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Fusion gene ID: 33735 |
FusionGeneSummary for SHANK3_MAPK1 |
Fusion gene summary |
Fusion gene information | Fusion gene name: SHANK3_MAPK1 | Fusion gene ID: 33735 | Hgene | Tgene | Gene symbol | SHANK3 | MAPK1 | Gene ID | 85358 | 5594 |
Gene name | SH3 and multiple ankyrin repeat domains 3 | mitogen-activated protein kinase 1 | |
Synonyms | DEL22q13.3|PROSAP2|PSAP2|SCZD15|SPANK-2 | ERK|ERK-2|ERK2|ERT1|MAPK2|P42MAPK|PRKM1|PRKM2|p38|p40|p41|p41mapk|p42-MAPK | |
Cytomap | 22q13.33 | 22q11.22 | |
Type of gene | protein-coding | protein-coding | |
Description | SH3 and multiple ankyrin repeat domains protein 3proline rich synapse associated protein 2shank postsynaptic density protein | mitogen-activated protein kinase 1MAP kinase 1MAP kinase 2MAP kinase isoform p42MAPK 2extracellular signal-regulated kinase 2mitogen-activated protein kinase 2protein tyrosine kinase ERK2 | |
Modification date | 20180523 | 20180529 | |
UniProtAcc | P28482 | ||
Ensembl transtripts involved in fusion gene | ENST00000414786, ENST00000445220, ENST00000262795, | ENST00000215832, ENST00000398822, ENST00000544786, ENST00000491588, | |
Fusion gene scores | * DoF score | 8 X 6 X 3=144 | 9 X 6 X 5=270 |
# samples | 7 | 9 | |
** MAII score | log2(7/144*10)=-1.04064198449735 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/270*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: SHANK3 [Title/Abstract] AND MAPK1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. Transcription factor involved fusion gene, inframe and retained DNA-binding domain. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | MAPK1 | GO:0006468 | protein phosphorylation | 23184662 |
Tgene | MAPK1 | GO:0010800 | positive regulation of peptidyl-threonine phosphorylation | 16314496 |
Tgene | MAPK1 | GO:0018105 | peptidyl-serine phosphorylation | 15850461 |
Tgene | MAPK1 | GO:0034198 | cellular response to amino acid starvation | 11096076 |
Tgene | MAPK1 | GO:0038127 | ERBB signaling pathway | 15133037 |
Tgene | MAPK1 | GO:0051403 | stress-activated MAPK cascade | 11096076 |
Tgene | MAPK1 | GO:0070371 | ERK1 and ERK2 cascade | 16314496 |
Tgene | MAPK1 | GO:0070849 | response to epidermal growth factor | 18794356 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | SKCM | TCGA-D3-A1Q3-06A | SHANK3 | chr22 | 51115121 | + | MAPK1 | chr22 | 22153417 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000414786 | ENST00000215832 | SHANK3 | chr22 | 51115121 | + | MAPK1 | chr22 | 22153417 | - |
In-frame | ENST00000414786 | ENST00000398822 | SHANK3 | chr22 | 51115121 | + | MAPK1 | chr22 | 22153417 | - |
In-frame | ENST00000414786 | ENST00000544786 | SHANK3 | chr22 | 51115121 | + | MAPK1 | chr22 | 22153417 | - |
5CDS-intron | ENST00000414786 | ENST00000491588 | SHANK3 | chr22 | 51115121 | + | MAPK1 | chr22 | 22153417 | - |
In-frame | ENST00000445220 | ENST00000215832 | SHANK3 | chr22 | 51115121 | + | MAPK1 | chr22 | 22153417 | - |
In-frame | ENST00000445220 | ENST00000398822 | SHANK3 | chr22 | 51115121 | + | MAPK1 | chr22 | 22153417 | - |
In-frame | ENST00000445220 | ENST00000544786 | SHANK3 | chr22 | 51115121 | + | MAPK1 | chr22 | 22153417 | - |
5CDS-intron | ENST00000445220 | ENST00000491588 | SHANK3 | chr22 | 51115121 | + | MAPK1 | chr22 | 22153417 | - |
In-frame | ENST00000262795 | ENST00000215832 | SHANK3 | chr22 | 51115121 | + | MAPK1 | chr22 | 22153417 | - |
In-frame | ENST00000262795 | ENST00000398822 | SHANK3 | chr22 | 51115121 | + | MAPK1 | chr22 | 22153417 | - |
In-frame | ENST00000262795 | ENST00000544786 | SHANK3 | chr22 | 51115121 | + | MAPK1 | chr22 | 22153417 | - |
5CDS-intron | ENST00000262795 | ENST00000491588 | SHANK3 | chr22 | 51115121 | + | MAPK1 | chr22 | 22153417 | - |
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FusionProtFeatures for SHANK3_MAPK1 |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
SHANK3 | MAPK1 |
Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. | Serine/threonine kinase which acts as an essentialcomponent of the MAP kinase signal transduction pathway.MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an importantrole in the MAPK/ERK cascade. They participate also in a signalingcascade initiated by activated KIT and KITLG/SCF. Depending on thecellular context, the MAPK/ERK cascade mediates diverse biologicalfunctions such as cell growth, adhesion, survival anddifferentiation through the regulation of transcription,translation, cytoskeletal rearrangements. The MAPK/ERK cascadeplays also a role in initiation and regulation of meiosis,mitosis, and postmitotic functions in differentiated cells byphosphorylating a number of transcription factors. About 160substrates have already been discovered for ERKs. Many of thesesubstrates are localized in the nucleus, and seem to participatein the regulation of transcription upon stimulation. However,other substrates are found in the cytosol as well as in othercellular organelles, and those are responsible for processes suchas translation, mitosis and apoptosis. Moreover, the MAPK/ERKcascade is also involved in the regulation of the endosomaldynamics, including lysosome processing and endosome cyclingthrough the perinuclear recycling compartment (PNRC); as well asin the fragmentation of the Golgi apparatus during mitosis. Thesubstrates include transcription factors (such as ATF2, BCL6,ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such asCANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators ofapoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG),regulators of translation (such as EIF4EBP1) and a variety ofother signaling-related molecules (like ARHGEF2, DCC, FRS2 orGRB10). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2,RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2,RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases(such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates whichenable the propagation the MAPK/ERK signal to additional cytosolicand nuclear targets, thereby extending the specificity of thecascade. Mediates phosphorylation of TPR in respons to EGFstimulation. May play a role in the spindle assembly checkpoint.Phosphorylates PML and promotes its interaction with PIN1, leadingto PML degradation. Phosphorylates CDK2AP2 (By similarity).{ECO:0000250|UniProtKB:P63086, ECO:0000269|PubMed:10617468,ECO:0000269|PubMed:10637505, ECO:0000269|PubMed:11154262,ECO:0000269|PubMed:12110590, ECO:0000269|PubMed:12356731,ECO:0000269|PubMed:12792650, ECO:0000269|PubMed:12794087,ECO:0000269|PubMed:12974390, ECO:0000269|PubMed:15184391,ECO:0000269|PubMed:15241487, ECO:0000269|PubMed:15616583,ECO:0000269|PubMed:15664191, ECO:0000269|PubMed:15788397,ECO:0000269|PubMed:15952796, ECO:0000269|PubMed:16581800,ECO:0000269|PubMed:18794356, ECO:0000269|PubMed:19265199,ECO:0000269|PubMed:19879846, ECO:0000269|PubMed:22033920,ECO:0000269|PubMed:7588608, ECO:0000269|PubMed:8622688,ECO:0000269|PubMed:9480836, ECO:0000269|PubMed:9596579,ECO:0000269|PubMed:9649500, ECO:0000269|PubMed:9687510,ECO:0000303|PubMed:15526160, ECO:0000303|PubMed:16393692,ECO:0000303|PubMed:19565474, ECO:0000303|PubMed:21779493}. Acts as a transcriptional repressor. Binds to a[GC]AAA[GC] consensus sequence. Repress the expression ofinterferon gamma-induced genes. Seems to bind to the promoter ofCCL5, DMP1, IFIH1, IFITM1, IRF7, IRF9, LAMP3, OAS1, OAS2, OAS3 andSTAT1. Transcriptional activity is independent of kinase activity.{ECO:0000269|PubMed:19879846}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | >MAPK1 | chr22:51115121 | chr22:22153417 | ENST00000215832 | - | 2 | 9 | 259_277 | 164 | 3486 | DNA binding | . |
Tgene | >MAPK1 | chr22:51115121 | chr22:22153417 | ENST00000398822 | - | 2 | 8 | 259_277 | 164 | 361 | DNA binding | . |
Tgene | >MAPK1 | chr22:51115121 | chr22:22153417 | ENST00000544786 | - | 2 | 7 | 259_277 | 164 | 317 | DNA binding | . |
Tgene | >MAPK1 | chr22:51115121 | chr22:22153417 | ENST00000215832 | - | 2 | 9 | 185_187 | 164 | 3486 | Motif | Note=TXY |
Tgene | >MAPK1 | chr22:51115121 | chr22:22153417 | ENST00000215832 | - | 2 | 9 | 318_322 | 164 | 3486 | Motif | Note=Cytoplasmic retention motif |
Tgene | >MAPK1 | chr22:51115121 | chr22:22153417 | ENST00000215832 | - | 2 | 9 | 327_333 | 164 | 3486 | Motif | Note=Nuclear translocation motif |
