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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 33581

FusionGeneSummary for SGPL1_ADAMTS14

check button Fusion gene summary
Fusion gene informationFusion gene name: SGPL1_ADAMTS14
Fusion gene ID: 33581
HgeneTgene
Gene symbol

SGPL1

ADAMTS14

Gene ID

8879

140766

Gene namesphingosine-1-phosphate lyase 1ADAM metallopeptidase with thrombospondin type 1 motif 14
SynonymsNPHS14|S1PL|SPL-
Cytomap

10q22.1

10q22.1

Type of geneprotein-codingprotein-coding
Descriptionsphingosine-1-phosphate lyase 1SP-lyase 1SPL 1hSPLsphingosine-1-phosphate aldolaseA disintegrin and metalloproteinase with thrombospondin motifs 14a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 14
Modification date2018052320180415
UniProtAcc

O95470

Q8WXS8

Ensembl transtripts involved in fusion geneENST00000373202, ENST00000486993, 
ENST00000373207, ENST00000373208, 
Fusion gene scores* DoF score5 X 4 X 4=801 X 3 X 2=6
# samples 73
** MAII scorelog2(7/80*10)=-0.192645077942396
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/6*10)=2.32192809488736
Context

PubMed: SGPL1 [Title/Abstract] AND ADAMTS14 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSGPL1

GO:0006631

fatty acid metabolic process

24809814

HgeneSGPL1

GO:0006672

ceramide metabolic process

14570870

HgeneSGPL1

GO:0030149

sphingolipid catabolic process

24809814

HgeneSGPL1

GO:0097190

apoptotic signaling pathway

14570870


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-13-1511-01ASGPL1chr10

72576636

+ADAMTS14chr10

72517718

+
TCGALDOVTCGA-24-1551-01ASGPL1chr10

72576636

+ADAMTS14chr10

72492010

+
TCGARVSTADTCGA-VQ-A91K-01ASGPL1chr10

72576636

+ADAMTS14chr10

72489050

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000373202ENST00000373207SGPL1chr10

72576636

+ADAMTS14chr10

72517718

+
In-frameENST00000373202ENST00000373208SGPL1chr10

72576636

+ADAMTS14chr10

72517718

+
3UTR-3CDSENST00000486993ENST00000373207SGPL1chr10

72576636

+ADAMTS14chr10

72517718

+
3UTR-3CDSENST00000486993ENST00000373208SGPL1chr10

72576636

+ADAMTS14chr10

72517718

+
Frame-shiftENST00000373202ENST00000373207SGPL1chr10

72576636

+ADAMTS14chr10

72492010

+
Frame-shiftENST00000373202ENST00000373208SGPL1chr10

72576636

+ADAMTS14chr10

72492010

+
3UTR-3CDSENST00000486993ENST00000373207SGPL1chr10

72576636

+ADAMTS14chr10

72492010

+
3UTR-3CDSENST00000486993ENST00000373208SGPL1chr10

72576636

+ADAMTS14chr10

72492010

+
In-frameENST00000373202ENST00000373207SGPL1chr10

72576636

+ADAMTS14chr10

72489050

+
In-frameENST00000373202ENST00000373208SGPL1chr10

72576636

+ADAMTS14chr10

72489050

+
3UTR-3CDSENST00000486993ENST00000373207SGPL1chr10

72576636

+ADAMTS14chr10

72489050

+
3UTR-3CDSENST00000486993ENST00000373208SGPL1chr10

72576636

+ADAMTS14chr10

72489050

+

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FusionProtFeatures for SGPL1_ADAMTS14


