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Fusion gene ID: 33588 |
FusionGeneSummary for SGPP2_ALG14 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SGPP2_ALG14 | Fusion gene ID: 33588 | Hgene | Tgene | Gene symbol | SGPP2 | ALG14 | Gene ID | 130367 | 199857 |
| Gene name | sphingosine-1-phosphate phosphatase 2 | ALG14, UDP-N-acetylglucosaminyltransferase subunit | |
| Synonyms | SPP2|SPPase2 | CMS15 | |
| Cytomap | 2q36.1 | 1p21.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | sphingosine-1-phosphate phosphatase 2sphingosine 1-phosphate phosphohydrolase 2sphingosine-1-phosphatase 2sphingosine-1-phosphate phosphotase 2 | UDP-N-acetylglucosamine transferase subunit ALG14 homolog | |
| Modification date | 20180329 | 20180519 | |
| UniProtAcc | Q8IWX5 | Q96F25 | |
| Ensembl transtripts involved in fusion gene | ENST00000321276, | ENST00000370205, ENST00000495856, | |
| Fusion gene scores | * DoF score | 4 X 3 X 4=48 | 4 X 3 X 4=48 |
| # samples | 4 | 6 | |
| ** MAII score | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/48*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: SGPP2 [Title/Abstract] AND ALG14 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | SGPP2 | GO:0006670 | sphingosine metabolic process | 12411432 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-B6-A0RE-01A | SGPP2 | chr2 | 223389752 | + | ALG14 | chr1 | 95492816 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000321276 | ENST00000370205 | SGPP2 | chr2 | 223389752 | + | ALG14 | chr1 | 95492816 | - |
| 5CDS-intron | ENST00000321276 | ENST00000495856 | SGPP2 | chr2 | 223389752 | + | ALG14 | chr1 | 95492816 | - |
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FusionProtFeatures for SGPP2_ALG14 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SGPP2 | ALG14 |
| Has specific phosphohydrolase activity towards sphingoidbase 1-phosphates. Has high phosphohydrolase activity againstdihydrosphingosine-1-phosphate and sphingosine-1-phosphate (S1P)in vitro. May play a role in attenuating intracellular sphingosine1-phosphate (S1P) signaling. May play a role in pro-inflammatorysignaling. {ECO:0000269|PubMed:12411432,ECO:0000269|PubMed:17113265}. | May be involved in protein N-glycosylation. May play arole in the second step of the dolichol-linked oligosaccharidepathway. May anchor the catalytic subunit ALG13 to the ER.{ECO:0000269|PubMed:16100110}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | SGPP2 | chr2:223389752 | chr1:95492816 | ENST00000321276 | + | 4 | 5 | 136_144 | 216 | 400 | Region | Phosphatase sequence motif I |
| Hgene | SGPP2 | chr2:223389752 | chr1:95492816 | ENST00000321276 | + | 4 | 5 | 163_166 | 216 | 400 | Region | Phosphatase sequence motif II |
| Hgene | SGPP2 | chr2:223389752 | chr1:95492816 | ENST00000321276 | + | 4 | 5 | 206_217 | 216 | 400 | Region | Phosphatase sequence motif III |
| Hgene | SGPP2 | chr2:223389752 | chr1:95492816 | ENST00000321276 | + | 4 | 5 | 121_141 | 216 | 400 | Transmembrane | Helical |
| Hgene | SGPP2 | chr2:223389752 | chr1:95492816 | ENST00000321276 | + | 4 | 5 | 160_180 | 216 | 400 | Transmembrane | Helical |
| Hgene | SGPP2 | chr2:223389752 | chr1:95492816 | ENST00000321276 | + | 4 | 5 | 185_205 | 216 | 400 | Transmembrane | Helical |
| Hgene | SGPP2 | chr2:223389752 | chr1:95492816 | ENST00000321276 | + | 4 | 5 | 88_108 | 216 | 400 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >SGPP2 | chr2:223389752 | chr1:95492816 | ENST00000321276 | + | 4 | 5 | 219_239 | 216 | 400 | Transmembrane | Helical |
| Hgene | >SGPP2 | chr2:223389752 | chr1:95492816 | ENST00000321276 | + | 4 | 5 | 247_267 | 216 | 400 | Transmembrane | Helical |
| Hgene | >SGPP2 | chr2:223389752 | chr1:95492816 | ENST00000321276 | + | 4 | 5 | 280_300 | 216 | 400 | Transmembrane | Helical |
| Hgene | >SGPP2 | chr2:223389752 | chr1:95492816 | ENST00000321276 | + | 4 | 5 | 318_338 | 216 | 400 | Transmembrane | Helical |
| Hgene | >SGPP2 | chr2:223389752 | chr1:95492816 | ENST00000321276 | + | 4 | 5 | 371_391 | 216 | 400 | Transmembrane | Helical |
| Tgene | ALG14 | chr2:223389752 | chr1:95492816 | ENST00000370205 | - | 1 | 4 | 1_3 | 96 | 217 | Topological domain | Lumenal |
| Tgene | ALG14 | chr2:223389752 | chr1:95492816 | ENST00000370205 | - | 1 | 4 | 25_216 | 96 | 217 | Topological domain | Cytoplasmic |
| Tgene | ALG14 | chr2:223389752 | chr1:95492816 | ENST00000370205 | - | 1 | 4 | 4_24 | 96 | 217 | Transmembrane | Helical |
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FusionGeneSequence for SGPP2_ALG14 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_SGPP2_ENST00000321276_chr2_223389752_+_ALG14_ENST00000370205_chr1_95492816_-_337aa MAELLRSLQDSQLVARFQRRCGLFPAPDEGPRENGADPTERAARVPGVEHLPAANGKGGEAPANGLRRAAAPEAYVQKYVVKNYFYYYLF QFSAALGQEVFYITFLPFTHWNIDPYLSRRLIIIWVLVMYIGQVAKDVLKWPRPSSPPVVKLEKRLIAEYGMPSTHAMAATAIAFTLLIS TMDRYQYPFVLGLVMAVVFSTLVCLSRLYTGMHTVLYTKYYIHRIPRSREVQQSWPSTVFTTLHSMWLSFPLIHRVKPDLVLCNGPGTCV |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_SGPP2_ENST00000321276_chr2_223389752_+_ALG14_ENST00000370205_chr1_95492816_-_1011nt ATGGCCGAGCTGCTGCGGAGCCTGCAGGATTCCCAGCTCGTCGCCCGCTTCCAGCGCCGCTGCGGGCTCTTCCCCGCTCCGGATGAAGGC CCCCGGGAGAACGGCGCGGACCCCACGGAGCGCGCGGCGCGGGTCCCCGGGGTCGAGCATCTCCCCGCAGCCAACGGCAAGGGCGGCGAG GCTCCGGCCAACGGGCTGCGCAGAGCCGCGGCGCCGGAGGCTTATGTACAGAAGTACGTCGTGAAGAATTATTTCTACTATTACCTATTC CAATTTTCAGCTGCTTTGGGCCAAGAAGTGTTCTACATCACGTTTCTTCCATTCACTCACTGGAATATTGACCCTTATTTATCCAGAAGA TTGATCATCATATGGGTTTTGGTGATGTATATTGGCCAAGTGGCCAAGGATGTCTTGAAGTGGCCCCGTCCCTCCTCCCCTCCAGTTGTA AAACTGGAAAAGAGACTGATCGCTGAATATGGAATGCCATCCACCCACGCCATGGCGGCCACTGCCATTGCCTTCACCCTCCTTATCTCT ACTATGGACAGATACCAGTATCCATTTGTGTTGGGACTGGTGATGGCCGTGGTGTTTTCCACCTTGGTGTGTCTCAGCAGGCTCTACACT GGGATGCATACGGTCCTGTATACCAAATACTACATTCACCGAATTCCAAGAAGCCGGGAGGTTCAGCAGTCCTGGCCCTCCACCGTTTTC ACCACCTTGCACTCCATGTGGCTCTCCTTTCCCCTAATTCACAGGGTGAAGCCAGATTTGGTGTTGTGTAACGGACCAGGAACATGTGTT CCTATCTGTGTATCTGCCCTTCTCCTTGGGATACTAGGAATAAAGAAAGTGATCATTGTCTACGTTGAAAGCATCTGCCGTGTAGAAACG TTATCCATGTCCGGAAAGATTCTGTTTCATCTCTCAGATTACTTCATTGTTCAGTGGCCGGCTCTGAAAGAAAAGTATCCCAAATCGGTG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_SGPP2_ENST00000321276_chr2_223389752_+_ALG14_ENST00000370205_chr1_95492816_-_9766nt GGCGGGGGCGAGGCGGGAGTGGCGGTGCCAGCGGAGGGCACCGGCCCGGCGTGGCAGCGGCGGCGGAGCGCGGCCCCGGGCACACCATGG CCGAGCTGCTGCGGAGCCTGCAGGATTCCCAGCTCGTCGCCCGCTTCCAGCGCCGCTGCGGGCTCTTCCCCGCTCCGGATGAAGGCCCCC GGGAGAACGGCGCGGACCCCACGGAGCGCGCGGCGCGGGTCCCCGGGGTCGAGCATCTCCCCGCAGCCAACGGCAAGGGCGGCGAGGCTC CGGCCAACGGGCTGCGCAGAGCCGCGGCGCCGGAGGCTTATGTACAGAAGTACGTCGTGAAGAATTATTTCTACTATTACCTATTCCAAT TTTCAGCTGCTTTGGGCCAAGAAGTGTTCTACATCACGTTTCTTCCATTCACTCACTGGAATATTGACCCTTATTTATCCAGAAGATTGA TCATCATATGGGTTTTGGTGATGTATATTGGCCAAGTGGCCAAGGATGTCTTGAAGTGGCCCCGTCCCTCCTCCCCTCCAGTTGTAAAAC TGGAAAAGAGACTGATCGCTGAATATGGAATGCCATCCACCCACGCCATGGCGGCCACTGCCATTGCCTTCACCCTCCTTATCTCTACTA TGGACAGATACCAGTATCCATTTGTGTTGGGACTGGTGATGGCCGTGGTGTTTTCCACCTTGGTGTGTCTCAGCAGGCTCTACACTGGGA TGCATACGGTCCTGTATACCAAATACTACATTCACCGAATTCCAAGAAGCCGGGAGGTTCAGCAGTCCTGGCCCTCCACCGTTTTCACCA CCTTGCACTCCATGTGGCTCTCCTTTCCCCTAATTCACAGGGTGAAGCCAGATTTGGTGTTGTGTAACGGACCAGGAACATGTGTTCCTA TCTGTGTATCTGCCCTTCTCCTTGGGATACTAGGAATAAAGAAAGTGATCATTGTCTACGTTGAAAGCATCTGCCGTGTAGAAACGTTAT CCATGTCCGGAAAGATTCTGTTTCATCTCTCAGATTACTTCATTGTTCAGTGGCCGGCTCTGAAAGAAAAGTATCCCAAATCGGTGTACC TTGGGCGAATTGTTTGACAAATGGCAACTGACTTCTTTAGAATTTTGCAGTTAACAGTAGTATGTACTCAAATTGGGGGGAAAAAAACCC TACATGTTTCTTGTAAAGGCGTCTGACAGTCCTGAGAATTATTGATGGTAAGGAATAAAAAATGTACAGATGACTCAGTGAAGAAACTGA GGCTTCTCTTATGAAACAAACATTGATAAACGTAACTACTAAATGTTTATGCCTCTGTAAACCAAATTTCTTTTCTAGATAAAAATATGT ATTACTACCTGCAAATTTTCTTCTGGCTGTTTTAGTAGTATTTTTTTTACAGAACTAAATATAGAGTTTGTATGATTAGTAATATTTCCT GTCCTACAGCTTTTTTTTTTTTTTTTTTTTTTTGTAAAGTATTCTGCATTGTAAAAGAAGAGAGAAAAAAAGTATTTCTGAGTTTTGGTT CAGATACAAAAGGCTTTATTTCCTGTATGGAAACAGTGATGTCCCCAGTGAATCCTTTCAGCATAAAGGAAGCAGTTATATTAAATTGGC TTCATGACAATTTGCACTCCACAAGCCTCCAGAACCTTGAGCATAAACCAGTATCATTTTTTGTACTTCAGTCTTGCTTTTTGAGTAGTT GGCCTTAATACAGAGTATCTTTTAAAATCTCTTGTTTAGGCCGGCATGACGGCTCACACCTGTAATCCCAGCACCTTGGGAGGCTAAGGC GGGTGGATCACTGGAGGTCAGGAGTTTGACACCAGCCTGACCAACATGGTGAAACCTTGTCTCTACTAAAAATACAAAAATTAGTCAGGC GTGGTGGCACATGCCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCGGGAGGCAGAGGCTGCAGTGAGCCGA GATTGCACCATTGCACTCCATCCAGCCTGGGTGACAAGAGTGAAACTTCGTCTCAAAAAAAAAAAAAAAAAACAAAACTCAATGATGTAG GGACTGTTATTATTCCCATTTTACAGATGACTTGTCCAAGATCACATGAGTAGTAAGTAGCAAAGCCAGAATTCAAGTTCAGGTAAACCT GACTTCTTAGTGGGGCCAGTTTCACGGGTGTGTGGCCTGTGCAGTCACACAGAGTTCTGCACTGAAGAGGGCCTCCACTTGGTTTAATGT TCTGCTGTGACTCTCTTGAACTTCTGAATATTTTTTTAAACAATGAACTTATATTTTAGACCCTCTGAATTCTTTCGCTGGTCCTGCTTG AGACTGTGTTTCTAGTGGTGCCATGTCTACTGGAATAGAAGTACAATAGTTAGTGCAGTGCCTGGCCCAGGAGCTCCTCAAAAACAGGAA TTCCATTTCCTTCCCTCTAACCTCTGCTTCTTTAACAAAGCAGCCAAAAAAAAAAAAAACAAAACAAAATAAAAAACAGAAAAGAGAAGA TTCTCTCCTGTAGTATATATAGGTTTTTTCCTCTTAAATCTTTTGCTTTATAAGTATGATATAAATCTAATAAATAGTGATTAGTGAAGT GATTGAATTTTTGTGAAAAGAGACATGATTATCCACGATCATGTAAGATTAAAATCCTGAGGCTGATCCAGCCTTTTTTCTTTTTTTTTT TTTTAAAAAAAAAAAGCAAAAAAAACAAAAAAACTGTCTTCTCTGAATCATGTAACAGGCGCATCTGTCAGCCGGACATCTTCCTAGGTT TTTGGCTGGAGAAATGTGTAGCCGAAGGTGTCTCAGAATGGTGAGAACACTTTGCTGTCTGGATTTAGTGGGCCTGGGGCAGCCAAATGA TAGTTCATTGTGCTTTGATTTTAATCCTCAAATCTCAGTCACTGGTTGCTTCCCTGGAGTATCAGAGCGTATTAGTATCATACAACCAGG GGCTGAGGTGAAATAAGCCTTGACTGTTCTAGAAAGAAAGTGATTTTTTCAGGGACAACAGCATCTGCATTTTATTGCTGTTTAAGGCTT TCTCTGCTCTGTACTTTGTTCCCTGAGTGGCACTAGGTAAATGAATGGTAAGGGAAAGTGAACTGCGTTTAGTGAATGCCTCTCTGTGCT GTGGGGCAGCTTCCCTGGGCCCCCACAGGTAATCCTGCTGCAGAGGCTTCTGTCAGGTCAGAGCTTAACAAAGATCAGACCAGAGAGAAT TGTAGAAAAGATGCTATAATTTTTTCCAGAAACATATGTCCCAGATGTTTTGCAGAGCCTTAACTTAAGACAGTGGTTAGCCTGGAATGT CAGAGAAAGAATGTGTATGTGTTATATCACCAAAAGTTTAGAAATGTTATATCTTTCATAGGTTCAGGCTGCTGTGTACTCATTCAGAGC CAGGCTGAGACATGTGTTATTGCATCTTCCTGATCATTCAGATTACTCTGGTAAACAAGTGCATGCTCTGCTGTGTGTTACTGTTATGGC TAATTTGAGTCCTCAAGGTCCCATTAGCAGAGGGGGCTGGTGGCACAATTTCCCTGCTGTGCATTTCTGTGACATTCAGAAAGATAGTGC GCCAGTCCCAACTCAAACTGAAGAAGATGAGTAGCTAGCTTGTCCCTTCCAGTTTCTCTTAGAACACTCTGAATGCAACTTTTACTGTAG GAGACTGTTCATGAAAAAATTAATTGAATCAGTCTTCAAATGAGAGGCAGGGAAACCACACATCCTGCCCACACCTACTTCCCTGGAAGA TTTCTATCTACAGTCCAGCTATCCTAAAAGGTCTCAGTAGCTTGCCAGGTCAGAATGTCTAACTGTTTCAAAAAGGATGCCCAAAAATCA TGACAGGAAACTTTAGCCTGGAACGAAGAGTGCTATGAAACCGTGTCAACAAGAGGAGTGGTGACAATTGTGAGTTGAATAGCAAGATGT CCTTGCTAGGAAGGAGATGACCCAAGCTTCCCCTTATAAAAGCAACTTGGAACACATCATTCTACCTTTCAAAGATACATGGTAAGTTAA AATTGAGAAACGTACCCCTTTACTATACAGTTCCTTGGGTTGAATGAGTGCTTTTTTTTTTTTCTGAAAAGCCCCATCCCCCAAAAGGCA TTTGATAGCAATGTATTAAGCACCTTTTACCAACAATAAGAACATCATTGTAAGTGTTAAAGAAAATTGTCCTTCTCCCTACAGGTCAGC GTTTGAGCCTCACGGGGTTTCTTCCCATGACTTCAGCCCTGGCGCACAATGAGCAGACACCCAAATCTTGTCCGCCTTCAACATTCTTTT GTTAGGGCCCATCCCTCTAGCACTCTAAAAACAAATCATCTACAACTGTGTTCCTGCTGCCCACTCATTTTAAACATGAATTTGACATAG CTCCTCCTTTTCGCACTGGAGTAGTTAACTAATGCTAGCCCACTAGCTTCTATCATGTCCCTCAAGCAACAAACTTTGGGATCATTTTTG CTTTTTCACTCTTTCTTTACCCAATTATAATTGGTTGCCTTTTTTGTTTCATTATCCCCAGAATTTTCTCGTCTTCCTCTTCTCTCCTTG AAATTACTTTTACTGTTCCTCTCCTTTGTCATCACCTATTGATTCTGCCTTTGACTTAGTTCATATCTACCCTTTCCTTTTCAGTCCCAT AGTTACAACCTAAGCCAGCTCTTCAACAAAAATTTCTTGCTTGATGAGCAAGTTTTATTGAGGAACTGAGGAAACACCTGTGGAAGGAAC AAATGAATGATTTTGTTAATTACTTATGTTTGTCTTCAGAGACTTCCCCTCATGCTAGTTCTGTATACTTGTTTCACTTTTTTCTTTCTT TTTTTTTTTTTTTTTTTTTTTTCGAGACAGTCTCGCTCCATCGCCCAGGCTGGAGTGCAGTGGTGCAATCTCACCTTACTGGCTCACTGT AACCTCTGCCTCCTGGCTTCAAGCGATTCTTGTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCATGCACCACCACACCTGGCTAATT TTTGTATTTTTAGTAGAGACAGGGTTTTACCATGTTGGCCAGGCTGATCTTGAACTCCCAACCTCAGGTGATCCACCCATCTTGGCCTCC CAAAGTGCTGGAATTACAGGTGTAAGCCACACGTCCGGCCCTTGTTCCACTTTTTATAATATTTACACCACAGAGAGGTTAAGTAATTTA TTAAAGATTATAGAACTAGAAAGTGACAAAGCTCAGATTTGAACCAAGGCATTCTAGCTCCAGCCAGGCTTACCTTAATAGCTACGTTAG GTGTTTTTTTTTTTTTTTAAAGAAAAAAGAAAAAATGTCCTCAAAAGGAAATAAATGGGGTAACAGGGTACTATGACGGAGTAGAAGGTA GTTGGTGTTCTAGATAGGGAAATCAGGAAAGGCCTTTCTAAGAAAGTGGTATTTTACCTGAGTTCCAAAGGATAATGCCTTAAATATTTG TCCTCCTTCTACTTCACTCCCAACTTAGATTTTGCCCCACCCACAAAGTCTTTGTCTTCATTTAGCTTGAGCAAATTCTCTAAATAACTC TGTGACATAGCCACCCATACCAAAGGTTAGTGCTGAGTTATATACCATCGAATTGCAGTCCTTGTTCTTAGAAACACCTGTGGAAGGAAT AATGAATGCTATTGCTGATTATTTATGTTTGTCTTCAGGGACTGTACCTCATTCTAGTTTTGTATCCTTGTTCCACTTTTGATAGTATTT ACACCACAGCTCTGTACAAAACATAGGCACTAATTAAATACATAAATTATTTGGCCAGGCATGGTGGCTCACGCCTGTAATCCCAGCACT TTGGGAGGCCAAGGTGGGTGTATCACAAGGTCAGGAGTTCAAGACCAGCCTGGCCAAGATGGTGAAACCCCATCTCTACTAAAAATACAA AAAATTTGCCGGCGTGGTGGCGGGCGCCTGTAATTCCAGCTACTTGGGAGGCTGAGGCAAATAATTGCTTGAACCAGGGAGGTGGAGGTT GCAGTGAACTGAGATGGCACCACTGCACTCCAGCCTGGGGGACAGAGCGAGACTCCACCTCAAAAAAAAAAAAAGAAAAAAATTATAGCT TCAGACTTGTCTAGGCTCACTTCAGTTATATTTTATCTAGACCAGTGCTTCACAAACGTTTTGATCTCAGGACCTCATTATACTAAAAAA TTATTGAAAACTGGCTGGGCACAGTGTTTCACACTTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGATGGATCACCTGAGCCCAGGAGT TTGAGATCAGCCTGGGCAACACAGTAAAACCCCATCTCTACAAAAAAAATACAAAAATTAGCCAGGCATGGTGATGCACACCTATAGTTC CAGCTACTTGGGAGGCTGAGGTGGTAGGATCACTTGAGCCTGGGAGGTGGAGGTTGCAGTGAGCCGAGATCATGGCACTGCACTCCAGCC TGGGTGACAGAGTGAGACCCTGCCTCAGAAAAAAAAAAAATATATCCCAATGAGCTTTTGTTTGTGTGAGCTATATTTGTCAATATTTAC CATTGTAGAAACTAGACAAAAATTTTAAACGCAAGAATATAAAAGGACATATTCCACTGGCTGTCAGAACAATATCATCACACATCTTGT AGCATCTGGAAAACTATACCATCATAAGAATGACAAGGAAAAGGCAAATAACATCTTAATATTACTATGAAAATAGTTTTGACCTCATAA ACCCCTAAAAACGTCTTGAAGACTCCCCAGGACCTTGGACCACATTTTAAGAACTGCTGCTTTACATAATGTCACATCAGCGAATTCATC TCTTCTTTTTTTAAAATAAGAGGCAGGGTTTCACTATGTTGTCCAGACTGGTCTCAAACTCCTGGTCTCAAGGAATCCTCCTATCTTGGC CTTCCAAAGTGCTGGAATCACAGGCATGCGGCACTGCGCCCGGCCTATCTCCTCTTTAGTCAGTCAGTGATCTGTGTATTAGTTTTATCG CTGTGTAAAAAATTGCCACACATATATTGGCTTAAAACAATACATTATCTCTGTAGGTTAGAAATCCAGGCAAAGAAGGTTTTCTGCTCA AGATCTCAAAAGGCTGAAATCAAGATGATGGCCAAGGCTGAGTTCTGATCTGCAACTCTGAATCCTTTTCAGATACCTTCAGATGGTTGT TGGCAGAATTCAGTTCCTTGCAGTTGTAGGATTTGTGGTGGCCTGCTTCCTATCTTTTAAGGACTCACATGACTGAGTCAGTGTAATCTC CCTTTTGATTAATTCAAGGTCAACTGATTAGGATCATAATTACGTCCCTTTTGCCATGTTAATGTAACATAATCAGAGGAATGACATGTC ATGATATTCACAGATCCCACCCATACTAACGGATAGTAGATTATCCAGGGCATGTAAATCAGGGGGTGGAATATTAGGGGACATCTTTTT TTTTTTTCTTTAAGACGGAGTCTCACTCTGTCACCCAGGCTGGAGTGCTGTGGTGCAATCTCAACTCACTGCAACCTCTACCTCCCTGGT TCAAGCGATTCTCGTGCCTCAGCCGCCTGACTAGCTGGGATTTCAGGAGTGCACCACCAGCCCGGCTAACTTTTGTATTTTTAGCAGAGA TGGGGTTTCACCATGTTGGCCGGGCTGGTCTCGAACTCCTGGGCTCAAGTGATCCGCCCACCTCGGCTTCCCAAAGTGCTGGAATTACAG GCGTCAGCCACCATGCCCGTTCTGGGGGCCATCTGAGACTTCTGCCAACCACAATCAGCTAGATGTTTTTTGTTTTGTTTTGAAAAAATA ATAATAATAACCTTTCACTTGGGCCACCAAACTCCTACCTTAGTATCCAAGTTCTCTAATTTTTTTTTAATATGGGAAATCCACATCTCC CAAACTCTATCCCTTTTCTGGCAAGTTACTTGACCTTTCTGTAAAATAAGCATAATGTACCTGCGTTAGAGTTGTAGGGAGCACTAAACA TTCAGATGATGTATGTACAGTGTTTAGCACAGAGCCTGCTAAATAGTAAGCCCTCAAGCCCTCAGTCACATTTGTCTCCATCAGTGGTAG CTCCCCTGGTGTGTTAAGGAGGCTCTTCTTTCTTTTTTTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCGCTCTGTTGCCCAGGCTGAAG TGCAGTGGCGCGATCTCGGCTCACTGCAAGCTCCGCCTCCTGGGTTCACGCCATTGTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACA GGCGCCTGTCACCACGCCCGGCTAATTTTTTTTTTGTTTGTTTTTTTTGTATTTTTAGTAGAGACAGGGTTTCACTGTGTTAGCCAGGAT GGTCTCCATCTCCTCACCTCGTGATCTGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGCGCCCGGCCAGGAGG CTCTTTTTAAACTAAGGGCAGCAACCCCCTAGGGTGGCTATAGTCCAAGAAAACCCAGAAAATACATGCTGCCAAGGATTTGGAGAAATT GGAGCCCTCCTACATTGCTGGTAGGAATGTAGAATGGTGCAGCAGCTGTGGAAAACAGTTCAGCAGTTTCACAAAAATCAAACATAGGGT TATCATATGACCCAGAAATTCTACCCATAGGTGTATACCCTGGAGAATTAAAAACATGTATTTACACAAAAACTTATATGTTCGCAGCAG CGTTATTCATAATAACCCGAAAGTAGAAACAACCCAAATGCTCTACTAATGAACAGATAAACAAAATGTGGTATATCCATATAGTGGAAT ATTACTCGATCACACAAAGGAATGAAGTACTAATACATGCTACAGTGTGGATGAACCTTGTAAACAGTAGGCTAAGTTACAGAAGCCAGC CACAAAAGACAACAAATGCATGATTCTATTCATATGAAATGTCCAGAGTAGGCAAGTCCATAGACAGAAAGTAGCTTAGTGGTTTCCAGG GGCAGTGAGAAGGGGAAATGGAGGGCAACTCCTAATGGGTATGAGGCTTCTTTTGGAGGTGATGAAAATGTTCTGGAATTCGACAGTGGT GATGGTTGTACATCTCTGTGAATATACTAAAAGCCACTGAATTGTATACTGGGTGAATTTTATGGTATCTGTAGACATTCCAATTGACAG TCACATCTTAGTATAGACTTTGAGTCATCTCACTGGAGGCACTAGACATGCAAGAGGAGAAGTCTCCAGATTATTCCAGCCCTGCCATTT GAGTCACTCCAGGCTTTCTGGTCTTCCCAGCTGAGGCTCAGACACCTTGGAAGAGAGAAAAGCTCTCCCTTCTGTGCCCTGTGATTTGCT GATCCACAGAGTTCATAGGCATGATTAAATGGTAGTAGTTTTCCACCACGAAGTTTTGGAATAATTTGTCACAAAGCAATAGGTAATTAG AAAAATAACCTTTCAGAAGGAGACAGTTTCTCCAAAGCTTGGGTACTTTCGCTTAATATTAAAAGAGGAAGAAATTTTTTGCCTGCCAGG CAAAAGGCAGAAGATGTATTTCTACACCATGGATAGGAAAATGATTTTTTTTCCTCCTTTCTCCTTGGCCTGCATGCAGCAGTGAAAAAG AAACCAATGGATTCTTTTAAATCTTTAACCATATGCAGATGAATAAGCACATGGTTGGACTTGATTCCTAATCTCTTTTCCTTTCCTGTA 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FusionGenePPI for SGPP2_ALG14 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| SGPP2 | ALG14 | HAUS7, FADS3 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SGPP2_ALG14 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SGPP2_ALG14 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | ALG14 | C4015596 | MYASTHENIC SYNDROME, CONGENITAL, 15 | 1 | UNIPROT |
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