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Fusion gene ID: 33581 |
FusionGeneSummary for SGPL1_ADAMTS14 |
Fusion gene summary |
Fusion gene information | Fusion gene name: SGPL1_ADAMTS14 | Fusion gene ID: 33581 | Hgene | Tgene | Gene symbol | SGPL1 | ADAMTS14 | Gene ID | 8879 | 140766 |
Gene name | sphingosine-1-phosphate lyase 1 | ADAM metallopeptidase with thrombospondin type 1 motif 14 | |
Synonyms | NPHS14|S1PL|SPL | - | |
Cytomap | 10q22.1 | 10q22.1 | |
Type of gene | protein-coding | protein-coding | |
Description | sphingosine-1-phosphate lyase 1SP-lyase 1SPL 1hSPLsphingosine-1-phosphate aldolase | A disintegrin and metalloproteinase with thrombospondin motifs 14a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 14 | |
Modification date | 20180523 | 20180415 | |
UniProtAcc | O95470 | Q8WXS8 | |
Ensembl transtripts involved in fusion gene | ENST00000373202, ENST00000486993, | ENST00000373207, ENST00000373208, | |
Fusion gene scores | * DoF score | 5 X 4 X 4=80 | 1 X 3 X 2=6 |
# samples | 7 | 3 | |
** MAII score | log2(7/80*10)=-0.192645077942396 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/6*10)=2.32192809488736 | |
Context | PubMed: SGPL1 [Title/Abstract] AND ADAMTS14 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | SGPL1 | GO:0006631 | fatty acid metabolic process | 24809814 |
Hgene | SGPL1 | GO:0006672 | ceramide metabolic process | 14570870 |
Hgene | SGPL1 | GO:0030149 | sphingolipid catabolic process | 24809814 |
Hgene | SGPL1 | GO:0097190 | apoptotic signaling pathway | 14570870 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | OV | TCGA-13-1511-01A | SGPL1 | chr10 | 72576636 | + | ADAMTS14 | chr10 | 72517718 | + |
TCGA | LD | OV | TCGA-24-1551-01A | SGPL1 | chr10 | 72576636 | + | ADAMTS14 | chr10 | 72492010 | + |
TCGA | RV | STAD | TCGA-VQ-A91K-01A | SGPL1 | chr10 | 72576636 | + | ADAMTS14 | chr10 | 72489050 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000373202 | ENST00000373207 | SGPL1 | chr10 | 72576636 | + | ADAMTS14 | chr10 | 72517718 | + |
In-frame | ENST00000373202 | ENST00000373208 | SGPL1 | chr10 | 72576636 | + | ADAMTS14 | chr10 | 72517718 | + |
3UTR-3CDS | ENST00000486993 | ENST00000373207 | SGPL1 | chr10 | 72576636 | + | ADAMTS14 | chr10 | 72517718 | + |
3UTR-3CDS | ENST00000486993 | ENST00000373208 | SGPL1 | chr10 | 72576636 | + | ADAMTS14 | chr10 | 72517718 | + |
Frame-shift | ENST00000373202 | ENST00000373207 | SGPL1 | chr10 | 72576636 | + | ADAMTS14 | chr10 | 72492010 | + |
Frame-shift | ENST00000373202 | ENST00000373208 | SGPL1 | chr10 | 72576636 | + | ADAMTS14 | chr10 | 72492010 | + |
3UTR-3CDS | ENST00000486993 | ENST00000373207 | SGPL1 | chr10 | 72576636 | + | ADAMTS14 | chr10 | 72492010 | + |
3UTR-3CDS | ENST00000486993 | ENST00000373208 | SGPL1 | chr10 | 72576636 | + | ADAMTS14 | chr10 | 72492010 | + |
In-frame | ENST00000373202 | ENST00000373207 | SGPL1 | chr10 | 72576636 | + | ADAMTS14 | chr10 | 72489050 | + |