Tgene | >MAPK1 | chr22:51115121 | chr22:22153417 | ENST00000398822 | - | 2 | 8 | 185_187 | 164 | 361 | Motif | Note=TXY |
Tgene | >MAPK1 | chr22:51115121 | chr22:22153417 | ENST00000398822 | - | 2 | 8 | 318_322 | 164 | 361 | Motif | Note=Cytoplasmic retention motif |
Tgene | >MAPK1 | chr22:51115121 | chr22:22153417 | ENST00000398822 | - | 2 | 8 | 327_333 | 164 | 361 | Motif | Note=Nuclear translocation motif |
Tgene | >MAPK1 | chr22:51115121 | chr22:22153417 | ENST00000544786 | - | 2 | 7 | 185_187 | 164 | 317 | Motif | Note=TXY |
Tgene | >MAPK1 | chr22:51115121 | chr22:22153417 | ENST00000544786 | - | 2 | 7 | 318_322 | 164 | 317 | Motif | Note=Cytoplasmic retention motif |
Tgene | >MAPK1 | chr22:51115121 | chr22:22153417 | ENST00000544786 | - | 2 | 7 | 327_333 | 164 | 317 | Motif | Note=Nuclear translocation motif |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | MAPK1 | chr22:51115121 | chr22:22153417 | ENST00000215832 | - | 2 | 9 | 2_9 | 164 | 3486 | Compositional bias | Note=Poly-Ala |
Tgene | MAPK1 | chr22:51115121 | chr22:22153417 | ENST00000398822 | - | 2 | 8 | 2_9 | 164 | 361 | Compositional bias | Note=Poly-Ala |
Tgene | MAPK1 | chr22:51115121 | chr22:22153417 | ENST00000544786 | - | 2 | 7 | 2_9 | 164 | 317 | Compositional bias | Note=Poly-Ala |
Tgene | MAPK1 | chr22:51115121 | chr22:22153417 | ENST00000215832 | - | 2 | 9 | 25_313 | 164 | 3486 | Domain | Protein kinase |
Tgene | MAPK1 | chr22:51115121 | chr22:22153417 | ENST00000398822 | - | 2 | 8 | 25_313 | 164 | 361 | Domain | Protein kinase |
Tgene | MAPK1 | chr22:51115121 | chr22:22153417 | ENST00000544786 | - | 2 | 7 | 25_313 | 164 | 317 | Domain | Protein kinase |
Tgene | MAPK1 | chr22:51115121 | chr22:22153417 | ENST00000215832 | - | 2 | 9 | 31_39 | 164 | 3486 | Nucleotide binding | ATP |
Tgene | MAPK1 | chr22:51115121 | chr22:22153417 | ENST00000398822 | - | 2 | 8 | 31_39 | 164 | 361 | Nucleotide binding | ATP |
Tgene | MAPK1 | chr22:51115121 | chr22:22153417 | ENST00000544786 | - | 2 | 7 | 31_39 | 164 | 317 | Nucleotide binding | ATP |
Tgene | MAPK1 | chr22:51115121 | chr22:22153417 | ENST00000215832 | - | 2 | 9 | 105_108 | 164 | 3486 | Region | Note=Inhibitor-binding |
Tgene | MAPK1 | chr22:51115121 | chr22:22153417 | ENST00000215832 | - | 2 | 9 | 153_154 | 164 | 3486 | Region | Note=Inhibitor-binding |
Tgene | MAPK1 | chr22:51115121 | chr22:22153417 | ENST00000398822 | - | 2 | 8 | 105_108 | 164 | 361 | Region | Note=Inhibitor-binding |
Tgene | MAPK1 | chr22:51115121 | chr22:22153417 | ENST00000398822 | - | 2 | 8 | 153_154 | 164 | 361 | Region | Note=Inhibitor-binding |
Tgene | MAPK1 | chr22:51115121 | chr22:22153417 | ENST00000544786 | - | 2 | 7 | 105_108 | 164 | 317 | Region | Note=Inhibitor-binding |
Tgene | MAPK1 | chr22:51115121 | chr22:22153417 | ENST00000544786 | - | 2 | 7 | 153_154 | 164 | 317 | Region | Note=Inhibitor-binding |
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FusionGeneSequence for SHANK3_MAPK1 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_SHANK3_ENST00000414786_chr22_51115121_+_MAPK1_ENST00000215832_chr22_22153417_-_310aa MDGPGASAVVVRVGIPDLQQTKCLRLDPAAPVWAAKQRVLCALNHSLQDALNYGLFQPPSRGRAGKFLDEERLLQEYPPNLDTPLPYLEF RYKRRVYAQNLIDDKQFAKLHTKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGK HYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSD >In-frame_SHANK3_ENST00000414786_chr22_51115121_+_MAPK1_ENST00000398822_chr22_22153417_-_310aa MDGPGASAVVVRVGIPDLQQTKCLRLDPAAPVWAAKQRVLCALNHSLQDALNYGLFQPPSRGRAGKFLDEERLLQEYPPNLDTPLPYLEF RYKRRVYAQNLIDDKQFAKLHTKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGK HYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSD >In-frame_SHANK3_ENST00000414786_chr22_51115121_+_MAPK1_ENST00000544786_chr22_22153417_-_266aa MDGPGASAVVVRVGIPDLQQTKCLRLDPAAPVWAAKQRVLCALNHSLQDALNYGLFQPPSRGRAGKFLDEERLLQEYPPNLDTPLPYLEF RYKRRVYAQNLIDDKQFAKLHTKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGK >In-frame_SHANK3_ENST00000445220_chr22_51115121_+_MAPK1_ENST00000215832_chr22_22153417_-_310aa MDGPGASAVVVRVGIPDLQQTKCLRLDPAAPVWAAKQRVLCALNHSLQDALNYGLFQPPSRGRAGKFLDEERLLQEYPPNLDTPLPYLEF RYKRRVYAQNLIDDKQFAKLHTKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGK HYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSD >In-frame_SHANK3_ENST00000445220_chr22_51115121_+_MAPK1_ENST00000398822_chr22_22153417_-_310aa MDGPGASAVVVRVGIPDLQQTKCLRLDPAAPVWAAKQRVLCALNHSLQDALNYGLFQPPSRGRAGKFLDEERLLQEYPPNLDTPLPYLEF RYKRRVYAQNLIDDKQFAKLHTKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGK HYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSD >In-frame_SHANK3_ENST00000445220_chr22_51115121_+_MAPK1_ENST00000544786_chr22_22153417_-_266aa MDGPGASAVVVRVGIPDLQQTKCLRLDPAAPVWAAKQRVLCALNHSLQDALNYGLFQPPSRGRAGKFLDEERLLQEYPPNLDTPLPYLEF RYKRRVYAQNLIDDKQFAKLHTKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGK >In-frame_SHANK3_ENST00000262795_chr22_51115121_+_MAPK1_ENST00000215832_chr22_22153417_-_310aa MDGPGASAVVVRVGIPDLQQTKCLRLDPAAPVWAAKQRVLCALNHSLQDALNYGLFQPPSRGRAGKFLDEERLLQEYPPNLDTPLPYLEF RYKRRVYAQNLIDDKQFAKLHTKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGK HYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSD >In-frame_SHANK3_ENST00000262795_chr22_51115121_+_MAPK1_ENST00000398822_chr22_22153417_-_310aa MDGPGASAVVVRVGIPDLQQTKCLRLDPAAPVWAAKQRVLCALNHSLQDALNYGLFQPPSRGRAGKFLDEERLLQEYPPNLDTPLPYLEF RYKRRVYAQNLIDDKQFAKLHTKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGK HYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSD >In-frame_SHANK3_ENST00000262795_chr22_51115121_+_MAPK1_ENST00000544786_chr22_22153417_-_266aa MDGPGASAVVVRVGIPDLQQTKCLRLDPAAPVWAAKQRVLCALNHSLQDALNYGLFQPPSRGRAGKFLDEERLLQEYPPNLDTPLPYLEF RYKRRVYAQNLIDDKQFAKLHTKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGK |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_SHANK3_ENST00000414786_chr22_51115121_+_MAPK1_ENST00000215832_chr22_22153417_-_930nt ATGGACGGCCCCGGGGCCAGCGCCGTGGTCGTGCGCGTCGGCATCCCGGACCTGCAGCAGACGAAGTGCCTGCGCCTGGACCCGGCCGCG CCCGTGTGGGCCGCCAAGCAGCGCGTGCTCTGCGCCCTCAACCACAGCCTCCAGGACGCGCTCAACTATGGGCTTTTCCAGCCGCCCTCC CGGGGCCGCGCCGGCAAGTTCCTGGATGAGGAGCGGCTCCTGCAGGAGTACCCGCCCAACCTGGACACGCCCCTGCCCTACCTGGAGTTT CGATACAAGCGGCGAGTTTATGCCCAGAACCTCATCGATGATAAGCAGTTTGCAAAGCTTCACACAAAGATCTGTGACTTTGGCCTGGCC CGTGTTGCAGATCCAGACCATGATCACACAGGGTTCCTGACAGAATATGTGGCCACACGTTGGTACAGGGCTCCAGAAATTATGTTGAAT TCCAAGGGCTACACCAAGTCCATTGATATTTGGTCTGTAGGCTGCATTCTGGCAGAAATGCTTTCTAACAGGCCCATCTTTCCAGGGAAG CATTATCTTGACCAGCTGAACCACATTTTGGGTATTCTTGGATCCCCATCACAAGAAGACCTGAATTGTATAATAAATTTAAAAGCTAGG AACTATTTGCTTTCTCTTCCACACAAAAATAAGGTGCCATGGAACAGGCTGTTCCCAAATGCTGACTCCAAAGCTCTGGACTTATTGGAC AAAATGTTGACATTCAACCCACACAAGAGGATTGAAGTAGAACAGGCTCTGGCCCACCCATATCTGGAGCAGTATTACGACCCGAGTGAC GAGCCCATCGCCGAAGCACCATTCAAGTTCGACATGGAATTGGATGACTTGCCTAAGGAAAAGCTCAAAGAACTAATTTTTGAAGAGACT >In-frame_SHANK3_ENST00000414786_chr22_51115121_+_MAPK1_ENST00000398822_chr22_22153417_-_930nt ATGGACGGCCCCGGGGCCAGCGCCGTGGTCGTGCGCGTCGGCATCCCGGACCTGCAGCAGACGAAGTGCCTGCGCCTGGACCCGGCCGCG CCCGTGTGGGCCGCCAAGCAGCGCGTGCTCTGCGCCCTCAACCACAGCCTCCAGGACGCGCTCAACTATGGGCTTTTCCAGCCGCCCTCC CGGGGCCGCGCCGGCAAGTTCCTGGATGAGGAGCGGCTCCTGCAGGAGTACCCGCCCAACCTGGACACGCCCCTGCCCTACCTGGAGTTT CGATACAAGCGGCGAGTTTATGCCCAGAACCTCATCGATGATAAGCAGTTTGCAAAGCTTCACACAAAGATCTGTGACTTTGGCCTGGCC CGTGTTGCAGATCCAGACCATGATCACACAGGGTTCCTGACAGAATATGTGGCCACACGTTGGTACAGGGCTCCAGAAATTATGTTGAAT TCCAAGGGCTACACCAAGTCCATTGATATTTGGTCTGTAGGCTGCATTCTGGCAGAAATGCTTTCTAACAGGCCCATCTTTCCAGGGAAG CATTATCTTGACCAGCTGAACCACATTTTGGGTATTCTTGGATCCCCATCACAAGAAGACCTGAATTGTATAATAAATTTAAAAGCTAGG AACTATTTGCTTTCTCTTCCACACAAAAATAAGGTGCCATGGAACAGGCTGTTCCCAAATGCTGACTCCAAAGCTCTGGACTTATTGGAC AAAATGTTGACATTCAACCCACACAAGAGGATTGAAGTAGAACAGGCTCTGGCCCACCCATATCTGGAGCAGTATTACGACCCGAGTGAC GAGCCCATCGCCGAAGCACCATTCAAGTTCGACATGGAATTGGATGACTTGCCTAAGGAAAAGCTCAAAGAACTAATTTTTGAAGAGACT >In-frame_SHANK3_ENST00000414786_chr22_51115121_+_MAPK1_ENST00000544786_chr22_22153417_-_798nt ATGGACGGCCCCGGGGCCAGCGCCGTGGTCGTGCGCGTCGGCATCCCGGACCTGCAGCAGACGAAGTGCCTGCGCCTGGACCCGGCCGCG CCCGTGTGGGCCGCCAAGCAGCGCGTGCTCTGCGCCCTCAACCACAGCCTCCAGGACGCGCTCAACTATGGGCTTTTCCAGCCGCCCTCC CGGGGCCGCGCCGGCAAGTTCCTGGATGAGGAGCGGCTCCTGCAGGAGTACCCGCCCAACCTGGACACGCCCCTGCCCTACCTGGAGTTT CGATACAAGCGGCGAGTTTATGCCCAGAACCTCATCGATGATAAGCAGTTTGCAAAGCTTCACACAAAGATCTGTGACTTTGGCCTGGCC CGTGTTGCAGATCCAGACCATGATCACACAGGGTTCCTGACAGAATATGTGGCCACACGTTGGTACAGGGCTCCAGAAATTATGTTGAAT TCCAAGGGCTACACCAAGTCCATTGATATTTGGTCTGTAGGCTGCATTCTGGCAGAAATGCTTTCTAACAGGCCCATCTTTCCAGGGAAG CATTATCTTGACCAGCTGAACCACATTTTGGCTCTGGACTTATTGGACAAAATGTTGACATTCAACCCACACAAGAGGATTGAAGTAGAA CAGGCTCTGGCCCACCCATATCTGGAGCAGTATTACGACCCGAGTGACGAGCCCATCGCCGAAGCACCATTCAAGTTCGACATGGAATTG >In-frame_SHANK3_ENST00000445220_chr22_51115121_+_MAPK1_ENST00000215832_chr22_22153417_-_930nt ATGGACGGCCCCGGGGCCAGCGCCGTGGTCGTGCGCGTCGGCATCCCGGACCTGCAGCAGACGAAGTGCCTGCGCCTGGACCCGGCCGCG CCCGTGTGGGCCGCCAAGCAGCGCGTGCTCTGCGCCCTCAACCACAGCCTCCAGGACGCGCTCAACTATGGGCTTTTCCAGCCGCCCTCC CGGGGCCGCGCCGGCAAGTTCCTGGATGAGGAGCGGCTCCTGCAGGAGTACCCGCCCAACCTGGACACGCCCCTGCCCTACCTGGAGTTT CGATACAAGCGGCGAGTTTATGCCCAGAACCTCATCGATGATAAGCAGTTTGCAAAGCTTCACACAAAGATCTGTGACTTTGGCCTGGCC CGTGTTGCAGATCCAGACCATGATCACACAGGGTTCCTGACAGAATATGTGGCCACACGTTGGTACAGGGCTCCAGAAATTATGTTGAAT TCCAAGGGCTACACCAAGTCCATTGATATTTGGTCTGTAGGCTGCATTCTGGCAGAAATGCTTTCTAACAGGCCCATCTTTCCAGGGAAG CATTATCTTGACCAGCTGAACCACATTTTGGGTATTCTTGGATCCCCATCACAAGAAGACCTGAATTGTATAATAAATTTAAAAGCTAGG AACTATTTGCTTTCTCTTCCACACAAAAATAAGGTGCCATGGAACAGGCTGTTCCCAAATGCTGACTCCAAAGCTCTGGACTTATTGGAC AAAATGTTGACATTCAACCCACACAAGAGGATTGAAGTAGAACAGGCTCTGGCCCACCCATATCTGGAGCAGTATTACGACCCGAGTGAC GAGCCCATCGCCGAAGCACCATTCAAGTTCGACATGGAATTGGATGACTTGCCTAAGGAAAAGCTCAAAGAACTAATTTTTGAAGAGACT >In-frame_SHANK3_ENST00000445220_chr22_51115121_+_MAPK1_ENST00000398822_chr22_22153417_-_930nt ATGGACGGCCCCGGGGCCAGCGCCGTGGTCGTGCGCGTCGGCATCCCGGACCTGCAGCAGACGAAGTGCCTGCGCCTGGACCCGGCCGCG CCCGTGTGGGCCGCCAAGCAGCGCGTGCTCTGCGCCCTCAACCACAGCCTCCAGGACGCGCTCAACTATGGGCTTTTCCAGCCGCCCTCC CGGGGCCGCGCCGGCAAGTTCCTGGATGAGGAGCGGCTCCTGCAGGAGTACCCGCCCAACCTGGACACGCCCCTGCCCTACCTGGAGTTT CGATACAAGCGGCGAGTTTATGCCCAGAACCTCATCGATGATAAGCAGTTTGCAAAGCTTCACACAAAGATCTGTGACTTTGGCCTGGCC CGTGTTGCAGATCCAGACCATGATCACACAGGGTTCCTGACAGAATATGTGGCCACACGTTGGTACAGGGCTCCAGAAATTATGTTGAAT TCCAAGGGCTACACCAAGTCCATTGATATTTGGTCTGTAGGCTGCATTCTGGCAGAAATGCTTTCTAACAGGCCCATCTTTCCAGGGAAG CATTATCTTGACCAGCTGAACCACATTTTGGGTATTCTTGGATCCCCATCACAAGAAGACCTGAATTGTATAATAAATTTAAAAGCTAGG AACTATTTGCTTTCTCTTCCACACAAAAATAAGGTGCCATGGAACAGGCTGTTCCCAAATGCTGACTCCAAAGCTCTGGACTTATTGGAC AAAATGTTGACATTCAACCCACACAAGAGGATTGAAGTAGAACAGGCTCTGGCCCACCCATATCTGGAGCAGTATTACGACCCGAGTGAC GAGCCCATCGCCGAAGCACCATTCAAGTTCGACATGGAATTGGATGACTTGCCTAAGGAAAAGCTCAAAGAACTAATTTTTGAAGAGACT >In-frame_SHANK3_ENST00000445220_chr22_51115121_+_MAPK1_ENST00000544786_chr22_22153417_-_798nt ATGGACGGCCCCGGGGCCAGCGCCGTGGTCGTGCGCGTCGGCATCCCGGACCTGCAGCAGACGAAGTGCCTGCGCCTGGACCCGGCCGCG CCCGTGTGGGCCGCCAAGCAGCGCGTGCTCTGCGCCCTCAACCACAGCCTCCAGGACGCGCTCAACTATGGGCTTTTCCAGCCGCCCTCC CGGGGCCGCGCCGGCAAGTTCCTGGATGAGGAGCGGCTCCTGCAGGAGTACCCGCCCAACCTGGACACGCCCCTGCCCTACCTGGAGTTT CGATACAAGCGGCGAGTTTATGCCCAGAACCTCATCGATGATAAGCAGTTTGCAAAGCTTCACACAAAGATCTGTGACTTTGGCCTGGCC CGTGTTGCAGATCCAGACCATGATCACACAGGGTTCCTGACAGAATATGTGGCCACACGTTGGTACAGGGCTCCAGAAATTATGTTGAAT TCCAAGGGCTACACCAAGTCCATTGATATTTGGTCTGTAGGCTGCATTCTGGCAGAAATGCTTTCTAACAGGCCCATCTTTCCAGGGAAG CATTATCTTGACCAGCTGAACCACATTTTGGCTCTGGACTTATTGGACAAAATGTTGACATTCAACCCACACAAGAGGATTGAAGTAGAA CAGGCTCTGGCCCACCCATATCTGGAGCAGTATTACGACCCGAGTGACGAGCCCATCGCCGAAGCACCATTCAAGTTCGACATGGAATTG >In-frame_SHANK3_ENST00000262795_chr22_51115121_+_MAPK1_ENST00000215832_chr22_22153417_-_930nt ATGGACGGCCCCGGGGCCAGCGCCGTGGTCGTGCGCGTCGGCATCCCGGACCTGCAGCAGACGAAGTGCCTGCGCCTGGACCCGGCCGCG CCCGTGTGGGCCGCCAAGCAGCGCGTGCTCTGCGCCCTCAACCACAGCCTCCAGGACGCGCTCAACTATGGGCTTTTCCAGCCGCCCTCC CGGGGCCGCGCCGGCAAGTTCCTGGATGAGGAGCGGCTCCTGCAGGAGTACCCGCCCAACCTGGACACGCCCCTGCCCTACCTGGAGTTT CGATACAAGCGGCGAGTTTATGCCCAGAACCTCATCGATGATAAGCAGTTTGCAAAGCTTCACACAAAGATCTGTGACTTTGGCCTGGCC CGTGTTGCAGATCCAGACCATGATCACACAGGGTTCCTGACAGAATATGTGGCCACACGTTGGTACAGGGCTCCAGAAATTATGTTGAAT TCCAAGGGCTACACCAAGTCCATTGATATTTGGTCTGTAGGCTGCATTCTGGCAGAAATGCTTTCTAACAGGCCCATCTTTCCAGGGAAG CATTATCTTGACCAGCTGAACCACATTTTGGGTATTCTTGGATCCCCATCACAAGAAGACCTGAATTGTATAATAAATTTAAAAGCTAGG AACTATTTGCTTTCTCTTCCACACAAAAATAAGGTGCCATGGAACAGGCTGTTCCCAAATGCTGACTCCAAAGCTCTGGACTTATTGGAC AAAATGTTGACATTCAACCCACACAAGAGGATTGAAGTAGAACAGGCTCTGGCCCACCCATATCTGGAGCAGTATTACGACCCGAGTGAC GAGCCCATCGCCGAAGCACCATTCAAGTTCGACATGGAATTGGATGACTTGCCTAAGGAAAAGCTCAAAGAACTAATTTTTGAAGAGACT >In-frame_SHANK3_ENST00000262795_chr22_51115121_+_MAPK1_ENST00000398822_chr22_22153417_-_930nt ATGGACGGCCCCGGGGCCAGCGCCGTGGTCGTGCGCGTCGGCATCCCGGACCTGCAGCAGACGAAGTGCCTGCGCCTGGACCCGGCCGCG CCCGTGTGGGCCGCCAAGCAGCGCGTGCTCTGCGCCCTCAACCACAGCCTCCAGGACGCGCTCAACTATGGGCTTTTCCAGCCGCCCTCC CGGGGCCGCGCCGGCAAGTTCCTGGATGAGGAGCGGCTCCTGCAGGAGTACCCGCCCAACCTGGACACGCCCCTGCCCTACCTGGAGTTT CGATACAAGCGGCGAGTTTATGCCCAGAACCTCATCGATGATAAGCAGTTTGCAAAGCTTCACACAAAGATCTGTGACTTTGGCCTGGCC CGTGTTGCAGATCCAGACCATGATCACACAGGGTTCCTGACAGAATATGTGGCCACACGTTGGTACAGGGCTCCAGAAATTATGTTGAAT TCCAAGGGCTACACCAAGTCCATTGATATTTGGTCTGTAGGCTGCATTCTGGCAGAAATGCTTTCTAACAGGCCCATCTTTCCAGGGAAG CATTATCTTGACCAGCTGAACCACATTTTGGGTATTCTTGGATCCCCATCACAAGAAGACCTGAATTGTATAATAAATTTAAAAGCTAGG AACTATTTGCTTTCTCTTCCACACAAAAATAAGGTGCCATGGAACAGGCTGTTCCCAAATGCTGACTCCAAAGCTCTGGACTTATTGGAC AAAATGTTGACATTCAACCCACACAAGAGGATTGAAGTAGAACAGGCTCTGGCCCACCCATATCTGGAGCAGTATTACGACCCGAGTGAC GAGCCCATCGCCGAAGCACCATTCAAGTTCGACATGGAATTGGATGACTTGCCTAAGGAAAAGCTCAAAGAACTAATTTTTGAAGAGACT >In-frame_SHANK3_ENST00000262795_chr22_51115121_+_MAPK1_ENST00000544786_chr22_22153417_-_798nt ATGGACGGCCCCGGGGCCAGCGCCGTGGTCGTGCGCGTCGGCATCCCGGACCTGCAGCAGACGAAGTGCCTGCGCCTGGACCCGGCCGCG CCCGTGTGGGCCGCCAAGCAGCGCGTGCTCTGCGCCCTCAACCACAGCCTCCAGGACGCGCTCAACTATGGGCTTTTCCAGCCGCCCTCC CGGGGCCGCGCCGGCAAGTTCCTGGATGAGGAGCGGCTCCTGCAGGAGTACCCGCCCAACCTGGACACGCCCCTGCCCTACCTGGAGTTT CGATACAAGCGGCGAGTTTATGCCCAGAACCTCATCGATGATAAGCAGTTTGCAAAGCTTCACACAAAGATCTGTGACTTTGGCCTGGCC CGTGTTGCAGATCCAGACCATGATCACACAGGGTTCCTGACAGAATATGTGGCCACACGTTGGTACAGGGCTCCAGAAATTATGTTGAAT TCCAAGGGCTACACCAAGTCCATTGATATTTGGTCTGTAGGCTGCATTCTGGCAGAAATGCTTTCTAACAGGCCCATCTTTCCAGGGAAG CATTATCTTGACCAGCTGAACCACATTTTGGCTCTGGACTTATTGGACAAAATGTTGACATTCAACCCACACAAGAGGATTGAAGTAGAA CAGGCTCTGGCCCACCCATATCTGGAGCAGTATTACGACCCGAGTGACGAGCCCATCGCCGAAGCACCATTCAAGTTCGACATGGAATTG |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_SHANK3_ENST00000414786_chr22_51115121_+_MAPK1_ENST00000215832_chr22_22153417_-_10907nt ATGCAGCTGAGCCGCGCCGCCGCCGCCGCCGCCGCCGCCCCTGCGGAGCCCCCGGAGCCGCTGTCCCCCGCGCCGGCCCCGGCCCCGGCC CCCCCCGGCCCCCTCCCGCGCAGCGCGGCCGACGGGGCTCCGGCGGGGGGGAAGGGGGGGCCGGGGCGCCGCGCGCGGAGTCCCCGGGCG CTCCGTTCCCCGGCGCGAGCGGCCCCGGCCCGGGCCCCGGCGCGGGGATGGACGGCCCCGGGGCCAGCGCCGTGGTCGTGCGCGTCGGCA TCCCGGACCTGCAGCAGACGAAGTGCCTGCGCCTGGACCCGGCCGCGCCCGTGTGGGCCGCCAAGCAGCGCGTGCTCTGCGCCCTCAACC ACAGCCTCCAGGACGCGCTCAACTATGGGCTTTTCCAGCCGCCCTCCCGGGGCCGCGCCGGCAAGTTCCTGGATGAGGAGCGGCTCCTGC AGGAGTACCCGCCCAACCTGGACACGCCCCTGCCCTACCTGGAGTTTCGATACAAGCGGCGAGTTTATGCCCAGAACCTCATCGATGATA AGCAGTTTGCAAAGCTTCACACAAAGATCTGTGACTTTGGCCTGGCCCGTGTTGCAGATCCAGACCATGATCACACAGGGTTCCTGACAG AATATGTGGCCACACGTTGGTACAGGGCTCCAGAAATTATGTTGAATTCCAAGGGCTACACCAAGTCCATTGATATTTGGTCTGTAGGCT GCATTCTGGCAGAAATGCTTTCTAACAGGCCCATCTTTCCAGGGAAGCATTATCTTGACCAGCTGAACCACATTTTGGGTATTCTTGGAT CCCCATCACAAGAAGACCTGAATTGTATAATAAATTTAAAAGCTAGGAACTATTTGCTTTCTCTTCCACACAAAAATAAGGTGCCATGGA ACAGGCTGTTCCCAAATGCTGACTCCAAAGCTCTGGACTTATTGGACAAAATGTTGACATTCAACCCACACAAGAGGATTGAAGTAGAAC AGGCTCTGGCCCACCCATATCTGGAGCAGTATTACGACCCGAGTGACGAGCCCATCGCCGAAGCACCATTCAAGTTCGACATGGAATTGG ATGACTTGCCTAAGGAAAAGCTCAAAGAACTAATTTTTGAAGAGACTGCTAGATTCCAGCCAGGATACAGATCTTAAATTTGTCAGGACA AGGGCTCAGAGGACTGGACGTGCTCAGACATCGGTGTTCTTCTTCCCAGTTCTTGACCCCTGGTCCTGTCTCCAGCCCGTCTTGGCTTAT CCACTTTGACTCCTTTGAGCCGTTTGGAGGGGCGGTTTCTGGTAGTTGTGGCTTTTATGCTTTCAAAGAATTTCTTCAGTCCAGAGAATT CCTCCTGGCAGCCCTGTGTGTGTCACCCATTGGTGACCTGCGGCAGTATGTACTTCAGTGCACCTACTGCTTACTGTTGCTTTAGTCACT AATTGCTTTCTGGTTTGAAAGATGCAGTGGTTCCTCCCTCTCCTGAATCCTTTTCTACATGATGCCCTGCTGACCATGCAGCCGCACCAG AGAGAGATTCTTCCCCAATTGGCTCTAGTCACTGGCATCTCACTTTATGATAGGGAAGGCTACTACCTAGGGCACTTTAAGTCAGTGACA GCCCCTTATTTGCACTTCACCTTTTGACCATAACTGTTTCCCCAGAGCAGGAGCTTGTGGAAATACCTTGGCTGATGTTGCAGCCTGCAG CAAGTGCTTCCGTCTCCGGAATCCTTGGGGAGCACTTGTCCACGTCTTTTCTCATATCATGGTAGTCACTAACATATATAAGGTATGTGC TATTGGCCCAGCTTTTAGAAAATGCAGTCATTTTTCTAAATAAAAAGGAAGTACTGCACCCAGCAGTGTCACTCTGTAGTTACTGTGGTC ACTTGTACCATATAGAGGTGTAACACTTGTCAAGAAGCGTTATGTGCAGTACTTAATGTTTGTAAGACTTACAAAAAAAGATTTAAAGTG GCAGCTTCACTCGACATTTGGTGAGAGAAGTACAAAGGTTGCAGTGCTGAGCTGTGGGCGGTTTCTGGGGATGTCCCAGGGTGGAACTCC ACATGCTGGTGCATATACGCCCTTGAGCTACTTCAAATGTGGGTGTTTCAGTAACCACGTTCCATGCCTGAGGATTTAGCAGAGAGGAAC ACTGCGTCTTTAAATGAGAAAGTATACAATTCTTTTTCCTTCTACAGCATGTCAGCATCTCAAGTTCATTTTTCAACCTACAGTATAACA ATTTGTAATAAAGCCTCCAGGAGCTCATGACGTGAAGCACTGTTCTGTCCTCAAGTACTCAAATATTTCTGATACTGCTGAGTCAGACTG TCAGAAAAAGCTAGCACTAACTCGTGTTTGGAGCTCTATCCATATTTTACTGATCTCTTTAAGTATTTGTTCCTGCCACTGTGTACTGTG GAGTTGACTCGGTGTTCTGTCCCAGTGCGGTGCCTCCTCTTGACTTCCCCACTGCTCTCTGTGGTGAGAAATTTGCCTTGTTCAATAATT ACTGTACCCTCGCATGACTGTTACAGCTTTCTGTGCAGAGATGACTGTCCAAGTGCCACATGCCTACGATTGAAATGAAAACTCTATTGT TACCTCTGAGTTGTGTTCCACGGAAAATGCTATCCAGCAGATCATTTAGGAAAAATAATTCTATTTTTAGCTTTTCATTTCTCAGCTGTC CTTTTTTCTTGTTTGATTTTTGACAGCAATGGAGAATGGGTTATATAAAGACTGCCTGCTAATATGAACAGAAATGCATTTGTAATTCAT GAAAATAAATGTACATCTTCTATCTTCACATTCATGTTAAGATTCAGTGTTGCTTTCCTCTGGATCAGCGTGTCTGAATGGACAGTCAGG TTCAGGTTGTGCTGAACACAGAAATGCTCACAGGCCTCACTTTGCCGCCCAGGCACTGGCCCAGCACTTGGATTTACATAAGATGAGTTA GAAAGGTACTTCTGTAGGGTCCTTTTTACCTCTGCTCGGCAGAGAATCGATGCTGTCATGTTCCTTTATTCACAATCTTAGGTCTCAAAT ATTCTGTCAAACCCTAACAAAGAAGCCCCGACATCTCAGGTTGGATTCCCTGGTTCTCTCTAAAGAGGGCCTGCCCTTGTGCCCCAGAGG TGCTGCTGGGCACAGCCAAGAGTTGGGAAGGGCCGCCCCACAGTACGCAGTCCTCACCACCCAGCCCAGGGTGCTCACGCTCACCACTCC TGTGGCTGAGGAAGGATAGCTGGCTCATCCTCGGAAAACAGACCCACATCTCTATTCTTGCCCTGAAATACGCGCTTTTCACTTGCGTGC TCAGAGCTGCCGTCTGAAGGTCCACACAGCATTGACGGGACACAGAAATGTGACTGTTACCGGATAACACTGATTAGTCAGTTTTCATTT ATAAAAAAGCATTGACAGTTTTATTACTCTTGTTTCTTTTTAAATGGAAAGTTACTATTATAAGGTTAATTTGGAGTCCTCTTCTAAATA GAAAACCATATCCTTGGCTACTAACATCTGGAGACTGTGAGCTCCTTCCCATTCCCCTTCCTGGTACTGTGGAGTCAGATTGGCATGAAA CCACTAACTTCATTCTAGAATCATTGTAGCCATAAGTTGTGTGCTTTTTATTAATCATGCCAAACATAATGTAACTGGGCAGAGAATGGT CCTAACCAAGGTACCTATGAAAAGCGCTAGCTATCATGTGTAGTAGATGCATCATTTTGGCTCTTCTTACATTTGTAAAAATGTACAGAT TAGGTCATCTTAATTCATATTAGTGACACGGAACAGCACCTCCACTATTTGTATGTTCAAATAAGCTTTCAGACTAATAGCTTTTTTGGT GTCTAAAATGTAAGCAAAAAATTCCTGCTGAAACATTCCAGTCCTTTCATTTAGTATAAAAGAAATACTGAACAAGCCAGTGGGATGGAA TTGAAAGAACTAATCATGAGGACTCTGTCCTGACACAGGTCCTCAAAGCTAGCAGAGATACGCAGACATTGTGGCATCTGGGTAGAAGAA TACTGTATTGTGTGTGCAGTGCACAGTGTGTGGTGTGTGCACACTCATTCCTTCTGCTCTTGGGCACAGGCAGTGGGTGTAGAGGTAACC AGTAGCTTTGAGAAGCTACATGTAGCTCACCAGTGGTTTTCTCTAAGGAATCACAAAAGTAAACTACCCAACCACATGCCACGTAATATT TCAGCCATTCAGAGGAAACTGTTTTCTCTTTATTTGCTTATATGTTAATATGGTTTTTAAATTGGTAACTTTTATATAGTATGGTAACAG TATGTTAATACACACATACATACGCACACATGCTTTGGGTCCTTCCATAATACTTTTATATTTGTAAATCAATGTTTTGGAGCAATCCCA AGTTTAAGGGAAATATTTTTGTAAATGTAATGGTTTTGAAAATCTGAGCAATCCTTTTGCTTATACATTTTTAAAGCATTTGTGCTTTAA AATTGTTATGCTGGTGTTTGAAACATGATACTCCTGTGGTGCAGATGAGAAGCTATAACAGTGAATATGTGGTTTCTCTTACGTCATCCA CCTTGACATGATGGGTCAGAAACAAATGGAAATCCAGAGCAAGTCCTCCAGGGTTGCACCAGGTTTACCTAAAGCTTGTTGCCTTTTCTT GTGCTGTTTATGCGTGTAGAGCACTCAAGAAAGTTCTGAAACTGCTTTGTATCTGCTTTGTACTGTTGGTGCCTTCTTGGTATTGTACCC CAAAATTCTGCATAGATTATTTAGTATAATGGTAAGTTAAAAAATGTTAAAGGAAGATTTTATTAAGAATCTGAATGTTTATTCATTATA TTGTTACAATTTAACATTAACATTTATTTGTGGTATTTGTGATTTGGTTAATCTGTATAAAAATTGTAAGTAGAAAGGTTTATATTTCAT CTTAATTCTTTTGATGTTGTAAACGTACTTTTTAAAAGATGGATTATTTGAATGTTTATGGCACCTGACTTGTAAAAAAAAAAAACTACA AAAAAATCCTTAGAATCATTAAATTGTGTCCCTGTATTACCAAAATAACACAGCACCGTGCATGTATAGTTTAATTGCAGTTTCATCTGT GAAAACGTGAAATTGTCTAGTCCTTCGTTATGTTCCCCAGATGTCTTCCAGATTTGCTCTGCATGTGGTAACTTGTGTTAGGGCTGTGAG CTGTTCCTCGAGTTGAATGGGGATGTCAGTGCTCCTAGGGTTCTCCAGGTGGTTCTTCAGACCTTCACCTGTGGGGGGGGGGGTAGGCGG TGCCCACGCCCATCTCCTCATCCTCCTGAACTTCTGCAACCCCACTGCTGGGCAGACATCCTGGGCAACCCCTTTTTTCAGAGCAAGAAG TCATAAAGATAGGATTTCTTGGACATTTGGTTCTTATCAATATTGGGCATTATGTAATGACTTATTTACAAAACAAAGATACTGGAAAAT GTTTTGGATGTGGTGTTATGGAAAGAGCACAGGCCTTGGACCCATCCAGCTGGGTTCAGAACTACCCCCTGCTTATAACTGCGGCTGGCT GTGGGCCAGTCATTCTGCGTCTCTGCTTTCTTCCTCTGCTTCAGACTGTCAGCTGTAAAGTGGAAGCAATATTACTTGCCTTGTATATGG TAAAGATTATAAAAATACATTTCAACTGTTCAGCATAGTACTTCAAAGCAAGTACTCAGTAAATAGCAAGTCTTTTTAAATGCTGCTTTA TTTCACTAAATTTTGTTGTGAGGTGTCACTAAAATGCCTGCAAACAAACGTAACTGCTAATCTGAGAGGAAACCCTCTTACTAATCAGAG AAGAAACCCTCCTGTCAGAAACCTTCAGGGAAGTGAGCTGATCACACCTAAACTGGGAGTTTGCAATGGGGTATTTGAAGCACTGTGGGA GTATTCCACTGGCCCTCTCCCTGAGAGACTTAACAGTCTTCCCTGTTGTCCAGATTCTGTATAAGGCAATCAGAATAATCATCTTCCTTG TTCAGCAGAGGAGCCTGGTCCCATTTTCCCCACTTTGTGATGGGCTTCTCTCAGCGGTAGCTCAGCAGTTCCAGATGGCAGTTTGGACCA GCATCTAGGCTGGCCAGTTCGCTGTGTTTACTTAGAACCAACACGTTCAGAGCTGGCCTGGACCATCTGAGGGGAACAGGAAACACCCCT AGGCTGTGGAAGCAAGTGCAGACCCCCACCCCCGGCCCTGAAGCCAAGGGGGCAGGGTTTGGGAGTGGCCAAAGAGAAGCAGTGCAGGGA TGGGTTTTCCTAGGGACAGGCTTAGCATTCCTGACTCTAGGAAGAAGGAGCAGTGAGGCGGAGAAACAGTGGAGGGGATGGTGGCATTGG GCCCCATGGGGCCGAGATGGACACAGGGCTCGTTCTCTTGAGTCTGGTGCCAAGGACAGCTGAAGACGACATCATTTTCAGGTGGAGAGG AGAGAGTGGAGGGAGATCATGCCCTGTGATGTGTCTTTTGCAGGTGAAGGTGGGAGACAAGGTCTCTGCTGACGATGAGGCAGAGCCACC GTGAAAGTTGTAATAGGAGGACTGCCCGCCGCTGGAAGGGCCTGCAGTGACGCTAGGACACCCTCTGCCTGCATGTCACGTTAGCTGGGC TGGGCGAAGTAGAAGACCAAGGGGAAGAGGTGCAGTGGGGAGACCAGGTGGGATGCAACCACAGGACCAGTGGAGGGGCTGTGGCACGTG GGCGGAGACTGAGTGGCTGGGCATGTGTTGTGGCTGAGCATGTGGTGTGGGCAGTGGTCCTAGACCCCGCCATGTCCGGACAATGATATA GAGCGTCTCAGCATCGCCAGTCTAGACTGTCTATGGAGAGCAGAAAGTTGTCTGGGGCTGCCTGGGGAACTGTGAGGCCAGCTATATCAC CGTCGCTGATGGTGACATTACGGTGGTGGCAGGAGCAAGGAGAGAGGGAAGAAGGACCCCGTCCAGCTTTAGTCACAAAATACCCAATGG AAGATGCCAGTGCCAATCCTGTGGGTTTCCTTGGGACTTCACACTGGCTTTCTTATCTGCTCCAGATCCATTCAGTAGTCACTGAGTTCC TGCCAAATACTTTGTAGCGCCAGAAGCCAGGAGCGGGGTCTGCAGCAGGGCAGTCCCCATTTTCAGGAAATGCCTGGAGCTGCTGGTCCC TGAGAGAAAGGAAAACATCTTTCAGCCGTACGCAGGCCAAGAAGGCCAATGTCCAGTAGCTTTGTGATTTTTTTTATATTTTTTTATTTA TTTATTTTTGAGATAGAGTCTTGCTCTGTCGCTCAGGCTGGAGTGCAGTGGCGTGATCTCCACTCACTGCAACTTCCGCCTCCTGGGGTC AAGCAGTTCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCACACGCCACCACACCCAGCTAATTTTTGTGTTTTTAGTAGAGACGGT TTCACCATGTCGGCCAGGCTGGTCTCAAACTCCTGACCTCAGATGATTCAGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACTGCA CCCAGCCTGTGATGTTTCTGTGGGGTTCCACAAATGTGTGTGTGTGTAAAAGCTGATGATTACAGCAAGAATGTGAACAGTAGCAGTTTT CCATTTGAAGGCAAGTTTTGTCTTTATCTGGGTATCAGAAGGACCCTCTGGGCCATTGTCGCTTCCTGTACTCAGAGCCACCCTAGTACT ACGGGCACACACAGAAAACAGCAGCCTGCGTACTTTCAAAGGAAAGGCATCTTTAATCACCAATGCCTGGAAAAATTATTTTGTTTCCCT CTTCCTTCCGTCTTGTTTCCTAACTTCTTACCAAAGTTTAGAGTCTGAGTTTTTCGTATAATAATGTCCCACATCCACACATCGGGCCTA CAGATGCTCTCCCTTGAATCGACTGGAAACATGACACCGGTTCCATGCTCTGGAACTGTCACCTGTGATGTGCTGGGCTGTGTCCCAAGC ACAGGAATCCCAGCAGTTTCAGCTCGATGCAGAACCACCATGCTCCAGACACAGGCTTGGGAAAGACACGTCAAAATTAAAATACTAGGT AAGAGAAGCACCTGATTGGGTAGAAGTTGGAGAGGAATCCTGGAATTTTGTGGCCAGAAGGAGCCACTGCCCCTTTTGTTTAGTAAGACT AGACAGTAACAGAAGCCAGTTGTCAGCTATGAAAGTGGTGGGTGAAGCAGGGGAGGCTCCTCTATGGTGGGACCCTGGACAAGGGAAGCC GAATGTGTGAAGAAGGGGTGCGGGGGTGTGCGGTGCCCTAGGACACTAGGGCAAAGGTTTCAAACCTGGAACAAGGCACTGGAGGAAGAT CTGCTGCCAGTCAGCAGTGCGGGCCCTCGAGTTAGCAGTCCGTGCGCAGAGGGGCCAGTTCTGAGACCAGTTTGGAGAGTCAGGCAGTGA CCCATTGGCCATGTCATAATTCCTTCAGCCTGCCTCCTCTTTAATCCCAGAGAGTGCTCTTTCTTCATACTTCCTTTAAAATACTAAATT GTTCCCATTCCATGGGGAGCTGGCTAGGCTTTACAGGCTAGGAAATGTAGGTTTTCTGAGATGGAACCATCTACACAAGGAGGAGGAAGG CACTAAGACTACAGATGAGACCCATGACAGGGCTGAGCATTTGGAAGCCAACCCTGGTTGCTTTTCAAGAATTGCTTTGTGGCTGGGTGC AGTGGTTCACACCTGTAATTGCAGCACTTTGGGAGGCTGAGGCAGGTGGATTGCTTGAACCCAGGAGTTCGAGACCAGCCTGGGCAACAT ATGGGACACCCCACCGCCCCCGGCTCTGCAAAAAAATTAAAAATTAGCCAGGCGTGGTGTCATGAGCCTGTGGTCTCAACTACTCAGGAG GCTGAGGCTGGAGGATCGCTTGAACCTGGGAGGTCAAGGCTCCAGTGAACCATAATTGTGCCACTGCACTGCAGCCTGGGCGACAATTTG TTTTCTAAATTGCTTTTGAAAGTCTACTGCATTACATATTCCAAAAAGCAGTGGTTTTCAAATACTTTTATCACCGATATCCTTTTATGA AATGAAATCAGTAGAACTTTCTCTGCTCTGAATAAGCAAGGGTGGGAACCTGTCTACCTCCCACAGATAGCATAATGTGCCTGCCATAGA GGAGCCAAAAAATGGTGATGGGAACTGAGAGGAGAGCAAATGTCACAAAAGACTGAGCAATTGAGAAAACAAAACAAGACCACAGATGAC TGTTAACGCCTCCACAGTGGACCAAGAAAGGACAGAGAGCTGGCAGCATGGGCATCACTGTCTGGTCGGCAGCAGGAAGGCCTCGCTAGG GAATTGAGTACAGTCATCTAACTAGTTTAAAAGTACAGGAAGGATGATTAAGGCTATTGGAGAGGTCATACAAATAGGGGAGGGGCAGGC AATGGCTGATAAGACATGAATTTGTAAGGCGATGAGTATTGCAGTCAGCAAAACAAACGAGACTGCTCTCCCAACACATAACTCAGCAGG GAGGCCAGGCATTGGTTTAACCATTTAATATAAAGAAGTTAAAATTACAAATGCGCTAAGTGCCTAAAGAAGAATAAGTGCAGGAATGAG AGCAGCATGGACTGCCACAGTTTTAGAATAAGCACTGTCACTGCTAGATTGGAAACAAAAATCCATAAATTTGGCCCGGTGTGGTGGCGG ACGCCTGTAGTCCCAGCTACTTGGAGGCTGAGGCGTGAGAATCGCTTGAACCCGGGAGGCGGAGGTTGCAGTGAGCCGAGATGGCGCCAC TGCACTCCAGCCTGGGCGTCAGAGTGAGAACTCTGTATCAAAAAATAAAAATAAAAAAAAGTCCATAAATCTGCAATGTCTCAGTTAAGA AAGAAAGACTGGGCCAATGCAGATTTCAAACCGGAGAAAGTCATACTGTCAGTGAAGGCCGCCTGTGGCCGGAAGGCGCCAGGGGATTAG CACCCTGGACTCAGTGTTGCTGGGAAACAGGGCCCCAAGGCTGGGAGCACAGTGTTTAAAGGGCATCTACCCAAGAAGGGAGCACAGGGC AAGGAGGAGCTGCAGGGGGGCTTGGCTGCCAAAGTGAATTCTGAGGAGAGAGCTATTGCTGCCTACGATATGCAGGCTGCACAGAACACA AGTGGAATCAGCAGGCAGGAGAGGCAGCTAACGACGCAGCCCGTTTCTTATTTCTGTTTTCTCACAAGCGATGAAAGTGGAAAAGAGGGT GAGCAGGTGGCCCACACATGTGCCTCCAGTGCTGCGGCCCCTCCGGGGACCATCAGCCAGGCCCCGGGGAGGGAGCCAGCCACAGTGTGT CCGGCTCTTCTCTGAAGGGAAGAGAGCCTTGAATAGACTGAAGCGAAGACGGTTCTGCAAGGACAAGGCAGACCGAAGGCATTGGTTTTT TTTTTCAGATAAGGAGAATTAGACTCCCAAGTAGACACCAGAGTCACTGTTTGGTTGGTGGGTGATAGTGGGGTCACAGTGGCTGCCTGT GCTCCCCCAGGGTGAGCGTGACTGTGCTAACCTGGGTGGGGCAGCATGCACACCCCTCTGGCAGCCCTTTGTTGCTCGCTGATGACAAGT TTGGATGATCCCGCCAAACAGCTTGCTAAGATGTAGTCCCCAGTGTTGGAGGTGGGGCCTGATGGGAGGTGCTACCCTTGTGAGATAAGG TTGTGTAAAAGCCTGTGGCACCTCCCCACACTGACGCTCTCACCCCTGCTCTGGCCATGTGCCGCGCCTGCTCCCACTTCCCCTTCTGCC AGGAGTAAAAGCCCCCGAGACCTCCCAGAAGCCAAGCAGATGCTAGTGCCATGCTTCCTCTGCAGCCTGCAGAACTGTGAGCCAATTAAA >In-frame_SHANK3_ENST00000414786_chr22_51115121_+_MAPK1_ENST00000398822_chr22_22153417_-_1321nt ATGCAGCTGAGCCGCGCCGCCGCCGCCGCCGCCGCCGCCCCTGCGGAGCCCCCGGAGCCGCTGTCCCCCGCGCCGGCCCCGGCCCCGGCC CCCCCCGGCCCCCTCCCGCGCAGCGCGGCCGACGGGGCTCCGGCGGGGGGGAAGGGGGGGCCGGGGCGCCGCGCGCGGAGTCCCCGGGCG CTCCGTTCCCCGGCGCGAGCGGCCCCGGCCCGGGCCCCGGCGCGGGGATGGACGGCCCCGGGGCCAGCGCCGTGGTCGTGCGCGTCGGCA TCCCGGACCTGCAGCAGACGAAGTGCCTGCGCCTGGACCCGGCCGCGCCCGTGTGGGCCGCCAAGCAGCGCGTGCTCTGCGCCCTCAACC ACAGCCTCCAGGACGCGCTCAACTATGGGCTTTTCCAGCCGCCCTCCCGGGGCCGCGCCGGCAAGTTCCTGGATGAGGAGCGGCTCCTGC AGGAGTACCCGCCCAACCTGGACACGCCCCTGCCCTACCTGGAGTTTCGATACAAGCGGCGAGTTTATGCCCAGAACCTCATCGATGATA AGCAGTTTGCAAAGCTTCACACAAAGATCTGTGACTTTGGCCTGGCCCGTGTTGCAGATCCAGACCATGATCACACAGGGTTCCTGACAG AATATGTGGCCACACGTTGGTACAGGGCTCCAGAAATTATGTTGAATTCCAAGGGCTACACCAAGTCCATTGATATTTGGTCTGTAGGCT GCATTCTGGCAGAAATGCTTTCTAACAGGCCCATCTTTCCAGGGAAGCATTATCTTGACCAGCTGAACCACATTTTGGGTATTCTTGGAT CCCCATCACAAGAAGACCTGAATTGTATAATAAATTTAAAAGCTAGGAACTATTTGCTTTCTCTTCCACACAAAAATAAGGTGCCATGGA ACAGGCTGTTCCCAAATGCTGACTCCAAAGCTCTGGACTTATTGGACAAAATGTTGACATTCAACCCACACAAGAGGATTGAAGTAGAAC AGGCTCTGGCCCACCCATATCTGGAGCAGTATTACGACCCGAGTGACGAGCCCATCGCCGAAGCACCATTCAAGTTCGACATGGAATTGG ATGACTTGCCTAAGGAAAAGCTCAAAGAACTAATTTTTGAAGAGACTGCTAGATTCCAGCCAGGATACAGATCTTAAATTTGTCAGGTAC CTGGAGTTTAATACAGTGAGCTCTAGCAAGGGAGGCGCTGCCTTTTGTTTCTAGAATATTATGTTCCTCAAGGTCCATTATTTTGTATTC >In-frame_SHANK3_ENST00000414786_chr22_51115121_+_MAPK1_ENST00000544786_chr22_22153417_-_1025nt ATGCAGCTGAGCCGCGCCGCCGCCGCCGCCGCCGCCGCCCCTGCGGAGCCCCCGGAGCCGCTGTCCCCCGCGCCGGCCCCGGCCCCGGCC CCCCCCGGCCCCCTCCCGCGCAGCGCGGCCGACGGGGCTCCGGCGGGGGGGAAGGGGGGGCCGGGGCGCCGCGCGCGGAGTCCCCGGGCG CTCCGTTCCCCGGCGCGAGCGGCCCCGGCCCGGGCCCCGGCGCGGGGATGGACGGCCCCGGGGCCAGCGCCGTGGTCGTGCGCGTCGGCA TCCCGGACCTGCAGCAGACGAAGTGCCTGCGCCTGGACCCGGCCGCGCCCGTGTGGGCCGCCAAGCAGCGCGTGCTCTGCGCCCTCAACC ACAGCCTCCAGGACGCGCTCAACTATGGGCTTTTCCAGCCGCCCTCCCGGGGCCGCGCCGGCAAGTTCCTGGATGAGGAGCGGCTCCTGC AGGAGTACCCGCCCAACCTGGACACGCCCCTGCCCTACCTGGAGTTTCGATACAAGCGGCGAGTTTATGCCCAGAACCTCATCGATGATA AGCAGTTTGCAAAGCTTCACACAAAGATCTGTGACTTTGGCCTGGCCCGTGTTGCAGATCCAGACCATGATCACACAGGGTTCCTGACAG AATATGTGGCCACACGTTGGTACAGGGCTCCAGAAATTATGTTGAATTCCAAGGGCTACACCAAGTCCATTGATATTTGGTCTGTAGGCT GCATTCTGGCAGAAATGCTTTCTAACAGGCCCATCTTTCCAGGGAAGCATTATCTTGACCAGCTGAACCACATTTTGGCTCTGGACTTAT TGGACAAAATGTTGACATTCAACCCACACAAGAGGATTGAAGTAGAACAGGCTCTGGCCCACCCATATCTGGAGCAGTATTACGACCCGA GTGACGAGCCCATCGCCGAAGCACCATTCAAGTTCGACATGGAATTGGATGACTTGCCTAAGGAAAAGCTCAAAGAACTAATTTTTGAAG >In-frame_SHANK3_ENST00000445220_chr22_51115121_+_MAPK1_ENST00000215832_chr22_22153417_-_10680nt ATGGACGGCCCCGGGGCCAGCGCCGTGGTCGTGCGCGTCGGCATCCCGGACCTGCAGCAGACGAAGTGCCTGCGCCTGGACCCGGCCGCG CCCGTGTGGGCCGCCAAGCAGCGCGTGCTCTGCGCCCTCAACCACAGCCTCCAGGACGCGCTCAACTATGGGCTTTTCCAGCCGCCCTCC CGGGGCCGCGCCGGCAAGTTCCTGGATGAGGAGCGGCTCCTGCAGGAGTACCCGCCCAACCTGGACACGCCCCTGCCCTACCTGGAGTTT CGATACAAGCGGCGAGTTTATGCCCAGAACCTCATCGATGATAAGCAGTTTGCAAAGCTTCACACAAAGATCTGTGACTTTGGCCTGGCC CGTGTTGCAGATCCAGACCATGATCACACAGGGTTCCTGACAGAATATGTGGCCACACGTTGGTACAGGGCTCCAGAAATTATGTTGAAT TCCAAGGGCTACACCAAGTCCATTGATATTTGGTCTGTAGGCTGCATTCTGGCAGAAATGCTTTCTAACAGGCCCATCTTTCCAGGGAAG CATTATCTTGACCAGCTGAACCACATTTTGGGTATTCTTGGATCCCCATCACAAGAAGACCTGAATTGTATAATAAATTTAAAAGCTAGG AACTATTTGCTTTCTCTTCCACACAAAAATAAGGTGCCATGGAACAGGCTGTTCCCAAATGCTGACTCCAAAGCTCTGGACTTATTGGAC AAAATGTTGACATTCAACCCACACAAGAGGATTGAAGTAGAACAGGCTCTGGCCCACCCATATCTGGAGCAGTATTACGACCCGAGTGAC GAGCCCATCGCCGAAGCACCATTCAAGTTCGACATGGAATTGGATGACTTGCCTAAGGAAAAGCTCAAAGAACTAATTTTTGAAGAGACT GCTAGATTCCAGCCAGGATACAGATCTTAAATTTGTCAGGACAAGGGCTCAGAGGACTGGACGTGCTCAGACATCGGTGTTCTTCTTCCC AGTTCTTGACCCCTGGTCCTGTCTCCAGCCCGTCTTGGCTTATCCACTTTGACTCCTTTGAGCCGTTTGGAGGGGCGGTTTCTGGTAGTT GTGGCTTTTATGCTTTCAAAGAATTTCTTCAGTCCAGAGAATTCCTCCTGGCAGCCCTGTGTGTGTCACCCATTGGTGACCTGCGGCAGT ATGTACTTCAGTGCACCTACTGCTTACTGTTGCTTTAGTCACTAATTGCTTTCTGGTTTGAAAGATGCAGTGGTTCCTCCCTCTCCTGAA TCCTTTTCTACATGATGCCCTGCTGACCATGCAGCCGCACCAGAGAGAGATTCTTCCCCAATTGGCTCTAGTCACTGGCATCTCACTTTA TGATAGGGAAGGCTACTACCTAGGGCACTTTAAGTCAGTGACAGCCCCTTATTTGCACTTCACCTTTTGACCATAACTGTTTCCCCAGAG CAGGAGCTTGTGGAAATACCTTGGCTGATGTTGCAGCCTGCAGCAAGTGCTTCCGTCTCCGGAATCCTTGGGGAGCACTTGTCCACGTCT TTTCTCATATCATGGTAGTCACTAACATATATAAGGTATGTGCTATTGGCCCAGCTTTTAGAAAATGCAGTCATTTTTCTAAATAAAAAG GAAGTACTGCACCCAGCAGTGTCACTCTGTAGTTACTGTGGTCACTTGTACCATATAGAGGTGTAACACTTGTCAAGAAGCGTTATGTGC AGTACTTAATGTTTGTAAGACTTACAAAAAAAGATTTAAAGTGGCAGCTTCACTCGACATTTGGTGAGAGAAGTACAAAGGTTGCAGTGC TGAGCTGTGGGCGGTTTCTGGGGATGTCCCAGGGTGGAACTCCACATGCTGGTGCATATACGCCCTTGAGCTACTTCAAATGTGGGTGTT TCAGTAACCACGTTCCATGCCTGAGGATTTAGCAGAGAGGAACACTGCGTCTTTAAATGAGAAAGTATACAATTCTTTTTCCTTCTACAG CATGTCAGCATCTCAAGTTCATTTTTCAACCTACAGTATAACAATTTGTAATAAAGCCTCCAGGAGCTCATGACGTGAAGCACTGTTCTG TCCTCAAGTACTCAAATATTTCTGATACTGCTGAGTCAGACTGTCAGAAAAAGCTAGCACTAACTCGTGTTTGGAGCTCTATCCATATTT TACTGATCTCTTTAAGTATTTGTTCCTGCCACTGTGTACTGTGGAGTTGACTCGGTGTTCTGTCCCAGTGCGGTGCCTCCTCTTGACTTC CCCACTGCTCTCTGTGGTGAGAAATTTGCCTTGTTCAATAATTACTGTACCCTCGCATGACTGTTACAGCTTTCTGTGCAGAGATGACTG TCCAAGTGCCACATGCCTACGATTGAAATGAAAACTCTATTGTTACCTCTGAGTTGTGTTCCACGGAAAATGCTATCCAGCAGATCATTT AGGAAAAATAATTCTATTTTTAGCTTTTCATTTCTCAGCTGTCCTTTTTTCTTGTTTGATTTTTGACAGCAATGGAGAATGGGTTATATA AAGACTGCCTGCTAATATGAACAGAAATGCATTTGTAATTCATGAAAATAAATGTACATCTTCTATCTTCACATTCATGTTAAGATTCAG TGTTGCTTTCCTCTGGATCAGCGTGTCTGAATGGACAGTCAGGTTCAGGTTGTGCTGAACACAGAAATGCTCACAGGCCTCACTTTGCCG CCCAGGCACTGGCCCAGCACTTGGATTTACATAAGATGAGTTAGAAAGGTACTTCTGTAGGGTCCTTTTTACCTCTGCTCGGCAGAGAAT CGATGCTGTCATGTTCCTTTATTCACAATCTTAGGTCTCAAATATTCTGTCAAACCCTAACAAAGAAGCCCCGACATCTCAGGTTGGATT CCCTGGTTCTCTCTAAAGAGGGCCTGCCCTTGTGCCCCAGAGGTGCTGCTGGGCACAGCCAAGAGTTGGGAAGGGCCGCCCCACAGTACG CAGTCCTCACCACCCAGCCCAGGGTGCTCACGCTCACCACTCCTGTGGCTGAGGAAGGATAGCTGGCTCATCCTCGGAAAACAGACCCAC ATCTCTATTCTTGCCCTGAAATACGCGCTTTTCACTTGCGTGCTCAGAGCTGCCGTCTGAAGGTCCACACAGCATTGACGGGACACAGAA ATGTGACTGTTACCGGATAACACTGATTAGTCAGTTTTCATTTATAAAAAAGCATTGACAGTTTTATTACTCTTGTTTCTTTTTAAATGG AAAGTTACTATTATAAGGTTAATTTGGAGTCCTCTTCTAAATAGAAAACCATATCCTTGGCTACTAACATCTGGAGACTGTGAGCTCCTT CCCATTCCCCTTCCTGGTACTGTGGAGTCAGATTGGCATGAAACCACTAACTTCATTCTAGAATCATTGTAGCCATAAGTTGTGTGCTTT TTATTAATCATGCCAAACATAATGTAACTGGGCAGAGAATGGTCCTAACCAAGGTACCTATGAAAAGCGCTAGCTATCATGTGTAGTAGA TGCATCATTTTGGCTCTTCTTACATTTGTAAAAATGTACAGATTAGGTCATCTTAATTCATATTAGTGACACGGAACAGCACCTCCACTA TTTGTATGTTCAAATAAGCTTTCAGACTAATAGCTTTTTTGGTGTCTAAAATGTAAGCAAAAAATTCCTGCTGAAACATTCCAGTCCTTT CATTTAGTATAAAAGAAATACTGAACAAGCCAGTGGGATGGAATTGAAAGAACTAATCATGAGGACTCTGTCCTGACACAGGTCCTCAAA GCTAGCAGAGATACGCAGACATTGTGGCATCTGGGTAGAAGAATACTGTATTGTGTGTGCAGTGCACAGTGTGTGGTGTGTGCACACTCA TTCCTTCTGCTCTTGGGCACAGGCAGTGGGTGTAGAGGTAACCAGTAGCTTTGAGAAGCTACATGTAGCTCACCAGTGGTTTTCTCTAAG GAATCACAAAAGTAAACTACCCAACCACATGCCACGTAATATTTCAGCCATTCAGAGGAAACTGTTTTCTCTTTATTTGCTTATATGTTA ATATGGTTTTTAAATTGGTAACTTTTATATAGTATGGTAACAGTATGTTAATACACACATACATACGCACACATGCTTTGGGTCCTTCCA TAATACTTTTATATTTGTAAATCAATGTTTTGGAGCAATCCCAAGTTTAAGGGAAATATTTTTGTAAATGTAATGGTTTTGAAAATCTGA GCAATCCTTTTGCTTATACATTTTTAAAGCATTTGTGCTTTAAAATTGTTATGCTGGTGTTTGAAACATGATACTCCTGTGGTGCAGATG AGAAGCTATAACAGTGAATATGTGGTTTCTCTTACGTCATCCACCTTGACATGATGGGTCAGAAACAAATGGAAATCCAGAGCAAGTCCT CCAGGGTTGCACCAGGTTTACCTAAAGCTTGTTGCCTTTTCTTGTGCTGTTTATGCGTGTAGAGCACTCAAGAAAGTTCTGAAACTGCTT TGTATCTGCTTTGTACTGTTGGTGCCTTCTTGGTATTGTACCCCAAAATTCTGCATAGATTATTTAGTATAATGGTAAGTTAAAAAATGT TAAAGGAAGATTTTATTAAGAATCTGAATGTTTATTCATTATATTGTTACAATTTAACATTAACATTTATTTGTGGTATTTGTGATTTGG TTAATCTGTATAAAAATTGTAAGTAGAAAGGTTTATATTTCATCTTAATTCTTTTGATGTTGTAAACGTACTTTTTAAAAGATGGATTAT TTGAATGTTTATGGCACCTGACTTGTAAAAAAAAAAAACTACAAAAAAATCCTTAGAATCATTAAATTGTGTCCCTGTATTACCAAAATA ACACAGCACCGTGCATGTATAGTTTAATTGCAGTTTCATCTGTGAAAACGTGAAATTGTCTAGTCCTTCGTTATGTTCCCCAGATGTCTT CCAGATTTGCTCTGCATGTGGTAACTTGTGTTAGGGCTGTGAGCTGTTCCTCGAGTTGAATGGGGATGTCAGTGCTCCTAGGGTTCTCCA GGTGGTTCTTCAGACCTTCACCTGTGGGGGGGGGGGTAGGCGGTGCCCACGCCCATCTCCTCATCCTCCTGAACTTCTGCAACCCCACTG CTGGGCAGACATCCTGGGCAACCCCTTTTTTCAGAGCAAGAAGTCATAAAGATAGGATTTCTTGGACATTTGGTTCTTATCAATATTGGG CATTATGTAATGACTTATTTACAAAACAAAGATACTGGAAAATGTTTTGGATGTGGTGTTATGGAAAGAGCACAGGCCTTGGACCCATCC AGCTGGGTTCAGAACTACCCCCTGCTTATAACTGCGGCTGGCTGTGGGCCAGTCATTCTGCGTCTCTGCTTTCTTCCTCTGCTTCAGACT GTCAGCTGTAAAGTGGAAGCAATATTACTTGCCTTGTATATGGTAAAGATTATAAAAATACATTTCAACTGTTCAGCATAGTACTTCAAA GCAAGTACTCAGTAAATAGCAAGTCTTTTTAAATGCTGCTTTATTTCACTAAATTTTGTTGTGAGGTGTCACTAAAATGCCTGCAAACAA ACGTAACTGCTAATCTGAGAGGAAACCCTCTTACTAATCAGAGAAGAAACCCTCCTGTCAGAAACCTTCAGGGAAGTGAGCTGATCACAC CTAAACTGGGAGTTTGCAATGGGGTATTTGAAGCACTGTGGGAGTATTCCACTGGCCCTCTCCCTGAGAGACTTAACAGTCTTCCCTGTT GTCCAGATTCTGTATAAGGCAATCAGAATAATCATCTTCCTTGTTCAGCAGAGGAGCCTGGTCCCATTTTCCCCACTTTGTGATGGGCTT CTCTCAGCGGTAGCTCAGCAGTTCCAGATGGCAGTTTGGACCAGCATCTAGGCTGGCCAGTTCGCTGTGTTTACTTAGAACCAACACGTT CAGAGCTGGCCTGGACCATCTGAGGGGAACAGGAAACACCCCTAGGCTGTGGAAGCAAGTGCAGACCCCCACCCCCGGCCCTGAAGCCAA GGGGGCAGGGTTTGGGAGTGGCCAAAGAGAAGCAGTGCAGGGATGGGTTTTCCTAGGGACAGGCTTAGCATTCCTGACTCTAGGAAGAAG GAGCAGTGAGGCGGAGAAACAGTGGAGGGGATGGTGGCATTGGGCCCCATGGGGCCGAGATGGACACAGGGCTCGTTCTCTTGAGTCTGG TGCCAAGGACAGCTGAAGACGACATCATTTTCAGGTGGAGAGGAGAGAGTGGAGGGAGATCATGCCCTGTGATGTGTCTTTTGCAGGTGA AGGTGGGAGACAAGGTCTCTGCTGACGATGAGGCAGAGCCACCGTGAAAGTTGTAATAGGAGGACTGCCCGCCGCTGGAAGGGCCTGCAG TGACGCTAGGACACCCTCTGCCTGCATGTCACGTTAGCTGGGCTGGGCGAAGTAGAAGACCAAGGGGAAGAGGTGCAGTGGGGAGACCAG GTGGGATGCAACCACAGGACCAGTGGAGGGGCTGTGGCACGTGGGCGGAGACTGAGTGGCTGGGCATGTGTTGTGGCTGAGCATGTGGTG TGGGCAGTGGTCCTAGACCCCGCCATGTCCGGACAATGATATAGAGCGTCTCAGCATCGCCAGTCTAGACTGTCTATGGAGAGCAGAAAG TTGTCTGGGGCTGCCTGGGGAACTGTGAGGCCAGCTATATCACCGTCGCTGATGGTGACATTACGGTGGTGGCAGGAGCAAGGAGAGAGG GAAGAAGGACCCCGTCCAGCTTTAGTCACAAAATACCCAATGGAAGATGCCAGTGCCAATCCTGTGGGTTTCCTTGGGACTTCACACTGG CTTTCTTATCTGCTCCAGATCCATTCAGTAGTCACTGAGTTCCTGCCAAATACTTTGTAGCGCCAGAAGCCAGGAGCGGGGTCTGCAGCA GGGCAGTCCCCATTTTCAGGAAATGCCTGGAGCTGCTGGTCCCTGAGAGAAAGGAAAACATCTTTCAGCCGTACGCAGGCCAAGAAGGCC AATGTCCAGTAGCTTTGTGATTTTTTTTATATTTTTTTATTTATTTATTTTTGAGATAGAGTCTTGCTCTGTCGCTCAGGCTGGAGTGCA GTGGCGTGATCTCCACTCACTGCAACTTCCGCCTCCTGGGGTCAAGCAGTTCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCACAC GCCACCACACCCAGCTAATTTTTGTGTTTTTAGTAGAGACGGTTTCACCATGTCGGCCAGGCTGGTCTCAAACTCCTGACCTCAGATGAT TCAGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACTGCACCCAGCCTGTGATGTTTCTGTGGGGTTCCACAAATGTGTGTGTGTGT AAAAGCTGATGATTACAGCAAGAATGTGAACAGTAGCAGTTTTCCATTTGAAGGCAAGTTTTGTCTTTATCTGGGTATCAGAAGGACCCT CTGGGCCATTGTCGCTTCCTGTACTCAGAGCCACCCTAGTACTACGGGCACACACAGAAAACAGCAGCCTGCGTACTTTCAAAGGAAAGG CATCTTTAATCACCAATGCCTGGAAAAATTATTTTGTTTCCCTCTTCCTTCCGTCTTGTTTCCTAACTTCTTACCAAAGTTTAGAGTCTG AGTTTTTCGTATAATAATGTCCCACATCCACACATCGGGCCTACAGATGCTCTCCCTTGAATCGACTGGAAACATGACACCGGTTCCATG CTCTGGAACTGTCACCTGTGATGTGCTGGGCTGTGTCCCAAGCACAGGAATCCCAGCAGTTTCAGCTCGATGCAGAACCACCATGCTCCA GACACAGGCTTGGGAAAGACACGTCAAAATTAAAATACTAGGTAAGAGAAGCACCTGATTGGGTAGAAGTTGGAGAGGAATCCTGGAATT TTGTGGCCAGAAGGAGCCACTGCCCCTTTTGTTTAGTAAGACTAGACAGTAACAGAAGCCAGTTGTCAGCTATGAAAGTGGTGGGTGAAG CAGGGGAGGCTCCTCTATGGTGGGACCCTGGACAAGGGAAGCCGAATGTGTGAAGAAGGGGTGCGGGGGTGTGCGGTGCCCTAGGACACT AGGGCAAAGGTTTCAAACCTGGAACAAGGCACTGGAGGAAGATCTGCTGCCAGTCAGCAGTGCGGGCCCTCGAGTTAGCAGTCCGTGCGC AGAGGGGCCAGTTCTGAGACCAGTTTGGAGAGTCAGGCAGTGACCCATTGGCCATGTCATAATTCCTTCAGCCTGCCTCCTCTTTAATCC CAGAGAGTGCTCTTTCTTCATACTTCCTTTAAAATACTAAATTGTTCCCATTCCATGGGGAGCTGGCTAGGCTTTACAGGCTAGGAAATG TAGGTTTTCTGAGATGGAACCATCTACACAAGGAGGAGGAAGGCACTAAGACTACAGATGAGACCCATGACAGGGCTGAGCATTTGGAAG CCAACCCTGGTTGCTTTTCAAGAATTGCTTTGTGGCTGGGTGCAGTGGTTCACACCTGTAATTGCAGCACTTTGGGAGGCTGAGGCAGGT GGATTGCTTGAACCCAGGAGTTCGAGACCAGCCTGGGCAACATATGGGACACCCCACCGCCCCCGGCTCTGCAAAAAAATTAAAAATTAG CCAGGCGTGGTGTCATGAGCCTGTGGTCTCAACTACTCAGGAGGCTGAGGCTGGAGGATCGCTTGAACCTGGGAGGTCAAGGCTCCAGTG AACCATAATTGTGCCACTGCACTGCAGCCTGGGCGACAATTTGTTTTCTAAATTGCTTTTGAAAGTCTACTGCATTACATATTCCAAAAA GCAGTGGTTTTCAAATACTTTTATCACCGATATCCTTTTATGAAATGAAATCAGTAGAACTTTCTCTGCTCTGAATAAGCAAGGGTGGGA ACCTGTCTACCTCCCACAGATAGCATAATGTGCCTGCCATAGAGGAGCCAAAAAATGGTGATGGGAACTGAGAGGAGAGCAAATGTCACA AAAGACTGAGCAATTGAGAAAACAAAACAAGACCACAGATGACTGTTAACGCCTCCACAGTGGACCAAGAAAGGACAGAGAGCTGGCAGC ATGGGCATCACTGTCTGGTCGGCAGCAGGAAGGCCTCGCTAGGGAATTGAGTACAGTCATCTAACTAGTTTAAAAGTACAGGAAGGATGA TTAAGGCTATTGGAGAGGTCATACAAATAGGGGAGGGGCAGGCAATGGCTGATAAGACATGAATTTGTAAGGCGATGAGTATTGCAGTCA GCAAAACAAACGAGACTGCTCTCCCAACACATAACTCAGCAGGGAGGCCAGGCATTGGTTTAACCATTTAATATAAAGAAGTTAAAATTA CAAATGCGCTAAGTGCCTAAAGAAGAATAAGTGCAGGAATGAGAGCAGCATGGACTGCCACAGTTTTAGAATAAGCACTGTCACTGCTAG ATTGGAAACAAAAATCCATAAATTTGGCCCGGTGTGGTGGCGGACGCCTGTAGTCCCAGCTACTTGGAGGCTGAGGCGTGAGAATCGCTT GAACCCGGGAGGCGGAGGTTGCAGTGAGCCGAGATGGCGCCACTGCACTCCAGCCTGGGCGTCAGAGTGAGAACTCTGTATCAAAAAATA AAAATAAAAAAAAGTCCATAAATCTGCAATGTCTCAGTTAAGAAAGAAAGACTGGGCCAATGCAGATTTCAAACCGGAGAAAGTCATACT GTCAGTGAAGGCCGCCTGTGGCCGGAAGGCGCCAGGGGATTAGCACCCTGGACTCAGTGTTGCTGGGAAACAGGGCCCCAAGGCTGGGAG CACAGTGTTTAAAGGGCATCTACCCAAGAAGGGAGCACAGGGCAAGGAGGAGCTGCAGGGGGGCTTGGCTGCCAAAGTGAATTCTGAGGA GAGAGCTATTGCTGCCTACGATATGCAGGCTGCACAGAACACAAGTGGAATCAGCAGGCAGGAGAGGCAGCTAACGACGCAGCCCGTTTC TTATTTCTGTTTTCTCACAAGCGATGAAAGTGGAAAAGAGGGTGAGCAGGTGGCCCACACATGTGCCTCCAGTGCTGCGGCCCCTCCGGG GACCATCAGCCAGGCCCCGGGGAGGGAGCCAGCCACAGTGTGTCCGGCTCTTCTCTGAAGGGAAGAGAGCCTTGAATAGACTGAAGCGAA GACGGTTCTGCAAGGACAAGGCAGACCGAAGGCATTGGTTTTTTTTTTCAGATAAGGAGAATTAGACTCCCAAGTAGACACCAGAGTCAC TGTTTGGTTGGTGGGTGATAGTGGGGTCACAGTGGCTGCCTGTGCTCCCCCAGGGTGAGCGTGACTGTGCTAACCTGGGTGGGGCAGCAT GCACACCCCTCTGGCAGCCCTTTGTTGCTCGCTGATGACAAGTTTGGATGATCCCGCCAAACAGCTTGCTAAGATGTAGTCCCCAGTGTT GGAGGTGGGGCCTGATGGGAGGTGCTACCCTTGTGAGATAAGGTTGTGTAAAAGCCTGTGGCACCTCCCCACACTGACGCTCTCACCCCT GCTCTGGCCATGTGCCGCGCCTGCTCCCACTTCCCCTTCTGCCAGGAGTAAAAGCCCCCGAGACCTCCCAGAAGCCAAGCAGATGCTAGT >In-frame_SHANK3_ENST00000445220_chr22_51115121_+_MAPK1_ENST00000398822_chr22_22153417_-_1094nt ATGGACGGCCCCGGGGCCAGCGCCGTGGTCGTGCGCGTCGGCATCCCGGACCTGCAGCAGACGAAGTGCCTGCGCCTGGACCCGGCCGCG CCCGTGTGGGCCGCCAAGCAGCGCGTGCTCTGCGCCCTCAACCACAGCCTCCAGGACGCGCTCAACTATGGGCTTTTCCAGCCGCCCTCC CGGGGCCGCGCCGGCAAGTTCCTGGATGAGGAGCGGCTCCTGCAGGAGTACCCGCCCAACCTGGACACGCCCCTGCCCTACCTGGAGTTT CGATACAAGCGGCGAGTTTATGCCCAGAACCTCATCGATGATAAGCAGTTTGCAAAGCTTCACACAAAGATCTGTGACTTTGGCCTGGCC CGTGTTGCAGATCCAGACCATGATCACACAGGGTTCCTGACAGAATATGTGGCCACACGTTGGTACAGGGCTCCAGAAATTATGTTGAAT TCCAAGGGCTACACCAAGTCCATTGATATTTGGTCTGTAGGCTGCATTCTGGCAGAAATGCTTTCTAACAGGCCCATCTTTCCAGGGAAG CATTATCTTGACCAGCTGAACCACATTTTGGGTATTCTTGGATCCCCATCACAAGAAGACCTGAATTGTATAATAAATTTAAAAGCTAGG AACTATTTGCTTTCTCTTCCACACAAAAATAAGGTGCCATGGAACAGGCTGTTCCCAAATGCTGACTCCAAAGCTCTGGACTTATTGGAC AAAATGTTGACATTCAACCCACACAAGAGGATTGAAGTAGAACAGGCTCTGGCCCACCCATATCTGGAGCAGTATTACGACCCGAGTGAC GAGCCCATCGCCGAAGCACCATTCAAGTTCGACATGGAATTGGATGACTTGCCTAAGGAAAAGCTCAAAGAACTAATTTTTGAAGAGACT GCTAGATTCCAGCCAGGATACAGATCTTAAATTTGTCAGGTACCTGGAGTTTAATACAGTGAGCTCTAGCAAGGGAGGCGCTGCCTTTTG TTTCTAGAATATTATGTTCCTCAAGGTCCATTATTTTGTATTCTTTTCCAAGCTCCTTATTGGAAGGTATTTTTTTAAATTTAGAATTAA >In-frame_SHANK3_ENST00000445220_chr22_51115121_+_MAPK1_ENST00000544786_chr22_22153417_-_798nt ATGGACGGCCCCGGGGCCAGCGCCGTGGTCGTGCGCGTCGGCATCCCGGACCTGCAGCAGACGAAGTGCCTGCGCCTGGACCCGGCCGCG CCCGTGTGGGCCGCCAAGCAGCGCGTGCTCTGCGCCCTCAACCACAGCCTCCAGGACGCGCTCAACTATGGGCTTTTCCAGCCGCCCTCC CGGGGCCGCGCCGGCAAGTTCCTGGATGAGGAGCGGCTCCTGCAGGAGTACCCGCCCAACCTGGACACGCCCCTGCCCTACCTGGAGTTT CGATACAAGCGGCGAGTTTATGCCCAGAACCTCATCGATGATAAGCAGTTTGCAAAGCTTCACACAAAGATCTGTGACTTTGGCCTGGCC CGTGTTGCAGATCCAGACCATGATCACACAGGGTTCCTGACAGAATATGTGGCCACACGTTGGTACAGGGCTCCAGAAATTATGTTGAAT TCCAAGGGCTACACCAAGTCCATTGATATTTGGTCTGTAGGCTGCATTCTGGCAGAAATGCTTTCTAACAGGCCCATCTTTCCAGGGAAG CATTATCTTGACCAGCTGAACCACATTTTGGCTCTGGACTTATTGGACAAAATGTTGACATTCAACCCACACAAGAGGATTGAAGTAGAA CAGGCTCTGGCCCACCCATATCTGGAGCAGTATTACGACCCGAGTGACGAGCCCATCGCCGAAGCACCATTCAAGTTCGACATGGAATTG >In-frame_SHANK3_ENST00000262795_chr22_51115121_+_MAPK1_ENST00000215832_chr22_22153417_-_10680nt ATGGACGGCCCCGGGGCCAGCGCCGTGGTCGTGCGCGTCGGCATCCCGGACCTGCAGCAGACGAAGTGCCTGCGCCTGGACCCGGCCGCG CCCGTGTGGGCCGCCAAGCAGCGCGTGCTCTGCGCCCTCAACCACAGCCTCCAGGACGCGCTCAACTATGGGCTTTTCCAGCCGCCCTCC CGGGGCCGCGCCGGCAAGTTCCTGGATGAGGAGCGGCTCCTGCAGGAGTACCCGCCCAACCTGGACACGCCCCTGCCCTACCTGGAGTTT CGATACAAGCGGCGAGTTTATGCCCAGAACCTCATCGATGATAAGCAGTTTGCAAAGCTTCACACAAAGATCTGTGACTTTGGCCTGGCC CGTGTTGCAGATCCAGACCATGATCACACAGGGTTCCTGACAGAATATGTGGCCACACGTTGGTACAGGGCTCCAGAAATTATGTTGAAT TCCAAGGGCTACACCAAGTCCATTGATATTTGGTCTGTAGGCTGCATTCTGGCAGAAATGCTTTCTAACAGGCCCATCTTTCCAGGGAAG CATTATCTTGACCAGCTGAACCACATTTTGGGTATTCTTGGATCCCCATCACAAGAAGACCTGAATTGTATAATAAATTTAAAAGCTAGG AACTATTTGCTTTCTCTTCCACACAAAAATAAGGTGCCATGGAACAGGCTGTTCCCAAATGCTGACTCCAAAGCTCTGGACTTATTGGAC AAAATGTTGACATTCAACCCACACAAGAGGATTGAAGTAGAACAGGCTCTGGCCCACCCATATCTGGAGCAGTATTACGACCCGAGTGAC GAGCCCATCGCCGAAGCACCATTCAAGTTCGACATGGAATTGGATGACTTGCCTAAGGAAAAGCTCAAAGAACTAATTTTTGAAGAGACT GCTAGATTCCAGCCAGGATACAGATCTTAAATTTGTCAGGACAAGGGCTCAGAGGACTGGACGTGCTCAGACATCGGTGTTCTTCTTCCC AGTTCTTGACCCCTGGTCCTGTCTCCAGCCCGTCTTGGCTTATCCACTTTGACTCCTTTGAGCCGTTTGGAGGGGCGGTTTCTGGTAGTT GTGGCTTTTATGCTTTCAAAGAATTTCTTCAGTCCAGAGAATTCCTCCTGGCAGCCCTGTGTGTGTCACCCATTGGTGACCTGCGGCAGT ATGTACTTCAGTGCACCTACTGCTTACTGTTGCTTTAGTCACTAATTGCTTTCTGGTTTGAAAGATGCAGTGGTTCCTCCCTCTCCTGAA TCCTTTTCTACATGATGCCCTGCTGACCATGCAGCCGCACCAGAGAGAGATTCTTCCCCAATTGGCTCTAGTCACTGGCATCTCACTTTA TGATAGGGAAGGCTACTACCTAGGGCACTTTAAGTCAGTGACAGCCCCTTATTTGCACTTCACCTTTTGACCATAACTGTTTCCCCAGAG CAGGAGCTTGTGGAAATACCTTGGCTGATGTTGCAGCCTGCAGCAAGTGCTTCCGTCTCCGGAATCCTTGGGGAGCACTTGTCCACGTCT TTTCTCATATCATGGTAGTCACTAACATATATAAGGTATGTGCTATTGGCCCAGCTTTTAGAAAATGCAGTCATTTTTCTAAATAAAAAG GAAGTACTGCACCCAGCAGTGTCACTCTGTAGTTACTGTGGTCACTTGTACCATATAGAGGTGTAACACTTGTCAAGAAGCGTTATGTGC AGTACTTAATGTTTGTAAGACTTACAAAAAAAGATTTAAAGTGGCAGCTTCACTCGACATTTGGTGAGAGAAGTACAAAGGTTGCAGTGC TGAGCTGTGGGCGGTTTCTGGGGATGTCCCAGGGTGGAACTCCACATGCTGGTGCATATACGCCCTTGAGCTACTTCAAATGTGGGTGTT TCAGTAACCACGTTCCATGCCTGAGGATTTAGCAGAGAGGAACACTGCGTCTTTAAATGAGAAAGTATACAATTCTTTTTCCTTCTACAG CATGTCAGCATCTCAAGTTCATTTTTCAACCTACAGTATAACAATTTGTAATAAAGCCTCCAGGAGCTCATGACGTGAAGCACTGTTCTG TCCTCAAGTACTCAAATATTTCTGATACTGCTGAGTCAGACTGTCAGAAAAAGCTAGCACTAACTCGTGTTTGGAGCTCTATCCATATTT TACTGATCTCTTTAAGTATTTGTTCCTGCCACTGTGTACTGTGGAGTTGACTCGGTGTTCTGTCCCAGTGCGGTGCCTCCTCTTGACTTC CCCACTGCTCTCTGTGGTGAGAAATTTGCCTTGTTCAATAATTACTGTACCCTCGCATGACTGTTACAGCTTTCTGTGCAGAGATGACTG TCCAAGTGCCACATGCCTACGATTGAAATGAAAACTCTATTGTTACCTCTGAGTTGTGTTCCACGGAAAATGCTATCCAGCAGATCATTT AGGAAAAATAATTCTATTTTTAGCTTTTCATTTCTCAGCTGTCCTTTTTTCTTGTTTGATTTTTGACAGCAATGGAGAATGGGTTATATA AAGACTGCCTGCTAATATGAACAGAAATGCATTTGTAATTCATGAAAATAAATGTACATCTTCTATCTTCACATTCATGTTAAGATTCAG TGTTGCTTTCCTCTGGATCAGCGTGTCTGAATGGACAGTCAGGTTCAGGTTGTGCTGAACACAGAAATGCTCACAGGCCTCACTTTGCCG CCCAGGCACTGGCCCAGCACTTGGATTTACATAAGATGAGTTAGAAAGGTACTTCTGTAGGGTCCTTTTTACCTCTGCTCGGCAGAGAAT CGATGCTGTCATGTTCCTTTATTCACAATCTTAGGTCTCAAATATTCTGTCAAACCCTAACAAAGAAGCCCCGACATCTCAGGTTGGATT CCCTGGTTCTCTCTAAAGAGGGCCTGCCCTTGTGCCCCAGAGGTGCTGCTGGGCACAGCCAAGAGTTGGGAAGGGCCGCCCCACAGTACG CAGTCCTCACCACCCAGCCCAGGGTGCTCACGCTCACCACTCCTGTGGCTGAGGAAGGATAGCTGGCTCATCCTCGGAAAACAGACCCAC ATCTCTATTCTTGCCCTGAAATACGCGCTTTTCACTTGCGTGCTCAGAGCTGCCGTCTGAAGGTCCACACAGCATTGACGGGACACAGAA ATGTGACTGTTACCGGATAACACTGATTAGTCAGTTTTCATTTATAAAAAAGCATTGACAGTTTTATTACTCTTGTTTCTTTTTAAATGG AAAGTTACTATTATAAGGTTAATTTGGAGTCCTCTTCTAAATAGAAAACCATATCCTTGGCTACTAACATCTGGAGACTGTGAGCTCCTT CCCATTCCCCTTCCTGGTACTGTGGAGTCAGATTGGCATGAAACCACTAACTTCATTCTAGAATCATTGTAGCCATAAGTTGTGTGCTTT TTATTAATCATGCCAAACATAATGTAACTGGGCAGAGAATGGTCCTAACCAAGGTACCTATGAAAAGCGCTAGCTATCATGTGTAGTAGA TGCATCATTTTGGCTCTTCTTACATTTGTAAAAATGTACAGATTAGGTCATCTTAATTCATATTAGTGACACGGAACAGCACCTCCACTA TTTGTATGTTCAAATAAGCTTTCAGACTAATAGCTTTTTTGGTGTCTAAAATGTAAGCAAAAAATTCCTGCTGAAACATTCCAGTCCTTT CATTTAGTATAAAAGAAATACTGAACAAGCCAGTGGGATGGAATTGAAAGAACTAATCATGAGGACTCTGTCCTGACACAGGTCCTCAAA GCTAGCAGAGATACGCAGACATTGTGGCATCTGGGTAGAAGAATACTGTATTGTGTGTGCAGTGCACAGTGTGTGGTGTGTGCACACTCA TTCCTTCTGCTCTTGGGCACAGGCAGTGGGTGTAGAGGTAACCAGTAGCTTTGAGAAGCTACATGTAGCTCACCAGTGGTTTTCTCTAAG GAATCACAAAAGTAAACTACCCAACCACATGCCACGTAATATTTCAGCCATTCAGAGGAAACTGTTTTCTCTTTATTTGCTTATATGTTA ATATGGTTTTTAAATTGGTAACTTTTATATAGTATGGTAACAGTATGTTAATACACACATACATACGCACACATGCTTTGGGTCCTTCCA TAATACTTTTATATTTGTAAATCAATGTTTTGGAGCAATCCCAAGTTTAAGGGAAATATTTTTGTAAATGTAATGGTTTTGAAAATCTGA GCAATCCTTTTGCTTATACATTTTTAAAGCATTTGTGCTTTAAAATTGTTATGCTGGTGTTTGAAACATGATACTCCTGTGGTGCAGATG AGAAGCTATAACAGTGAATATGTGGTTTCTCTTACGTCATCCACCTTGACATGATGGGTCAGAAACAAATGGAAATCCAGAGCAAGTCCT CCAGGGTTGCACCAGGTTTACCTAAAGCTTGTTGCCTTTTCTTGTGCTGTTTATGCGTGTAGAGCACTCAAGAAAGTTCTGAAACTGCTT TGTATCTGCTTTGTACTGTTGGTGCCTTCTTGGTATTGTACCCCAAAATTCTGCATAGATTATTTAGTATAATGGTAAGTTAAAAAATGT TAAAGGAAGATTTTATTAAGAATCTGAATGTTTATTCATTATATTGTTACAATTTAACATTAACATTTATTTGTGGTATTTGTGATTTGG TTAATCTGTATAAAAATTGTAAGTAGAAAGGTTTATATTTCATCTTAATTCTTTTGATGTTGTAAACGTACTTTTTAAAAGATGGATTAT TTGAATGTTTATGGCACCTGACTTGTAAAAAAAAAAAACTACAAAAAAATCCTTAGAATCATTAAATTGTGTCCCTGTATTACCAAAATA ACACAGCACCGTGCATGTATAGTTTAATTGCAGTTTCATCTGTGAAAACGTGAAATTGTCTAGTCCTTCGTTATGTTCCCCAGATGTCTT CCAGATTTGCTCTGCATGTGGTAACTTGTGTTAGGGCTGTGAGCTGTTCCTCGAGTTGAATGGGGATGTCAGTGCTCCTAGGGTTCTCCA GGTGGTTCTTCAGACCTTCACCTGTGGGGGGGGGGGTAGGCGGTGCCCACGCCCATCTCCTCATCCTCCTGAACTTCTGCAACCCCACTG CTGGGCAGACATCCTGGGCAACCCCTTTTTTCAGAGCAAGAAGTCATAAAGATAGGATTTCTTGGACATTTGGTTCTTATCAATATTGGG CATTATGTAATGACTTATTTACAAAACAAAGATACTGGAAAATGTTTTGGATGTGGTGTTATGGAAAGAGCACAGGCCTTGGACCCATCC AGCTGGGTTCAGAACTACCCCCTGCTTATAACTGCGGCTGGCTGTGGGCCAGTCATTCTGCGTCTCTGCTTTCTTCCTCTGCTTCAGACT GTCAGCTGTAAAGTGGAAGCAATATTACTTGCCTTGTATATGGTAAAGATTATAAAAATACATTTCAACTGTTCAGCATAGTACTTCAAA GCAAGTACTCAGTAAATAGCAAGTCTTTTTAAATGCTGCTTTATTTCACTAAATTTTGTTGTGAGGTGTCACTAAAATGCCTGCAAACAA ACGTAACTGCTAATCTGAGAGGAAACCCTCTTACTAATCAGAGAAGAAACCCTCCTGTCAGAAACCTTCAGGGAAGTGAGCTGATCACAC CTAAACTGGGAGTTTGCAATGGGGTATTTGAAGCACTGTGGGAGTATTCCACTGGCCCTCTCCCTGAGAGACTTAACAGTCTTCCCTGTT GTCCAGATTCTGTATAAGGCAATCAGAATAATCATCTTCCTTGTTCAGCAGAGGAGCCTGGTCCCATTTTCCCCACTTTGTGATGGGCTT CTCTCAGCGGTAGCTCAGCAGTTCCAGATGGCAGTTTGGACCAGCATCTAGGCTGGCCAGTTCGCTGTGTTTACTTAGAACCAACACGTT CAGAGCTGGCCTGGACCATCTGAGGGGAACAGGAAACACCCCTAGGCTGTGGAAGCAAGTGCAGACCCCCACCCCCGGCCCTGAAGCCAA GGGGGCAGGGTTTGGGAGTGGCCAAAGAGAAGCAGTGCAGGGATGGGTTTTCCTAGGGACAGGCTTAGCATTCCTGACTCTAGGAAGAAG GAGCAGTGAGGCGGAGAAACAGTGGAGGGGATGGTGGCATTGGGCCCCATGGGGCCGAGATGGACACAGGGCTCGTTCTCTTGAGTCTGG TGCCAAGGACAGCTGAAGACGACATCATTTTCAGGTGGAGAGGAGAGAGTGGAGGGAGATCATGCCCTGTGATGTGTCTTTTGCAGGTGA AGGTGGGAGACAAGGTCTCTGCTGACGATGAGGCAGAGCCACCGTGAAAGTTGTAATAGGAGGACTGCCCGCCGCTGGAAGGGCCTGCAG TGACGCTAGGACACCCTCTGCCTGCATGTCACGTTAGCTGGGCTGGGCGAAGTAGAAGACCAAGGGGAAGAGGTGCAGTGGGGAGACCAG GTGGGATGCAACCACAGGACCAGTGGAGGGGCTGTGGCACGTGGGCGGAGACTGAGTGGCTGGGCATGTGTTGTGGCTGAGCATGTGGTG TGGGCAGTGGTCCTAGACCCCGCCATGTCCGGACAATGATATAGAGCGTCTCAGCATCGCCAGTCTAGACTGTCTATGGAGAGCAGAAAG TTGTCTGGGGCTGCCTGGGGAACTGTGAGGCCAGCTATATCACCGTCGCTGATGGTGACATTACGGTGGTGGCAGGAGCAAGGAGAGAGG GAAGAAGGACCCCGTCCAGCTTTAGTCACAAAATACCCAATGGAAGATGCCAGTGCCAATCCTGTGGGTTTCCTTGGGACTTCACACTGG CTTTCTTATCTGCTCCAGATCCATTCAGTAGTCACTGAGTTCCTGCCAAATACTTTGTAGCGCCAGAAGCCAGGAGCGGGGTCTGCAGCA GGGCAGTCCCCATTTTCAGGAAATGCCTGGAGCTGCTGGTCCCTGAGAGAAAGGAAAACATCTTTCAGCCGTACGCAGGCCAAGAAGGCC AATGTCCAGTAGCTTTGTGATTTTTTTTATATTTTTTTATTTATTTATTTTTGAGATAGAGTCTTGCTCTGTCGCTCAGGCTGGAGTGCA GTGGCGTGATCTCCACTCACTGCAACTTCCGCCTCCTGGGGTCAAGCAGTTCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCACAC GCCACCACACCCAGCTAATTTTTGTGTTTTTAGTAGAGACGGTTTCACCATGTCGGCCAGGCTGGTCTCAAACTCCTGACCTCAGATGAT TCAGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACTGCACCCAGCCTGTGATGTTTCTGTGGGGTTCCACAAATGTGTGTGTGTGT AAAAGCTGATGATTACAGCAAGAATGTGAACAGTAGCAGTTTTCCATTTGAAGGCAAGTTTTGTCTTTATCTGGGTATCAGAAGGACCCT CTGGGCCATTGTCGCTTCCTGTACTCAGAGCCACCCTAGTACTACGGGCACACACAGAAAACAGCAGCCTGCGTACTTTCAAAGGAAAGG CATCTTTAATCACCAATGCCTGGAAAAATTATTTTGTTTCCCTCTTCCTTCCGTCTTGTTTCCTAACTTCTTACCAAAGTTTAGAGTCTG AGTTTTTCGTATAATAATGTCCCACATCCACACATCGGGCCTACAGATGCTCTCCCTTGAATCGACTGGAAACATGACACCGGTTCCATG CTCTGGAACTGTCACCTGTGATGTGCTGGGCTGTGTCCCAAGCACAGGAATCCCAGCAGTTTCAGCTCGATGCAGAACCACCATGCTCCA GACACAGGCTTGGGAAAGACACGTCAAAATTAAAATACTAGGTAAGAGAAGCACCTGATTGGGTAGAAGTTGGAGAGGAATCCTGGAATT TTGTGGCCAGAAGGAGCCACTGCCCCTTTTGTTTAGTAAGACTAGACAGTAACAGAAGCCAGTTGTCAGCTATGAAAGTGGTGGGTGAAG CAGGGGAGGCTCCTCTATGGTGGGACCCTGGACAAGGGAAGCCGAATGTGTGAAGAAGGGGTGCGGGGGTGTGCGGTGCCCTAGGACACT AGGGCAAAGGTTTCAAACCTGGAACAAGGCACTGGAGGAAGATCTGCTGCCAGTCAGCAGTGCGGGCCCTCGAGTTAGCAGTCCGTGCGC AGAGGGGCCAGTTCTGAGACCAGTTTGGAGAGTCAGGCAGTGACCCATTGGCCATGTCATAATTCCTTCAGCCTGCCTCCTCTTTAATCC CAGAGAGTGCTCTTTCTTCATACTTCCTTTAAAATACTAAATTGTTCCCATTCCATGGGGAGCTGGCTAGGCTTTACAGGCTAGGAAATG TAGGTTTTCTGAGATGGAACCATCTACACAAGGAGGAGGAAGGCACTAAGACTACAGATGAGACCCATGACAGGGCTGAGCATTTGGAAG CCAACCCTGGTTGCTTTTCAAGAATTGCTTTGTGGCTGGGTGCAGTGGTTCACACCTGTAATTGCAGCACTTTGGGAGGCTGAGGCAGGT GGATTGCTTGAACCCAGGAGTTCGAGACCAGCCTGGGCAACATATGGGACACCCCACCGCCCCCGGCTCTGCAAAAAAATTAAAAATTAG CCAGGCGTGGTGTCATGAGCCTGTGGTCTCAACTACTCAGGAGGCTGAGGCTGGAGGATCGCTTGAACCTGGGAGGTCAAGGCTCCAGTG AACCATAATTGTGCCACTGCACTGCAGCCTGGGCGACAATTTGTTTTCTAAATTGCTTTTGAAAGTCTACTGCATTACATATTCCAAAAA GCAGTGGTTTTCAAATACTTTTATCACCGATATCCTTTTATGAAATGAAATCAGTAGAACTTTCTCTGCTCTGAATAAGCAAGGGTGGGA ACCTGTCTACCTCCCACAGATAGCATAATGTGCCTGCCATAGAGGAGCCAAAAAATGGTGATGGGAACTGAGAGGAGAGCAAATGTCACA AAAGACTGAGCAATTGAGAAAACAAAACAAGACCACAGATGACTGTTAACGCCTCCACAGTGGACCAAGAAAGGACAGAGAGCTGGCAGC ATGGGCATCACTGTCTGGTCGGCAGCAGGAAGGCCTCGCTAGGGAATTGAGTACAGTCATCTAACTAGTTTAAAAGTACAGGAAGGATGA TTAAGGCTATTGGAGAGGTCATACAAATAGGGGAGGGGCAGGCAATGGCTGATAAGACATGAATTTGTAAGGCGATGAGTATTGCAGTCA GCAAAACAAACGAGACTGCTCTCCCAACACATAACTCAGCAGGGAGGCCAGGCATTGGTTTAACCATTTAATATAAAGAAGTTAAAATTA CAAATGCGCTAAGTGCCTAAAGAAGAATAAGTGCAGGAATGAGAGCAGCATGGACTGCCACAGTTTTAGAATAAGCACTGTCACTGCTAG ATTGGAAACAAAAATCCATAAATTTGGCCCGGTGTGGTGGCGGACGCCTGTAGTCCCAGCTACTTGGAGGCTGAGGCGTGAGAATCGCTT GAACCCGGGAGGCGGAGGTTGCAGTGAGCCGAGATGGCGCCACTGCACTCCAGCCTGGGCGTCAGAGTGAGAACTCTGTATCAAAAAATA AAAATAAAAAAAAGTCCATAAATCTGCAATGTCTCAGTTAAGAAAGAAAGACTGGGCCAATGCAGATTTCAAACCGGAGAAAGTCATACT GTCAGTGAAGGCCGCCTGTGGCCGGAAGGCGCCAGGGGATTAGCACCCTGGACTCAGTGTTGCTGGGAAACAGGGCCCCAAGGCTGGGAG CACAGTGTTTAAAGGGCATCTACCCAAGAAGGGAGCACAGGGCAAGGAGGAGCTGCAGGGGGGCTTGGCTGCCAAAGTGAATTCTGAGGA GAGAGCTATTGCTGCCTACGATATGCAGGCTGCACAGAACACAAGTGGAATCAGCAGGCAGGAGAGGCAGCTAACGACGCAGCCCGTTTC TTATTTCTGTTTTCTCACAAGCGATGAAAGTGGAAAAGAGGGTGAGCAGGTGGCCCACACATGTGCCTCCAGTGCTGCGGCCCCTCCGGG GACCATCAGCCAGGCCCCGGGGAGGGAGCCAGCCACAGTGTGTCCGGCTCTTCTCTGAAGGGAAGAGAGCCTTGAATAGACTGAAGCGAA GACGGTTCTGCAAGGACAAGGCAGACCGAAGGCATTGGTTTTTTTTTTCAGATAAGGAGAATTAGACTCCCAAGTAGACACCAGAGTCAC TGTTTGGTTGGTGGGTGATAGTGGGGTCACAGTGGCTGCCTGTGCTCCCCCAGGGTGAGCGTGACTGTGCTAACCTGGGTGGGGCAGCAT GCACACCCCTCTGGCAGCCCTTTGTTGCTCGCTGATGACAAGTTTGGATGATCCCGCCAAACAGCTTGCTAAGATGTAGTCCCCAGTGTT GGAGGTGGGGCCTGATGGGAGGTGCTACCCTTGTGAGATAAGGTTGTGTAAAAGCCTGTGGCACCTCCCCACACTGACGCTCTCACCCCT GCTCTGGCCATGTGCCGCGCCTGCTCCCACTTCCCCTTCTGCCAGGAGTAAAAGCCCCCGAGACCTCCCAGAAGCCAAGCAGATGCTAGT >In-frame_SHANK3_ENST00000262795_chr22_51115121_+_MAPK1_ENST00000398822_chr22_22153417_-_1094nt ATGGACGGCCCCGGGGCCAGCGCCGTGGTCGTGCGCGTCGGCATCCCGGACCTGCAGCAGACGAAGTGCCTGCGCCTGGACCCGGCCGCG CCCGTGTGGGCCGCCAAGCAGCGCGTGCTCTGCGCCCTCAACCACAGCCTCCAGGACGCGCTCAACTATGGGCTTTTCCAGCCGCCCTCC CGGGGCCGCGCCGGCAAGTTCCTGGATGAGGAGCGGCTCCTGCAGGAGTACCCGCCCAACCTGGACACGCCCCTGCCCTACCTGGAGTTT CGATACAAGCGGCGAGTTTATGCCCAGAACCTCATCGATGATAAGCAGTTTGCAAAGCTTCACACAAAGATCTGTGACTTTGGCCTGGCC CGTGTTGCAGATCCAGACCATGATCACACAGGGTTCCTGACAGAATATGTGGCCACACGTTGGTACAGGGCTCCAGAAATTATGTTGAAT TCCAAGGGCTACACCAAGTCCATTGATATTTGGTCTGTAGGCTGCATTCTGGCAGAAATGCTTTCTAACAGGCCCATCTTTCCAGGGAAG CATTATCTTGACCAGCTGAACCACATTTTGGGTATTCTTGGATCCCCATCACAAGAAGACCTGAATTGTATAATAAATTTAAAAGCTAGG AACTATTTGCTTTCTCTTCCACACAAAAATAAGGTGCCATGGAACAGGCTGTTCCCAAATGCTGACTCCAAAGCTCTGGACTTATTGGAC AAAATGTTGACATTCAACCCACACAAGAGGATTGAAGTAGAACAGGCTCTGGCCCACCCATATCTGGAGCAGTATTACGACCCGAGTGAC GAGCCCATCGCCGAAGCACCATTCAAGTTCGACATGGAATTGGATGACTTGCCTAAGGAAAAGCTCAAAGAACTAATTTTTGAAGAGACT GCTAGATTCCAGCCAGGATACAGATCTTAAATTTGTCAGGTACCTGGAGTTTAATACAGTGAGCTCTAGCAAGGGAGGCGCTGCCTTTTG TTTCTAGAATATTATGTTCCTCAAGGTCCATTATTTTGTATTCTTTTCCAAGCTCCTTATTGGAAGGTATTTTTTTAAATTTAGAATTAA >In-frame_SHANK3_ENST00000262795_chr22_51115121_+_MAPK1_ENST00000544786_chr22_22153417_-_798nt ATGGACGGCCCCGGGGCCAGCGCCGTGGTCGTGCGCGTCGGCATCCCGGACCTGCAGCAGACGAAGTGCCTGCGCCTGGACCCGGCCGCG CCCGTGTGGGCCGCCAAGCAGCGCGTGCTCTGCGCCCTCAACCACAGCCTCCAGGACGCGCTCAACTATGGGCTTTTCCAGCCGCCCTCC CGGGGCCGCGCCGGCAAGTTCCTGGATGAGGAGCGGCTCCTGCAGGAGTACCCGCCCAACCTGGACACGCCCCTGCCCTACCTGGAGTTT CGATACAAGCGGCGAGTTTATGCCCAGAACCTCATCGATGATAAGCAGTTTGCAAAGCTTCACACAAAGATCTGTGACTTTGGCCTGGCC CGTGTTGCAGATCCAGACCATGATCACACAGGGTTCCTGACAGAATATGTGGCCACACGTTGGTACAGGGCTCCAGAAATTATGTTGAAT TCCAAGGGCTACACCAAGTCCATTGATATTTGGTCTGTAGGCTGCATTCTGGCAGAAATGCTTTCTAACAGGCCCATCTTTCCAGGGAAG CATTATCTTGACCAGCTGAACCACATTTTGGCTCTGGACTTATTGGACAAAATGTTGACATTCAACCCACACAAGAGGATTGAAGTAGAA CAGGCTCTGGCCCACCCATATCTGGAGCAGTATTACGACCCGAGTGACGAGCCCATCGCCGAAGCACCATTCAAGTTCGACATGGAATTG |
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FusionGenePPI for SHANK3_MAPK1 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
SHANK3 | ARHGEF7, DLGAP1, DLGAP2, DLGAP3, DLGAP4, SPTAN1, PPP1CC, ABCC2, CSNK2B, CRKL, GRB2, NCK1, MAPK1, COPS5, SHANK1, PRMT2 | MAPK1 | NEK2, MYC, AR, SORBS3, MAPKAPK2, ATP1A1, FHL2, MKNK2, RPS6KA1, RPS6KA2, CASP9, MAP2K1, MAPK14, ELK1, UBR5, TPR, RPS6KA5, RPS6KA3, ADAM17, PTPN7, MAP2K2, RAF1, INSR, PRKCE, ESR1, PEBP1, PTPRR, PTPN5, SNCG, SNCA, LAMTOR3, MKNK1, VAV1, TSC2, GATA4, IER3, PECAM1, TNIP1, TNKS2, HMMR, STAT5A, DYRK1B, DUSP3, PEA15, CEBPB, ATF2, MAP3K1, DUSP16, SHC1, C1QBP, DUSP1, TOB1, DUSP6, HDAC4, SREBF1, SREBF2, TP53, TH, KRT8, CIITA, JUN, FOS, ALK, CDC25C, MTPN, PGR, ARRB2, JUND, TFCP2, ESR2, ARHGEF2, TOP2A, CENPE, EP300, VDR, HNF4A, RXRA, SFPQ, CCND1, SMAD1, RYK, DCC, AGTR1, PPP1CC, MINOS1, YBX3, YBX1, NUP153, CTSD, GAPDH, ID2, IFI35, GTF2I, ARRB1, TNFRSF1A, TNFRSF25, UBTF, SP1, RARA, CAV1, PTPRE, NCOA3, RPS6KA4, SMAD3, HIST1H2AB, HIST1H4A, VDAC1, RABGEF1, KARS, PARK2, FOXO3, SYNE2, PML, MAPK1, CACYBP, RPTOR, ICK, WDR83, GSTP1, CASP8, EIF4EBP1, BRCA1, MBP, GAB2, GSK3B, MAP2K7, STAB2, HSF4, NTMT1, NEB, HSF1, GORASP2, STAT3, ARHGAP9, IQGAP1, BARD1, ITGB6, ECT2, TP53BP1, NOTCH1, DAPK1, KLF11, VCP, PPP2R5B, PPP2R5C, CAPN2, ADAM15, NOXA1, MAP3K10, LCK, TIAL1, GADD45A, MAP2K4, BRAF, CUEDC2, SQSTM1, CRP, SUPT20H, TNIP2, MTIF3, PRPSAP1, ENAH, GNPTAB, SHANK3, EGLN3, KRAS, PDE4D, MAPK3, MAPK12, PDCD6IP, CEP350, NAV1, HMGB1, DGCR8, HDAC6, MAP2K6, PTGDR, ZC3HC1, HIF1A, CREBBP, TTN, PPARG, CUL7, ABCE1, ATP6V1D, CHEK1, CHEK2, DNAAF5, HNRNPR, ILKAP, ITPK1, DCUN1D1, FERMT2, LMNB2, PFKM, PTPRF, RRM2, XPO6, NTRK1, PAX5, ELK4, BCL2, BANP, ETS1, FGF5, MAPKAPK5, PXN, RET, CITED2, COPS6, MCM2, OTUB1, REST, PLA2G4A, ITGAV, SRC, PRDX6, CSNK2A1, BCL2L11, DUSP2, DUSP4, DUSP9, PTPDC1, DUSP12, DUSP19, DUSP8, PKM, SLC9A3R1, KDR, RMDN3, FH, MTOR, RPS11, STYX, PTTG1, TRIM25, BCL3 |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SHANK3_MAPK1 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | MAPK1 | P28482 | DB01064 | Isoprenaline | Mitogen-activated protein kinase 1 | small molecule | approved|investigational |
Tgene | MAPK1 | P28482 | DB01169 | Arsenic trioxide | Mitogen-activated protein kinase 1 | small molecule | approved|investigational |
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RelatedDiseases for SHANK3_MAPK1 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | SHANK3 | C0004352 | Autistic Disorder | 2 | CTD_human |
Hgene | SHANK3 | C0023014 | Language Development Disorders | 2 | CTD_human |
Hgene | SHANK3 | C1510586 | Autism Spectrum Disorders | 2 | CTD_human |
Hgene | SHANK3 | C0008073 | Developmental Disabilities | 1 | CTD_human |
Hgene | SHANK3 | C0338831 | Manic | 1 | PSYGENET |
Hgene | SHANK3 | C0564408 | Manic mood | 1 | PSYGENET |
Hgene | SHANK3 | C1853490 | 22q13.3 Deletion Syndrome | 1 | ORPHANET;UNIPROT |
Hgene | SHANK3 | C3151380 | SCHIZOPHRENIA 15 | 1 | UNIPROT |
Hgene | SHANK3 | C3714756 | Intellectual Disability | 1 | CTD_human |
Hgene | SHANK3 | C4048800 | Telomeric 22q13 Monosomy Syndrome | 1 | CTD_human |
Tgene | MAPK1 | C0020429 | Hyperalgesia | 2 | CTD_human |
Tgene | MAPK1 | C0024121 | Lung Neoplasms | 2 | CTD_human |
Tgene | MAPK1 | C0236736 | Cocaine-Related Disorders | 2 | CTD_human |
Tgene | MAPK1 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
Tgene | MAPK1 | C0007137 | Squamous cell carcinoma | 1 | CTD_human |
Tgene | MAPK1 | C0007786 | Brain Ischemia | 1 | CTD_human |
Tgene | MAPK1 | C0017639 | Gliosis | 1 | CTD_human |
Tgene | MAPK1 | C0018671 | Head and Neck Neoplasms | 1 | CTD_human |
Tgene | MAPK1 | C0020564 | Hypertrophy | 1 | CTD_human |
Tgene | MAPK1 | C0021361 | Female infertility | 1 | CTD_human |
Tgene | MAPK1 | C0022665 | Kidney Neoplasm | 1 | CTD_human |
Tgene | MAPK1 | C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
Tgene | MAPK1 | C0027627 | Neoplasm Metastasis | 1 | CTD_human |
Tgene | MAPK1 | C0027746 | Nerve Degeneration | 1 | CTD_human |
Tgene | MAPK1 | C0036341 | Schizophrenia | 1 | PSYGENET |
Tgene | MAPK1 | C0036920 | Sezary Syndrome | 1 | CTD_human |
Tgene | MAPK1 | C0038356 | Stomach Neoplasms | 1 | CTD_human |
Tgene | MAPK1 | C0038587 | Substance Withdrawal Syndrome | 1 | CTD_human |
Tgene | MAPK1 | C0040997 | Trigeminal Neuralgia | 1 | CTD_human |
Tgene | MAPK1 | C0155862 | Streptococcal pneumonia | 1 | CTD_human |
Tgene | MAPK1 | C0178417 | Anhedonia | 1 | PSYGENET |
Tgene | MAPK1 | C0243026 | Sepsis | 1 | CTD_human |
Tgene | MAPK1 | C0878544 | Cardiomyopathies | 1 | CTD_human |
Tgene | MAPK1 | C0919267 | ovarian neoplasm | 1 | CTD_human |
Tgene | MAPK1 | C1866282 | CEROID LIPOFUSCINOSIS, NEURONAL, 6 | 1 | CTD_human |
Tgene | MAPK1 | C3495559 | Juvenile arthritis | 1 | CTD_human |