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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 33698

FusionGeneSummary for SH3RF3_SH3RF3

check button Fusion gene summary
Fusion gene informationFusion gene name: SH3RF3_SH3RF3
Fusion gene ID: 33698
HgeneTgene
Gene symbol

SH3RF3

SH3RF3

Gene ID

344558

344558

Gene nameSH3 domain containing ring finger 3SH3 domain containing ring finger 3
SynonymsPOSH2|SH3MD4POSH2|SH3MD4
Cytomap

2q13

2q13

Type of geneprotein-codingprotein-coding
DescriptionSH3 domain-containing RING finger protein 3SH3 multiple domains 4plenty of SH3s-2SH3 domain-containing RING finger protein 3SH3 multiple domains 4plenty of SH3s-2
Modification date2018051920180519
UniProtAcc

Q8TEJ3

Q8TEJ3

Ensembl transtripts involved in fusion geneENST00000309415, ENST00000309415, 
Fusion gene scores* DoF score2 X 2 X 1=44 X 4 X 2=32
# samples 24
** MAII scorelog2(2/4*10)=2.32192809488736log2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SH3RF3 [Title/Abstract] AND SH3RF3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA179627SH3RF3chr2

109872839

-SH3RF3chr2

109876821

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000309415ENST00000309415SH3RF3chr2

109872839

-SH3RF3chr2

109876821

-

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FusionProtFeatures for SH3RF3_SH3RF3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SH3RF3

Q8TEJ3

SH3RF3

Q8TEJ3

Has E3 ubiquitin-protein ligase activity.{ECO:0000269|PubMed:20696164}. Has E3 ubiquitin-protein ligase activity.{ECO:0000269|PubMed:20696164}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SH3RF3_SH3RF3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SH3RF3_SH3RF3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SH3RF3_SH3RF3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SH3RF3_SH3RF3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSH3RF3C0236733Amphetamine-Related Disorders1CTD_human
TgeneSH3RF3C0236733Amphetamine-Related Disorders1CTD_human