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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 33626

FusionGeneSummary for SH3BGRL3_TPM3

check button Fusion gene summary
Fusion gene informationFusion gene name: SH3BGRL3_TPM3
Fusion gene ID: 33626
HgeneTgene
Gene symbol

SH3BGRL3

TPM3

Gene ID

83442

7170

Gene nameSH3 domain binding glutamate rich protein like 3tropomyosin 3
SynonymsHEL-S-297|SH3BP-1|TIP-B1CAPM1|CFTD|HEL-189|HEL-S-82p|NEM1|OK/SW-cl.5|TM-5|TM3|TM30|TM30nm|TM5|TPM3nu|TPMsk3|TRK|hscp30
Cytomap

1p36.11

1q21.3

Type of geneprotein-codingprotein-coding
DescriptionSH3 domain-binding glutamic acid-rich-like protein 3SH3 domain binding glutamic acid-rich protein like 3SH3 domain-binding protein 1SH3BGRL3-like proteinTNF inhibitory proteinepididymis secretory protein Li 297tropomyosin alpha-3 chainalpha-tropomyosin, slow skeletalcytoskeletal tropomyosin TM30epididymis luminal protein 189epididymis secretory sperm binding protein Li 82pheat-stable cytoskeletal protein 30 kDatropomyosin 3 nutropomyosin gammatropomyosi
Modification date2018051920180523
UniProtAcc

Q9H299

P06753

Ensembl transtripts involved in fusion geneENST00000270792, ENST00000319041, 
ENST00000368533, ENST00000469717, 
ENST00000330188, ENST00000341485, 
ENST00000341372, ENST00000328159, 
ENST00000271850, ENST00000302206, 
ENST00000368531, ENST00000323144, 
ENST00000368530, 
Fusion gene scores* DoF score9 X 8 X 3=2167 X 6 X 4=168
# samples 99
** MAII scorelog2(9/216*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(9/168*10)=-0.900464326449086
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SH3BGRL3 [Title/Abstract] AND TPM3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CA417208SH3BGRL3chr1

26607746

-TPM3chr1

154130055

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000270792ENST00000368533SH3BGRL3chr1

26607746

-TPM3chr1

154130055

+
3UTR-5UTRENST00000270792ENST00000469717SH3BGRL3chr1

26607746

-TPM3chr1

154130055

+
3UTR-3UTRENST00000270792ENST00000330188SH3BGRL3chr1

26607746

-TPM3chr1

154130055

+
3UTR-3UTRENST00000270792ENST00000341485SH3BGRL3chr1

26607746

-TPM3chr1

154130055

+
3UTR-3UTRENST00000270792ENST00000341372SH3BGRL3chr1

26607746

-TPM3chr1

154130055

+
3UTR-3UTRENST00000270792ENST00000328159SH3BGRL3chr1

26607746

-TPM3chr1

154130055

+
3UTR-3UTRENST00000270792ENST00000271850SH3BGRL3chr1

26607746

-TPM3chr1

154130055

+
3UTR-intronENST00000270792ENST00000302206SH3BGRL3chr1

26607746

-TPM3chr1

154130055

+
3UTR-intronENST00000270792ENST00000368531SH3BGRL3chr1

26607746

-TPM3chr1

154130055

+
3UTR-intronENST00000270792ENST00000323144SH3BGRL3chr1

26607746

-TPM3chr1

154130055

+
3UTR-intronENST00000270792ENST00000368530SH3BGRL3chr1

26607746

-TPM3chr1

154130055

+
3UTR-3UTRENST00000319041ENST00000368533SH3BGRL3chr1

26607746

-TPM3chr1

154130055

+
3UTR-5UTRENST00000319041ENST00000469717SH3BGRL3chr1

26607746

-TPM3chr1

154130055

+
3UTR-3UTRENST00000319041ENST00000330188SH3BGRL3chr1

26607746

-TPM3chr1

154130055

+
3UTR-3UTRENST00000319041ENST00000341485SH3BGRL3chr1

26607746

-TPM3chr1

154130055

+
3UTR-3UTRENST00000319041ENST00000341372SH3BGRL3chr1

26607746

-TPM3chr1

154130055

+
3UTR-3UTRENST00000319041ENST00000328159SH3BGRL3chr1

26607746

-TPM3chr1

154130055

+
3UTR-3UTRENST00000319041ENST00000271850SH3BGRL3chr1

26607746

-TPM3chr1

154130055

+
3UTR-intronENST00000319041ENST00000302206SH3BGRL3chr1

26607746

-TPM3chr1

154130055

+
3UTR-intronENST00000319041ENST00000368531SH3BGRL3chr1

26607746

-TPM3chr1

154130055

+
3UTR-intronENST00000319041ENST00000323144SH3BGRL3chr1

26607746

-TPM3chr1

154130055

+
3UTR-intronENST00000319041ENST00000368530SH3BGRL3chr1

26607746

-TPM3chr1

154130055

+

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FusionProtFeatures for SH3BGRL3_TPM3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SH3BGRL3

Q9H299

TPM3

P06753

Could act as a modulator of glutaredoxin biologicalactivity.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SH3BGRL3_TPM3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SH3BGRL3_TPM3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SH3BGRL3APP, PIPSL, USP3, STXBP3, AHCYL1, TESTPM3KXD1, TFPT, MCC, EIF4A2, TPM3, TP73, NEK2, RAD21, ELAVL1, SP1, CUL3, CDK2, LRRK2, TPM4, SEC23IP, KYNU, TPM2, TPM1, PRDX1, THOC1, CDC123, SF3A2, SEPT9, HSPB1, BRCA1, MDC1, PAXIP1, HSP90AA1, HSP90AB1, FN1, PAN2, HDAC8, FBXO5, TRAP1, PARK2, FASN, FKBP4, FKBP5, MAGED2, CAP1, MCM3, MGEA5, TP53, HSF2, IFIT3, KCNE1, KIFC3, MAGEA11, PBX3, TRIM27, VPS52, TNNT1, TRIP6, MAD1L1, TLK1, OIP5, BLOC1S6, CCHCR1, THAP1, CCDC146, CCDC102B, CCDC114, SYCE1, IKBIP, C1orf216, LCA5L, FAM9C, HDDC3, WASH3P, LURAP1, SHMT2, MOV10, NXF1, CUL7, OBSL1, RNF2, EGFR, DAPK1, ACTN2, AHCYL1, ATP1A1, CKB, CKMT1B, CKMT1A, COX5A, CYC1, OSTF1, ACTN1, ACTN4, ATP5F1, COX4I1, MTCH1, MYH7B, NDUFB10, PSMA2, PSMA6, STMN1, TBCD, UQCRC2, NTRK1, DVL2, HOOK2, ADD1, CAPZA2, MYH9, PPP1CB, PPP1CC, IQGAP1, PDLIM7, ANLN, MYO5C, MYO19, MYO18A, MCM2, RNF20, IMP3, CALCOCO1, JUN, METTL2B, CCDC101, SPAG9, PARK7, PDHA1, VDAC1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SH3BGRL3_TPM3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SH3BGRL3_TPM3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSH3BGRL3C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneTPM3C1836448Nemaline myopathy 19CTD_human;ORPHANET;UNIPROT
TgeneTPM3C0546264Congenital Fiber Type Disproportion5ORPHANET;UNIPROT
TgeneTPM3C0024667Animal Mammary Neoplasms2CTD_human
TgeneTPM3C0024668Mammary Neoplasms, Experimental2CTD_human
TgeneTPM3C0001418Adenocarcinoma1CTD_human
TgeneTPM3C0009375Colonic Neoplasms1CTD_human
TgeneTPM3C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneTPM3C0038356Stomach Neoplasms1CTD_human
TgeneTPM3C0040136Thyroid Neoplasm1CTD_human