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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 33735

FusionGeneSummary for SHANK3_MAPK1

check button Fusion gene summary
Fusion gene informationFusion gene name: SHANK3_MAPK1
Fusion gene ID: 33735
HgeneTgene
Gene symbol

SHANK3

MAPK1

Gene ID

85358

5594

Gene nameSH3 and multiple ankyrin repeat domains 3mitogen-activated protein kinase 1
SynonymsDEL22q13.3|PROSAP2|PSAP2|SCZD15|SPANK-2ERK|ERK-2|ERK2|ERT1|MAPK2|P42MAPK|PRKM1|PRKM2|p38|p40|p41|p41mapk|p42-MAPK
Cytomap

22q13.33

22q11.22

Type of geneprotein-codingprotein-coding
DescriptionSH3 and multiple ankyrin repeat domains protein 3proline rich synapse associated protein 2shank postsynaptic density proteinmitogen-activated protein kinase 1MAP kinase 1MAP kinase 2MAP kinase isoform p42MAPK 2extracellular signal-regulated kinase 2mitogen-activated protein kinase 2protein tyrosine kinase ERK2
Modification date2018052320180529
UniProtAcc

P28482

Ensembl transtripts involved in fusion geneENST00000414786, ENST00000445220, 
ENST00000262795, 		ENST00000215832, 
ENST00000398822, ENST00000544786, 
ENST00000491588, 
Fusion gene scores* DoF score8 X 6 X 3=1449 X 6 X 5=270
# samples 79
** MAII scorelog2(7/144*10)=-1.04064198449735
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/270*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SHANK3 [Title/Abstract] AND MAPK1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
Transcription factor involved fusion gene, inframe and retained DNA-binding domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMAPK1

GO:0006468

protein phosphorylation

23184662

TgeneMAPK1

GO:0010800

positive regulation of peptidyl-threonine phosphorylation

16314496

TgeneMAPK1

GO:0018105

peptidyl-serine phosphorylation

15850461

TgeneMAPK1

GO:0034198

cellular response to amino acid starvation

11096076

TgeneMAPK1

GO:0038127

ERBB signaling pathway

15133037

TgeneMAPK1

GO:0051403

stress-activated MAPK cascade

11096076

TgeneMAPK1

GO:0070371

ERK1 and ERK2 cascade

16314496

TgeneMAPK1

GO:0070849

response to epidermal growth factor

18794356


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSKCMTCGA-D3-A1Q3-06ASHANK3chr22

51115121

+MAPK1chr22

22153417

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000414786ENST00000215832SHANK3chr22

51115121

+MAPK1chr22

22153417

-
In-frameENST00000414786ENST00000398822SHANK3chr22

51115121

+MAPK1chr22

22153417

-
In-frameENST00000414786ENST00000544786SHANK3chr22

51115121

+MAPK1chr22

22153417

-
5CDS-intronENST00000414786ENST00000491588SHANK3chr22

51115121

+MAPK1chr22

22153417

-
In-frameENST00000445220ENST00000215832SHANK3chr22

51115121

+MAPK1chr22

22153417

-
In-frameENST00000445220ENST00000398822SHANK3chr22

51115121

+MAPK1chr22

22153417

-
In-frameENST00000445220ENST00000544786SHANK3chr22

51115121

+MAPK1chr22

22153417

-
5CDS-intronENST00000445220ENST00000491588SHANK3chr22

51115121

+MAPK1chr22

22153417

-
In-frameENST00000262795ENST00000215832SHANK3chr22

51115121

+MAPK1chr22

22153417

-
In-frameENST00000262795ENST00000398822SHANK3chr22

51115121

+MAPK1chr22

22153417

-
In-frameENST00000262795ENST00000544786SHANK3chr22

51115121

+MAPK1chr22

22153417

-
5CDS-intronENST00000262795ENST00000491588SHANK3chr22

51115121

+MAPK1chr22

22153417

-

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FusionProtFeatures for SHANK3_MAPK1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SHANK3

MAPK1

P28482

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. Serine/threonine kinase which acts as an essentialcomponent of the MAP kinase signal transduction pathway.MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an importantrole in the MAPK/ERK cascade. They participate also in a signalingcascade initiated by activated KIT and KITLG/SCF. Depending on thecellular context, the MAPK/ERK cascade mediates diverse biologicalfunctions such as cell growth, adhesion, survival anddifferentiation through the regulation of transcription,translation, cytoskeletal rearrangements. The MAPK/ERK cascadeplays also a role in initiation and regulation of meiosis,mitosis, and postmitotic functions in differentiated cells byphosphorylating a number of transcription factors. About 160substrates have already been discovered for ERKs. Many of thesesubstrates are localized in the nucleus, and seem to participatein the regulation of transcription upon stimulation. However,other substrates are found in the cytosol as well as in othercellular organelles, and those are responsible for processes suchas translation, mitosis and apoptosis. Moreover, the MAPK/ERKcascade is also involved in the regulation of the endosomaldynamics, including lysosome processing and endosome cyclingthrough the perinuclear recycling compartment (PNRC); as well asin the fragmentation of the Golgi apparatus during mitosis. Thesubstrates include transcription factors (such as ATF2, BCL6,ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such asCANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators ofapoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG),regulators of translation (such as EIF4EBP1) and a variety ofother signaling-related molecules (like ARHGEF2, DCC, FRS2 orGRB10). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2,RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2,RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases(such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates whichenable the propagation the MAPK/ERK signal to additional cytosolicand nuclear targets, thereby extending the specificity of thecascade. Mediates phosphorylation of TPR in respons to EGFstimulation. May play a role in the spindle assembly checkpoint.Phosphorylates PML and promotes its interaction with PIN1, leadingto PML degradation. Phosphorylates CDK2AP2 (By similarity).{ECO:0000250|UniProtKB:P63086, ECO:0000269|PubMed:10617468,ECO:0000269|PubMed:10637505, ECO:0000269|PubMed:11154262,ECO:0000269|PubMed:12110590, ECO:0000269|PubMed:12356731,ECO:0000269|PubMed:12792650, ECO:0000269|PubMed:12794087,ECO:0000269|PubMed:12974390, ECO:0000269|PubMed:15184391,ECO:0000269|PubMed:15241487, ECO:0000269|PubMed:15616583,ECO:0000269|PubMed:15664191, ECO:0000269|PubMed:15788397,ECO:0000269|PubMed:15952796, ECO:0000269|PubMed:16581800,ECO:0000269|PubMed:18794356, ECO:0000269|PubMed:19265199,ECO:0000269|PubMed:19879846, ECO:0000269|PubMed:22033920,ECO:0000269|PubMed:7588608, ECO:0000269|PubMed:8622688,ECO:0000269|PubMed:9480836, ECO:0000269|PubMed:9596579,ECO:0000269|PubMed:9649500, ECO:0000269|PubMed:9687510,ECO:0000303|PubMed:15526160, ECO:0000303|PubMed:16393692,ECO:0000303|PubMed:19565474, ECO:0000303|PubMed:21779493}. Acts as a transcriptional repressor. Binds to a[GC]AAA[GC] consensus sequence. Repress the expression ofinterferon gamma-induced genes. Seems to bind to the promoter ofCCL5, DMP1, IFIH1, IFITM1, IRF7, IRF9, LAMP3, OAS1, OAS2, OAS3 andSTAT1. Transcriptional activity is independent of kinase activity.{ECO:0000269|PubMed:19879846}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMAPK1chr22:51115121chr22:22153417ENST00000215832-29259_2771643486DNA binding.
TgeneMAPK1chr22:51115121chr22:22153417ENST00000398822-28259_277164361DNA binding.
TgeneMAPK1chr22:51115121chr22:22153417ENST00000544786-27259_277164317DNA binding.
TgeneMAPK1chr22:51115121chr22:22153417ENST00000215832-29185_1871643486MotifNote=TXY
TgeneMAPK1chr22:51115121chr22:22153417ENST00000215832-29318_3221643486MotifNote=Cytoplasmic retention motif
TgeneMAPK1chr22:51115121chr22:22153417ENST00000215832-29327_3331643486MotifNote=Nuclear translocation motif
TgeneMAPK1chr22:51115121chr22:22153417ENST00000398822-28185_187164361MotifNote=TXY
TgeneMAPK1chr22:51115121chr22:22153417ENST00000398822-28318_322164361MotifNote=Cytoplasmic retention motif
TgeneMAPK1chr22:51115121chr22:22153417ENST00000398822-28327_333164361MotifNote=Nuclear translocation motif
TgeneMAPK1chr22:51115121chr22:22153417ENST00000544786-27185_187164317MotifNote=TXY
TgeneMAPK1chr22:51115121chr22:22153417ENST00000544786-27318_322164317MotifNote=Cytoplasmic retention motif
TgeneMAPK1chr22:51115121chr22:22153417ENST00000544786-27327_333164317MotifNote=Nuclear translocation motif

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMAPK1chr22:51115121chr22:22153417ENST00000215832-292_91643486Compositional biasNote=Poly-Ala
TgeneMAPK1chr22:51115121chr22:22153417ENST00000398822-282_9164361Compositional biasNote=Poly-Ala
TgeneMAPK1chr22:51115121chr22:22153417ENST00000544786-272_9164317Compositional biasNote=Poly-Ala
TgeneMAPK1chr22:51115121chr22:22153417ENST00000215832-2925_3131643486DomainProtein kinase
TgeneMAPK1chr22:51115121chr22:22153417ENST00000398822-2825_313164361DomainProtein kinase
TgeneMAPK1chr22:51115121chr22:22153417ENST00000544786-2725_313164317DomainProtein kinase
TgeneMAPK1chr22:51115121chr22:22153417ENST00000215832-2931_391643486Nucleotide bindingATP
TgeneMAPK1chr22:51115121chr22:22153417ENST00000398822-2831_39164361Nucleotide bindingATP
TgeneMAPK1chr22:51115121chr22:22153417ENST00000544786-2731_39164317Nucleotide bindingATP
TgeneMAPK1chr22:51115121chr22:22153417ENST00000215832-29105_1081643486RegionNote=Inhibitor-binding
TgeneMAPK1chr22:51115121chr22:22153417ENST00000215832-29153_1541643486RegionNote=Inhibitor-binding
TgeneMAPK1chr22:51115121chr22:22153417ENST00000398822-28105_108164361RegionNote=Inhibitor-binding
TgeneMAPK1chr22:51115121chr22:22153417ENST00000398822-28153_154164361RegionNote=Inhibitor-binding
TgeneMAPK1chr22:51115121chr22:22153417ENST00000544786-27105_108164317RegionNote=Inhibitor-binding
TgeneMAPK1chr22:51115121chr22:22153417ENST00000544786-27153_154164317RegionNote=Inhibitor-binding


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FusionGeneSequence for SHANK3_MAPK1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_SHANK3_ENST00000414786_chr22_51115121_+_MAPK1_ENST00000215832_chr22_22153417_-_310aa
MDGPGASAVVVRVGIPDLQQTKCLRLDPAAPVWAAKQRVLCALNHSLQDALNYGLFQPPSRGRAGKFLDEERLLQEYPPNLDTPLPYLEF
RYKRRVYAQNLIDDKQFAKLHTKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGK
HYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSD

>In-frame_SHANK3_ENST00000414786_chr22_51115121_+_MAPK1_ENST00000398822_chr22_22153417_-_310aa
MDGPGASAVVVRVGIPDLQQTKCLRLDPAAPVWAAKQRVLCALNHSLQDALNYGLFQPPSRGRAGKFLDEERLLQEYPPNLDTPLPYLEF
RYKRRVYAQNLIDDKQFAKLHTKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGK
HYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSD

>In-frame_SHANK3_ENST00000414786_chr22_51115121_+_MAPK1_ENST00000544786_chr22_22153417_-_266aa
MDGPGASAVVVRVGIPDLQQTKCLRLDPAAPVWAAKQRVLCALNHSLQDALNYGLFQPPSRGRAGKFLDEERLLQEYPPNLDTPLPYLEF
RYKRRVYAQNLIDDKQFAKLHTKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGK

>In-frame_SHANK3_ENST00000445220_chr22_51115121_+_MAPK1_ENST00000215832_chr22_22153417_-_310aa
MDGPGASAVVVRVGIPDLQQTKCLRLDPAAPVWAAKQRVLCALNHSLQDALNYGLFQPPSRGRAGKFLDEERLLQEYPPNLDTPLPYLEF
RYKRRVYAQNLIDDKQFAKLHTKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGK
HYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSD

>In-frame_SHANK3_ENST00000445220_chr22_51115121_+_MAPK1_ENST00000398822_chr22_22153417_-_310aa
MDGPGASAVVVRVGIPDLQQTKCLRLDPAAPVWAAKQRVLCALNHSLQDALNYGLFQPPSRGRAGKFLDEERLLQEYPPNLDTPLPYLEF
RYKRRVYAQNLIDDKQFAKLHTKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGK
HYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSD

>In-frame_SHANK3_ENST00000445220_chr22_51115121_+_MAPK1_ENST00000544786_chr22_22153417_-_266aa
MDGPGASAVVVRVGIPDLQQTKCLRLDPAAPVWAAKQRVLCALNHSLQDALNYGLFQPPSRGRAGKFLDEERLLQEYPPNLDTPLPYLEF
RYKRRVYAQNLIDDKQFAKLHTKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGK

>In-frame_SHANK3_ENST00000262795_chr22_51115121_+_MAPK1_ENST00000215832_chr22_22153417_-_310aa
MDGPGASAVVVRVGIPDLQQTKCLRLDPAAPVWAAKQRVLCALNHSLQDALNYGLFQPPSRGRAGKFLDEERLLQEYPPNLDTPLPYLEF
RYKRRVYAQNLIDDKQFAKLHTKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGK
HYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSD

>In-frame_SHANK3_ENST00000262795_chr22_51115121_+_MAPK1_ENST00000398822_chr22_22153417_-_310aa
MDGPGASAVVVRVGIPDLQQTKCLRLDPAAPVWAAKQRVLCALNHSLQDALNYGLFQPPSRGRAGKFLDEERLLQEYPPNLDTPLPYLEF
RYKRRVYAQNLIDDKQFAKLHTKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGK
HYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSD

>In-frame_SHANK3_ENST00000262795_chr22_51115121_+_MAPK1_ENST00000544786_chr22_22153417_-_266aa
MDGPGASAVVVRVGIPDLQQTKCLRLDPAAPVWAAKQRVLCALNHSLQDALNYGLFQPPSRGRAGKFLDEERLLQEYPPNLDTPLPYLEF
RYKRRVYAQNLIDDKQFAKLHTKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGK


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_SHANK3_ENST00000414786_chr22_51115121_+_MAPK1_ENST00000215832_chr22_22153417_-_930nt
ATGGACGGCCCCGGGGCCAGCGCCGTGGTCGTGCGCGTCGGCATCCCGGACCTGCAGCAGACGAAGTGCCTGCGCCTGGACCCGGCCGCG
CCCGTGTGGGCCGCCAAGCAGCGCGTGCTCTGCGCCCTCAACCACAGCCTCCAGGACGCGCTCAACTATGGGCTTTTCCAGCCGCCCTCC
CGGGGCCGCGCCGGCAAGTTCCTGGATGAGGAGCGGCTCCTGCAGGAGTACCCGCCCAACCTGGACACGCCCCTGCCCTACCTGGAGTTT
CGATACAAGCGGCGAGTTTATGCCCAGAACCTCATCGATGATAAGCAGTTTGCAAAGCTTCACACAAAGATCTGTGACTTTGGCCTGGCC
CGTGTTGCAGATCCAGACCATGATCACACAGGGTTCCTGACAGAATATGTGGCCACACGTTGGTACAGGGCTCCAGAAATTATGTTGAAT
TCCAAGGGCTACACCAAGTCCATTGATATTTGGTCTGTAGGCTGCATTCTGGCAGAAATGCTTTCTAACAGGCCCATCTTTCCAGGGAAG
CATTATCTTGACCAGCTGAACCACATTTTGGGTATTCTTGGATCCCCATCACAAGAAGACCTGAATTGTATAATAAATTTAAAAGCTAGG
AACTATTTGCTTTCTCTTCCACACAAAAATAAGGTGCCATGGAACAGGCTGTTCCCAAATGCTGACTCCAAAGCTCTGGACTTATTGGAC
AAAATGTTGACATTCAACCCACACAAGAGGATTGAAGTAGAACAGGCTCTGGCCCACCCATATCTGGAGCAGTATTACGACCCGAGTGAC
GAGCCCATCGCCGAAGCACCATTCAAGTTCGACATGGAATTGGATGACTTGCCTAAGGAAAAGCTCAAAGAACTAATTTTTGAAGAGACT

>In-frame_SHANK3_ENST00000414786_chr22_51115121_+_MAPK1_ENST00000398822_chr22_22153417_-_930nt
ATGGACGGCCCCGGGGCCAGCGCCGTGGTCGTGCGCGTCGGCATCCCGGACCTGCAGCAGACGAAGTGCCTGCGCCTGGACCCGGCCGCG
CCCGTGTGGGCCGCCAAGCAGCGCGTGCTCTGCGCCCTCAACCACAGCCTCCAGGACGCGCTCAACTATGGGCTTTTCCAGCCGCCCTCC
CGGGGCCGCGCCGGCAAGTTCCTGGATGAGGAGCGGCTCCTGCAGGAGTACCCGCCCAACCTGGACACGCCCCTGCCCTACCTGGAGTTT
CGATACAAGCGGCGAGTTTATGCCCAGAACCTCATCGATGATAAGCAGTTTGCAAAGCTTCACACAAAGATCTGTGACTTTGGCCTGGCC
CGTGTTGCAGATCCAGACCATGATCACACAGGGTTCCTGACAGAATATGTGGCCACACGTTGGTACAGGGCTCCAGAAATTATGTTGAAT
TCCAAGGGCTACACCAAGTCCATTGATATTTGGTCTGTAGGCTGCATTCTGGCAGAAATGCTTTCTAACAGGCCCATCTTTCCAGGGAAG
CATTATCTTGACCAGCTGAACCACATTTTGGGTATTCTTGGATCCCCATCACAAGAAGACCTGAATTGTATAATAAATTTAAAAGCTAGG
AACTATTTGCTTTCTCTTCCACACAAAAATAAGGTGCCATGGAACAGGCTGTTCCCAAATGCTGACTCCAAAGCTCTGGACTTATTGGAC
AAAATGTTGACATTCAACCCACACAAGAGGATTGAAGTAGAACAGGCTCTGGCCCACCCATATCTGGAGCAGTATTACGACCCGAGTGAC
GAGCCCATCGCCGAAGCACCATTCAAGTTCGACATGGAATTGGATGACTTGCCTAAGGAAAAGCTCAAAGAACTAATTTTTGAAGAGACT

>In-frame_SHANK3_ENST00000414786_chr22_51115121_+_MAPK1_ENST00000544786_chr22_22153417_-_798nt
ATGGACGGCCCCGGGGCCAGCGCCGTGGTCGTGCGCGTCGGCATCCCGGACCTGCAGCAGACGAAGTGCCTGCGCCTGGACCCGGCCGCG
CCCGTGTGGGCCGCCAAGCAGCGCGTGCTCTGCGCCCTCAACCACAGCCTCCAGGACGCGCTCAACTATGGGCTTTTCCAGCCGCCCTCC
CGGGGCCGCGCCGGCAAGTTCCTGGATGAGGAGCGGCTCCTGCAGGAGTACCCGCCCAACCTGGACACGCCCCTGCCCTACCTGGAGTTT
CGATACAAGCGGCGAGTTTATGCCCAGAACCTCATCGATGATAAGCAGTTTGCAAAGCTTCACACAAAGATCTGTGACTTTGGCCTGGCC
CGTGTTGCAGATCCAGACCATGATCACACAGGGTTCCTGACAGAATATGTGGCCACACGTTGGTACAGGGCTCCAGAAATTATGTTGAAT
TCCAAGGGCTACACCAAGTCCATTGATATTTGGTCTGTAGGCTGCATTCTGGCAGAAATGCTTTCTAACAGGCCCATCTTTCCAGGGAAG
CATTATCTTGACCAGCTGAACCACATTTTGGCTCTGGACTTATTGGACAAAATGTTGACATTCAACCCACACAAGAGGATTGAAGTAGAA
CAGGCTCTGGCCCACCCATATCTGGAGCAGTATTACGACCCGAGTGACGAGCCCATCGCCGAAGCACCATTCAAGTTCGACATGGAATTG

>In-frame_SHANK3_ENST00000445220_chr22_51115121_+_MAPK1_ENST00000215832_chr22_22153417_-_930nt
ATGGACGGCCCCGGGGCCAGCGCCGTGGTCGTGCGCGTCGGCATCCCGGACCTGCAGCAGACGAAGTGCCTGCGCCTGGACCCGGCCGCG
CCCGTGTGGGCCGCCAAGCAGCGCGTGCTCTGCGCCCTCAACCACAGCCTCCAGGACGCGCTCAACTATGGGCTTTTCCAGCCGCCCTCC
CGGGGCCGCGCCGGCAAGTTCCTGGATGAGGAGCGGCTCCTGCAGGAGTACCCGCCCAACCTGGACACGCCCCTGCCCTACCTGGAGTTT
CGATACAAGCGGCGAGTTTATGCCCAGAACCTCATCGATGATAAGCAGTTTGCAAAGCTTCACACAAAGATCTGTGACTTTGGCCTGGCC
CGTGTTGCAGATCCAGACCATGATCACACAGGGTTCCTGACAGAATATGTGGCCACACGTTGGTACAGGGCTCCAGAAATTATGTTGAAT
TCCAAGGGCTACACCAAGTCCATTGATATTTGGTCTGTAGGCTGCATTCTGGCAGAAATGCTTTCTAACAGGCCCATCTTTCCAGGGAAG
CATTATCTTGACCAGCTGAACCACATTTTGGGTATTCTTGGATCCCCATCACAAGAAGACCTGAATTGTATAATAAATTTAAAAGCTAGG
AACTATTTGCTTTCTCTTCCACACAAAAATAAGGTGCCATGGAACAGGCTGTTCCCAAATGCTGACTCCAAAGCTCTGGACTTATTGGAC
AAAATGTTGACATTCAACCCACACAAGAGGATTGAAGTAGAACAGGCTCTGGCCCACCCATATCTGGAGCAGTATTACGACCCGAGTGAC
GAGCCCATCGCCGAAGCACCATTCAAGTTCGACATGGAATTGGATGACTTGCCTAAGGAAAAGCTCAAAGAACTAATTTTTGAAGAGACT

>In-frame_SHANK3_ENST00000445220_chr22_51115121_+_MAPK1_ENST00000398822_chr22_22153417_-_930nt
ATGGACGGCCCCGGGGCCAGCGCCGTGGTCGTGCGCGTCGGCATCCCGGACCTGCAGCAGACGAAGTGCCTGCGCCTGGACCCGGCCGCG
CCCGTGTGGGCCGCCAAGCAGCGCGTGCTCTGCGCCCTCAACCACAGCCTCCAGGACGCGCTCAACTATGGGCTTTTCCAGCCGCCCTCC
CGGGGCCGCGCCGGCAAGTTCCTGGATGAGGAGCGGCTCCTGCAGGAGTACCCGCCCAACCTGGACACGCCCCTGCCCTACCTGGAGTTT
CGATACAAGCGGCGAGTTTATGCCCAGAACCTCATCGATGATAAGCAGTTTGCAAAGCTTCACACAAAGATCTGTGACTTTGGCCTGGCC
CGTGTTGCAGATCCAGACCATGATCACACAGGGTTCCTGACAGAATATGTGGCCACACGTTGGTACAGGGCTCCAGAAATTATGTTGAAT
TCCAAGGGCTACACCAAGTCCATTGATATTTGGTCTGTAGGCTGCATTCTGGCAGAAATGCTTTCTAACAGGCCCATCTTTCCAGGGAAG
CATTATCTTGACCAGCTGAACCACATTTTGGGTATTCTTGGATCCCCATCACAAGAAGACCTGAATTGTATAATAAATTTAAAAGCTAGG
AACTATTTGCTTTCTCTTCCACACAAAAATAAGGTGCCATGGAACAGGCTGTTCCCAAATGCTGACTCCAAAGCTCTGGACTTATTGGAC
AAAATGTTGACATTCAACCCACACAAGAGGATTGAAGTAGAACAGGCTCTGGCCCACCCATATCTGGAGCAGTATTACGACCCGAGTGAC
GAGCCCATCGCCGAAGCACCATTCAAGTTCGACATGGAATTGGATGACTTGCCTAAGGAAAAGCTCAAAGAACTAATTTTTGAAGAGACT

>In-frame_SHANK3_ENST00000445220_chr22_51115121_+_MAPK1_ENST00000544786_chr22_22153417_-_798nt
ATGGACGGCCCCGGGGCCAGCGCCGTGGTCGTGCGCGTCGGCATCCCGGACCTGCAGCAGACGAAGTGCCTGCGCCTGGACCCGGCCGCG
CCCGTGTGGGCCGCCAAGCAGCGCGTGCTCTGCGCCCTCAACCACAGCCTCCAGGACGCGCTCAACTATGGGCTTTTCCAGCCGCCCTCC
CGGGGCCGCGCCGGCAAGTTCCTGGATGAGGAGCGGCTCCTGCAGGAGTACCCGCCCAACCTGGACACGCCCCTGCCCTACCTGGAGTTT
CGATACAAGCGGCGAGTTTATGCCCAGAACCTCATCGATGATAAGCAGTTTGCAAAGCTTCACACAAAGATCTGTGACTTTGGCCTGGCC
CGTGTTGCAGATCCAGACCATGATCACACAGGGTTCCTGACAGAATATGTGGCCACACGTTGGTACAGGGCTCCAGAAATTATGTTGAAT
TCCAAGGGCTACACCAAGTCCATTGATATTTGGTCTGTAGGCTGCATTCTGGCAGAAATGCTTTCTAACAGGCCCATCTTTCCAGGGAAG
CATTATCTTGACCAGCTGAACCACATTTTGGCTCTGGACTTATTGGACAAAATGTTGACATTCAACCCACACAAGAGGATTGAAGTAGAA
CAGGCTCTGGCCCACCCATATCTGGAGCAGTATTACGACCCGAGTGACGAGCCCATCGCCGAAGCACCATTCAAGTTCGACATGGAATTG

>In-frame_SHANK3_ENST00000262795_chr22_51115121_+_MAPK1_ENST00000215832_chr22_22153417_-_930nt
ATGGACGGCCCCGGGGCCAGCGCCGTGGTCGTGCGCGTCGGCATCCCGGACCTGCAGCAGACGAAGTGCCTGCGCCTGGACCCGGCCGCG
CCCGTGTGGGCCGCCAAGCAGCGCGTGCTCTGCGCCCTCAACCACAGCCTCCAGGACGCGCTCAACTATGGGCTTTTCCAGCCGCCCTCC
CGGGGCCGCGCCGGCAAGTTCCTGGATGAGGAGCGGCTCCTGCAGGAGTACCCGCCCAACCTGGACACGCCCCTGCCCTACCTGGAGTTT
CGATACAAGCGGCGAGTTTATGCCCAGAACCTCATCGATGATAAGCAGTTTGCAAAGCTTCACACAAAGATCTGTGACTTTGGCCTGGCC
CGTGTTGCAGATCCAGACCATGATCACACAGGGTTCCTGACAGAATATGTGGCCACACGTTGGTACAGGGCTCCAGAAATTATGTTGAAT
TCCAAGGGCTACACCAAGTCCATTGATATTTGGTCTGTAGGCTGCATTCTGGCAGAAATGCTTTCTAACAGGCCCATCTTTCCAGGGAAG
CATTATCTTGACCAGCTGAACCACATTTTGGGTATTCTTGGATCCCCATCACAAGAAGACCTGAATTGTATAATAAATTTAAAAGCTAGG
AACTATTTGCTTTCTCTTCCACACAAAAATAAGGTGCCATGGAACAGGCTGTTCCCAAATGCTGACTCCAAAGCTCTGGACTTATTGGAC
AAAATGTTGACATTCAACCCACACAAGAGGATTGAAGTAGAACAGGCTCTGGCCCACCCATATCTGGAGCAGTATTACGACCCGAGTGAC
GAGCCCATCGCCGAAGCACCATTCAAGTTCGACATGGAATTGGATGACTTGCCTAAGGAAAAGCTCAAAGAACTAATTTTTGAAGAGACT

>In-frame_SHANK3_ENST00000262795_chr22_51115121_+_MAPK1_ENST00000398822_chr22_22153417_-_930nt
ATGGACGGCCCCGGGGCCAGCGCCGTGGTCGTGCGCGTCGGCATCCCGGACCTGCAGCAGACGAAGTGCCTGCGCCTGGACCCGGCCGCG
CCCGTGTGGGCCGCCAAGCAGCGCGTGCTCTGCGCCCTCAACCACAGCCTCCAGGACGCGCTCAACTATGGGCTTTTCCAGCCGCCCTCC
CGGGGCCGCGCCGGCAAGTTCCTGGATGAGGAGCGGCTCCTGCAGGAGTACCCGCCCAACCTGGACACGCCCCTGCCCTACCTGGAGTTT
CGATACAAGCGGCGAGTTTATGCCCAGAACCTCATCGATGATAAGCAGTTTGCAAAGCTTCACACAAAGATCTGTGACTTTGGCCTGGCC
CGTGTTGCAGATCCAGACCATGATCACACAGGGTTCCTGACAGAATATGTGGCCACACGTTGGTACAGGGCTCCAGAAATTATGTTGAAT
TCCAAGGGCTACACCAAGTCCATTGATATTTGGTCTGTAGGCTGCATTCTGGCAGAAATGCTTTCTAACAGGCCCATCTTTCCAGGGAAG
CATTATCTTGACCAGCTGAACCACATTTTGGGTATTCTTGGATCCCCATCACAAGAAGACCTGAATTGTATAATAAATTTAAAAGCTAGG
AACTATTTGCTTTCTCTTCCACACAAAAATAAGGTGCCATGGAACAGGCTGTTCCCAAATGCTGACTCCAAAGCTCTGGACTTATTGGAC
AAAATGTTGACATTCAACCCACACAAGAGGATTGAAGTAGAACAGGCTCTGGCCCACCCATATCTGGAGCAGTATTACGACCCGAGTGAC
GAGCCCATCGCCGAAGCACCATTCAAGTTCGACATGGAATTGGATGACTTGCCTAAGGAAAAGCTCAAAGAACTAATTTTTGAAGAGACT

>In-frame_SHANK3_ENST00000262795_chr22_51115121_+_MAPK1_ENST00000544786_chr22_22153417_-_798nt
ATGGACGGCCCCGGGGCCAGCGCCGTGGTCGTGCGCGTCGGCATCCCGGACCTGCAGCAGACGAAGTGCCTGCGCCTGGACCCGGCCGCG
CCCGTGTGGGCCGCCAAGCAGCGCGTGCTCTGCGCCCTCAACCACAGCCTCCAGGACGCGCTCAACTATGGGCTTTTCCAGCCGCCCTCC
CGGGGCCGCGCCGGCAAGTTCCTGGATGAGGAGCGGCTCCTGCAGGAGTACCCGCCCAACCTGGACACGCCCCTGCCCTACCTGGAGTTT
CGATACAAGCGGCGAGTTTATGCCCAGAACCTCATCGATGATAAGCAGTTTGCAAAGCTTCACACAAAGATCTGTGACTTTGGCCTGGCC
CGTGTTGCAGATCCAGACCATGATCACACAGGGTTCCTGACAGAATATGTGGCCACACGTTGGTACAGGGCTCCAGAAATTATGTTGAAT
TCCAAGGGCTACACCAAGTCCATTGATATTTGGTCTGTAGGCTGCATTCTGGCAGAAATGCTTTCTAACAGGCCCATCTTTCCAGGGAAG
CATTATCTTGACCAGCTGAACCACATTTTGGCTCTGGACTTATTGGACAAAATGTTGACATTCAACCCACACAAGAGGATTGAAGTAGAA
CAGGCTCTGGCCCACCCATATCTGGAGCAGTATTACGACCCGAGTGACGAGCCCATCGCCGAAGCACCATTCAAGTTCGACATGGAATTG


* Fusion transcript sequences (Full-length transcript).
>In-frame_SHANK3_ENST00000414786_chr22_51115121_+_MAPK1_ENST00000215832_chr22_22153417_-_10907nt
ATGCAGCTGAGCCGCGCCGCCGCCGCCGCCGCCGCCGCCCCTGCGGAGCCCCCGGAGCCGCTGTCCCCCGCGCCGGCCCCGGCCCCGGCC
CCCCCCGGCCCCCTCCCGCGCAGCGCGGCCGACGGGGCTCCGGCGGGGGGGAAGGGGGGGCCGGGGCGCCGCGCGCGGAGTCCCCGGGCG
CTCCGTTCCCCGGCGCGAGCGGCCCCGGCCCGGGCCCCGGCGCGGGGATGGACGGCCCCGGGGCCAGCGCCGTGGTCGTGCGCGTCGGCA
TCCCGGACCTGCAGCAGACGAAGTGCCTGCGCCTGGACCCGGCCGCGCCCGTGTGGGCCGCCAAGCAGCGCGTGCTCTGCGCCCTCAACC
ACAGCCTCCAGGACGCGCTCAACTATGGGCTTTTCCAGCCGCCCTCCCGGGGCCGCGCCGGCAAGTTCCTGGATGAGGAGCGGCTCCTGC
AGGAGTACCCGCCCAACCTGGACACGCCCCTGCCCTACCTGGAGTTTCGATACAAGCGGCGAGTTTATGCCCAGAACCTCATCGATGATA
AGCAGTTTGCAAAGCTTCACACAAAGATCTGTGACTTTGGCCTGGCCCGTGTTGCAGATCCAGACCATGATCACACAGGGTTCCTGACAG
AATATGTGGCCACACGTTGGTACAGGGCTCCAGAAATTATGTTGAATTCCAAGGGCTACACCAAGTCCATTGATATTTGGTCTGTAGGCT
GCATTCTGGCAGAAATGCTTTCTAACAGGCCCATCTTTCCAGGGAAGCATTATCTTGACCAGCTGAACCACATTTTGGGTATTCTTGGAT
CCCCATCACAAGAAGACCTGAATTGTATAATAAATTTAAAAGCTAGGAACTATTTGCTTTCTCTTCCACACAAAAATAAGGTGCCATGGA
ACAGGCTGTTCCCAAATGCTGACTCCAAAGCTCTGGACTTATTGGACAAAATGTTGACATTCAACCCACACAAGAGGATTGAAGTAGAAC
AGGCTCTGGCCCACCCATATCTGGAGCAGTATTACGACCCGAGTGACGAGCCCATCGCCGAAGCACCATTCAAGTTCGACATGGAATTGG
ATGACTTGCCTAAGGAAAAGCTCAAAGAACTAATTTTTGAAGAGACTGCTAGATTCCAGCCAGGATACAGATCTTAAATTTGTCAGGACA
AGGGCTCAGAGGACTGGACGTGCTCAGACATCGGTGTTCTTCTTCCCAGTTCTTGACCCCTGGTCCTGTCTCCAGCCCGTCTTGGCTTAT
CCACTTTGACTCCTTTGAGCCGTTTGGAGGGGCGGTTTCTGGTAGTTGTGGCTTTTATGCTTTCAAAGAATTTCTTCAGTCCAGAGAATT
CCTCCTGGCAGCCCTGTGTGTGTCACCCATTGGTGACCTGCGGCAGTATGTACTTCAGTGCACCTACTGCTTACTGTTGCTTTAGTCACT
AATTGCTTTCTGGTTTGAAAGATGCAGTGGTTCCTCCCTCTCCTGAATCCTTTTCTACATGATGCCCTGCTGACCATGCAGCCGCACCAG
AGAGAGATTCTTCCCCAATTGGCTCTAGTCACTGGCATCTCACTTTATGATAGGGAAGGCTACTACCTAGGGCACTTTAAGTCAGTGACA
GCCCCTTATTTGCACTTCACCTTTTGACCATAACTGTTTCCCCAGAGCAGGAGCTTGTGGAAATACCTTGGCTGATGTTGCAGCCTGCAG
CAAGTGCTTCCGTCTCCGGAATCCTTGGGGAGCACTTGTCCACGTCTTTTCTCATATCATGGTAGTCACTAACATATATAAGGTATGTGC
TATTGGCCCAGCTTTTAGAAAATGCAGTCATTTTTCTAAATAAAAAGGAAGTACTGCACCCAGCAGTGTCACTCTGTAGTTACTGTGGTC
ACTTGTACCATATAGAGGTGTAACACTTGTCAAGAAGCGTTATGTGCAGTACTTAATGTTTGTAAGACTTACAAAAAAAGATTTAAAGTG
GCAGCTTCACTCGACATTTGGTGAGAGAAGTACAAAGGTTGCAGTGCTGAGCTGTGGGCGGTTTCTGGGGATGTCCCAGGGTGGAACTCC
ACATGCTGGTGCATATACGCCCTTGAGCTACTTCAAATGTGGGTGTTTCAGTAACCACGTTCCATGCCTGAGGATTTAGCAGAGAGGAAC
ACTGCGTCTTTAAATGAGAAAGTATACAATTCTTTTTCCTTCTACAGCATGTCAGCATCTCAAGTTCATTTTTCAACCTACAGTATAACA
ATTTGTAATAAAGCCTCCAGGAGCTCATGACGTGAAGCACTGTTCTGTCCTCAAGTACTCAAATATTTCTGATACTGCTGAGTCAGACTG
TCAGAAAAAGCTAGCACTAACTCGTGTTTGGAGCTCTATCCATATTTTACTGATCTCTTTAAGTATTTGTTCCTGCCACTGTGTACTGTG
GAGTTGACTCGGTGTTCTGTCCCAGTGCGGTGCCTCCTCTTGACTTCCCCACTGCTCTCTGTGGTGAGAAATTTGCCTTGTTCAATAATT
ACTGTACCCTCGCATGACTGTTACAGCTTTCTGTGCAGAGATGACTGTCCAAGTGCCACATGCCTACGATTGAAATGAAAACTCTATTGT
TACCTCTGAGTTGTGTTCCACGGAAAATGCTATCCAGCAGATCATTTAGGAAAAATAATTCTATTTTTAGCTTTTCATTTCTCAGCTGTC
CTTTTTTCTTGTTTGATTTTTGACAGCAATGGAGAATGGGTTATATAAAGACTGCCTGCTAATATGAACAGAAATGCATTTGTAATTCAT
GAAAATAAATGTACATCTTCTATCTTCACATTCATGTTAAGATTCAGTGTTGCTTTCCTCTGGATCAGCGTGTCTGAATGGACAGTCAGG
TTCAGGTTGTGCTGAACACAGAAATGCTCACAGGCCTCACTTTGCCGCCCAGGCACTGGCCCAGCACTTGGATTTACATAAGATGAGTTA
GAAAGGTACTTCTGTAGGGTCCTTTTTACCTCTGCTCGGCAGAGAATCGATGCTGTCATGTTCCTTTATTCACAATCTTAGGTCTCAAAT
ATTCTGTCAAACCCTAACAAAGAAGCCCCGACATCTCAGGTTGGATTCCCTGGTTCTCTCTAAAGAGGGCCTGCCCTTGTGCCCCAGAGG
TGCTGCTGGGCACAGCCAAGAGTTGGGAAGGGCCGCCCCACAGTACGCAGTCCTCACCACCCAGCCCAGGGTGCTCACGCTCACCACTCC
TGTGGCTGAGGAAGGATAGCTGGCTCATCCTCGGAAAACAGACCCACATCTCTATTCTTGCCCTGAAATACGCGCTTTTCACTTGCGTGC
TCAGAGCTGCCGTCTGAAGGTCCACACAGCATTGACGGGACACAGAAATGTGACTGTTACCGGATAACACTGATTAGTCAGTTTTCATTT
ATAAAAAAGCATTGACAGTTTTATTACTCTTGTTTCTTTTTAAATGGAAAGTTACTATTATAAGGTTAATTTGGAGTCCTCTTCTAAATA
GAAAACCATATCCTTGGCTACTAACATCTGGAGACTGTGAGCTCCTTCCCATTCCCCTTCCTGGTACTGTGGAGTCAGATTGGCATGAAA
CCACTAACTTCATTCTAGAATCATTGTAGCCATAAGTTGTGTGCTTTTTATTAATCATGCCAAACATAATGTAACTGGGCAGAGAATGGT
CCTAACCAAGGTACCTATGAAAAGCGCTAGCTATCATGTGTAGTAGATGCATCATTTTGGCTCTTCTTACATTTGTAAAAATGTACAGAT
TAGGTCATCTTAATTCATATTAGTGACACGGAACAGCACCTCCACTATTTGTATGTTCAAATAAGCTTTCAGACTAATAGCTTTTTTGGT
GTCTAAAATGTAAGCAAAAAATTCCTGCTGAAACATTCCAGTCCTTTCATTTAGTATAAAAGAAATACTGAACAAGCCAGTGGGATGGAA
TTGAAAGAACTAATCATGAGGACTCTGTCCTGACACAGGTCCTCAAAGCTAGCAGAGATACGCAGACATTGTGGCATCTGGGTAGAAGAA
TACTGTATTGTGTGTGCAGTGCACAGTGTGTGGTGTGTGCACACTCATTCCTTCTGCTCTTGGGCACAGGCAGTGGGTGTAGAGGTAACC
AGTAGCTTTGAGAAGCTACATGTAGCTCACCAGTGGTTTTCTCTAAGGAATCACAAAAGTAAACTACCCAACCACATGCCACGTAATATT
TCAGCCATTCAGAGGAAACTGTTTTCTCTTTATTTGCTTATATGTTAATATGGTTTTTAAATTGGTAACTTTTATATAGTATGGTAACAG
TATGTTAATACACACATACATACGCACACATGCTTTGGGTCCTTCCATAATACTTTTATATTTGTAAATCAATGTTTTGGAGCAATCCCA
AGTTTAAGGGAAATATTTTTGTAAATGTAATGGTTTTGAAAATCTGAGCAATCCTTTTGCTTATACATTTTTAAAGCATTTGTGCTTTAA
AATTGTTATGCTGGTGTTTGAAACATGATACTCCTGTGGTGCAGATGAGAAGCTATAACAGTGAATATGTGGTTTCTCTTACGTCATCCA
CCTTGACATGATGGGTCAGAAACAAATGGAAATCCAGAGCAAGTCCTCCAGGGTTGCACCAGGTTTACCTAAAGCTTGTTGCCTTTTCTT
GTGCTGTTTATGCGTGTAGAGCACTCAAGAAAGTTCTGAAACTGCTTTGTATCTGCTTTGTACTGTTGGTGCCTTCTTGGTATTGTACCC
CAAAATTCTGCATAGATTATTTAGTATAATGGTAAGTTAAAAAATGTTAAAGGAAGATTTTATTAAGAATCTGAATGTTTATTCATTATA
TTGTTACAATTTAACATTAACATTTATTTGTGGTATTTGTGATTTGGTTAATCTGTATAAAAATTGTAAGTAGAAAGGTTTATATTTCAT
CTTAATTCTTTTGATGTTGTAAACGTACTTTTTAAAAGATGGATTATTTGAATGTTTATGGCACCTGACTTGTAAAAAAAAAAAACTACA
AAAAAATCCTTAGAATCATTAAATTGTGTCCCTGTATTACCAAAATAACACAGCACCGTGCATGTATAGTTTAATTGCAGTTTCATCTGT
GAAAACGTGAAATTGTCTAGTCCTTCGTTATGTTCCCCAGATGTCTTCCAGATTTGCTCTGCATGTGGTAACTTGTGTTAGGGCTGTGAG
CTGTTCCTCGAGTTGAATGGGGATGTCAGTGCTCCTAGGGTTCTCCAGGTGGTTCTTCAGACCTTCACCTGTGGGGGGGGGGGTAGGCGG
TGCCCACGCCCATCTCCTCATCCTCCTGAACTTCTGCAACCCCACTGCTGGGCAGACATCCTGGGCAACCCCTTTTTTCAGAGCAAGAAG
TCATAAAGATAGGATTTCTTGGACATTTGGTTCTTATCAATATTGGGCATTATGTAATGACTTATTTACAAAACAAAGATACTGGAAAAT
GTTTTGGATGTGGTGTTATGGAAAGAGCACAGGCCTTGGACCCATCCAGCTGGGTTCAGAACTACCCCCTGCTTATAACTGCGGCTGGCT
GTGGGCCAGTCATTCTGCGTCTCTGCTTTCTTCCTCTGCTTCAGACTGTCAGCTGTAAAGTGGAAGCAATATTACTTGCCTTGTATATGG
TAAAGATTATAAAAATACATTTCAACTGTTCAGCATAGTACTTCAAAGCAAGTACTCAGTAAATAGCAAGTCTTTTTAAATGCTGCTTTA
TTTCACTAAATTTTGTTGTGAGGTGTCACTAAAATGCCTGCAAACAAACGTAACTGCTAATCTGAGAGGAAACCCTCTTACTAATCAGAG
AAGAAACCCTCCTGTCAGAAACCTTCAGGGAAGTGAGCTGATCACACCTAAACTGGGAGTTTGCAATGGGGTATTTGAAGCACTGTGGGA
GTATTCCACTGGCCCTCTCCCTGAGAGACTTAACAGTCTTCCCTGTTGTCCAGATTCTGTATAAGGCAATCAGAATAATCATCTTCCTTG
TTCAGCAGAGGAGCCTGGTCCCATTTTCCCCACTTTGTGATGGGCTTCTCTCAGCGGTAGCTCAGCAGTTCCAGATGGCAGTTTGGACCA
GCATCTAGGCTGGCCAGTTCGCTGTGTTTACTTAGAACCAACACGTTCAGAGCTGGCCTGGACCATCTGAGGGGAACAGGAAACACCCCT
AGGCTGTGGAAGCAAGTGCAGACCCCCACCCCCGGCCCTGAAGCCAAGGGGGCAGGGTTTGGGAGTGGCCAAAGAGAAGCAGTGCAGGGA
TGGGTTTTCCTAGGGACAGGCTTAGCATTCCTGACTCTAGGAAGAAGGAGCAGTGAGGCGGAGAAACAGTGGAGGGGATGGTGGCATTGG
GCCCCATGGGGCCGAGATGGACACAGGGCTCGTTCTCTTGAGTCTGGTGCCAAGGACAGCTGAAGACGACATCATTTTCAGGTGGAGAGG
AGAGAGTGGAGGGAGATCATGCCCTGTGATGTGTCTTTTGCAGGTGAAGGTGGGAGACAAGGTCTCTGCTGACGATGAGGCAGAGCCACC
GTGAAAGTTGTAATAGGAGGACTGCCCGCCGCTGGAAGGGCCTGCAGTGACGCTAGGACACCCTCTGCCTGCATGTCACGTTAGCTGGGC
TGGGCGAAGTAGAAGACCAAGGGGAAGAGGTGCAGTGGGGAGACCAGGTGGGATGCAACCACAGGACCAGTGGAGGGGCTGTGGCACGTG
GGCGGAGACTGAGTGGCTGGGCATGTGTTGTGGCTGAGCATGTGGTGTGGGCAGTGGTCCTAGACCCCGCCATGTCCGGACAATGATATA
GAGCGTCTCAGCATCGCCAGTCTAGACTGTCTATGGAGAGCAGAAAGTTGTCTGGGGCTGCCTGGGGAACTGTGAGGCCAGCTATATCAC
CGTCGCTGATGGTGACATTACGGTGGTGGCAGGAGCAAGGAGAGAGGGAAGAAGGACCCCGTCCAGCTTTAGTCACAAAATACCCAATGG
AAGATGCCAGTGCCAATCCTGTGGGTTTCCTTGGGACTTCACACTGGCTTTCTTATCTGCTCCAGATCCATTCAGTAGTCACTGAGTTCC
TGCCAAATACTTTGTAGCGCCAGAAGCCAGGAGCGGGGTCTGCAGCAGGGCAGTCCCCATTTTCAGGAAATGCCTGGAGCTGCTGGTCCC
TGAGAGAAAGGAAAACATCTTTCAGCCGTACGCAGGCCAAGAAGGCCAATGTCCAGTAGCTTTGTGATTTTTTTTATATTTTTTTATTTA
TTTATTTTTGAGATAGAGTCTTGCTCTGTCGCTCAGGCTGGAGTGCAGTGGCGTGATCTCCACTCACTGCAACTTCCGCCTCCTGGGGTC
AAGCAGTTCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCACACGCCACCACACCCAGCTAATTTTTGTGTTTTTAGTAGAGACGGT
TTCACCATGTCGGCCAGGCTGGTCTCAAACTCCTGACCTCAGATGATTCAGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACTGCA
CCCAGCCTGTGATGTTTCTGTGGGGTTCCACAAATGTGTGTGTGTGTAAAAGCTGATGATTACAGCAAGAATGTGAACAGTAGCAGTTTT
CCATTTGAAGGCAAGTTTTGTCTTTATCTGGGTATCAGAAGGACCCTCTGGGCCATTGTCGCTTCCTGTACTCAGAGCCACCCTAGTACT
ACGGGCACACACAGAAAACAGCAGCCTGCGTACTTTCAAAGGAAAGGCATCTTTAATCACCAATGCCTGGAAAAATTATTTTGTTTCCCT
CTTCCTTCCGTCTTGTTTCCTAACTTCTTACCAAAGTTTAGAGTCTGAGTTTTTCGTATAATAATGTCCCACATCCACACATCGGGCCTA
CAGATGCTCTCCCTTGAATCGACTGGAAACATGACACCGGTTCCATGCTCTGGAACTGTCACCTGTGATGTGCTGGGCTGTGTCCCAAGC
ACAGGAATCCCAGCAGTTTCAGCTCGATGCAGAACCACCATGCTCCAGACACAGGCTTGGGAAAGACACGTCAAAATTAAAATACTAGGT
AAGAGAAGCACCTGATTGGGTAGAAGTTGGAGAGGAATCCTGGAATTTTGTGGCCAGAAGGAGCCACTGCCCCTTTTGTTTAGTAAGACT
AGACAGTAACAGAAGCCAGTTGTCAGCTATGAAAGTGGTGGGTGAAGCAGGGGAGGCTCCTCTATGGTGGGACCCTGGACAAGGGAAGCC
GAATGTGTGAAGAAGGGGTGCGGGGGTGTGCGGTGCCCTAGGACACTAGGGCAAAGGTTTCAAACCTGGAACAAGGCACTGGAGGAAGAT
CTGCTGCCAGTCAGCAGTGCGGGCCCTCGAGTTAGCAGTCCGTGCGCAGAGGGGCCAGTTCTGAGACCAGTTTGGAGAGTCAGGCAGTGA
CCCATTGGCCATGTCATAATTCCTTCAGCCTGCCTCCTCTTTAATCCCAGAGAGTGCTCTTTCTTCATACTTCCTTTAAAATACTAAATT
GTTCCCATTCCATGGGGAGCTGGCTAGGCTTTACAGGCTAGGAAATGTAGGTTTTCTGAGATGGAACCATCTACACAAGGAGGAGGAAGG
CACTAAGACTACAGATGAGACCCATGACAGGGCTGAGCATTTGGAAGCCAACCCTGGTTGCTTTTCAAGAATTGCTTTGTGGCTGGGTGC
AGTGGTTCACACCTGTAATTGCAGCACTTTGGGAGGCTGAGGCAGGTGGATTGCTTGAACCCAGGAGTTCGAGACCAGCCTGGGCAACAT
ATGGGACACCCCACCGCCCCCGGCTCTGCAAAAAAATTAAAAATTAGCCAGGCGTGGTGTCATGAGCCTGTGGTCTCAACTACTCAGGAG
GCTGAGGCTGGAGGATCGCTTGAACCTGGGAGGTCAAGGCTCCAGTGAACCATAATTGTGCCACTGCACTGCAGCCTGGGCGACAATTTG
TTTTCTAAATTGCTTTTGAAAGTCTACTGCATTACATATTCCAAAAAGCAGTGGTTTTCAAATACTTTTATCACCGATATCCTTTTATGA
AATGAAATCAGTAGAACTTTCTCTGCTCTGAATAAGCAAGGGTGGGAACCTGTCTACCTCCCACAGATAGCATAATGTGCCTGCCATAGA
GGAGCCAAAAAATGGTGATGGGAACTGAGAGGAGAGCAAATGTCACAAAAGACTGAGCAATTGAGAAAACAAAACAAGACCACAGATGAC
TGTTAACGCCTCCACAGTGGACCAAGAAAGGACAGAGAGCTGGCAGCATGGGCATCACTGTCTGGTCGGCAGCAGGAAGGCCTCGCTAGG
GAATTGAGTACAGTCATCTAACTAGTTTAAAAGTACAGGAAGGATGATTAAGGCTATTGGAGAGGTCATACAAATAGGGGAGGGGCAGGC
AATGGCTGATAAGACATGAATTTGTAAGGCGATGAGTATTGCAGTCAGCAAAACAAACGAGACTGCTCTCCCAACACATAACTCAGCAGG
GAGGCCAGGCATTGGTTTAACCATTTAATATAAAGAAGTTAAAATTACAAATGCGCTAAGTGCCTAAAGAAGAATAAGTGCAGGAATGAG
AGCAGCATGGACTGCCACAGTTTTAGAATAAGCACTGTCACTGCTAGATTGGAAACAAAAATCCATAAATTTGGCCCGGTGTGGTGGCGG
ACGCCTGTAGTCCCAGCTACTTGGAGGCTGAGGCGTGAGAATCGCTTGAACCCGGGAGGCGGAGGTTGCAGTGAGCCGAGATGGCGCCAC
TGCACTCCAGCCTGGGCGTCAGAGTGAGAACTCTGTATCAAAAAATAAAAATAAAAAAAAGTCCATAAATCTGCAATGTCTCAGTTAAGA
AAGAAAGACTGGGCCAATGCAGATTTCAAACCGGAGAAAGTCATACTGTCAGTGAAGGCCGCCTGTGGCCGGAAGGCGCCAGGGGATTAG
CACCCTGGACTCAGTGTTGCTGGGAAACAGGGCCCCAAGGCTGGGAGCACAGTGTTTAAAGGGCATCTACCCAAGAAGGGAGCACAGGGC
AAGGAGGAGCTGCAGGGGGGCTTGGCTGCCAAAGTGAATTCTGAGGAGAGAGCTATTGCTGCCTACGATATGCAGGCTGCACAGAACACA
AGTGGAATCAGCAGGCAGGAGAGGCAGCTAACGACGCAGCCCGTTTCTTATTTCTGTTTTCTCACAAGCGATGAAAGTGGAAAAGAGGGT
GAGCAGGTGGCCCACACATGTGCCTCCAGTGCTGCGGCCCCTCCGGGGACCATCAGCCAGGCCCCGGGGAGGGAGCCAGCCACAGTGTGT
CCGGCTCTTCTCTGAAGGGAAGAGAGCCTTGAATAGACTGAAGCGAAGACGGTTCTGCAAGGACAAGGCAGACCGAAGGCATTGGTTTTT
TTTTTCAGATAAGGAGAATTAGACTCCCAAGTAGACACCAGAGTCACTGTTTGGTTGGTGGGTGATAGTGGGGTCACAGTGGCTGCCTGT
GCTCCCCCAGGGTGAGCGTGACTGTGCTAACCTGGGTGGGGCAGCATGCACACCCCTCTGGCAGCCCTTTGTTGCTCGCTGATGACAAGT
TTGGATGATCCCGCCAAACAGCTTGCTAAGATGTAGTCCCCAGTGTTGGAGGTGGGGCCTGATGGGAGGTGCTACCCTTGTGAGATAAGG
TTGTGTAAAAGCCTGTGGCACCTCCCCACACTGACGCTCTCACCCCTGCTCTGGCCATGTGCCGCGCCTGCTCCCACTTCCCCTTCTGCC
AGGAGTAAAAGCCCCCGAGACCTCCCAGAAGCCAAGCAGATGCTAGTGCCATGCTTCCTCTGCAGCCTGCAGAACTGTGAGCCAATTAAA

>In-frame_SHANK3_ENST00000414786_chr22_51115121_+_MAPK1_ENST00000398822_chr22_22153417_-_1321nt
ATGCAGCTGAGCCGCGCCGCCGCCGCCGCCGCCGCCGCCCCTGCGGAGCCCCCGGAGCCGCTGTCCCCCGCGCCGGCCCCGGCCCCGGCC
CCCCCCGGCCCCCTCCCGCGCAGCGCGGCCGACGGGGCTCCGGCGGGGGGGAAGGGGGGGCCGGGGCGCCGCGCGCGGAGTCCCCGGGCG
CTCCGTTCCCCGGCGCGAGCGGCCCCGGCCCGGGCCCCGGCGCGGGGATGGACGGCCCCGGGGCCAGCGCCGTGGTCGTGCGCGTCGGCA
TCCCGGACCTGCAGCAGACGAAGTGCCTGCGCCTGGACCCGGCCGCGCCCGTGTGGGCCGCCAAGCAGCGCGTGCTCTGCGCCCTCAACC
ACAGCCTCCAGGACGCGCTCAACTATGGGCTTTTCCAGCCGCCCTCCCGGGGCCGCGCCGGCAAGTTCCTGGATGAGGAGCGGCTCCTGC
AGGAGTACCCGCCCAACCTGGACACGCCCCTGCCCTACCTGGAGTTTCGATACAAGCGGCGAGTTTATGCCCAGAACCTCATCGATGATA
AGCAGTTTGCAAAGCTTCACACAAAGATCTGTGACTTTGGCCTGGCCCGTGTTGCAGATCCAGACCATGATCACACAGGGTTCCTGACAG
AATATGTGGCCACACGTTGGTACAGGGCTCCAGAAATTATGTTGAATTCCAAGGGCTACACCAAGTCCATTGATATTTGGTCTGTAGGCT
GCATTCTGGCAGAAATGCTTTCTAACAGGCCCATCTTTCCAGGGAAGCATTATCTTGACCAGCTGAACCACATTTTGGGTATTCTTGGAT
CCCCATCACAAGAAGACCTGAATTGTATAATAAATTTAAAAGCTAGGAACTATTTGCTTTCTCTTCCACACAAAAATAAGGTGCCATGGA
ACAGGCTGTTCCCAAATGCTGACTCCAAAGCTCTGGACTTATTGGACAAAATGTTGACATTCAACCCACACAAGAGGATTGAAGTAGAAC
AGGCTCTGGCCCACCCATATCTGGAGCAGTATTACGACCCGAGTGACGAGCCCATCGCCGAAGCACCATTCAAGTTCGACATGGAATTGG
ATGACTTGCCTAAGGAAAAGCTCAAAGAACTAATTTTTGAAGAGACTGCTAGATTCCAGCCAGGATACAGATCTTAAATTTGTCAGGTAC
CTGGAGTTTAATACAGTGAGCTCTAGCAAGGGAGGCGCTGCCTTTTGTTTCTAGAATATTATGTTCCTCAAGGTCCATTATTTTGTATTC

>In-frame_SHANK3_ENST00000414786_chr22_51115121_+_MAPK1_ENST00000544786_chr22_22153417_-_1025nt
ATGCAGCTGAGCCGCGCCGCCGCCGCCGCCGCCGCCGCCCCTGCGGAGCCCCCGGAGCCGCTGTCCCCCGCGCCGGCCCCGGCCCCGGCC
CCCCCCGGCCCCCTCCCGCGCAGCGCGGCCGACGGGGCTCCGGCGGGGGGGAAGGGGGGGCCGGGGCGCCGCGCGCGGAGTCCCCGGGCG
CTCCGTTCCCCGGCGCGAGCGGCCCCGGCCCGGGCCCCGGCGCGGGGATGGACGGCCCCGGGGCCAGCGCCGTGGTCGTGCGCGTCGGCA
TCCCGGACCTGCAGCAGACGAAGTGCCTGCGCCTGGACCCGGCCGCGCCCGTGTGGGCCGCCAAGCAGCGCGTGCTCTGCGCCCTCAACC
ACAGCCTCCAGGACGCGCTCAACTATGGGCTTTTCCAGCCGCCCTCCCGGGGCCGCGCCGGCAAGTTCCTGGATGAGGAGCGGCTCCTGC
AGGAGTACCCGCCCAACCTGGACACGCCCCTGCCCTACCTGGAGTTTCGATACAAGCGGCGAGTTTATGCCCAGAACCTCATCGATGATA
AGCAGTTTGCAAAGCTTCACACAAAGATCTGTGACTTTGGCCTGGCCCGTGTTGCAGATCCAGACCATGATCACACAGGGTTCCTGACAG
AATATGTGGCCACACGTTGGTACAGGGCTCCAGAAATTATGTTGAATTCCAAGGGCTACACCAAGTCCATTGATATTTGGTCTGTAGGCT
GCATTCTGGCAGAAATGCTTTCTAACAGGCCCATCTTTCCAGGGAAGCATTATCTTGACCAGCTGAACCACATTTTGGCTCTGGACTTAT
TGGACAAAATGTTGACATTCAACCCACACAAGAGGATTGAAGTAGAACAGGCTCTGGCCCACCCATATCTGGAGCAGTATTACGACCCGA
GTGACGAGCCCATCGCCGAAGCACCATTCAAGTTCGACATGGAATTGGATGACTTGCCTAAGGAAAAGCTCAAAGAACTAATTTTTGAAG

>In-frame_SHANK3_ENST00000445220_chr22_51115121_+_MAPK1_ENST00000215832_chr22_22153417_-_10680nt
ATGGACGGCCCCGGGGCCAGCGCCGTGGTCGTGCGCGTCGGCATCCCGGACCTGCAGCAGACGAAGTGCCTGCGCCTGGACCCGGCCGCG
CCCGTGTGGGCCGCCAAGCAGCGCGTGCTCTGCGCCCTCAACCACAGCCTCCAGGACGCGCTCAACTATGGGCTTTTCCAGCCGCCCTCC
CGGGGCCGCGCCGGCAAGTTCCTGGATGAGGAGCGGCTCCTGCAGGAGTACCCGCCCAACCTGGACACGCCCCTGCCCTACCTGGAGTTT
CGATACAAGCGGCGAGTTTATGCCCAGAACCTCATCGATGATAAGCAGTTTGCAAAGCTTCACACAAAGATCTGTGACTTTGGCCTGGCC
CGTGTTGCAGATCCAGACCATGATCACACAGGGTTCCTGACAGAATATGTGGCCACACGTTGGTACAGGGCTCCAGAAATTATGTTGAAT
TCCAAGGGCTACACCAAGTCCATTGATATTTGGTCTGTAGGCTGCATTCTGGCAGAAATGCTTTCTAACAGGCCCATCTTTCCAGGGAAG
CATTATCTTGACCAGCTGAACCACATTTTGGGTATTCTTGGATCCCCATCACAAGAAGACCTGAATTGTATAATAAATTTAAAAGCTAGG
AACTATTTGCTTTCTCTTCCACACAAAAATAAGGTGCCATGGAACAGGCTGTTCCCAAATGCTGACTCCAAAGCTCTGGACTTATTGGAC
AAAATGTTGACATTCAACCCACACAAGAGGATTGAAGTAGAACAGGCTCTGGCCCACCCATATCTGGAGCAGTATTACGACCCGAGTGAC
GAGCCCATCGCCGAAGCACCATTCAAGTTCGACATGGAATTGGATGACTTGCCTAAGGAAAAGCTCAAAGAACTAATTTTTGAAGAGACT
GCTAGATTCCAGCCAGGATACAGATCTTAAATTTGTCAGGACAAGGGCTCAGAGGACTGGACGTGCTCAGACATCGGTGTTCTTCTTCCC
AGTTCTTGACCCCTGGTCCTGTCTCCAGCCCGTCTTGGCTTATCCACTTTGACTCCTTTGAGCCGTTTGGAGGGGCGGTTTCTGGTAGTT
GTGGCTTTTATGCTTTCAAAGAATTTCTTCAGTCCAGAGAATTCCTCCTGGCAGCCCTGTGTGTGTCACCCATTGGTGACCTGCGGCAGT
ATGTACTTCAGTGCACCTACTGCTTACTGTTGCTTTAGTCACTAATTGCTTTCTGGTTTGAAAGATGCAGTGGTTCCTCCCTCTCCTGAA
TCCTTTTCTACATGATGCCCTGCTGACCATGCAGCCGCACCAGAGAGAGATTCTTCCCCAATTGGCTCTAGTCACTGGCATCTCACTTTA
TGATAGGGAAGGCTACTACCTAGGGCACTTTAAGTCAGTGACAGCCCCTTATTTGCACTTCACCTTTTGACCATAACTGTTTCCCCAGAG
CAGGAGCTTGTGGAAATACCTTGGCTGATGTTGCAGCCTGCAGCAAGTGCTTCCGTCTCCGGAATCCTTGGGGAGCACTTGTCCACGTCT
TTTCTCATATCATGGTAGTCACTAACATATATAAGGTATGTGCTATTGGCCCAGCTTTTAGAAAATGCAGTCATTTTTCTAAATAAAAAG
GAAGTACTGCACCCAGCAGTGTCACTCTGTAGTTACTGTGGTCACTTGTACCATATAGAGGTGTAACACTTGTCAAGAAGCGTTATGTGC
AGTACTTAATGTTTGTAAGACTTACAAAAAAAGATTTAAAGTGGCAGCTTCACTCGACATTTGGTGAGAGAAGTACAAAGGTTGCAGTGC
TGAGCTGTGGGCGGTTTCTGGGGATGTCCCAGGGTGGAACTCCACATGCTGGTGCATATACGCCCTTGAGCTACTTCAAATGTGGGTGTT
TCAGTAACCACGTTCCATGCCTGAGGATTTAGCAGAGAGGAACACTGCGTCTTTAAATGAGAAAGTATACAATTCTTTTTCCTTCTACAG
CATGTCAGCATCTCAAGTTCATTTTTCAACCTACAGTATAACAATTTGTAATAAAGCCTCCAGGAGCTCATGACGTGAAGCACTGTTCTG
TCCTCAAGTACTCAAATATTTCTGATACTGCTGAGTCAGACTGTCAGAAAAAGCTAGCACTAACTCGTGTTTGGAGCTCTATCCATATTT
TACTGATCTCTTTAAGTATTTGTTCCTGCCACTGTGTACTGTGGAGTTGACTCGGTGTTCTGTCCCAGTGCGGTGCCTCCTCTTGACTTC
CCCACTGCTCTCTGTGGTGAGAAATTTGCCTTGTTCAATAATTACTGTACCCTCGCATGACTGTTACAGCTTTCTGTGCAGAGATGACTG
TCCAAGTGCCACATGCCTACGATTGAAATGAAAACTCTATTGTTACCTCTGAGTTGTGTTCCACGGAAAATGCTATCCAGCAGATCATTT
AGGAAAAATAATTCTATTTTTAGCTTTTCATTTCTCAGCTGTCCTTTTTTCTTGTTTGATTTTTGACAGCAATGGAGAATGGGTTATATA
AAGACTGCCTGCTAATATGAACAGAAATGCATTTGTAATTCATGAAAATAAATGTACATCTTCTATCTTCACATTCATGTTAAGATTCAG
TGTTGCTTTCCTCTGGATCAGCGTGTCTGAATGGACAGTCAGGTTCAGGTTGTGCTGAACACAGAAATGCTCACAGGCCTCACTTTGCCG
CCCAGGCACTGGCCCAGCACTTGGATTTACATAAGATGAGTTAGAAAGGTACTTCTGTAGGGTCCTTTTTACCTCTGCTCGGCAGAGAAT
CGATGCTGTCATGTTCCTTTATTCACAATCTTAGGTCTCAAATATTCTGTCAAACCCTAACAAAGAAGCCCCGACATCTCAGGTTGGATT
CCCTGGTTCTCTCTAAAGAGGGCCTGCCCTTGTGCCCCAGAGGTGCTGCTGGGCACAGCCAAGAGTTGGGAAGGGCCGCCCCACAGTACG
CAGTCCTCACCACCCAGCCCAGGGTGCTCACGCTCACCACTCCTGTGGCTGAGGAAGGATAGCTGGCTCATCCTCGGAAAACAGACCCAC
ATCTCTATTCTTGCCCTGAAATACGCGCTTTTCACTTGCGTGCTCAGAGCTGCCGTCTGAAGGTCCACACAGCATTGACGGGACACAGAA
ATGTGACTGTTACCGGATAACACTGATTAGTCAGTTTTCATTTATAAAAAAGCATTGACAGTTTTATTACTCTTGTTTCTTTTTAAATGG
AAAGTTACTATTATAAGGTTAATTTGGAGTCCTCTTCTAAATAGAAAACCATATCCTTGGCTACTAACATCTGGAGACTGTGAGCTCCTT
CCCATTCCCCTTCCTGGTACTGTGGAGTCAGATTGGCATGAAACCACTAACTTCATTCTAGAATCATTGTAGCCATAAGTTGTGTGCTTT
TTATTAATCATGCCAAACATAATGTAACTGGGCAGAGAATGGTCCTAACCAAGGTACCTATGAAAAGCGCTAGCTATCATGTGTAGTAGA
TGCATCATTTTGGCTCTTCTTACATTTGTAAAAATGTACAGATTAGGTCATCTTAATTCATATTAGTGACACGGAACAGCACCTCCACTA
TTTGTATGTTCAAATAAGCTTTCAGACTAATAGCTTTTTTGGTGTCTAAAATGTAAGCAAAAAATTCCTGCTGAAACATTCCAGTCCTTT
CATTTAGTATAAAAGAAATACTGAACAAGCCAGTGGGATGGAATTGAAAGAACTAATCATGAGGACTCTGTCCTGACACAGGTCCTCAAA
GCTAGCAGAGATACGCAGACATTGTGGCATCTGGGTAGAAGAATACTGTATTGTGTGTGCAGTGCACAGTGTGTGGTGTGTGCACACTCA
TTCCTTCTGCTCTTGGGCACAGGCAGTGGGTGTAGAGGTAACCAGTAGCTTTGAGAAGCTACATGTAGCTCACCAGTGGTTTTCTCTAAG
GAATCACAAAAGTAAACTACCCAACCACATGCCACGTAATATTTCAGCCATTCAGAGGAAACTGTTTTCTCTTTATTTGCTTATATGTTA
ATATGGTTTTTAAATTGGTAACTTTTATATAGTATGGTAACAGTATGTTAATACACACATACATACGCACACATGCTTTGGGTCCTTCCA
TAATACTTTTATATTTGTAAATCAATGTTTTGGAGCAATCCCAAGTTTAAGGGAAATATTTTTGTAAATGTAATGGTTTTGAAAATCTGA
GCAATCCTTTTGCTTATACATTTTTAAAGCATTTGTGCTTTAAAATTGTTATGCTGGTGTTTGAAACATGATACTCCTGTGGTGCAGATG
AGAAGCTATAACAGTGAATATGTGGTTTCTCTTACGTCATCCACCTTGACATGATGGGTCAGAAACAAATGGAAATCCAGAGCAAGTCCT
CCAGGGTTGCACCAGGTTTACCTAAAGCTTGTTGCCTTTTCTTGTGCTGTTTATGCGTGTAGAGCACTCAAGAAAGTTCTGAAACTGCTT
TGTATCTGCTTTGTACTGTTGGTGCCTTCTTGGTATTGTACCCCAAAATTCTGCATAGATTATTTAGTATAATGGTAAGTTAAAAAATGT
TAAAGGAAGATTTTATTAAGAATCTGAATGTTTATTCATTATATTGTTACAATTTAACATTAACATTTATTTGTGGTATTTGTGATTTGG
TTAATCTGTATAAAAATTGTAAGTAGAAAGGTTTATATTTCATCTTAATTCTTTTGATGTTGTAAACGTACTTTTTAAAAGATGGATTAT
TTGAATGTTTATGGCACCTGACTTGTAAAAAAAAAAAACTACAAAAAAATCCTTAGAATCATTAAATTGTGTCCCTGTATTACCAAAATA
ACACAGCACCGTGCATGTATAGTTTAATTGCAGTTTCATCTGTGAAAACGTGAAATTGTCTAGTCCTTCGTTATGTTCCCCAGATGTCTT
CCAGATTTGCTCTGCATGTGGTAACTTGTGTTAGGGCTGTGAGCTGTTCCTCGAGTTGAATGGGGATGTCAGTGCTCCTAGGGTTCTCCA
GGTGGTTCTTCAGACCTTCACCTGTGGGGGGGGGGGTAGGCGGTGCCCACGCCCATCTCCTCATCCTCCTGAACTTCTGCAACCCCACTG
CTGGGCAGACATCCTGGGCAACCCCTTTTTTCAGAGCAAGAAGTCATAAAGATAGGATTTCTTGGACATTTGGTTCTTATCAATATTGGG
CATTATGTAATGACTTATTTACAAAACAAAGATACTGGAAAATGTTTTGGATGTGGTGTTATGGAAAGAGCACAGGCCTTGGACCCATCC
AGCTGGGTTCAGAACTACCCCCTGCTTATAACTGCGGCTGGCTGTGGGCCAGTCATTCTGCGTCTCTGCTTTCTTCCTCTGCTTCAGACT
GTCAGCTGTAAAGTGGAAGCAATATTACTTGCCTTGTATATGGTAAAGATTATAAAAATACATTTCAACTGTTCAGCATAGTACTTCAAA
GCAAGTACTCAGTAAATAGCAAGTCTTTTTAAATGCTGCTTTATTTCACTAAATTTTGTTGTGAGGTGTCACTAAAATGCCTGCAAACAA
ACGTAACTGCTAATCTGAGAGGAAACCCTCTTACTAATCAGAGAAGAAACCCTCCTGTCAGAAACCTTCAGGGAAGTGAGCTGATCACAC
CTAAACTGGGAGTTTGCAATGGGGTATTTGAAGCACTGTGGGAGTATTCCACTGGCCCTCTCCCTGAGAGACTTAACAGTCTTCCCTGTT
GTCCAGATTCTGTATAAGGCAATCAGAATAATCATCTTCCTTGTTCAGCAGAGGAGCCTGGTCCCATTTTCCCCACTTTGTGATGGGCTT
CTCTCAGCGGTAGCTCAGCAGTTCCAGATGGCAGTTTGGACCAGCATCTAGGCTGGCCAGTTCGCTGTGTTTACTTAGAACCAACACGTT
CAGAGCTGGCCTGGACCATCTGAGGGGAACAGGAAACACCCCTAGGCTGTGGAAGCAAGTGCAGACCCCCACCCCCGGCCCTGAAGCCAA
GGGGGCAGGGTTTGGGAGTGGCCAAAGAGAAGCAGTGCAGGGATGGGTTTTCCTAGGGACAGGCTTAGCATTCCTGACTCTAGGAAGAAG
GAGCAGTGAGGCGGAGAAACAGTGGAGGGGATGGTGGCATTGGGCCCCATGGGGCCGAGATGGACACAGGGCTCGTTCTCTTGAGTCTGG
TGCCAAGGACAGCTGAAGACGACATCATTTTCAGGTGGAGAGGAGAGAGTGGAGGGAGATCATGCCCTGTGATGTGTCTTTTGCAGGTGA
AGGTGGGAGACAAGGTCTCTGCTGACGATGAGGCAGAGCCACCGTGAAAGTTGTAATAGGAGGACTGCCCGCCGCTGGAAGGGCCTGCAG
TGACGCTAGGACACCCTCTGCCTGCATGTCACGTTAGCTGGGCTGGGCGAAGTAGAAGACCAAGGGGAAGAGGTGCAGTGGGGAGACCAG
GTGGGATGCAACCACAGGACCAGTGGAGGGGCTGTGGCACGTGGGCGGAGACTGAGTGGCTGGGCATGTGTTGTGGCTGAGCATGTGGTG
TGGGCAGTGGTCCTAGACCCCGCCATGTCCGGACAATGATATAGAGCGTCTCAGCATCGCCAGTCTAGACTGTCTATGGAGAGCAGAAAG
TTGTCTGGGGCTGCCTGGGGAACTGTGAGGCCAGCTATATCACCGTCGCTGATGGTGACATTACGGTGGTGGCAGGAGCAAGGAGAGAGG
GAAGAAGGACCCCGTCCAGCTTTAGTCACAAAATACCCAATGGAAGATGCCAGTGCCAATCCTGTGGGTTTCCTTGGGACTTCACACTGG
CTTTCTTATCTGCTCCAGATCCATTCAGTAGTCACTGAGTTCCTGCCAAATACTTTGTAGCGCCAGAAGCCAGGAGCGGGGTCTGCAGCA
GGGCAGTCCCCATTTTCAGGAAATGCCTGGAGCTGCTGGTCCCTGAGAGAAAGGAAAACATCTTTCAGCCGTACGCAGGCCAAGAAGGCC
AATGTCCAGTAGCTTTGTGATTTTTTTTATATTTTTTTATTTATTTATTTTTGAGATAGAGTCTTGCTCTGTCGCTCAGGCTGGAGTGCA
GTGGCGTGATCTCCACTCACTGCAACTTCCGCCTCCTGGGGTCAAGCAGTTCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCACAC
GCCACCACACCCAGCTAATTTTTGTGTTTTTAGTAGAGACGGTTTCACCATGTCGGCCAGGCTGGTCTCAAACTCCTGACCTCAGATGAT
TCAGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACTGCACCCAGCCTGTGATGTTTCTGTGGGGTTCCACAAATGTGTGTGTGTGT
AAAAGCTGATGATTACAGCAAGAATGTGAACAGTAGCAGTTTTCCATTTGAAGGCAAGTTTTGTCTTTATCTGGGTATCAGAAGGACCCT
CTGGGCCATTGTCGCTTCCTGTACTCAGAGCCACCCTAGTACTACGGGCACACACAGAAAACAGCAGCCTGCGTACTTTCAAAGGAAAGG
CATCTTTAATCACCAATGCCTGGAAAAATTATTTTGTTTCCCTCTTCCTTCCGTCTTGTTTCCTAACTTCTTACCAAAGTTTAGAGTCTG
AGTTTTTCGTATAATAATGTCCCACATCCACACATCGGGCCTACAGATGCTCTCCCTTGAATCGACTGGAAACATGACACCGGTTCCATG
CTCTGGAACTGTCACCTGTGATGTGCTGGGCTGTGTCCCAAGCACAGGAATCCCAGCAGTTTCAGCTCGATGCAGAACCACCATGCTCCA
GACACAGGCTTGGGAAAGACACGTCAAAATTAAAATACTAGGTAAGAGAAGCACCTGATTGGGTAGAAGTTGGAGAGGAATCCTGGAATT
TTGTGGCCAGAAGGAGCCACTGCCCCTTTTGTTTAGTAAGACTAGACAGTAACAGAAGCCAGTTGTCAGCTATGAAAGTGGTGGGTGAAG
CAGGGGAGGCTCCTCTATGGTGGGACCCTGGACAAGGGAAGCCGAATGTGTGAAGAAGGGGTGCGGGGGTGTGCGGTGCCCTAGGACACT
AGGGCAAAGGTTTCAAACCTGGAACAAGGCACTGGAGGAAGATCTGCTGCCAGTCAGCAGTGCGGGCCCTCGAGTTAGCAGTCCGTGCGC
AGAGGGGCCAGTTCTGAGACCAGTTTGGAGAGTCAGGCAGTGACCCATTGGCCATGTCATAATTCCTTCAGCCTGCCTCCTCTTTAATCC
CAGAGAGTGCTCTTTCTTCATACTTCCTTTAAAATACTAAATTGTTCCCATTCCATGGGGAGCTGGCTAGGCTTTACAGGCTAGGAAATG
TAGGTTTTCTGAGATGGAACCATCTACACAAGGAGGAGGAAGGCACTAAGACTACAGATGAGACCCATGACAGGGCTGAGCATTTGGAAG
CCAACCCTGGTTGCTTTTCAAGAATTGCTTTGTGGCTGGGTGCAGTGGTTCACACCTGTAATTGCAGCACTTTGGGAGGCTGAGGCAGGT
GGATTGCTTGAACCCAGGAGTTCGAGACCAGCCTGGGCAACATATGGGACACCCCACCGCCCCCGGCTCTGCAAAAAAATTAAAAATTAG
CCAGGCGTGGTGTCATGAGCCTGTGGTCTCAACTACTCAGGAGGCTGAGGCTGGAGGATCGCTTGAACCTGGGAGGTCAAGGCTCCAGTG
AACCATAATTGTGCCACTGCACTGCAGCCTGGGCGACAATTTGTTTTCTAAATTGCTTTTGAAAGTCTACTGCATTACATATTCCAAAAA
GCAGTGGTTTTCAAATACTTTTATCACCGATATCCTTTTATGAAATGAAATCAGTAGAACTTTCTCTGCTCTGAATAAGCAAGGGTGGGA
ACCTGTCTACCTCCCACAGATAGCATAATGTGCCTGCCATAGAGGAGCCAAAAAATGGTGATGGGAACTGAGAGGAGAGCAAATGTCACA
AAAGACTGAGCAATTGAGAAAACAAAACAAGACCACAGATGACTGTTAACGCCTCCACAGTGGACCAAGAAAGGACAGAGAGCTGGCAGC
ATGGGCATCACTGTCTGGTCGGCAGCAGGAAGGCCTCGCTAGGGAATTGAGTACAGTCATCTAACTAGTTTAAAAGTACAGGAAGGATGA
TTAAGGCTATTGGAGAGGTCATACAAATAGGGGAGGGGCAGGCAATGGCTGATAAGACATGAATTTGTAAGGCGATGAGTATTGCAGTCA
GCAAAACAAACGAGACTGCTCTCCCAACACATAACTCAGCAGGGAGGCCAGGCATTGGTTTAACCATTTAATATAAAGAAGTTAAAATTA
CAAATGCGCTAAGTGCCTAAAGAAGAATAAGTGCAGGAATGAGAGCAGCATGGACTGCCACAGTTTTAGAATAAGCACTGTCACTGCTAG
ATTGGAAACAAAAATCCATAAATTTGGCCCGGTGTGGTGGCGGACGCCTGTAGTCCCAGCTACTTGGAGGCTGAGGCGTGAGAATCGCTT
GAACCCGGGAGGCGGAGGTTGCAGTGAGCCGAGATGGCGCCACTGCACTCCAGCCTGGGCGTCAGAGTGAGAACTCTGTATCAAAAAATA
AAAATAAAAAAAAGTCCATAAATCTGCAATGTCTCAGTTAAGAAAGAAAGACTGGGCCAATGCAGATTTCAAACCGGAGAAAGTCATACT
GTCAGTGAAGGCCGCCTGTGGCCGGAAGGCGCCAGGGGATTAGCACCCTGGACTCAGTGTTGCTGGGAAACAGGGCCCCAAGGCTGGGAG
CACAGTGTTTAAAGGGCATCTACCCAAGAAGGGAGCACAGGGCAAGGAGGAGCTGCAGGGGGGCTTGGCTGCCAAAGTGAATTCTGAGGA
GAGAGCTATTGCTGCCTACGATATGCAGGCTGCACAGAACACAAGTGGAATCAGCAGGCAGGAGAGGCAGCTAACGACGCAGCCCGTTTC
TTATTTCTGTTTTCTCACAAGCGATGAAAGTGGAAAAGAGGGTGAGCAGGTGGCCCACACATGTGCCTCCAGTGCTGCGGCCCCTCCGGG
GACCATCAGCCAGGCCCCGGGGAGGGAGCCAGCCACAGTGTGTCCGGCTCTTCTCTGAAGGGAAGAGAGCCTTGAATAGACTGAAGCGAA
GACGGTTCTGCAAGGACAAGGCAGACCGAAGGCATTGGTTTTTTTTTTCAGATAAGGAGAATTAGACTCCCAAGTAGACACCAGAGTCAC
TGTTTGGTTGGTGGGTGATAGTGGGGTCACAGTGGCTGCCTGTGCTCCCCCAGGGTGAGCGTGACTGTGCTAACCTGGGTGGGGCAGCAT
GCACACCCCTCTGGCAGCCCTTTGTTGCTCGCTGATGACAAGTTTGGATGATCCCGCCAAACAGCTTGCTAAGATGTAGTCCCCAGTGTT
GGAGGTGGGGCCTGATGGGAGGTGCTACCCTTGTGAGATAAGGTTGTGTAAAAGCCTGTGGCACCTCCCCACACTGACGCTCTCACCCCT
GCTCTGGCCATGTGCCGCGCCTGCTCCCACTTCCCCTTCTGCCAGGAGTAAAAGCCCCCGAGACCTCCCAGAAGCCAAGCAGATGCTAGT

>In-frame_SHANK3_ENST00000445220_chr22_51115121_+_MAPK1_ENST00000398822_chr22_22153417_-_1094nt
ATGGACGGCCCCGGGGCCAGCGCCGTGGTCGTGCGCGTCGGCATCCCGGACCTGCAGCAGACGAAGTGCCTGCGCCTGGACCCGGCCGCG
CCCGTGTGGGCCGCCAAGCAGCGCGTGCTCTGCGCCCTCAACCACAGCCTCCAGGACGCGCTCAACTATGGGCTTTTCCAGCCGCCCTCC
CGGGGCCGCGCCGGCAAGTTCCTGGATGAGGAGCGGCTCCTGCAGGAGTACCCGCCCAACCTGGACACGCCCCTGCCCTACCTGGAGTTT
CGATACAAGCGGCGAGTTTATGCCCAGAACCTCATCGATGATAAGCAGTTTGCAAAGCTTCACACAAAGATCTGTGACTTTGGCCTGGCC
CGTGTTGCAGATCCAGACCATGATCACACAGGGTTCCTGACAGAATATGTGGCCACACGTTGGTACAGGGCTCCAGAAATTATGTTGAAT
TCCAAGGGCTACACCAAGTCCATTGATATTTGGTCTGTAGGCTGCATTCTGGCAGAAATGCTTTCTAACAGGCCCATCTTTCCAGGGAAG
CATTATCTTGACCAGCTGAACCACATTTTGGGTATTCTTGGATCCCCATCACAAGAAGACCTGAATTGTATAATAAATTTAAAAGCTAGG
AACTATTTGCTTTCTCTTCCACACAAAAATAAGGTGCCATGGAACAGGCTGTTCCCAAATGCTGACTCCAAAGCTCTGGACTTATTGGAC
AAAATGTTGACATTCAACCCACACAAGAGGATTGAAGTAGAACAGGCTCTGGCCCACCCATATCTGGAGCAGTATTACGACCCGAGTGAC
GAGCCCATCGCCGAAGCACCATTCAAGTTCGACATGGAATTGGATGACTTGCCTAAGGAAAAGCTCAAAGAACTAATTTTTGAAGAGACT
GCTAGATTCCAGCCAGGATACAGATCTTAAATTTGTCAGGTACCTGGAGTTTAATACAGTGAGCTCTAGCAAGGGAGGCGCTGCCTTTTG
TTTCTAGAATATTATGTTCCTCAAGGTCCATTATTTTGTATTCTTTTCCAAGCTCCTTATTGGAAGGTATTTTTTTAAATTTAGAATTAA

>In-frame_SHANK3_ENST00000445220_chr22_51115121_+_MAPK1_ENST00000544786_chr22_22153417_-_798nt
ATGGACGGCCCCGGGGCCAGCGCCGTGGTCGTGCGCGTCGGCATCCCGGACCTGCAGCAGACGAAGTGCCTGCGCCTGGACCCGGCCGCG
CCCGTGTGGGCCGCCAAGCAGCGCGTGCTCTGCGCCCTCAACCACAGCCTCCAGGACGCGCTCAACTATGGGCTTTTCCAGCCGCCCTCC
CGGGGCCGCGCCGGCAAGTTCCTGGATGAGGAGCGGCTCCTGCAGGAGTACCCGCCCAACCTGGACACGCCCCTGCCCTACCTGGAGTTT
CGATACAAGCGGCGAGTTTATGCCCAGAACCTCATCGATGATAAGCAGTTTGCAAAGCTTCACACAAAGATCTGTGACTTTGGCCTGGCC
CGTGTTGCAGATCCAGACCATGATCACACAGGGTTCCTGACAGAATATGTGGCCACACGTTGGTACAGGGCTCCAGAAATTATGTTGAAT
TCCAAGGGCTACACCAAGTCCATTGATATTTGGTCTGTAGGCTGCATTCTGGCAGAAATGCTTTCTAACAGGCCCATCTTTCCAGGGAAG
CATTATCTTGACCAGCTGAACCACATTTTGGCTCTGGACTTATTGGACAAAATGTTGACATTCAACCCACACAAGAGGATTGAAGTAGAA
CAGGCTCTGGCCCACCCATATCTGGAGCAGTATTACGACCCGAGTGACGAGCCCATCGCCGAAGCACCATTCAAGTTCGACATGGAATTG

>In-frame_SHANK3_ENST00000262795_chr22_51115121_+_MAPK1_ENST00000215832_chr22_22153417_-_10680nt
ATGGACGGCCCCGGGGCCAGCGCCGTGGTCGTGCGCGTCGGCATCCCGGACCTGCAGCAGACGAAGTGCCTGCGCCTGGACCCGGCCGCG
CCCGTGTGGGCCGCCAAGCAGCGCGTGCTCTGCGCCCTCAACCACAGCCTCCAGGACGCGCTCAACTATGGGCTTTTCCAGCCGCCCTCC
CGGGGCCGCGCCGGCAAGTTCCTGGATGAGGAGCGGCTCCTGCAGGAGTACCCGCCCAACCTGGACACGCCCCTGCCCTACCTGGAGTTT
CGATACAAGCGGCGAGTTTATGCCCAGAACCTCATCGATGATAAGCAGTTTGCAAAGCTTCACACAAAGATCTGTGACTTTGGCCTGGCC
CGTGTTGCAGATCCAGACCATGATCACACAGGGTTCCTGACAGAATATGTGGCCACACGTTGGTACAGGGCTCCAGAAATTATGTTGAAT
TCCAAGGGCTACACCAAGTCCATTGATATTTGGTCTGTAGGCTGCATTCTGGCAGAAATGCTTTCTAACAGGCCCATCTTTCCAGGGAAG
CATTATCTTGACCAGCTGAACCACATTTTGGGTATTCTTGGATCCCCATCACAAGAAGACCTGAATTGTATAATAAATTTAAAAGCTAGG
AACTATTTGCTTTCTCTTCCACACAAAAATAAGGTGCCATGGAACAGGCTGTTCCCAAATGCTGACTCCAAAGCTCTGGACTTATTGGAC
AAAATGTTGACATTCAACCCACACAAGAGGATTGAAGTAGAACAGGCTCTGGCCCACCCATATCTGGAGCAGTATTACGACCCGAGTGAC
GAGCCCATCGCCGAAGCACCATTCAAGTTCGACATGGAATTGGATGACTTGCCTAAGGAAAAGCTCAAAGAACTAATTTTTGAAGAGACT
GCTAGATTCCAGCCAGGATACAGATCTTAAATTTGTCAGGACAAGGGCTCAGAGGACTGGACGTGCTCAGACATCGGTGTTCTTCTTCCC
AGTTCTTGACCCCTGGTCCTGTCTCCAGCCCGTCTTGGCTTATCCACTTTGACTCCTTTGAGCCGTTTGGAGGGGCGGTTTCTGGTAGTT
GTGGCTTTTATGCTTTCAAAGAATTTCTTCAGTCCAGAGAATTCCTCCTGGCAGCCCTGTGTGTGTCACCCATTGGTGACCTGCGGCAGT
ATGTACTTCAGTGCACCTACTGCTTACTGTTGCTTTAGTCACTAATTGCTTTCTGGTTTGAAAGATGCAGTGGTTCCTCCCTCTCCTGAA
TCCTTTTCTACATGATGCCCTGCTGACCATGCAGCCGCACCAGAGAGAGATTCTTCCCCAATTGGCTCTAGTCACTGGCATCTCACTTTA
TGATAGGGAAGGCTACTACCTAGGGCACTTTAAGTCAGTGACAGCCCCTTATTTGCACTTCACCTTTTGACCATAACTGTTTCCCCAGAG
CAGGAGCTTGTGGAAATACCTTGGCTGATGTTGCAGCCTGCAGCAAGTGCTTCCGTCTCCGGAATCCTTGGGGAGCACTTGTCCACGTCT
TTTCTCATATCATGGTAGTCACTAACATATATAAGGTATGTGCTATTGGCCCAGCTTTTAGAAAATGCAGTCATTTTTCTAAATAAAAAG
GAAGTACTGCACCCAGCAGTGTCACTCTGTAGTTACTGTGGTCACTTGTACCATATAGAGGTGTAACACTTGTCAAGAAGCGTTATGTGC
AGTACTTAATGTTTGTAAGACTTACAAAAAAAGATTTAAAGTGGCAGCTTCACTCGACATTTGGTGAGAGAAGTACAAAGGTTGCAGTGC
TGAGCTGTGGGCGGTTTCTGGGGATGTCCCAGGGTGGAACTCCACATGCTGGTGCATATACGCCCTTGAGCTACTTCAAATGTGGGTGTT
TCAGTAACCACGTTCCATGCCTGAGGATTTAGCAGAGAGGAACACTGCGTCTTTAAATGAGAAAGTATACAATTCTTTTTCCTTCTACAG
CATGTCAGCATCTCAAGTTCATTTTTCAACCTACAGTATAACAATTTGTAATAAAGCCTCCAGGAGCTCATGACGTGAAGCACTGTTCTG
TCCTCAAGTACTCAAATATTTCTGATACTGCTGAGTCAGACTGTCAGAAAAAGCTAGCACTAACTCGTGTTTGGAGCTCTATCCATATTT
TACTGATCTCTTTAAGTATTTGTTCCTGCCACTGTGTACTGTGGAGTTGACTCGGTGTTCTGTCCCAGTGCGGTGCCTCCTCTTGACTTC
CCCACTGCTCTCTGTGGTGAGAAATTTGCCTTGTTCAATAATTACTGTACCCTCGCATGACTGTTACAGCTTTCTGTGCAGAGATGACTG
TCCAAGTGCCACATGCCTACGATTGAAATGAAAACTCTATTGTTACCTCTGAGTTGTGTTCCACGGAAAATGCTATCCAGCAGATCATTT
AGGAAAAATAATTCTATTTTTAGCTTTTCATTTCTCAGCTGTCCTTTTTTCTTGTTTGATTTTTGACAGCAATGGAGAATGGGTTATATA
AAGACTGCCTGCTAATATGAACAGAAATGCATTTGTAATTCATGAAAATAAATGTACATCTTCTATCTTCACATTCATGTTAAGATTCAG
TGTTGCTTTCCTCTGGATCAGCGTGTCTGAATGGACAGTCAGGTTCAGGTTGTGCTGAACACAGAAATGCTCACAGGCCTCACTTTGCCG
CCCAGGCACTGGCCCAGCACTTGGATTTACATAAGATGAGTTAGAAAGGTACTTCTGTAGGGTCCTTTTTACCTCTGCTCGGCAGAGAAT
CGATGCTGTCATGTTCCTTTATTCACAATCTTAGGTCTCAAATATTCTGTCAAACCCTAACAAAGAAGCCCCGACATCTCAGGTTGGATT
CCCTGGTTCTCTCTAAAGAGGGCCTGCCCTTGTGCCCCAGAGGTGCTGCTGGGCACAGCCAAGAGTTGGGAAGGGCCGCCCCACAGTACG
CAGTCCTCACCACCCAGCCCAGGGTGCTCACGCTCACCACTCCTGTGGCTGAGGAAGGATAGCTGGCTCATCCTCGGAAAACAGACCCAC
ATCTCTATTCTTGCCCTGAAATACGCGCTTTTCACTTGCGTGCTCAGAGCTGCCGTCTGAAGGTCCACACAGCATTGACGGGACACAGAA
ATGTGACTGTTACCGGATAACACTGATTAGTCAGTTTTCATTTATAAAAAAGCATTGACAGTTTTATTACTCTTGTTTCTTTTTAAATGG
AAAGTTACTATTATAAGGTTAATTTGGAGTCCTCTTCTAAATAGAAAACCATATCCTTGGCTACTAACATCTGGAGACTGTGAGCTCCTT
CCCATTCCCCTTCCTGGTACTGTGGAGTCAGATTGGCATGAAACCACTAACTTCATTCTAGAATCATTGTAGCCATAAGTTGTGTGCTTT
TTATTAATCATGCCAAACATAATGTAACTGGGCAGAGAATGGTCCTAACCAAGGTACCTATGAAAAGCGCTAGCTATCATGTGTAGTAGA
TGCATCATTTTGGCTCTTCTTACATTTGTAAAAATGTACAGATTAGGTCATCTTAATTCATATTAGTGACACGGAACAGCACCTCCACTA
TTTGTATGTTCAAATAAGCTTTCAGACTAATAGCTTTTTTGGTGTCTAAAATGTAAGCAAAAAATTCCTGCTGAAACATTCCAGTCCTTT
CATTTAGTATAAAAGAAATACTGAACAAGCCAGTGGGATGGAATTGAAAGAACTAATCATGAGGACTCTGTCCTGACACAGGTCCTCAAA
GCTAGCAGAGATACGCAGACATTGTGGCATCTGGGTAGAAGAATACTGTATTGTGTGTGCAGTGCACAGTGTGTGGTGTGTGCACACTCA
TTCCTTCTGCTCTTGGGCACAGGCAGTGGGTGTAGAGGTAACCAGTAGCTTTGAGAAGCTACATGTAGCTCACCAGTGGTTTTCTCTAAG
GAATCACAAAAGTAAACTACCCAACCACATGCCACGTAATATTTCAGCCATTCAGAGGAAACTGTTTTCTCTTTATTTGCTTATATGTTA
ATATGGTTTTTAAATTGGTAACTTTTATATAGTATGGTAACAGTATGTTAATACACACATACATACGCACACATGCTTTGGGTCCTTCCA
TAATACTTTTATATTTGTAAATCAATGTTTTGGAGCAATCCCAAGTTTAAGGGAAATATTTTTGTAAATGTAATGGTTTTGAAAATCTGA
GCAATCCTTTTGCTTATACATTTTTAAAGCATTTGTGCTTTAAAATTGTTATGCTGGTGTTTGAAACATGATACTCCTGTGGTGCAGATG
AGAAGCTATAACAGTGAATATGTGGTTTCTCTTACGTCATCCACCTTGACATGATGGGTCAGAAACAAATGGAAATCCAGAGCAAGTCCT
CCAGGGTTGCACCAGGTTTACCTAAAGCTTGTTGCCTTTTCTTGTGCTGTTTATGCGTGTAGAGCACTCAAGAAAGTTCTGAAACTGCTT
TGTATCTGCTTTGTACTGTTGGTGCCTTCTTGGTATTGTACCCCAAAATTCTGCATAGATTATTTAGTATAATGGTAAGTTAAAAAATGT
TAAAGGAAGATTTTATTAAGAATCTGAATGTTTATTCATTATATTGTTACAATTTAACATTAACATTTATTTGTGGTATTTGTGATTTGG
TTAATCTGTATAAAAATTGTAAGTAGAAAGGTTTATATTTCATCTTAATTCTTTTGATGTTGTAAACGTACTTTTTAAAAGATGGATTAT
TTGAATGTTTATGGCACCTGACTTGTAAAAAAAAAAAACTACAAAAAAATCCTTAGAATCATTAAATTGTGTCCCTGTATTACCAAAATA
ACACAGCACCGTGCATGTATAGTTTAATTGCAGTTTCATCTGTGAAAACGTGAAATTGTCTAGTCCTTCGTTATGTTCCCCAGATGTCTT
CCAGATTTGCTCTGCATGTGGTAACTTGTGTTAGGGCTGTGAGCTGTTCCTCGAGTTGAATGGGGATGTCAGTGCTCCTAGGGTTCTCCA
GGTGGTTCTTCAGACCTTCACCTGTGGGGGGGGGGGTAGGCGGTGCCCACGCCCATCTCCTCATCCTCCTGAACTTCTGCAACCCCACTG
CTGGGCAGACATCCTGGGCAACCCCTTTTTTCAGAGCAAGAAGTCATAAAGATAGGATTTCTTGGACATTTGGTTCTTATCAATATTGGG
CATTATGTAATGACTTATTTACAAAACAAAGATACTGGAAAATGTTTTGGATGTGGTGTTATGGAAAGAGCACAGGCCTTGGACCCATCC
AGCTGGGTTCAGAACTACCCCCTGCTTATAACTGCGGCTGGCTGTGGGCCAGTCATTCTGCGTCTCTGCTTTCTTCCTCTGCTTCAGACT
GTCAGCTGTAAAGTGGAAGCAATATTACTTGCCTTGTATATGGTAAAGATTATAAAAATACATTTCAACTGTTCAGCATAGTACTTCAAA
GCAAGTACTCAGTAAATAGCAAGTCTTTTTAAATGCTGCTTTATTTCACTAAATTTTGTTGTGAGGTGTCACTAAAATGCCTGCAAACAA
ACGTAACTGCTAATCTGAGAGGAAACCCTCTTACTAATCAGAGAAGAAACCCTCCTGTCAGAAACCTTCAGGGAAGTGAGCTGATCACAC
CTAAACTGGGAGTTTGCAATGGGGTATTTGAAGCACTGTGGGAGTATTCCACTGGCCCTCTCCCTGAGAGACTTAACAGTCTTCCCTGTT
GTCCAGATTCTGTATAAGGCAATCAGAATAATCATCTTCCTTGTTCAGCAGAGGAGCCTGGTCCCATTTTCCCCACTTTGTGATGGGCTT
CTCTCAGCGGTAGCTCAGCAGTTCCAGATGGCAGTTTGGACCAGCATCTAGGCTGGCCAGTTCGCTGTGTTTACTTAGAACCAACACGTT
CAGAGCTGGCCTGGACCATCTGAGGGGAACAGGAAACACCCCTAGGCTGTGGAAGCAAGTGCAGACCCCCACCCCCGGCCCTGAAGCCAA
GGGGGCAGGGTTTGGGAGTGGCCAAAGAGAAGCAGTGCAGGGATGGGTTTTCCTAGGGACAGGCTTAGCATTCCTGACTCTAGGAAGAAG
GAGCAGTGAGGCGGAGAAACAGTGGAGGGGATGGTGGCATTGGGCCCCATGGGGCCGAGATGGACACAGGGCTCGTTCTCTTGAGTCTGG
TGCCAAGGACAGCTGAAGACGACATCATTTTCAGGTGGAGAGGAGAGAGTGGAGGGAGATCATGCCCTGTGATGTGTCTTTTGCAGGTGA
AGGTGGGAGACAAGGTCTCTGCTGACGATGAGGCAGAGCCACCGTGAAAGTTGTAATAGGAGGACTGCCCGCCGCTGGAAGGGCCTGCAG
TGACGCTAGGACACCCTCTGCCTGCATGTCACGTTAGCTGGGCTGGGCGAAGTAGAAGACCAAGGGGAAGAGGTGCAGTGGGGAGACCAG
GTGGGATGCAACCACAGGACCAGTGGAGGGGCTGTGGCACGTGGGCGGAGACTGAGTGGCTGGGCATGTGTTGTGGCTGAGCATGTGGTG
TGGGCAGTGGTCCTAGACCCCGCCATGTCCGGACAATGATATAGAGCGTCTCAGCATCGCCAGTCTAGACTGTCTATGGAGAGCAGAAAG
TTGTCTGGGGCTGCCTGGGGAACTGTGAGGCCAGCTATATCACCGTCGCTGATGGTGACATTACGGTGGTGGCAGGAGCAAGGAGAGAGG
GAAGAAGGACCCCGTCCAGCTTTAGTCACAAAATACCCAATGGAAGATGCCAGTGCCAATCCTGTGGGTTTCCTTGGGACTTCACACTGG
CTTTCTTATCTGCTCCAGATCCATTCAGTAGTCACTGAGTTCCTGCCAAATACTTTGTAGCGCCAGAAGCCAGGAGCGGGGTCTGCAGCA
GGGCAGTCCCCATTTTCAGGAAATGCCTGGAGCTGCTGGTCCCTGAGAGAAAGGAAAACATCTTTCAGCCGTACGCAGGCCAAGAAGGCC
AATGTCCAGTAGCTTTGTGATTTTTTTTATATTTTTTTATTTATTTATTTTTGAGATAGAGTCTTGCTCTGTCGCTCAGGCTGGAGTGCA
GTGGCGTGATCTCCACTCACTGCAACTTCCGCCTCCTGGGGTCAAGCAGTTCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCACAC
GCCACCACACCCAGCTAATTTTTGTGTTTTTAGTAGAGACGGTTTCACCATGTCGGCCAGGCTGGTCTCAAACTCCTGACCTCAGATGAT
TCAGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACTGCACCCAGCCTGTGATGTTTCTGTGGGGTTCCACAAATGTGTGTGTGTGT
AAAAGCTGATGATTACAGCAAGAATGTGAACAGTAGCAGTTTTCCATTTGAAGGCAAGTTTTGTCTTTATCTGGGTATCAGAAGGACCCT
CTGGGCCATTGTCGCTTCCTGTACTCAGAGCCACCCTAGTACTACGGGCACACACAGAAAACAGCAGCCTGCGTACTTTCAAAGGAAAGG
CATCTTTAATCACCAATGCCTGGAAAAATTATTTTGTTTCCCTCTTCCTTCCGTCTTGTTTCCTAACTTCTTACCAAAGTTTAGAGTCTG
AGTTTTTCGTATAATAATGTCCCACATCCACACATCGGGCCTACAGATGCTCTCCCTTGAATCGACTGGAAACATGACACCGGTTCCATG
CTCTGGAACTGTCACCTGTGATGTGCTGGGCTGTGTCCCAAGCACAGGAATCCCAGCAGTTTCAGCTCGATGCAGAACCACCATGCTCCA
GACACAGGCTTGGGAAAGACACGTCAAAATTAAAATACTAGGTAAGAGAAGCACCTGATTGGGTAGAAGTTGGAGAGGAATCCTGGAATT
TTGTGGCCAGAAGGAGCCACTGCCCCTTTTGTTTAGTAAGACTAGACAGTAACAGAAGCCAGTTGTCAGCTATGAAAGTGGTGGGTGAAG
CAGGGGAGGCTCCTCTATGGTGGGACCCTGGACAAGGGAAGCCGAATGTGTGAAGAAGGGGTGCGGGGGTGTGCGGTGCCCTAGGACACT
AGGGCAAAGGTTTCAAACCTGGAACAAGGCACTGGAGGAAGATCTGCTGCCAGTCAGCAGTGCGGGCCCTCGAGTTAGCAGTCCGTGCGC
AGAGGGGCCAGTTCTGAGACCAGTTTGGAGAGTCAGGCAGTGACCCATTGGCCATGTCATAATTCCTTCAGCCTGCCTCCTCTTTAATCC
CAGAGAGTGCTCTTTCTTCATACTTCCTTTAAAATACTAAATTGTTCCCATTCCATGGGGAGCTGGCTAGGCTTTACAGGCTAGGAAATG
TAGGTTTTCTGAGATGGAACCATCTACACAAGGAGGAGGAAGGCACTAAGACTACAGATGAGACCCATGACAGGGCTGAGCATTTGGAAG
CCAACCCTGGTTGCTTTTCAAGAATTGCTTTGTGGCTGGGTGCAGTGGTTCACACCTGTAATTGCAGCACTTTGGGAGGCTGAGGCAGGT
GGATTGCTTGAACCCAGGAGTTCGAGACCAGCCTGGGCAACATATGGGACACCCCACCGCCCCCGGCTCTGCAAAAAAATTAAAAATTAG
CCAGGCGTGGTGTCATGAGCCTGTGGTCTCAACTACTCAGGAGGCTGAGGCTGGAGGATCGCTTGAACCTGGGAGGTCAAGGCTCCAGTG
AACCATAATTGTGCCACTGCACTGCAGCCTGGGCGACAATTTGTTTTCTAAATTGCTTTTGAAAGTCTACTGCATTACATATTCCAAAAA
GCAGTGGTTTTCAAATACTTTTATCACCGATATCCTTTTATGAAATGAAATCAGTAGAACTTTCTCTGCTCTGAATAAGCAAGGGTGGGA
ACCTGTCTACCTCCCACAGATAGCATAATGTGCCTGCCATAGAGGAGCCAAAAAATGGTGATGGGAACTGAGAGGAGAGCAAATGTCACA
AAAGACTGAGCAATTGAGAAAACAAAACAAGACCACAGATGACTGTTAACGCCTCCACAGTGGACCAAGAAAGGACAGAGAGCTGGCAGC
ATGGGCATCACTGTCTGGTCGGCAGCAGGAAGGCCTCGCTAGGGAATTGAGTACAGTCATCTAACTAGTTTAAAAGTACAGGAAGGATGA
TTAAGGCTATTGGAGAGGTCATACAAATAGGGGAGGGGCAGGCAATGGCTGATAAGACATGAATTTGTAAGGCGATGAGTATTGCAGTCA
GCAAAACAAACGAGACTGCTCTCCCAACACATAACTCAGCAGGGAGGCCAGGCATTGGTTTAACCATTTAATATAAAGAAGTTAAAATTA
CAAATGCGCTAAGTGCCTAAAGAAGAATAAGTGCAGGAATGAGAGCAGCATGGACTGCCACAGTTTTAGAATAAGCACTGTCACTGCTAG
ATTGGAAACAAAAATCCATAAATTTGGCCCGGTGTGGTGGCGGACGCCTGTAGTCCCAGCTACTTGGAGGCTGAGGCGTGAGAATCGCTT
GAACCCGGGAGGCGGAGGTTGCAGTGAGCCGAGATGGCGCCACTGCACTCCAGCCTGGGCGTCAGAGTGAGAACTCTGTATCAAAAAATA
AAAATAAAAAAAAGTCCATAAATCTGCAATGTCTCAGTTAAGAAAGAAAGACTGGGCCAATGCAGATTTCAAACCGGAGAAAGTCATACT
GTCAGTGAAGGCCGCCTGTGGCCGGAAGGCGCCAGGGGATTAGCACCCTGGACTCAGTGTTGCTGGGAAACAGGGCCCCAAGGCTGGGAG
CACAGTGTTTAAAGGGCATCTACCCAAGAAGGGAGCACAGGGCAAGGAGGAGCTGCAGGGGGGCTTGGCTGCCAAAGTGAATTCTGAGGA
GAGAGCTATTGCTGCCTACGATATGCAGGCTGCACAGAACACAAGTGGAATCAGCAGGCAGGAGAGGCAGCTAACGACGCAGCCCGTTTC
TTATTTCTGTTTTCTCACAAGCGATGAAAGTGGAAAAGAGGGTGAGCAGGTGGCCCACACATGTGCCTCCAGTGCTGCGGCCCCTCCGGG
GACCATCAGCCAGGCCCCGGGGAGGGAGCCAGCCACAGTGTGTCCGGCTCTTCTCTGAAGGGAAGAGAGCCTTGAATAGACTGAAGCGAA
GACGGTTCTGCAAGGACAAGGCAGACCGAAGGCATTGGTTTTTTTTTTCAGATAAGGAGAATTAGACTCCCAAGTAGACACCAGAGTCAC
TGTTTGGTTGGTGGGTGATAGTGGGGTCACAGTGGCTGCCTGTGCTCCCCCAGGGTGAGCGTGACTGTGCTAACCTGGGTGGGGCAGCAT
GCACACCCCTCTGGCAGCCCTTTGTTGCTCGCTGATGACAAGTTTGGATGATCCCGCCAAACAGCTTGCTAAGATGTAGTCCCCAGTGTT
GGAGGTGGGGCCTGATGGGAGGTGCTACCCTTGTGAGATAAGGTTGTGTAAAAGCCTGTGGCACCTCCCCACACTGACGCTCTCACCCCT
GCTCTGGCCATGTGCCGCGCCTGCTCCCACTTCCCCTTCTGCCAGGAGTAAAAGCCCCCGAGACCTCCCAGAAGCCAAGCAGATGCTAGT

>In-frame_SHANK3_ENST00000262795_chr22_51115121_+_MAPK1_ENST00000398822_chr22_22153417_-_1094nt
ATGGACGGCCCCGGGGCCAGCGCCGTGGTCGTGCGCGTCGGCATCCCGGACCTGCAGCAGACGAAGTGCCTGCGCCTGGACCCGGCCGCG
CCCGTGTGGGCCGCCAAGCAGCGCGTGCTCTGCGCCCTCAACCACAGCCTCCAGGACGCGCTCAACTATGGGCTTTTCCAGCCGCCCTCC
CGGGGCCGCGCCGGCAAGTTCCTGGATGAGGAGCGGCTCCTGCAGGAGTACCCGCCCAACCTGGACACGCCCCTGCCCTACCTGGAGTTT
CGATACAAGCGGCGAGTTTATGCCCAGAACCTCATCGATGATAAGCAGTTTGCAAAGCTTCACACAAAGATCTGTGACTTTGGCCTGGCC
CGTGTTGCAGATCCAGACCATGATCACACAGGGTTCCTGACAGAATATGTGGCCACACGTTGGTACAGGGCTCCAGAAATTATGTTGAAT
TCCAAGGGCTACACCAAGTCCATTGATATTTGGTCTGTAGGCTGCATTCTGGCAGAAATGCTTTCTAACAGGCCCATCTTTCCAGGGAAG
CATTATCTTGACCAGCTGAACCACATTTTGGGTATTCTTGGATCCCCATCACAAGAAGACCTGAATTGTATAATAAATTTAAAAGCTAGG
AACTATTTGCTTTCTCTTCCACACAAAAATAAGGTGCCATGGAACAGGCTGTTCCCAAATGCTGACTCCAAAGCTCTGGACTTATTGGAC
AAAATGTTGACATTCAACCCACACAAGAGGATTGAAGTAGAACAGGCTCTGGCCCACCCATATCTGGAGCAGTATTACGACCCGAGTGAC
GAGCCCATCGCCGAAGCACCATTCAAGTTCGACATGGAATTGGATGACTTGCCTAAGGAAAAGCTCAAAGAACTAATTTTTGAAGAGACT
GCTAGATTCCAGCCAGGATACAGATCTTAAATTTGTCAGGTACCTGGAGTTTAATACAGTGAGCTCTAGCAAGGGAGGCGCTGCCTTTTG
TTTCTAGAATATTATGTTCCTCAAGGTCCATTATTTTGTATTCTTTTCCAAGCTCCTTATTGGAAGGTATTTTTTTAAATTTAGAATTAA

>In-frame_SHANK3_ENST00000262795_chr22_51115121_+_MAPK1_ENST00000544786_chr22_22153417_-_798nt
ATGGACGGCCCCGGGGCCAGCGCCGTGGTCGTGCGCGTCGGCATCCCGGACCTGCAGCAGACGAAGTGCCTGCGCCTGGACCCGGCCGCG
CCCGTGTGGGCCGCCAAGCAGCGCGTGCTCTGCGCCCTCAACCACAGCCTCCAGGACGCGCTCAACTATGGGCTTTTCCAGCCGCCCTCC
CGGGGCCGCGCCGGCAAGTTCCTGGATGAGGAGCGGCTCCTGCAGGAGTACCCGCCCAACCTGGACACGCCCCTGCCCTACCTGGAGTTT
CGATACAAGCGGCGAGTTTATGCCCAGAACCTCATCGATGATAAGCAGTTTGCAAAGCTTCACACAAAGATCTGTGACTTTGGCCTGGCC
CGTGTTGCAGATCCAGACCATGATCACACAGGGTTCCTGACAGAATATGTGGCCACACGTTGGTACAGGGCTCCAGAAATTATGTTGAAT
TCCAAGGGCTACACCAAGTCCATTGATATTTGGTCTGTAGGCTGCATTCTGGCAGAAATGCTTTCTAACAGGCCCATCTTTCCAGGGAAG
CATTATCTTGACCAGCTGAACCACATTTTGGCTCTGGACTTATTGGACAAAATGTTGACATTCAACCCACACAAGAGGATTGAAGTAGAA
CAGGCTCTGGCCCACCCATATCTGGAGCAGTATTACGACCCGAGTGACGAGCCCATCGCCGAAGCACCATTCAAGTTCGACATGGAATTG


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FusionGenePPI for SHANK3_MAPK1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SHANK3ARHGEF7, DLGAP1, DLGAP2, DLGAP3, DLGAP4, SPTAN1, PPP1CC, ABCC2, CSNK2B, CRKL, GRB2, NCK1, MAPK1, COPS5, SHANK1, PRMT2MAPK1NEK2, MYC, AR, SORBS3, MAPKAPK2, ATP1A1, FHL2, MKNK2, RPS6KA1, RPS6KA2, CASP9, MAP2K1, MAPK14, ELK1, UBR5, TPR, RPS6KA5, RPS6KA3, ADAM17, PTPN7, MAP2K2, RAF1, INSR, PRKCE, ESR1, PEBP1, PTPRR, PTPN5, SNCG, SNCA, LAMTOR3, MKNK1, VAV1, TSC2, GATA4, IER3, PECAM1, TNIP1, TNKS2, HMMR, STAT5A, DYRK1B, DUSP3, PEA15, CEBPB, ATF2, MAP3K1, DUSP16, SHC1, C1QBP, DUSP1, TOB1, DUSP6, HDAC4, SREBF1, SREBF2, TP53, TH, KRT8, CIITA, JUN, FOS, ALK, CDC25C, MTPN, PGR, ARRB2, JUND, TFCP2, ESR2, ARHGEF2, TOP2A, CENPE, EP300, VDR, HNF4A, RXRA, SFPQ, CCND1, SMAD1, RYK, DCC, AGTR1, PPP1CC, MINOS1, YBX3, YBX1, NUP153, CTSD, GAPDH, ID2, IFI35, GTF2I, ARRB1, TNFRSF1A, TNFRSF25, UBTF, SP1, RARA, CAV1, PTPRE, NCOA3, RPS6KA4, SMAD3, HIST1H2AB, HIST1H4A, VDAC1, RABGEF1, KARS, PARK2, FOXO3, SYNE2, PML, MAPK1, CACYBP, RPTOR, ICK, WDR83, GSTP1, CASP8, EIF4EBP1, BRCA1, MBP, GAB2, GSK3B, MAP2K7, STAB2, HSF4, NTMT1, NEB, HSF1, GORASP2, STAT3, ARHGAP9, IQGAP1, BARD1, ITGB6, ECT2, TP53BP1, NOTCH1, DAPK1, KLF11, VCP, PPP2R5B, PPP2R5C, CAPN2, ADAM15, NOXA1, MAP3K10, LCK, TIAL1, GADD45A, MAP2K4, BRAF, CUEDC2, SQSTM1, CRP, SUPT20H, TNIP2, MTIF3, PRPSAP1, ENAH, GNPTAB, SHANK3, EGLN3, KRAS, PDE4D, MAPK3, MAPK12, PDCD6IP, CEP350, NAV1, HMGB1, DGCR8, HDAC6, MAP2K6, PTGDR, ZC3HC1, HIF1A, CREBBP, TTN, PPARG, CUL7, ABCE1, ATP6V1D, CHEK1, CHEK2, DNAAF5, HNRNPR, ILKAP, ITPK1, DCUN1D1, FERMT2, LMNB2, PFKM, PTPRF, RRM2, XPO6, NTRK1, PAX5, ELK4, BCL2, BANP, ETS1, FGF5, MAPKAPK5, PXN, RET, CITED2, COPS6, MCM2, OTUB1, REST, PLA2G4A, ITGAV, SRC, PRDX6, CSNK2A1, BCL2L11, DUSP2, DUSP4, DUSP9, PTPDC1, DUSP12, DUSP19, DUSP8, PKM, SLC9A3R1, KDR, RMDN3, FH, MTOR, RPS11, STYX, PTTG1, TRIM25, BCL3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SHANK3_MAPK1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneMAPK1P28482DB01064IsoprenalineMitogen-activated protein kinase 1small moleculeapproved|investigational
TgeneMAPK1P28482DB01169Arsenic trioxideMitogen-activated protein kinase 1small moleculeapproved|investigational

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RelatedDiseases for SHANK3_MAPK1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSHANK3C0004352Autistic Disorder2CTD_human
HgeneSHANK3C0023014Language Development Disorders2CTD_human
HgeneSHANK3C1510586Autism Spectrum Disorders2CTD_human
HgeneSHANK3C0008073Developmental Disabilities1CTD_human
HgeneSHANK3C0338831Manic1PSYGENET
HgeneSHANK3C0564408Manic mood1PSYGENET
HgeneSHANK3C185349022q13.3 Deletion Syndrome1ORPHANET;UNIPROT
HgeneSHANK3C3151380SCHIZOPHRENIA 151UNIPROT
HgeneSHANK3C3714756Intellectual Disability1CTD_human
HgeneSHANK3C4048800Telomeric 22q13 Monosomy Syndrome1CTD_human
TgeneMAPK1C0020429Hyperalgesia2CTD_human
TgeneMAPK1C0024121Lung Neoplasms2CTD_human
TgeneMAPK1C0236736Cocaine-Related Disorders2CTD_human
TgeneMAPK1C0005586Bipolar Disorder1PSYGENET
TgeneMAPK1C0007137Squamous cell carcinoma1CTD_human
TgeneMAPK1C0007786Brain Ischemia1CTD_human
TgeneMAPK1C0017639Gliosis1CTD_human
TgeneMAPK1C0018671Head and Neck Neoplasms1CTD_human
TgeneMAPK1C0020564Hypertrophy1CTD_human
TgeneMAPK1C0021361Female infertility1CTD_human
TgeneMAPK1C0022665Kidney Neoplasm1CTD_human
TgeneMAPK1C0027626Neoplasm Invasiveness1CTD_human
TgeneMAPK1C0027627Neoplasm Metastasis1CTD_human
TgeneMAPK1C0027746Nerve Degeneration1CTD_human
TgeneMAPK1C0036341Schizophrenia1PSYGENET
TgeneMAPK1C0036920Sezary Syndrome1CTD_human
TgeneMAPK1C0038356Stomach Neoplasms1CTD_human
TgeneMAPK1C0038587Substance Withdrawal Syndrome1CTD_human
TgeneMAPK1C0040997Trigeminal Neuralgia1CTD_human
TgeneMAPK1C0155862Streptococcal pneumonia1CTD_human
TgeneMAPK1C0178417Anhedonia1PSYGENET
TgeneMAPK1C0243026Sepsis1CTD_human
TgeneMAPK1C0878544Cardiomyopathies1CTD_human
TgeneMAPK1C0919267ovarian neoplasm1CTD_human
TgeneMAPK1C1866282CEROID LIPOFUSCINOSIS, NEURONAL, 61CTD_human
TgeneMAPK1C3495559Juvenile arthritis1CTD_human