In-frame | ENST00000373202 | ENST00000373208 | SGPL1 | chr10 | 72576636 | + | ADAMTS14 | chr10 | 72489050 | + |
3UTR-3CDS | ENST00000486993 | ENST00000373207 | SGPL1 | chr10 | 72576636 | + | ADAMTS14 | chr10 | 72489050 | + |
3UTR-3CDS | ENST00000486993 | ENST00000373208 | SGPL1 | chr10 | 72576636 | + | ADAMTS14 | chr10 | 72489050 | + |
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FusionProtFeatures for SGPL1_ADAMTS14 |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
SGPL1 | ADAMTS14 |
Cleaves phosphorylated sphingoid bases (PSBs), such assphingosine-1-phosphate, into fatty aldehydes andphosphoethanolamine. Elevates stress-induced ceramide productionand apoptosis. {ECO:0000269|PubMed:11018465,ECO:0000269|PubMed:14570870, ECO:0000269|PubMed:24809814,ECO:0000269|PubMed:28165339}. | Has a aminoprocollagen type I activity processingactivity in the absence of ADAMTS2. Seems to be synthesized as alatent enzyme that requires activation to display aminoprocollagenpeptidase activity. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | >ADAMTS14 | chr10:72576636 | chr10:72489050 | ENST00000373207 | + | 3 | 22 | 1100_1221 | 290 | 1224 | Compositional bias | Note=Pro-rich |
Tgene | >ADAMTS14 | chr10:72576636 | chr10:72489050 | ENST00000373207 | + | 3 | 22 | 608_729 | 290 | 1224 | Compositional bias | Note=Cys-rich |
Tgene | >ADAMTS14 | chr10:72576636 | chr10:72489050 | ENST00000373207 | + | 3 | 22 | 875_878 | 290 | 1224 | Compositional bias | Note=Poly-Arg |
Tgene | >ADAMTS14 | chr10:72576636 | chr10:72489050 | ENST00000373208 | + | 3 | 22 | 1100_1221 | 290 | 1227 | Compositional bias | Note=Pro-rich |
Tgene | >ADAMTS14 | chr10:72576636 | chr10:72489050 | ENST00000373208 | + | 3 | 22 | 608_729 | 290 | 1227 | Compositional bias | Note=Cys-rich |
Tgene | >ADAMTS14 | chr10:72576636 | chr10:72489050 | ENST00000373208 | + | 3 | 22 | 875_878 | 290 | 1227 | Compositional bias | Note=Poly-Arg |
Tgene | >ADAMTS14 | chr10:72576636 | chr10:72517718 | ENST00000373207 | + | 18 | 22 | 1100_1221 | 979 | 1224 | Compositional bias | Note=Pro-rich |
Tgene | >ADAMTS14 | chr10:72576636 | chr10:72517718 | ENST00000373208 | + | 18 | 22 | 1100_1221 | 982 | 1227 | Compositional bias | Note=Pro-rich |
Tgene | >ADAMTS14 | chr10:72576636 | chr10:72489050 | ENST00000373207 | + | 3 | 22 | 1059_1097 | 290 | 1224 | Domain | PLAC |
Tgene | >ADAMTS14 | chr10:72576636 | chr10:72489050 | ENST00000373207 | + | 3 | 22 | 461_551 | 290 | 1224 | Domain | Note=Disintegrin |
Tgene | >ADAMTS14 | chr10:72576636 | chr10:72489050 | ENST00000373207 | + | 3 | 22 | 552_607 | 290 | 1224 | Domain | TSP type-1 1 |
Tgene | >ADAMTS14 | chr10:72576636 | chr10:72489050 | ENST00000373207 | + | 3 | 22 | 847_907 | 290 | 1224 | Domain | TSP type-1 2 |
Tgene | >ADAMTS14 | chr10:72576636 | chr10:72489050 | ENST00000373207 | + | 3 | 22 | 908_967 | 290 | 1224 | Domain | TSP type-1 3 |
Tgene | >ADAMTS14 | chr10:72576636 | chr10:72489050 | ENST00000373207 | + | 3 | 22 | 968_1022 | 290 | 1224 | Domain | TSP type-1 4 |