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SGPL1

O95470

ADAMTS14

Q8WXS8

Cleaves phosphorylated sphingoid bases (PSBs), such assphingosine-1-phosphate, into fatty aldehydes andphosphoethanolamine. Elevates stress-induced ceramide productionand apoptosis. {ECO:0000269|PubMed:11018465,ECO:0000269|PubMed:14570870, ECO:0000269|PubMed:24809814,ECO:0000269|PubMed:28165339}. Has a aminoprocollagen type I activity processingactivity in the absence of ADAMTS2. Seems to be synthesized as alatent enzyme that requires activation to display aminoprocollagenpeptidase activity.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneADAMTS14chr10:72576636chr10:72489050ENST00000373207+3221100_12212901224Compositional biasNote=Pro-rich
TgeneADAMTS14chr10:72576636chr10:72489050ENST00000373207+322608_7292901224Compositional biasNote=Cys-rich
TgeneADAMTS14chr10:72576636chr10:72489050ENST00000373207+322875_8782901224Compositional biasNote=Poly-Arg
TgeneADAMTS14chr10:72576636chr10:72489050ENST00000373208+3221100_12212901227Compositional biasNote=Pro-rich
TgeneADAMTS14chr10:72576636chr10:72489050ENST00000373208+322608_7292901227Compositional biasNote=Cys-rich
TgeneADAMTS14chr10:72576636chr10:72489050ENST00000373208+322875_8782901227Compositional biasNote=Poly-Arg
TgeneADAMTS14chr10:72576636chr10:72517718ENST00000373207+18221100_12219791224Compositional biasNote=Pro-rich
TgeneADAMTS14chr10:72576636chr10:72517718ENST00000373208+18221100_12219821227Compositional biasNote=Pro-rich
TgeneADAMTS14chr10:72576636chr10:72489050ENST00000373207+3221059_10972901224DomainPLAC
TgeneADAMTS14chr10:72576636chr10:72489050ENST00000373207+322461_5512901224DomainNote=Disintegrin
TgeneADAMTS14chr10:72576636chr10:72489050ENST00000373207+322552_6072901224DomainTSP type-1 1
TgeneADAMTS14chr10:72576636chr10:72489050ENST00000373207+322847_9072901224DomainTSP type-1 2
TgeneADAMTS14chr10:72576636chr10:72489050ENST00000373207+322908_9672901224DomainTSP type-1 3
TgeneADAMTS14chr10:72576636chr10:72489050ENST00000373207+322968_10222901224DomainTSP type-1 4
TgeneADAMTS14chr10:72576636chr10:72489050ENST00000373208+3221059_10972901227DomainPLAC
TgeneADAMTS14chr10:72576636chr10:72489050ENST00000373208+322461_5512901227DomainNote=Disintegrin
TgeneADAMTS14chr10:72576636chr10:72489050ENST00000373208+322552_6072901227DomainTSP type-1 1
TgeneADAMTS14chr10:72576636chr10:72489050ENST00000373208+322847_9072901227DomainTSP type-1 2
TgeneADAMTS14chr10:72576636chr10:72489050ENST00000373208+322908_9672901227DomainTSP type-1 3
TgeneADAMTS14chr10:72576636chr10:72489050ENST00000373208+322968_10222901227DomainTSP type-1 4
TgeneADAMTS14chr10:72576636chr10:72517718ENST00000373207+18221059_10979791224DomainPLAC
TgeneADAMTS14chr10:72576636chr10:72517718ENST00000373208+18221059_10979821227DomainPLAC
TgeneADAMTS14chr10:72576636chr10:72489050ENST00000373207+322730_8462901224RegionNote=Spacer
TgeneADAMTS14chr10:72576636chr10:72489050ENST00000373208+322730_8462901227RegionNote=Spacer

