymsSCK|SHCB|SLICREB-H|CREBH|HYST1481
Cytomap

19p13.3

19p13.3

Type of geneprotein-codingprotein-coding
DescriptionSHC-transforming protein 2SH2 domain protein C2SHC (Src homology 2 domain containing) transforming protein 2SHC-transforming protein Bneuronal Shc adaptor homologprotein Scksrc homology 2 domain-containing-transforming protein C2cyclic AMP-responsive element-binding protein 3-like protein 3CREB/ATF family transcription factor
Modification date2018052320180522
UniProtAcc

P98077

Q68CJ9

Ensembl transtripts involved in fusion geneENST00000264554, ENST00000078445, 
ENST00000252587, ENST00000595923, 
ENST00000602257, ENST00000602147, 
Fusion gene scores* DoF score6 X 4 X 4=964 X 4 X 4=64
# samples 64
** MAII scorelog2(6/96*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SHC2 [Title/Abstract] AND CREB3L3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTranscription factor involved fusion gene, inframe and retained DNA-binding domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCREB3L3

GO:1990440

positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress

16469704


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUADTCGA-44-8119-01ASHC2chr19

460529

-CREB3L3chr19

4164500

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000264554ENST00000078445SHC2chr19

460529

-CREB3L3chr19

4164500

+
In-frameENST00000264554ENST00000252587SHC2chr19

460529

-CREB3L3chr19

4164500

+
In-frameENST00000264554ENST00000595923SHC2chr19

460529

-CREB3L3chr19

4164500

+
In-frameENST00000264554ENST00000602257SHC2chr19

460529

-CREB3L3chr19

4164500

+
In-frameENST00000264554ENST00000602147SHC2chr19

460529

-CREB3L3chr19

4164500

+

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FusionProtFeatures for SHC2_CREB3L3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SHC2

P98077

CREB3L3

Q68CJ9

Signaling adapter that couples activated growth factorreceptors to signaling pathway in neurons. Involved in the signaltransduction pathways of neurotrophin-activated Trk receptors incortical neurons (By similarity). {ECO:0000250}. Transcription factor that may act during endoplasmicreticulum stress by activating unfolded protein response targetgenes. Activated in response to cAMP stimulation. In vitro, bindsto the cAMP response element (CRE) and box-B element. Activatestranscription through box-B element. Activates transcriptionthrough CRE (By similarity). Seems to function synergisticallywith ATF6. In acute inflammatory response, may activate expressionof acute phase response (APR) genes. May be involved in growthsuppression. {ECO:0000250, ECO:0000269|PubMed:11353085,ECO:0000269|PubMed:15800215, ECO:0000269|PubMed:16469704}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCREB3L3chr19:460529chr19:4164500ENST00000078445+310243_306192462DomainbZIP
TgeneCREB3L3chr19:460529chr19:4164500ENST00000595923+310243_306191461DomainbZIP
TgeneCREB3L3chr19:460529chr19:4164500ENST00000078445+310245_274192462RegionBasic motif
TgeneCREB3L3chr19:460529chr19:4164500ENST00000078445+310285_306192462RegionLeucine-zipper
TgeneCREB3L3chr19:460529chr19:4164500ENST00000595923+310245_274191461RegionBasic motif
TgeneCREB3L3chr19:460529chr19:4164500ENST00000595923+310285_306191461RegionLeucine-zipper
TgeneCREB3L3chr19:460529chr19:4164500ENST00000078445+310344_461192462Topological domainLumenal
TgeneCREB3L3chr19:460529chr19:4164500ENST00000595923+310344_461191461Topological domainLumenal
TgeneCREB3L3chr19:460529chr19:4164500ENST00000078445+310323_343192462TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneCREB3L3chr19:460529chr19:4164500ENST00000595923+310323_343191461TransmembraneHelical%3B Signal-anchor for type II membrane protein

- In-frame and not-retained protein feature among the 13 regional features.
>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSHC2chr19:460529chr19:4164500ENST00000264554-113147_329156694DomainPID
HgeneSHC2chr19:460529chr19:4164500ENST00000264554-113487_578156694DomainSH2
HgeneSHC2chr19:460529chr19:4164500ENST00000264554-113330_486156694RegionNote=CH1
TgeneCREB3L3chr19:460529chr19:4164500ENST00000078445+3101_322192462Topological domainCytoplasmic
TgeneCREB3L3chr19:460529chr19:4164500ENST00000595923+3101_322191461Topological domainCytoplasmic


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FusionGeneSequence for SHC2_CREB3L3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_SHC2_ENST00000264554_chr19_460529_-_CREB3L3_ENST00000078445_chr19_4164500_+_426aa
MTQGPGGRAPPAPPAPPEPEAPTTFCALLPRMPQWKFAAPGGFLGRGPAAARAAGASGGADPQPEPAGPGGVPALAAAVLGACEPRCAAP
CPLPALSRCRGAGSRGSRGGRGAAGSGDAAAAAEWIRKGSFIHKPAHGWLHPDARVLGPGVSYVVRQQHHLGASYLLRPGAGHCQELVLT
EDEKKLLAKEGITLPTQLPLTKYEERVLKKIRRKIRNKQSAQESRKKKKEYIDGLETRMSACTAQNQELQRKVLHLEKQNLSLLEQLKKL
QAIVVQSTSKSAQTGTCVAVLLLSFALIILPSISPFGPNKTESPGDFAPVRVFSRTLHNDAASRVAADAVPGSEAPGPRPEADTTREESP

>In-frame_SHC2_ENST00000264554_chr19_460529_-_CREB3L3_ENST00000252587_chr19_4164500_+_324aa
MTQGPGGRAPPAPPAPPEPEAPTTFCALLPRMPQWKFAAPGGFLGRGPAAARAAGASGGADPQPEPAGPGGVPALAAAVLGACEPRCAAP
CPLPALSRCRGAGSRGSRGGRGAAGSGDAAAAAEWIRKGSFIHKPAHGWLHPDARVLGPGVSYVVRQQHHLGASYLLRPGAGHCQELVLT
EDEKKLLAKEGITLPTQLPLTKYEERVLKKIRRKIRNKQSAQESRKKKKEYIDGLETRSCCCPLPSSSSPPSALLAPTKPRALGTLRLYE

>In-frame_SHC2_ENST00000264554_chr19_460529_-_CREB3L3_ENST00000595923_chr19_4164500_+_426aa
MTQGPGGRAPPAPPAPPEPEAPTTFCALLPRMPQWKFAAPGGFLGRGPAAARAAGASGGADPQPEPAGPGGVPALAAAVLGACEPRCAAP
CPLPALSRCRGAGSRGSRGGRGAAGSGDAAAAAEWIRKGSFIHKPAHGWLHPDARVLGPGVSYVVRQQHHLGASYLLRPGAGHCQELVLT
EDEKKLLAKEGITLPTQLPLTKYEERVLKKIRRKIRNKQSAQESRKKKKEYIDGLETRMSACTAQNQELQRKVLHLEKQNLSLLEQLKKL
QAIVVQSTSKSAQTGTCVAVLLLSFALIILPSISPFGPNKTESPGDFAPVRVFSRTLHNDAASRVAADAVPGSEAPGPRPEADTTREESP

>In-frame_SHC2_ENST00000264554_chr19_460529_-_CREB3L3_ENST00000602257_chr19_4164500_+_424aa
MTQGPGGRAPPAPPAPPEPEAPTTFCALLPRMPQWKFAAPGGFLGRGPAAARAAGASGGADPQPEPAGPGGVPALAAAVLGACEPRCAAP
CPLPALSRCRGAGSRGSRGGRGAAGSGDAAAAAEWIRKGSFIHKPAHGWLHPDARVLGPGVSYVVRHHLGASYLLRPGAGHCQELVLTED
EKKLLAKEGITLPTQLPLTKYEERVLKKIRRKIRNKQSAQESRKKKKEYIDGLETRMSACTAQNQELQRKVLHLEKQNLSLLEQLKKLQA
IVVQSTSKSAQTGTCVAVLLLSFALIILPSISPFGPNKTESPGDFAPVRVFSRTLHNDAASRVAADAVPGSEAPGPRPEADTTREESPGS

>In-frame_SHC2_ENST00000264554_chr19_460529_-_CREB3L3_ENST00000602147_chr19_4164500_+_302aa
MTQGPGGRAPPAPPAPPEPEAPTTFCALLPRMPQWKFAAPGGFLGRGPAAARAAGASGGADPQPEPAGPGGVPALAAAVLGACEPRCAAP
CPLPALSRCRGAGSRGSRGGRGAAGSGDAAAAAEWIRKGSFIHKPAHGWLHPDARVLGPGVSYVVRQQHHLGASYLLRPGAGHCQELVLT
EDEKKLLAKEGITLPTQLPLTKDVSLHCSESGVTEESLASREAKPVPLGATEETPGHCGAVHQQVSPDRHLCRSPVAVLCPHHPPLHQPF


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_SHC2_ENST00000264554_chr19_460529_-_CREB3L3_ENST00000078445_chr19_4164500_+_1278nt
ATGACGCAGGGTCCGGGCGGGCGCGCGCCCCCGGCGCCCCCCGCGCCCCCCGAGCCCGAGGCGCCCACCACCTTCTGCGCGTTGCTGCCC
CGAATGCCGCAGTGGAAGTTCGCGGCCCCGGGCGGCTTCCTGGGCCGCGGCCCGGCGGCGGCGCGGGCGGCTGGGGCCTCGGGGGGCGCG
GACCCCCAACCCGAGCCGGCGGGCCCGGGGGGCGTCCCGGCGCTGGCGGCCGCCGTCCTGGGCGCCTGCGAGCCCCGCTGCGCCGCGCCC
TGTCCCCTGCCCGCGCTCAGCCGCTGTCGGGGCGCGGGGTCGCGGGGGTCGCGGGGCGGGCGGGGGGCGGCGGGGTCCGGGGACGCCGCC
GCCGCCGCCGAGTGGATCCGGAAGGGCAGCTTCATCCACAAACCCGCGCACGGCTGGCTACACCCCGACGCCAGGGTCCTGGGGCCCGGG
GTCTCCTACGTCGTGCGGCAACAGCATCACCTGGGGGCCTCCTACCTCCTGCGACCTGGGGCTGGGCACTGTCAGGAGCTGGTGCTCACC
GAGGATGAGAAGAAGCTGCTGGCTAAAGAAGGCATCACCCTGCCCACTCAGCTGCCCCTCACTAAGTACGAGGAGCGAGTGCTGAAAAAA
ATCCGCCGGAAAATCCGGAACAAGCAGTCGGCGCAAGAAAGCAGGAAGAAGAAGAAGGAATATATCGATGGCCTGGAGACTCGGATGTCA
GCTTGCACTGCTCAGAATCAGGAGTTACAGAGGAAAGTCTTGCATCTCGAGAAGCAAAACCTGTCCCTCTTGGAGCAACTGAAGAAACTC
CAGGCCATTGTGGTGCAGTCCACCAGCAAGTCAGCCCAGACAGGCACCTGTGTCGCAGTCCTGTTGCTGTCCTTTGCCCTCATCATCCTC
CCCTCCATCAGCCCTTTTGGCCCCAACAAAACCGAGAGCCCTGGGGACTTTGCGCCTGTACGAGTGTTCTCCAGAACTTTGCACAACGAT
GCTGCCTCCCGCGTGGCTGCTGATGCTGTGCCAGGCTCCGAGGCCCCAGGACCCCGACCCGAGGCTGACACAACCCGAGAAGAGTCTCCA
GGAAGCCCCGGGGCAGACTGGGGCTTCCAGGACACCGCGAACCTGACCAATTCGACGGAGGAGCTGGACAACGCCACCCTGGTCCTGAGG
AATGCAACAGAGGGGCTGGGCCAGGTCGCCCTGCTGGACTGGGTGGCGCCTGGGCCGAGCACTGGCTCAGGACGTGCAGGGCTGGAGGCG

>In-frame_SHC2_ENST00000264554_chr19_460529_-_CREB3L3_ENST00000252587_chr19_4164500_+_972nt
ATGACGCAGGGTCCGGGCGGGCGCGCGCCCCCGGCGCCCCCCGCGCCCCCCGAGCCCGAGGCGCCCACCACCTTCTGCGCGTTGCTGCCC
CGAATGCCGCAGTGGAAGTTCGCGGCCCCGGGCGGCTTCCTGGGCCGCGGCCCGGCGGCGGCGCGGGCGGCTGGGGCCTCGGGGGGCGCG
GACCCCCAACCCGAGCCGGCGGGCCCGGGGGGCGTCCCGGCGCTGGCGGCCGCCGTCCTGGGCGCCTGCGAGCCCCGCTGCGCCGCGCCC
TGTCCCCTGCCCGCGCTCAGCCGCTGTCGGGGCGCGGGGTCGCGGGGGTCGCGGGGCGGGCGGGGGGCGGCGGGGTCCGGGGACGCCGCC
GCCGCCGCCGAGTGGATCCGGAAGGGCAGCTTCATCCACAAACCCGCGCACGGCTGGCTACACCCCGACGCCAGGGTCCTGGGGCCCGGG
GTCTCCTACGTCGTGCGGCAACAGCATCACCTGGGGGCCTCCTACCTCCTGCGACCTGGGGCTGGGCACTGTCAGGAGCTGGTGCTCACC
GAGGATGAGAAGAAGCTGCTGGCTAAAGAAGGCATCACCCTGCCCACTCAGCTGCCCCTCACTAAGTACGAGGAGCGAGTGCTGAAAAAA
ATCCGCCGGAAAATCCGGAACAAGCAGTCGGCGCAAGAAAGCAGGAAGAAGAAGAAGGAATATATCGATGGCCTGGAGACTCGGTCCTGT
TGCTGTCCTTTGCCCTCATCATCCTCCCCTCCATCAGCCCTTTTGGCCCCAACAAAACCGAGAGCCCTGGGGACTTTGCGCCTGTACGAG
TGTTCTCCAGAACTTTGCACAACGATGCTGCCTCCCGCGTGGCTGCTGATGCTGTGCCAGGCTCCGAGGCCCCAGGACCCCGACCCGAGG

>In-frame_SHC2_ENST00000264554_chr19_460529_-_CREB3L3_ENST00000595923_chr19_4164500_+_1278nt
ATGACGCAGGGTCCGGGCGGGCGCGCGCCCCCGGCGCCCCCCGCGCCCCCCGAGCCCGAGGCGCCCACCACCTTCTGCGCGTTGCTGCCC
CGAATGCCGCAGTGGAAGTTCGCGGCCCCGGGCGGCTTCCTGGGCCGCGGCCCGGCGGCGGCGCGGGCGGCTGGGGCCTCGGGGGGCGCG
GACCCCCAACCCGAGCCGGCGGGCCCGGGGGGCGTCCCGGCGCTGGCGGCCGCCGTCCTGGGCGCCTGCGAGCCCCGCTGCGCCGCGCCC
TGTCCCCTGCCCGCGCTCAGCCGCTGTCGGGGCGCGGGGTCGCGGGGGTCGCGGGGCGGGCGGGGGGCGGCGGGGTCCGGGGACGCCGCC
GCCGCCGCCGAGTGGATCCGGAAGGGCAGCTTCATCCACAAACCCGCGCACGGCTGGCTACACCCCGACGCCAGGGTCCTGGGGCCCGGG
GTCTCCTACGTCGTGCGGCAACAGCATCACCTGGGGGCCTCCTACCTCCTGCGACCTGGGGCTGGGCACTGTCAGGAGCTGGTGCTCACC
GAGGATGAGAAGAAGCTGCTGGCTAAAGAAGGCATCACCCTGCCCACTCAGCTGCCCCTCACTAAGTACGAGGAGCGAGTGCTGAAAAAA
ATCCGCCGGAAAATCCGGAACAAGCAGTCGGCGCAAGAAAGCAGGAAGAAGAAGAAGGAATATATCGATGGCCTGGAGACTCGGATGTCA
GCTTGCACTGCTCAGAATCAGGAGTTACAGAGGAAAGTCTTGCATCTCGAGAAGCAAAACCTGTCCCTCTTGGAGCAACTGAAGAAACTC
CAGGCCATTGTGGTGCAGTCCACCAGCAAGTCAGCCCAGACAGGCACCTGTGTCGCAGTCCTGTTGCTGTCCTTTGCCCTCATCATCCTC
CCCTCCATCAGCCCTTTTGGCCCCAACAAAACCGAGAGCCCTGGGGACTTTGCGCCTGTACGAGTGTTCTCCAGAACTTTGCACAACGAT
GCTGCCTCCCGCGTGGCTGCTGATGCTGTGCCAGGCTCCGAGGCCCCAGGACCCCGACCCGAGGCTGACACAACCCGAGAAGAGTCTCCA
GGAAGCCCCGGGGCAGACTGGGGCTTCCAGGACACCGCGAACCTGACCAATTCGACGGAGGAGCTGGACAACGCCACCCTGGTCCTGAGG
AATGCAACAGAGGGGCTGGGCCAGGTCGCCCTGCTGGACTGGGTGGCGCCTGGGCCGAGCACTGGCTCAGGACGTGCAGGGCTGGAGGCG

>In-frame_SHC2_ENST00000264554_chr19_460529_-_CREB3L3_ENST00000602257_chr19_4164500_+_1272nt
ATGACGCAGGGTCCGGGCGGGCGCGCGCCCCCGGCGCCCCCCGCGCCCCCCGAGCCCGAGGCGCCCACCACCTTCTGCGCGTTGCTGCCC
CGAATGCCGCAGTGGAAGTTCGCGGCCCCGGGCGGCTTCCTGGGCCGCGGCCCGGCGGCGGCGCGGGCGGCTGGGGCCTCGGGGGGCGCG
GACCCCCAACCCGAGCCGGCGGGCCCGGGGGGCGTCCCGGCGCTGGCGGCCGCCGTCCTGGGCGCCTGCGAGCCCCGCTGCGCCGCGCCC
TGTCCCCTGCCCGCGCTCAGCCGCTGTCGGGGCGCGGGGTCGCGGGGGTCGCGGGGCGGGCGGGGGGCGGCGGGGTCCGGGGACGCCGCC
GCCGCCGCCGAGTGGATCCGGAAGGGCAGCTTCATCCACAAACCCGCGCACGGCTGGCTACACCCCGACGCCAGGGTCCTGGGGCCCGGG
GTCTCCTACGTCGTGCGGCATCACCTGGGGGCCTCCTACCTCCTGCGACCTGGGGCTGGGCACTGTCAGGAGCTGGTGCTCACCGAGGAT
GAGAAGAAGCTGCTGGCTAAAGAAGGCATCACCCTGCCCACTCAGCTGCCCCTCACTAAGTACGAGGAGCGAGTGCTGAAAAAAATCCGC
CGGAAAATCCGGAACAAGCAGTCGGCGCAAGAAAGCAGGAAGAAGAAGAAGGAATATATCGATGGCCTGGAGACTCGGATGTCAGCTTGC
ACTGCTCAGAATCAGGAGTTACAGAGGAAAGTCTTGCATCTCGAGAAGCAAAACCTGTCCCTCTTGGAGCAACTGAAGAAACTCCAGGCC
ATTGTGGTGCAGTCCACCAGCAAGTCAGCCCAGACAGGCACCTGTGTCGCAGTCCTGTTGCTGTCCTTTGCCCTCATCATCCTCCCCTCC
ATCAGCCCTTTTGGCCCCAACAAAACCGAGAGCCCTGGGGACTTTGCGCCTGTACGAGTGTTCTCCAGAACTTTGCACAACGATGCTGCC
TCCCGCGTGGCTGCTGATGCTGTGCCAGGCTCCGAGGCCCCAGGACCCCGACCCGAGGCTGACACAACCCGAGAAGAGTCTCCAGGAAGC
CCCGGGGCAGACTGGGGCTTCCAGGACACCGCGAACCTGACCAATTCGACGGAGGAGCTGGACAACGCCACCCTGGTCCTGAGGAATGCA
ACAGAGGGGCTGGGCCAGGTCGCCCTGCTGGACTGGGTGGCGCCTGGGCCGAGCACTGGCTCAGGACGTGCAGGGCTGGAGGCGGCGGGA

>In-frame_SHC2_ENST00000264554_chr19_460529_-_CREB3L3_ENST00000602147_chr19_4164500_+_906nt
ATGACGCAGGGTCCGGGCGGGCGCGCGCCCCCGGCGCCCCCCGCGCCCCCCGAGCCCGAGGCGCCCACCACCTTCTGCGCGTTGCTGCCC
CGAATGCCGCAGTGGAAGTTCGCGGCCCCGGGCGGCTTCCTGGGCCGCGGCCCGGCGGCGGCGCGGGCGGCTGGGGCCTCGGGGGGCGCG
GACCCCCAACCCGAGCCGGCGGGCCCGGGGGGCGTCCCGGCGCTGGCGGCCGCCGTCCTGGGCGCCTGCGAGCCCCGCTGCGCCGCGCCC
TGTCCCCTGCCCGCGCTCAGCCGCTGTCGGGGCGCGGGGTCGCGGGGGTCGCGGGGCGGGCGGGGGGCGGCGGGGTCCGGGGACGCCGCC
GCCGCCGCCGAGTGGATCCGGAAGGGCAGCTTCATCCACAAACCCGCGCACGGCTGGCTACACCCCGACGCCAGGGTCCTGGGGCCCGGG
GTCTCCTACGTCGTGCGGCAACAGCATCACCTGGGGGCCTCCTACCTCCTGCGACCTGGGGCTGGGCACTGTCAGGAGCTGGTGCTCACC
GAGGATGAGAAGAAGCTGCTGGCTAAAGAAGGCATCACCCTGCCCACTCAGCTGCCCCTCACTAAGGATGTCAGCTTGCACTGCTCAGAA
TCAGGAGTTACAGAGGAAAGTCTTGCATCTCGAGAAGCAAAACCTGTCCCTCTTGGAGCAACTGAAGAAACTCCAGGCCATTGTGGTGCA
GTCCACCAGCAAGTCAGCCCAGACAGGCACCTGTGTCGCAGTCCTGTTGCTGTCCTTTGCCCTCATCATCCTCCCCTCCATCAGCCCTTT
TGGCCCCAACAAAACCGAGAGCCCTGGGGACTTTGCGCCTGTACGAGTGTTCTCCAGAACTTTGCACAACGATGCTGCCTCCCGCGTGGC


* Fusion transcript sequences (Full-length transcript).
>In-frame_SHC2_ENST00000264554_chr19_460529_-_CREB3L3_ENST00000078445_chr19_4164500_+_2363nt
ATGACGCAGGGTCCGGGCGGGCGCGCGCCCCCGGCGCCCCCCGCGCCCCCCGAGCCCGAGGCGCCCACCACCTTCTGCGCGTTGCTGCCC
CGAATGCCGCAGTGGAAGTTCGCGGCCCCGGGCGGCTTCCTGGGCCGCGGCCCGGCGGCGGCGCGGGCGGCTGGGGCCTCGGGGGGCGCG
GACCCCCAACCCGAGCCGGCGGGCCCGGGGGGCGTCCCGGCGCTGGCGGCCGCCGTCCTGGGCGCCTGCGAGCCCCGCTGCGCCGCGCCC
TGTCCCCTGCCCGCGCTCAGCCGCTGTCGGGGCGCGGGGTCGCGGGGGTCGCGGGGCGGGCGGGGGGCGGCGGGGTCCGGGGACGCCGCC
GCCGCCGCCGAGTGGATCCGGAAGGGCAGCTTCATCCACAAACCCGCGCACGGCTGGCTACACCCCGACGCCAGGGTCCTGGGGCCCGGG
GTCTCCTACGTCGTGCGGCAACAGCATCACCTGGGGGCCTCCTACCTCCTGCGACCTGGGGCTGGGCACTGTCAGGAGCTGGTGCTCACC
GAGGATGAGAAGAAGCTGCTGGCTAAAGAAGGCATCACCCTGCCCACTCAGCTGCCCCTCACTAAGTACGAGGAGCGAGTGCTGAAAAAA
ATCCGCCGGAAAATCCGGAACAAGCAGTCGGCGCAAGAAAGCAGGAAGAAGAAGAAGGAATATATCGATGGCCTGGAGACTCGGATGTCA
GCTTGCACTGCTCAGAATCAGGAGTTACAGAGGAAAGTCTTGCATCTCGAGAAGCAAAACCTGTCCCTCTTGGAGCAACTGAAGAAACTC
CAGGCCATTGTGGTGCAGTCCACCAGCAAGTCAGCCCAGACAGGCACCTGTGTCGCAGTCCTGTTGCTGTCCTTTGCCCTCATCATCCTC
CCCTCCATCAGCCCTTTTGGCCCCAACAAAACCGAGAGCCCTGGGGACTTTGCGCCTGTACGAGTGTTCTCCAGAACTTTGCACAACGAT
GCTGCCTCCCGCGTGGCTGCTGATGCTGTGCCAGGCTCCGAGGCCCCAGGACCCCGACCCGAGGCTGACACAACCCGAGAAGAGTCTCCA
GGAAGCCCCGGGGCAGACTGGGGCTTCCAGGACACCGCGAACCTGACCAATTCGACGGAGGAGCTGGACAACGCCACCCTGGTCCTGAGG
AATGCAACAGAGGGGCTGGGCCAGGTCGCCCTGCTGGACTGGGTGGCGCCTGGGCCGAGCACTGGCTCAGGACGTGCAGGGCTGGAGGCG
GCGGGAGACGAGCTGTGAGCCCCGCCAGGACTATGCTCCCAGGCCCCTCTGCCCAGGGGTGCCTTGGGGATGCTGCACTGGGCAGCTACC
CACCTGGGGATGGGACGTGAGGCCAAGACCCCAGCAGAGATGCCAGAATGGGGGAGGCACAGCTCATAGCCACACACCCAGGGCCTGACT
GAGGCCCACGCAGGAACCGACACTCAGACACAAGGCAAAGAGGGCCACAGGACCCGGGAAATACACACAGAGCCAGGAGCAGAAGCAAAG
AGCAGACACACATACAGCCTGAAACAGACCTGGACAGACAGACACAGCCTGAAACAGACCCGGACAGACAGACACAGCCTGAAACAGACC
CAGACAAACAGACAGACAGACACAGCCTGAAACAGACCCAGACAGACAGACAGACAGCCTGAAACAGACCCAGACACAGCCTGAAACAGA
TCCGGACAGACAGACAGAAACAGCCTGAAACAGACCCAGACAGACAGACAGACACAGCCTGAAACAGACCCGGACAGACAGACAGACACA
GCCTGAAACAGACCCGGACAGACAGACAGACACAGCCTGAAACAGACCCGGACAGACAGACAGACACAGCCTGAAACAGACCTAGACAGA
CAGACACAGATTGAAACAGACCCAGACAAACAGACAGACACAGCCTGAAACAGACCCAGACACAGCCTGAAACAGACCCGGACAGACAGA
CAGACACAGCCTGAAACAGACCCAGACAGACAGACAGACACAGCCTGAAACAGACCCAGACAGACAGACCGACGCAGCCTGAAAGAGACC
CAGACAGAGAGACAGGCAGACACAGCCTAAAACAGACCTGGACAGACAGGCAGACGTAGTCTGAAACAGACCTGAACAGACAGACAGACG
CACACACACAACAGATGCGCAGCAACTCCCCGCCCAGGGACCCCTCCCGGCCTCCCTCGCACACTGGGAGGAGGAAGCCGCCGAGACTGC
AGGGAGCCTGGCCCCGGAGCCCCGGGTGCGCCCTGGTCTTTGGAGCAGCCACGGCCCACAATCACCCCCCTTTTCTAAGACTGCCTGATC

>In-frame_SHC2_ENST00000264554_chr19_460529_-_CREB3L3_ENST00000252587_chr19_4164500_+_2208nt
ATGACGCAGGGTCCGGGCGGGCGCGCGCCCCCGGCGCCCCCCGCGCCCCCCGAGCCCGAGGCGCCCACCACCTTCTGCGCGTTGCTGCCC
CGAATGCCGCAGTGGAAGTTCGCGGCCCCGGGCGGCTTCCTGGGCCGCGGCCCGGCGGCGGCGCGGGCGGCTGGGGCCTCGGGGGGCGCG
GACCCCCAACCCGAGCCGGCGGGCCCGGGGGGCGTCCCGGCGCTGGCGGCCGCCGTCCTGGGCGCCTGCGAGCCCCGCTGCGCCGCGCCC
TGTCCCCTGCCCGCGCTCAGCCGCTGTCGGGGCGCGGGGTCGCGGGGGTCGCGGGGCGGGCGGGGGGCGGCGGGGTCCGGGGACGCCGCC
GCCGCCGCCGAGTGGATCCGGAAGGGCAGCTTCATCCACAAACCCGCGCACGGCTGGCTACACCCCGACGCCAGGGTCCTGGGGCCCGGG
GTCTCCTACGTCGTGCGGCAACAGCATCACCTGGGGGCCTCCTACCTCCTGCGACCTGGGGCTGGGCACTGTCAGGAGCTGGTGCTCACC
GAGGATGAGAAGAAGCTGCTGGCTAAAGAAGGCATCACCCTGCCCACTCAGCTGCCCCTCACTAAGTACGAGGAGCGAGTGCTGAAAAAA
ATCCGCCGGAAAATCCGGAACAAGCAGTCGGCGCAAGAAAGCAGGAAGAAGAAGAAGGAATATATCGATGGCCTGGAGACTCGGTCCTGT
TGCTGTCCTTTGCCCTCATCATCCTCCCCTCCATCAGCCCTTTTGGCCCCAACAAAACCGAGAGCCCTGGGGACTTTGCGCCTGTACGAG
TGTTCTCCAGAACTTTGCACAACGATGCTGCCTCCCGCGTGGCTGCTGATGCTGTGCCAGGCTCCGAGGCCCCAGGACCCCGACCCGAGG
CTGACACAACCCGAGAAGAGTCTCCAGGAAGCCCCGGGGCAGACTGGGGCTTCCAGGACACCGCGAACCTGACCAATTCGACGGAGGAGC
TGGACAACGCCACCCTGGTCCTGAGGAATGCAACAGAGGGGCTGGGCCAGGTCGCCCTGCTGGACTGGGTGGCGCCTGGGCCGAGCACTG
GCTCAGGACGTGCAGGGCTGGAGGCGGCGGGAGACGAGCTGTGAGCCCCGCCAGGACTATGCTCCCAGGCCCCTCTGCCCAGGGGTGCCT
TGGGGATGCTGCACTGGGCAGCTACCCACCTGGGGATGGGACGTGAGGCCAAGACCCCAGCAGAGATGCCAGAATGGGGGAGGCACAGCT
CATAGCCACACACCCAGGGCCTGACTGAGGCCCACGCAGGAACCGACACTCAGACACAAGGCAAAGAGGGCCACAGGACCCGGGAAATAC
ACACAGAGCCAGGAGCAGAAGCAAAGAGCAGACACACATACAGCCTGAAACAGACCTGGACAGACAGACACAGCCTGAAACAGACCCGGA
CAGACAGACACAGCCTGAAACAGACCCAGACAAACAGACAGACAGACACAGCCTGAAACAGACCCAGACAGACAGACAGACAGCCTGAAA
CAGACCCAGACACAGCCTGAAACAGATCCGGACAGACAGACAGAAACAGCCTGAAACAGACCCAGACAGACAGACAGACACAGCCTGAAA
CAGACCCGGACAGACAGACAGACACAGCCTGAAACAGACCCGGACAGACAGACAGACACAGCCTGAAACAGACCCGGACAGACAGACAGA
CACAGCCTGAAACAGACCTAGACAGACAGACACAGATTGAAACAGACCCAGACAAACAGACAGACACAGCCTGAAACAGACCCAGACACA
GCCTGAAACAGACCCGGACAGACAGACAGACACAGCCTGAAACAGACCCAGACAGACAGACAGACACAGCCTGAAACAGACCCAGACAGA
CAGACCGACGCAGCCTGAAAGAGACCCAGACAGAGAGACAGGCAGACACAGCCTAAAACAGACCTGGACAGACAGGCAGACGTAGTCTGA
AACAGACCTGAACAGACAGACAGACGCACACACACAACAGATGCGCAGCAACTCCCCGCCCAGGGACCCCTCCCGGCCTCCCTCGCACAC
TGGGAGGAGGAAGCCGCCGAGACTGCAGGGAGCCTGGCCCCGGAGCCCCGGGTGCGCCCTGGTCTTTGGAGCAGCCACGGCCCACAATCA

>In-frame_SHC2_ENST00000264554_chr19_460529_-_CREB3L3_ENST00000595923_chr19_4164500_+_1278nt
ATGACGCAGGGTCCGGGCGGGCGCGCGCCCCCGGCGCCCCCCGCGCCCCCCGAGCCCGAGGCGCCCACCACCTTCTGCGCGTTGCTGCCC
CGAATGCCGCAGTGGAAGTTCGCGGCCCCGGGCGGCTTCCTGGGCCGCGGCCCGGCGGCGGCGCGGGCGGCTGGGGCCTCGGGGGGCGCG
GACCCCCAACCCGAGCCGGCGGGCCCGGGGGGCGTCCCGGCGCTGGCGGCCGCCGTCCTGGGCGCCTGCGAGCCCCGCTGCGCCGCGCCC
TGTCCCCTGCCCGCGCTCAGCCGCTGTCGGGGCGCGGGGTCGCGGGGGTCGCGGGGCGGGCGGGGGGCGGCGGGGTCCGGGGACGCCGCC
GCCGCCGCCGAGTGGATCCGGAAGGGCAGCTTCATCCACAAACCCGCGCACGGCTGGCTACACCCCGACGCCAGGGTCCTGGGGCCCGGG
GTCTCCTACGTCGTGCGGCAACAGCATCACCTGGGGGCCTCCTACCTCCTGCGACCTGGGGCTGGGCACTGTCAGGAGCTGGTGCTCACC
GAGGATGAGAAGAAGCTGCTGGCTAAAGAAGGCATCACCCTGCCCACTCAGCTGCCCCTCACTAAGTACGAGGAGCGAGTGCTGAAAAAA
ATCCGCCGGAAAATCCGGAACAAGCAGTCGGCGCAAGAAAGCAGGAAGAAGAAGAAGGAATATATCGATGGCCTGGAGACTCGGATGTCA
GCTTGCACTGCTCAGAATCAGGAGTTACAGAGGAAAGTCTTGCATCTCGAGAAGCAAAACCTGTCCCTCTTGGAGCAACTGAAGAAACTC
CAGGCCATTGTGGTGCAGTCCACCAGCAAGTCAGCCCAGACAGGCACCTGTGTCGCAGTCCTGTTGCTGTCCTTTGCCCTCATCATCCTC
CCCTCCATCAGCCCTTTTGGCCCCAACAAAACCGAGAGCCCTGGGGACTTTGCGCCTGTACGAGTGTTCTCCAGAACTTTGCACAACGAT
GCTGCCTCCCGCGTGGCTGCTGATGCTGTGCCAGGCTCCGAGGCCCCAGGACCCCGACCCGAGGCTGACACAACCCGAGAAGAGTCTCCA
GGAAGCCCCGGGGCAGACTGGGGCTTCCAGGACACCGCGAACCTGACCAATTCGACGGAGGAGCTGGACAACGCCACCCTGGTCCTGAGG
AATGCAACAGAGGGGCTGGGCCAGGTCGCCCTGCTGGACTGGGTGGCGCCTGGGCCGAGCACTGGCTCAGGACGTGCAGGGCTGGAGGCG