Tgene | >ADAMTS14 | chr10:72576636 | chr10:72489050 | ENST00000373208 | + | 3 | 22 | 1059_1097 | 290 | 1227 | Domain | PLAC |
Tgene | >ADAMTS14 | chr10:72576636 | chr10:72489050 | ENST00000373208 | + | 3 | 22 | 461_551 | 290 | 1227 | Domain | Note=Disintegrin |
Tgene | >ADAMTS14 | chr10:72576636 | chr10:72489050 | ENST00000373208 | + | 3 | 22 | 552_607 | 290 | 1227 | Domain | TSP type-1 1 |
Tgene | >ADAMTS14 | chr10:72576636 | chr10:72489050 | ENST00000373208 | + | 3 | 22 | 847_907 | 290 | 1227 | Domain | TSP type-1 2 |
Tgene | >ADAMTS14 | chr10:72576636 | chr10:72489050 | ENST00000373208 | + | 3 | 22 | 908_967 | 290 | 1227 | Domain | TSP type-1 3 |
Tgene | >ADAMTS14 | chr10:72576636 | chr10:72489050 | ENST00000373208 | + | 3 | 22 | 968_1022 | 290 | 1227 | Domain | TSP type-1 4 |
Tgene | >ADAMTS14 | chr10:72576636 | chr10:72517718 | ENST00000373207 | + | 18 | 22 | 1059_1097 | 979 | 1224 | Domain | PLAC |
Tgene | >ADAMTS14 | chr10:72576636 | chr10:72517718 | ENST00000373208 | + | 18 | 22 | 1059_1097 | 982 | 1227 | Domain | PLAC |
Tgene | >ADAMTS14 | chr10:72576636 | chr10:72489050 | ENST00000373207 | + | 3 | 22 | 730_846 | 290 | 1224 | Region | Note=Spacer |
Tgene | >ADAMTS14 | chr10:72576636 | chr10:72489050 | ENST00000373208 | + | 3 | 22 | 730_846 | 290 | 1227 | Region | Note=Spacer |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >SGPL1 | chr10:72576636 | chr10:72489050 | ENST00000373202 | + | 2 | 15 | 1_40 | 9 | 569 | Topological domain | Lumenal |
Hgene | >SGPL1 | chr10:72576636 | chr10:72489050 | ENST00000373202 | + | 2 | 15 | 62_568 | 9 | 569 | Topological domain | Cytoplasmic |
Hgene | >SGPL1 | chr10:72576636 | chr10:72517718 | ENST00000373202 | + | 2 | 15 | 1_40 | 9 | 569 | Topological domain | Lumenal |
Hgene | >SGPL1 | chr10:72576636 | chr10:72517718 | ENST00000373202 | + | 2 | 15 | 62_568 | 9 | 569 | Topological domain | Cytoplasmic |
Hgene | >SGPL1 | chr10:72576636 | chr10:72489050 | ENST00000373202 | + | 2 | 15 | 41_61 | 9 | 569 | Transmembrane | Helical%3B Signal-anchor for type III membrane protein |
Hgene | >SGPL1 | chr10:72576636 | chr10:72517718 | ENST00000373202 | + | 2 | 15 | 41_61 | 9 | 569 | Transmembrane | Helical%3B Signal-anchor for type III membrane protein |
Tgene | ADAMTS14 | chr10:72576636 | chr10:72517718 | ENST00000373207 | + | 18 | 22 | 608_729 | 979 | 1224 | Compositional bias | Note=Cys-rich |
Tgene | ADAMTS14 | chr10:72576636 | chr10:72517718 | ENST00000373207 | + | 18 | 22 | 875_878 | 979 | 1224 | Compositional bias | Note=Poly-Arg |
Tgene | ADAMTS14 | chr10:72576636 | chr10:72517718 | ENST00000373208 | + | 18 | 22 | 608_729 | 982 | 1227 | Compositional bias | Note=Cys-rich |
Tgene | ADAMTS14 | chr10:72576636 | chr10:72517718 | ENST00000373208 | + | 18 | 22 | 875_878 | 982 | 1227 | Compositional bias | Note=Poly-Arg |
Tgene | ADAMTS14 | chr10:72576636 | chr10:72489050 | ENST00000373207 | + | 3 | 22 | 259_460 | 290 | 1224 | Domain | Peptidase M12B |
Tgene | ADAMTS14 | chr10:72576636 | chr10:72489050 | ENST00000373208 | + | 3 | 22 | 259_460 | 290 | 1227 | Domain | Peptidase M12B |
Tgene | ADAMTS14 | chr10:72576636 | chr10:72517718 | ENST00000373207 | + | 18 | 22 | 259_460 | 979 | 1224 | Domain | Peptidase M12B |
Tgene | ADAMTS14 | chr10:72576636 | chr10:72517718 | ENST00000373207 | + | 18 | 22 | 461_551 | 979 | 1224 | Domain | Note=Disintegrin |
Tgene | ADAMTS14 | chr10:72576636 | chr10:72517718 | ENST00000373207 | + | 18 | 22 | 552_607 | 979 | 1224 | Domain | TSP type-1 1 |
Tgene | ADAMTS14 | chr10:72576636 | chr10:72517718 | ENST00000373207 | + | 18 | 22 | 847_907 | 979 | 1224 | Domain | TSP type-1 2 |
Tgene | ADAMTS14 | chr10:72576636 | chr10:72517718 | ENST00000373207 | + | 18 | 22 | 908_967 | 979 | 1224 | Domain | TSP type-1 3 |
Tgene | ADAMTS14 | chr10:72576636 | chr10:72517718 | ENST00000373207 | + | 18 | 22 | 968_1022 | 979 | 1224 | Domain | TSP type-1 4 |
Tgene | ADAMTS14 | chr10:72576636 | chr10:72517718 | ENST00000373208 | + | 18 | 22 | 259_460 | 982 | 1227 | Domain | Peptidase M12B |
Tgene | ADAMTS14 | chr10:72576636 | chr10:72517718 | ENST00000373208 | + | 18 | 22 | 461_551 | 982 | 1227 | Domain | Note=Disintegrin |
Tgene | ADAMTS14 | chr10:72576636 | chr10:72517718 | ENST00000373208 | + | 18 | 22 | 552_607 | 982 | 1227 | Domain | TSP type-1 1 |
Tgene | ADAMTS14 | chr10:72576636 | chr10:72517718 | ENST00000373208 | + | 18 | 22 | 847_907 | 982 | 1227 | Domain | TSP type-1 2 |
Tgene | ADAMTS14 | chr10:72576636 | chr10:72517718 | ENST00000373208 | + | 18 | 22 | 908_967 | 982 | 1227 | Domain | TSP type-1 3 |
Tgene | ADAMTS14 | chr10:72576636 | chr10:72517718 | ENST00000373208 | + | 18 | 22 | 968_1022 | 982 | 1227 | Domain | TSP type-1 4 |
Tgene | ADAMTS14 | chr10:72576636 | chr10:72517718 | ENST00000373207 | + | 18 | 22 | 730_846 | 979 | 1224 | Region | Note=Spacer |
Tgene | ADAMTS14 | chr10:72576636 | chr10:72517718 | ENST00000373208 | + | 18 | 22 | 730_846 | 982 | 1227 | Region | Note=Spacer |
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FusionGeneSequence for SGPL1_ADAMTS14 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SGPL1_ADAMTS14 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
SGPL1 | TMEM173, ELAVL1, IQCB1, EGFR, PPP6R1, ANKRD12, BTN2A1, TXNDC15, VSIG4, ISLR, TUSC5, NTRK1, ATP5L, ATP5F1, ATP5O, CYC1, IMMT, MTCH2, PSAT1, TECR, TOMM40, UQCRQ, VDAC1, VDAC2, VDAC3, TM9SF4, SRPK2, TCTN2, TCTN3, CNTRL, TMEM216, PKN2, RPL10, ESRRB, TRIM9, CDH5, CACNG5, AIFM1, TMEM206, ZNRF4, IL13RA2, SEMA7A, MED21, P2RX1, MORF4L1, TPTE | ADAMTS14 |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SGPL1_ADAMTS14 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | SGPL1 | O95470 | DB00114 | Pyridoxal Phosphate | Sphingosine-1-phosphate lyase 1 {ECO:0000305} | small molecule | approved|investigational|nutraceutical |
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RelatedDiseases for SGPL1_ADAMTS14 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |