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Fusion gene ID: 33755 |
FusionGeneSummary for SHC1_CDH18 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SHC1_CDH18 | Fusion gene ID: 33755 | Hgene | Tgene | Gene symbol | SHC1 | CDH18 | Gene ID | 6464 | 1016 |
| Gene name | SHC adaptor protein 1 | cadherin 18 | |
| Synonyms | SHC|SHCA | CDH14|CDH14L|CDH24 | |
| Cytomap | 1q21.3 | 5p14.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | SHC-transforming protein 1SH2 domain protein C1SHC (Src homology 2 domain containing) transforming protein 1SHC-transforming protein 3SHC-transforming protein A | cadherin-18cadherin 18, type 2cadherin-14cadherin-like 24ey-cadherin | |
| Modification date | 20180527 | 20180523 | |
| UniProtAcc | P29353 | Q13634 | |
| Ensembl transtripts involved in fusion gene | ENST00000368445, ENST00000368449, ENST00000448116, ENST00000368450, ENST00000368453, ENST00000606391, ENST00000490667, | ENST00000382275, ENST00000507958, ENST00000502796, ENST00000511273, ENST00000274170, ENST00000506372, ENST00000510297, | |
| Fusion gene scores | * DoF score | 10 X 7 X 7=490 | 9 X 6 X 6=324 |
| # samples | 10 | 9 | |
| ** MAII score | log2(10/490*10)=-2.29278174922785 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/324*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SHC1 [Title/Abstract] AND CDH18 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | SHC1 | GO:0000165 | MAPK cascade | 14676841 |
| Hgene | SHC1 | GO:0000187 | activation of MAPK activity | 14676841 |
| Hgene | SHC1 | GO:0071363 | cellular response to growth factor stimulus | 20010870 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | CD238366 | SHC1 | chr1 | 154934774 | - | CDH18 | chr5 | 19835607 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000368445 | ENST00000382275 | SHC1 | chr1 | 154934774 | - | CDH18 | chr5 | 19835607 | - |
| 5CDS-intron | ENST00000368445 | ENST00000507958 | SHC1 | chr1 | 154934774 | - | CDH18 | chr5 | 19835607 | - |
| 5CDS-intron | ENST00000368445 | ENST00000502796 | SHC1 | chr1 | 154934774 | - | CDH18 | chr5 | 19835607 | - |
| 5CDS-intron | ENST00000368445 | ENST00000511273 | SHC1 | chr1 | 154934774 | - | CDH18 | chr5 | 19835607 | - |
| 5CDS-intron | ENST00000368445 | ENST00000274170 | SHC1 | chr1 | 154934774 | - | CDH18 | chr5 | 19835607 | - |
| 5CDS-intron | ENST00000368445 | ENST00000506372 | SHC1 | chr1 | 154934774 | - | CDH18 | chr5 | 19835607 | - |
| 5CDS-intron | ENST00000368445 | ENST00000510297 | SHC1 | chr1 | 154934774 | - | CDH18 | chr5 | 19835607 | - |
| 5CDS-intron | ENST00000368449 | ENST00000382275 | SHC1 | chr1 | 154934774 | - | CDH18 | chr5 | 19835607 | - |
| 5CDS-intron | ENST00000368449 | ENST00000507958 | SHC1 | chr1 | 154934774 | - | CDH18 | chr5 | 19835607 | - |
| 5CDS-intron | ENST00000368449 | ENST00000502796 | SHC1 | chr1 | 154934774 | - | CDH18 | chr5 | 19835607 | - |
| 5CDS-intron | ENST00000368449 | ENST00000511273 | SHC1 | chr1 | 154934774 | - | CDH18 | chr5 | 19835607 | - |
| 5CDS-intron | ENST00000368449 | ENST00000274170 | SHC1 | chr1 | 154934774 | - | CDH18 | chr5 | 19835607 | - |
| 5CDS-intron | ENST00000368449 | ENST00000506372 | SHC1 | chr1 | 154934774 | - | CDH18 | chr5 | 19835607 | - |
| 5CDS-intron | ENST00000368449 | ENST00000510297 | SHC1 | chr1 | 154934774 | - | CDH18 | chr5 | 19835607 | - |
| 5CDS-intron | ENST00000448116 | ENST00000382275 | SHC1 | chr1 | 154934774 | - | CDH18 | chr5 | 19835607 | - |
| 5CDS-intron | ENST00000448116 | ENST00000507958 | SHC1 | chr1 | 154934774 | - | CDH18 | chr5 | 19835607 | - |
| 5CDS-intron | ENST00000448116 | ENST00000502796 | SHC1 | chr1 | 154934774 | - | CDH18 | chr5 | 19835607 | - |
| 5CDS-intron | ENST00000448116 | ENST00000511273 | SHC1 | chr1 | 154934774 | - | CDH18 | chr5 | 19835607 | - |
| 5CDS-intron | ENST00000448116 | ENST00000274170 | SHC1 | chr1 | 154934774 | - | CDH18 | chr5 | 19835607 | - |
| 5CDS-intron | ENST00000448116 | ENST00000506372 | SHC1 | chr1 | 154934774 | - | CDH18 | chr5 | 19835607 | - |
| 5CDS-intron | ENST00000448116 | ENST00000510297 | SHC1 | chr1 | 154934774 | - | CDH18 | chr5 | 19835607 | - |
| 5CDS-intron | ENST00000368450 | ENST00000382275 | SHC1 | chr1 | 154934774 | - | CDH18 | chr5 | 19835607 | - |
| 5CDS-intron | ENST00000368450 | ENST00000507958 | SHC1 | chr1 | 154934774 | - | CDH18 | chr5 | 19835607 | - |
| 5CDS-intron | ENST00000368450 | ENST00000502796 | SHC1 | chr1 | 154934774 | - | CDH18 | chr5 | 19835607 | - |
| 5CDS-intron | ENST00000368450 | ENST00000511273 | SHC1 | chr1 | 154934774 | - | CDH18 | chr5 | 19835607 | - |
| 5CDS-intron | ENST00000368450 | ENST00000274170 | SHC1 | chr1 | 154934774 | - | CDH18 | chr5 | 19835607 | - |
| 5CDS-intron | ENST00000368450 | ENST00000506372 | SHC1 | chr1 | 154934774 | - | CDH18 | chr5 | 19835607 | - |
| 5CDS-intron | ENST00000368450 | ENST00000510297 | SHC1 | chr1 | 154934774 | - | CDH18 | chr5 | 19835607 | - |
| 5CDS-intron | ENST00000368453 | ENST00000382275 | SHC1 | chr1 | 154934774 | - | CDH18 | chr5 | 19835607 | - |
| 5CDS-intron | ENST00000368453 | ENST00000507958 | SHC1 | chr1 | 154934774 | - | CDH18 | chr5 | 19835607 | - |
| 5CDS-intron | ENST00000368453 | ENST00000502796 | SHC1 | chr1 | 154934774 | - | CDH18 | chr5 | 19835607 | - |
| 5CDS-intron | ENST00000368453 | ENST00000511273 | SHC1 | chr1 | 154934774 | - | CDH18 | chr5 | 19835607 | - |
| 5CDS-intron | ENST00000368453 | ENST00000274170 | SHC1 | chr1 | 154934774 | - | CDH18 | chr5 | 19835607 | - |
| 5CDS-intron | ENST00000368453 | ENST00000506372 | SHC1 | chr1 | 154934774 | - | CDH18 | chr5 | 19835607 | - |
| 5CDS-intron | ENST00000368453 | ENST00000510297 | SHC1 | chr1 | 154934774 | - | CDH18 | chr5 | 19835607 | - |
| 5CDS-intron | ENST00000606391 | ENST00000382275 | SHC1 | chr1 | 154934774 | - | CDH18 | chr5 | 19835607 | - |
| 5CDS-intron | ENST00000606391 | ENST00000507958 | SHC1 | chr1 | 154934774 | - | CDH18 | chr5 | 19835607 | - |
| 5CDS-intron | ENST00000606391 | ENST00000502796 | SHC1 | chr1 | 154934774 | - | CDH18 | chr5 | 19835607 | - |
| 5CDS-intron | ENST00000606391 | ENST00000511273 | SHC1 | chr1 | 154934774 | - | CDH18 | chr5 | 19835607 | - |
| 5CDS-intron | ENST00000606391 | ENST00000274170 | SHC1 | chr1 | 154934774 | - | CDH18 | chr5 | 19835607 | - |
| 5CDS-intron | ENST00000606391 | ENST00000506372 | SHC1 | chr1 | 154934774 | - | CDH18 | chr5 | 19835607 | - |
| 5CDS-intron | ENST00000606391 | ENST00000510297 | SHC1 | chr1 | 154934774 | - | CDH18 | chr5 | 19835607 | - |
| intron-intron | ENST00000490667 | ENST00000382275 | SHC1 | chr1 | 154934774 | - | CDH18 | chr5 | 19835607 | - |
| intron-intron | ENST00000490667 | ENST00000507958 | SHC1 | chr1 | 154934774 | - | CDH18 | chr5 | 19835607 | - |
| intron-intron | ENST00000490667 | ENST00000502796 | SHC1 | chr1 | 154934774 | - | CDH18 | chr5 | 19835607 | - |
| intron-intron | ENST00000490667 | ENST00000511273 | SHC1 | chr1 | 154934774 | - | CDH18 | chr5 | 19835607 | - |
| intron-intron | ENST00000490667 | ENST00000274170 | SHC1 | chr1 | 154934774 | - | CDH18 | chr5 | 19835607 | - |
| intron-intron | ENST00000490667 | ENST00000506372 | SHC1 | chr1 | 154934774 | - | CDH18 | chr5 | 19835607 | - |
| intron-intron | ENST00000490667 | ENST00000510297 | SHC1 | chr1 | 154934774 | - | CDH18 | chr5 | 19835607 | - |
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FusionProtFeatures for SHC1_CDH18 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SHC1 | CDH18 |
| Cadherins are calcium-dependent cell adhesion proteins.They preferentially interact with themselves in a homophilicmanner in connecting cells; cadherins may thus contribute to thesorting of heterogeneous cell types. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SHC1_CDH18 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SHC1_CDH18 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SHC1_CDH18 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SHC1_CDH18 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | SHC1 | C0018800 | Cardiomegaly | 1 | CTD_human |
| Hgene | SHC1 | C1862939 | AMYOTROPHIC LATERAL SCLEROSIS 1 | 1 | CTD_human |
| Tgene | CDH18 | C0001973 | Alcoholic Intoxication, Chronic | 1 | PSYGENET |
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