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSGPL1chr10:72576636chr10:72489050ENST00000373202+2151_409569Topological domainLumenal
HgeneSGPL1chr10:72576636chr10:72489050ENST00000373202+21562_5689569Topological domainCytoplasmic
HgeneSGPL1chr10:72576636chr10:72517718ENST00000373202+2151_409569Topological domainLumenal
HgeneSGPL1chr10:72576636chr10:72517718ENST00000373202+21562_5689569Topological domainCytoplasmic
HgeneSGPL1chr10:72576636chr10:72489050ENST00000373202+21541_619569TransmembraneHelical%3B Signal-anchor for type III membrane protein
HgeneSGPL1chr10:72576636chr10:72517718ENST00000373202+21541_619569TransmembraneHelical%3B Signal-anchor for type III membrane protein
TgeneADAMTS14chr10:72576636chr10:72517718ENST00000373207+1822608_7299791224Compositional biasNote=Cys-rich
TgeneADAMTS14chr10:72576636chr10:72517718ENST00000373207+1822875_8789791224Compositional biasNote=Poly-Arg
TgeneADAMTS14chr10:72576636chr10:72517718ENST00000373208+1822608_7299821227Compositional biasNote=Cys-rich
TgeneADAMTS14chr10:72576636chr10:72517718ENST00000373208+1822875_8789821227Compositional biasNote=Poly-Arg
TgeneADAMTS14chr10:72576636chr10:72489050ENST00000373207+322259_4602901224DomainPeptidase M12B
TgeneADAMTS14chr10:72576636chr10:72489050ENST00000373208+322259_4602901227DomainPeptidase M12B
TgeneADAMTS14chr10:72576636chr10:72517718ENST00000373207+1822259_4609791224DomainPeptidase M12B
TgeneADAMTS14chr10:72576636chr10:72517718ENST00000373207+1822461_5519791224DomainNote=Disintegrin
TgeneADAMTS14chr10:72576636chr10:72517718ENST00000373207+1822552_6079791224DomainTSP type-1 1
TgeneADAMTS14chr10:72576636chr10:72517718ENST00000373207+1822847_9079791224DomainTSP type-1 2
TgeneADAMTS14chr10:72576636chr10:72517718ENST00000373207+1822908_9679791224DomainTSP type-1 3
TgeneADAMTS14chr10:72576636chr10:72517718ENST00000373207+1822968_10229791224DomainTSP type-1 4
TgeneADAMTS14chr10:72576636chr10:72517718ENST00000373208+1822259_4609821227DomainPeptidase M12B
TgeneADAMTS14chr10:72576636chr10:72517718ENST00000373208+1822461_5519821227DomainNote=Disintegrin
TgeneADAMTS14chr10:72576636chr10:72517718ENST00000373208+1822552_6079821227DomainTSP type-1 1
TgeneADAMTS14chr10:72576636chr10:72517718ENST00000373208+1822847_9079821227DomainTSP type-1 2
TgeneADAMTS14chr10:72576636chr10:72517718ENST00000373208+1822908_9679821227DomainTSP type-1 3
TgeneADAMTS14chr10:72576636chr10:72517718ENST00000373208+1822968_10229821227DomainTSP type-1 4
TgeneADAMTS14chr10:72576636chr10:72517718ENST00000373207+1822730_8469791224RegionNote=Spacer
TgeneADAMTS14chr10:72576636chr10:72517718ENST00000373208+1822730_8469821227RegionNote=Spacer


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FusionGeneSequence for SGPL1_ADAMTS14


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SGPL1_ADAMTS14


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SGPL1TMEM173, ELAVL1, IQCB1, EGFR, PPP6R1, ANKRD12, BTN2A1, TXNDC15, VSIG4, ISLR, TUSC5, NTRK1, ATP5L, ATP5F1, ATP5O, CYC1, IMMT, MTCH2, PSAT1, TECR, TOMM40, UQCRQ, VDAC1, VDAC2, VDAC3, TM9SF4, SRPK2, TCTN2, TCTN3, CNTRL, TMEM216, PKN2, RPL10, ESRRB, TRIM9, CDH5, CACNG5, AIFM1, TMEM206, ZNRF4, IL13RA2, SEMA7A, MED21, P2RX1, MORF4L1, TPTEADAMTS14


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SGPL1_ADAMTS14


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneSGPL1O95470DB00114Pyridoxal PhosphateSphingosine-1-phosphate lyase 1 {ECO:0000305}small moleculeapproved|investigational|nutraceutical

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RelatedDiseases for SGPL1_ADAMTS14


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource