![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 33613 |
FusionGeneSummary for SH2D3A_GPM6A |
![]() |
Fusion gene information | Fusion gene name: SH2D3A_GPM6A | Fusion gene ID: 33613 | Hgene | Tgene | Gene symbol | SH2D3A | GPM6A | Gene ID | 10045 | 2823 |
Gene name | SH2 domain containing 3A | glycoprotein M6A | |
Synonyms | NSP1 | GPM6|M6A | |
Cytomap | 19p13.3 | 4q34.2 | |
Type of gene | protein-coding | protein-coding | |
Description | SH2 domain-containing protein 3Anovel SH2-containing protein 1 | neuronal membrane glycoprotein M6-a | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q9BRG2 | P51674 | |
Ensembl transtripts involved in fusion gene | ENST00000437152, ENST00000245908, ENST00000599563, | ENST00000280187, ENST00000393658, ENST00000506894, ENST00000515090, ENST00000506219, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 4 X 4 X 2=32 |
# samples | 1 | 4 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: SH2D3A [Title/Abstract] AND GPM6A [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | GPM6A | GO:0001764 | neuron migration | 19298174 |
Tgene | GPM6A | GO:0048863 | stem cell differentiation | 19298174 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | HNSC | TCGA-CQ-A4CI-01A | SH2D3A | chr19 | 6767398 | - | GPM6A | chr4 | 176573138 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-3CDS | ENST00000437152 | ENST00000280187 | SH2D3A | chr19 | 6767398 | - | GPM6A | chr4 | 176573138 | - |
5UTR-3CDS | ENST00000437152 | ENST00000393658 | SH2D3A | chr19 | 6767398 | - | GPM6A | chr4 | 176573138 | - |
5UTR-3CDS | ENST00000437152 | ENST00000506894 | SH2D3A | chr19 | 6767398 | - | GPM6A | chr4 | 176573138 | - |
5UTR-3CDS | ENST00000437152 | ENST00000515090 | SH2D3A | chr19 | 6767398 | - | GPM6A | chr4 | 176573138 | - |
5UTR-intron | ENST00000437152 | ENST00000506219 | SH2D3A | chr19 | 6767398 | - | GPM6A | chr4 | 176573138 | - |
5UTR-3CDS | ENST00000245908 | ENST00000280187 | SH2D3A | chr19 | 6767398 | - | GPM6A | chr4 | 176573138 | - |
5UTR-3CDS | ENST00000245908 | ENST00000393658 | SH2D3A | chr19 | 6767398 | - | GPM6A | chr4 | 176573138 | - |
5UTR-3CDS | ENST00000245908 | ENST00000506894 | SH2D3A | chr19 | 6767398 | - | GPM6A | chr4 | 176573138 | - |
5UTR-3CDS | ENST00000245908 | ENST00000515090 | SH2D3A | chr19 | 6767398 | - | GPM6A | chr4 | 176573138 | - |
5UTR-intron | ENST00000245908 | ENST00000506219 | SH2D3A | chr19 | 6767398 | - | GPM6A | chr4 | 176573138 | - |
intron-3CDS | ENST00000599563 | ENST00000280187 | SH2D3A | chr19 | 6767398 | - | GPM6A | chr4 | 176573138 | - |
intron-3CDS | ENST00000599563 | ENST00000393658 | SH2D3A | chr19 | 6767398 | - | GPM6A | chr4 | 176573138 | - |
intron-3CDS | ENST00000599563 | ENST00000506894 | SH2D3A | chr19 | 6767398 | - | GPM6A | chr4 | 176573138 | - |
intron-3CDS | ENST00000599563 | ENST00000515090 | SH2D3A | chr19 | 6767398 | - | GPM6A | chr4 | 176573138 | - |
intron-intron | ENST00000599563 | ENST00000506219 | SH2D3A | chr19 | 6767398 | - | GPM6A | chr4 | 176573138 | - |
Top |
FusionProtFeatures for SH2D3A_GPM6A |
![]() |
Hgene | Tgene |
SH2D3A | GPM6A |
May play a role in JNK activation. | Involved in neuronal differentiation, includingdifferentiation and migration of neuronal stem cells. Plays a rolein neuronal plasticity and is involved in neurite and filopodiaoutgrowth, filopodia motility and probably synapse formation.GPM6A-induced filopodia formation involves mitogen-activatedprotein kinase (MAPK) and Src signaling pathways. May be involvedin neuronal NGF-dependent Ca(2+) influx. May be involved inregulation of endocytosis and intracellular trafficking of G-protein-coupled receptors (GPCRs); enhances internalization andrecycling of mu-type opioid receptor.{ECO:0000269|PubMed:19298174}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for SH2D3A_GPM6A |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for SH2D3A_GPM6A |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
SH2D3A | SFN, BCAR1, EGFR, MAPK8, NXF1, ERBB2, KRAS, CENPB | GPM6A | PAM16, ZDHHC17, CCDC126, MGAT5, RMDN3, SLC35B2, AGPAT3, FITM2, ERMP1, HAX1, IKBIP, RFT1, UQCR10, YIPF3, FAM189B, SCAMP2, PXMP2, GP1BB, VKORC1L1, ZDHHC18, ARMC1, NUFIP1, DNAAF2, TSPAN17, EDA, GPR114, TSPAN3, HTR3A, VNN2, P2RY1, FKRP, TRIM25 |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for SH2D3A_GPM6A |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for SH2D3A_GPM6A |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | GPM6A | C0036341 | Schizophrenia | 1 | PSYGENET |