>In-frame_SHC2_ENST00000264554_chr19_460529_-_CREB3L3_ENST00000602257_chr19_4164500_+_1287nt
ATGACGCAGGGTCCGGGCGGGCGCGCGCCCCCGGCGCCCCCCGCGCCCCCCGAGCCCGAGGCGCCCACCACCTTCTGCGCGTTGCTGCCC
CGAATGCCGCAGTGGAAGTTCGCGGCCCCGGGCGGCTTCCTGGGCCGCGGCCCGGCGGCGGCGCGGGCGGCTGGGGCCTCGGGGGGCGCG
GACCCCCAACCCGAGCCGGCGGGCCCGGGGGGCGTCCCGGCGCTGGCGGCCGCCGTCCTGGGCGCCTGCGAGCCCCGCTGCGCCGCGCCC
TGTCCCCTGCCCGCGCTCAGCCGCTGTCGGGGCGCGGGGTCGCGGGGGTCGCGGGGCGGGCGGGGGGCGGCGGGGTCCGGGGACGCCGCC
GCCGCCGCCGAGTGGATCCGGAAGGGCAGCTTCATCCACAAACCCGCGCACGGCTGGCTACACCCCGACGCCAGGGTCCTGGGGCCCGGG
GTCTCCTACGTCGTGCGGCATCACCTGGGGGCCTCCTACCTCCTGCGACCTGGGGCTGGGCACTGTCAGGAGCTGGTGCTCACCGAGGAT
GAGAAGAAGCTGCTGGCTAAAGAAGGCATCACCCTGCCCACTCAGCTGCCCCTCACTAAGTACGAGGAGCGAGTGCTGAAAAAAATCCGC
CGGAAAATCCGGAACAAGCAGTCGGCGCAAGAAAGCAGGAAGAAGAAGAAGGAATATATCGATGGCCTGGAGACTCGGATGTCAGCTTGC
ACTGCTCAGAATCAGGAGTTACAGAGGAAAGTCTTGCATCTCGAGAAGCAAAACCTGTCCCTCTTGGAGCAACTGAAGAAACTCCAGGCC
ATTGTGGTGCAGTCCACCAGCAAGTCAGCCCAGACAGGCACCTGTGTCGCAGTCCTGTTGCTGTCCTTTGCCCTCATCATCCTCCCCTCC
ATCAGCCCTTTTGGCCCCAACAAAACCGAGAGCCCTGGGGACTTTGCGCCTGTACGAGTGTTCTCCAGAACTTTGCACAACGATGCTGCC
TCCCGCGTGGCTGCTGATGCTGTGCCAGGCTCCGAGGCCCCAGGACCCCGACCCGAGGCTGACACAACCCGAGAAGAGTCTCCAGGAAGC
CCCGGGGCAGACTGGGGCTTCCAGGACACCGCGAACCTGACCAATTCGACGGAGGAGCTGGACAACGCCACCCTGGTCCTGAGGAATGCA
ACAGAGGGGCTGGGCCAGGTCGCCCTGCTGGACTGGGTGGCGCCTGGGCCGAGCACTGGCTCAGGACGTGCAGGGCTGGAGGCGGCGGGA

>In-frame_SHC2_ENST00000264554_chr19_460529_-_CREB3L3_ENST00000602147_chr19_4164500_+_1194nt
ATGACGCAGGGTCCGGGCGGGCGCGCGCCCCCGGCGCCCCCCGCGCCCCCCGAGCCCGAGGCGCCCACCACCTTCTGCGCGTTGCTGCCC
CGAATGCCGCAGTGGAAGTTCGCGGCCCCGGGCGGCTTCCTGGGCCGCGGCCCGGCGGCGGCGCGGGCGGCTGGGGCCTCGGGGGGCGCG
GACCCCCAACCCGAGCCGGCGGGCCCGGGGGGCGTCCCGGCGCTGGCGGCCGCCGTCCTGGGCGCCTGCGAGCCCCGCTGCGCCGCGCCC
TGTCCCCTGCCCGCGCTCAGCCGCTGTCGGGGCGCGGGGTCGCGGGGGTCGCGGGGCGGGCGGGGGGCGGCGGGGTCCGGGGACGCCGCC
GCCGCCGCCGAGTGGATCCGGAAGGGCAGCTTCATCCACAAACCCGCGCACGGCTGGCTACACCCCGACGCCAGGGTCCTGGGGCCCGGG
GTCTCCTACGTCGTGCGGCAACAGCATCACCTGGGGGCCTCCTACCTCCTGCGACCTGGGGCTGGGCACTGTCAGGAGCTGGTGCTCACC
GAGGATGAGAAGAAGCTGCTGGCTAAAGAAGGCATCACCCTGCCCACTCAGCTGCCCCTCACTAAGGATGTCAGCTTGCACTGCTCAGAA
TCAGGAGTTACAGAGGAAAGTCTTGCATCTCGAGAAGCAAAACCTGTCCCTCTTGGAGCAACTGAAGAAACTCCAGGCCATTGTGGTGCA
GTCCACCAGCAAGTCAGCCCAGACAGGCACCTGTGTCGCAGTCCTGTTGCTGTCCTTTGCCCTCATCATCCTCCCCTCCATCAGCCCTTT
TGGCCCCAACAAAACCGAGAGCCCTGGGGACTTTGCGCCTGTACGAGTGTTCTCCAGAACTTTGCACAACGATGCTGCCTCCCGCGTGGC
TGCTGATGCTGTGCCAGGCTCCGAGGCCCCAGGACCCCGACCCGAGGCTGACACAACCCGAGAAGAGTCTCCAGGAAGCCCCGGGGCAGA
CTGGGGCTTCCAGGACACCGCGAACCTGACCAATTCGACGGAGGAGCTGGACAACGCCACCCTGGTCCTGAGGAATGCAACAGAGGGGCT
GGGCCAGGTCGCCCTGCTGGACTGGGTGGCGCCTGGGCCGAGCACTGGCTCAGGACGTGCAGGGCTGGAGGCGGCGGGAGACGAGCTGTG


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FusionGenePPI for SHC2_CREB3L3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SHC2KDR, ARHGAP32, FLT1, EGFR, ERBB2, ERRFI1, GRB2, SHC1CREB3L3CREBZF, USP7, CREB3L1, CREB3L3, CREB3, KPNA2, RIOK3, KHDRBS1, PELI2, BAD, PPARGC1A, GSK3B, CSNK2A1, BTRC, CUL1, RBX1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SHC2_CREB3L3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SHC2_CREB3L3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource