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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 3358

FusionGeneSummary for ATP2B4_NFASC

check button Fusion gene summary
Fusion gene informationFusion gene name: ATP2B4_NFASC
Fusion gene ID: 3358
HgeneTgene
Gene symbol

ATP2B4

NFASC

Gene ID

493

23114

Gene nameATPase plasma membrane Ca2+ transporting 4neurofascin
SynonymsATP2B2|MXRA1|PMCA4|PMCA4b|PMCA4xNF|NRCAML
Cytomap

1q32.1

1q32.1

Type of geneprotein-codingprotein-coding
Descriptionplasma membrane calcium-transporting ATPase 4ATPase, Ca++ transporting, plasma membrane 4matrix-remodeling-associated protein 1sarcolemmal calcium pumpneurofascinneurofascin homolog
Modification date2018052320180522
UniProtAcc

P23634

O94856

Ensembl transtripts involved in fusion geneENST00000357681, ENST00000391954, 
ENST00000367218, ENST00000367219, 
ENST00000341360, ENST00000466407, 
ENST00000338586, ENST00000338515, 
ENST00000367171, ENST00000367169, 
ENST00000539706, ENST00000339876, 
ENST00000367170, ENST00000360049, 
ENST00000367172, ENST00000403080, 
ENST00000404076, ENST00000401399, 
ENST00000404907, ENST00000513543, 
ENST00000495396, 
Fusion gene scores* DoF score8 X 4 X 6=1926 X 4 X 4=96
# samples 86
** MAII scorelog2(8/192*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/96*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ATP2B4 [Title/Abstract] AND NFASC [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneATP2B4

GO:0006874

cellular calcium ion homeostasis

19278978

HgeneATP2B4

GO:0010751

negative regulation of nitric oxide mediated signal transduction

19278978

HgeneATP2B4

GO:0033138

positive regulation of peptidyl-serine phosphorylation

19278978

HgeneATP2B4

GO:0045019

negative regulation of nitric oxide biosynthetic process

11591728|19278978

HgeneATP2B4

GO:0051001

negative regulation of nitric-oxide synthase activity

11591728|17242280|19278978|19287093

HgeneATP2B4

GO:0070885

negative regulation of calcineurin-NFAT signaling cascade

19287093

HgeneATP2B4

GO:0071872

cellular response to epinephrine stimulus

19278978

HgeneATP2B4

GO:0098736

negative regulation of the force of heart contraction

17242280

HgeneATP2B4

GO:0140199

negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process

17242280

HgeneATP2B4

GO:1900082

negative regulation of arginine catabolic process

19278978

HgeneATP2B4

GO:1903249

negative regulation of citrulline biosynthetic process

19278978

HgeneATP2B4

GO:2000481

positive regulation of cAMP-dependent protein kinase activity

19278978


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVGBMTCGA-06-5411-01AATP2B4chr1

203596347

+NFASCchr1

204889760

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-5UTRENST00000357681ENST00000338586ATP2B4chr1

203596347

+NFASCchr1

204889760

+
5UTR-5UTRENST00000357681ENST00000338515ATP2B4chr1

203596347

+NFASCchr1

204889760

+
5UTR-5UTRENST00000357681ENST00000367171ATP2B4chr1

203596347

+NFASCchr1

204889760

+
5UTR-5UTRENST00000357681ENST00000367169ATP2B4chr1

203596347

+NFASCchr1

204889760

+
5UTR-5UTRENST00000357681ENST00000539706ATP2B4chr1

203596347

+NFASCchr1

204889760

+
5UTR-5UTRENST00000357681ENST00000339876ATP2B4chr1

203596347

+NFASCchr1

204889760

+
5UTR-5UTRENST00000357681ENST00000367170ATP2B4chr1

203596347

+NFASCchr1

204889760

+
5UTR-5UTRENST00000357681ENST00000360049ATP2B4chr1

203596347

+NFASCchr1

204889760

+
5UTR-5UTRENST00000357681ENST00000367172ATP2B4chr1

203596347

+NFASCchr1

204889760

+
5UTR-5UTRENST00000357681ENST00000403080ATP2B4chr1

203596347

+NFASCchr1

204889760

+
5UTR-5UTRENST00000357681ENST00000404076ATP2B4chr1

203596347

+NFASCchr1

204889760

+
5UTR-5UTRENST00000357681ENST00000401399ATP2B4chr1

203596347

+NFASCchr1

204889760

+
5UTR-intronENST00000357681ENST00000404907ATP2B4chr1

203596347

+NFASCchr1

204889760

+
5UTR-intronENST00000357681ENST00000513543ATP2B4chr1

203596347

+NFASCchr1

204889760

+
5UTR-intronENST00000357681ENST00000495396ATP2B4chr1

203596347

+NFASCchr1

204889760

+
5UTR-5UTRENST00000391954ENST00000338586ATP2B4chr1

203596347

+NFASCchr1

204889760

+
5UTR-5UTRENST00000391954ENST00000338515ATP2B4chr1

203596347

+NFASCchr1

204889760

+
5UTR-5UTRENST00000391954ENST00000367171ATP2B4chr1

203596347

+NFASCchr1

204889760

+
5UTR-5UTRENST00000391954ENST00000367169ATP2B4chr1

203596347

+NFASCchr1

204889760

+
5UTR-5UTRENST00000391954ENST00000539706ATP2B4chr1

203596347

+NFASCchr1

204889760

+
5UTR-5UTRENST00000391954ENST00000339876ATP2B4chr1

203596347

+NFASCchr1

204889760

+
5UTR-5UTRENST00000391954ENST00000367170ATP2B4chr1

203596347

+NFASCchr1

204889760

+
5UTR-5UTRENST00000391954ENST00000360049ATP2B4chr1

203596347

+NFASCchr1

204889760

+
5UTR-5UTRENST00000391954ENST00000367172ATP2B4chr1

203596347

+NFASCchr1

204889760

+
5UTR-5UTRENST00000391954ENST00000403080ATP2B4chr1

203596347

+NFASCchr1

204889760

+
5UTR-5UTRENST00000391954ENST00000404076ATP2B4chr1

203596347

+NFASCchr1

204889760

+
5UTR-5UTRENST00000391954ENST00000401399ATP2B4chr1

203596347

+NFASCchr1

204889760

+
5UTR-intronENST00000391954ENST00000404907ATP2B4chr1

203596347

+NFASCchr1

204889760

+
5UTR-intronENST00000391954ENST00000513543ATP2B4chr1

203596347

+NFASCchr1

204889760

+
5UTR-intronENST00000391954ENST00000495396ATP2B4chr1

203596347

+NFASCchr1

204889760

+
5UTR-5UTRENST00000367218ENST00000338586ATP2B4chr1

203596347

+NFASCchr1

204889760

+
5UTR-5UTRENST00000367218ENST00000338515ATP2B4chr1

203596347

+NFASCchr1

204889760

+
5UTR-5UTRENST00000367218ENST00000367171ATP2B4chr1

203596347

+NFASCchr1

204889760

+
5UTR-5UTRENST00000367218ENST00000367169ATP2B4chr1

203596347

+NFASCchr1

204889760

+
5UTR-5UTRENST00000367218ENST00000539706ATP2B4chr1

203596347

+NFASCchr1

204889760

+
5UTR-5UTRENST00000367218ENST00000339876ATP2B4chr1

203596347

+NFASCchr1

204889760

+
5UTR-5UTRENST00000367218ENST00000367170ATP2B4chr1

203596347

+NFASCchr1

204889760

+
5UTR-5UTRENST00000367218ENST00000360049ATP2B4chr1

203596347

+NFASCchr1

204889760

+
5UTR-5UTRENST00000367218ENST00000367172ATP2B4chr1

203596347

+NFASCchr1

204889760

+
5UTR-5UTRENST00000367218ENST00000403080ATP2B4chr1

203596347

+NFASCchr1

204889760

+
5UTR-5UTRENST00000367218ENST00000404076ATP2B4chr1

203596347

+NFASCchr1

204889760

+
5UTR-5UTRENST00000367218ENST00000401399ATP2B4chr1

203596347

+NFASCchr1

204889760

+
5UTR-intronENST00000367218ENST00000404907ATP2B4chr1

203596347

+NFASCchr1

204889760

+
5UTR-intronENST00000367218ENST00000513543ATP2B4chr1

203596347

+NFASCchr1

204889760

+
5UTR-intronENST00000367218ENST00000495396ATP2B4chr1

203596347

+NFASCchr1

204889760

+
5UTR-5UTRENST00000367219ENST00000338586ATP2B4chr1

203596347

+NFASCchr1

204889760

+
5UTR-5UTRENST00000367219ENST00000338515ATP2B4chr1

203596347

+NFASCchr1

204889760

+
5UTR-5UTRENST00000367219ENST00000367171ATP2B4chr1

203596347

+NFASCchr1

204889760

+
5UTR-5UTRENST00000367219ENST00000367169ATP2B4chr1

203596347

+NFASCchr1

204889760

+
5UTR-5UTRENST00000367219ENST00000539706ATP2B4chr1

203596347

+NFASCchr1

204889760

+
5UTR-5UTRENST00000367219ENST00000339876ATP2B4chr1

203596347

+NFASCchr1

204889760

+
5UTR-5UTRENST00000367219ENST00000367170ATP2B4chr1

203596347

+NFASCchr1

204889760

+
5UTR-5UTRENST00000367219ENST00000360049ATP2B4chr1

203596347

+NFASCchr1

204889760

+
5UTR-5UTRENST00000367219ENST00000367172ATP2B4chr1

203596347

+NFASCchr1

204889760

+
5UTR-5UTRENST00000367219ENST00000403080ATP2B4chr1

203596347

+NFASCchr1

204889760

+
5UTR-5UTRENST00000367219ENST00000404076ATP2B4chr1

203596347

+NFASCchr1

204889760

+
5UTR-5UTRENST00000367219ENST00000401399ATP2B4chr1

203596347

+NFASCchr1

204889760

+
5UTR-intronENST00000367219ENST00000404907ATP2B4chr1

203596347

+NFASCchr1

204889760

+
5UTR-intronENST00000367219ENST00000513543ATP2B4chr1

203596347

+NFASCchr1

204889760

+
5UTR-intronENST00000367219ENST00000495396ATP2B4chr1

203596347

+NFASCchr1

204889760

+
intron-5UTRENST00000341360ENST00000338586ATP2B4chr1

203596347

+NFASCchr1

204889760

+
intron-5UTRENST00000341360ENST00000338515ATP2B4chr1

203596347

+NFASCchr1

204889760

+
intron-5UTRENST00000341360ENST00000367171ATP2B4chr1

203596347

+NFASCchr1

204889760

+
intron-5UTRENST00000341360ENST00000367169ATP2B4chr1

203596347

+NFASCchr1

204889760

+
intron-5UTRENST00000341360ENST00000539706ATP2B4chr1

203596347

+NFASCchr1

204889760

+
intron-5UTRENST00000341360ENST00000339876ATP2B4chr1

203596347

+NFASCchr1

204889760

+
intron-5UTRENST00000341360ENST00000367170ATP2B4chr1

203596347

+NFASCchr1

204889760

+
intron-5UTRENST00000341360ENST00000360049ATP2B4chr1

203596347

+NFASCchr1

204889760

+
intron-5UTRENST00000341360ENST00000367172ATP2B4chr1

203596347

+NFASCchr1

204889760

+
intron-5UTRENST00000341360ENST00000403080ATP2B4chr1

203596347

+NFASCchr1

204889760

+
intron-5UTRENST00000341360ENST00000404076ATP2B4chr1

203596347

+NFASCchr1

204889760

+
intron-5UTRENST00000341360ENST00000401399ATP2B4chr1

203596347

+NFASCchr1

204889760

+
intron-intronENST00000341360ENST00000404907ATP2B4chr1

203596347

+NFASCchr1

204889760

+
intron-intronENST00000341360ENST00000513543ATP2B4chr1

203596347

+NFASCchr1

204889760

+
intron-intronENST00000341360ENST00000495396ATP2B4chr1

203596347

+NFASCchr1

204889760

+
intron-5UTRENST00000466407ENST00000338586ATP2B4chr1

203596347

+NFASCchr1

204889760

+
intron-5UTRENST00000466407ENST00000338515ATP2B4chr1

203596347

+NFASCchr1

204889760

+
intron-5UTRENST00000466407ENST00000367171ATP2B4chr1

203596347

+NFASCchr1

204889760

+
intron-5UTRENST00000466407ENST00000367169ATP2B4chr1

203596347

+NFASCchr1

204889760

+
intron-5UTRENST00000466407ENST00000539706ATP2B4chr1

203596347

+NFASCchr1

204889760

+
intron-5UTRENST00000466407ENST00000339876ATP2B4chr1

203596347

+NFASCchr1

204889760

+
intron-5UTRENST00000466407ENST00000367170ATP2B4chr1

203596347

+NFASCchr1

204889760

+
intron-5UTRENST00000466407ENST00000360049ATP2B4chr1

203596347

+NFASCchr1

204889760

+
intron-5UTRENST00000466407ENST00000367172ATP2B4chr1

203596347

+NFASCchr1

204889760

+
intron-5UTRENST00000466407ENST00000403080ATP2B4chr1

203596347

+NFASCchr1

204889760

+
intron-5UTRENST00000466407ENST00000404076ATP2B4chr1

203596347

+NFASCchr1

204889760

+
intron-5UTRENST00000466407ENST00000401399ATP2B4chr1

203596347

+NFASCchr1

204889760

+
intron-intronENST00000466407ENST00000404907ATP2B4chr1

203596347

+NFASCchr1

204889760

+
intron-intronENST00000466407ENST00000513543ATP2B4chr1

203596347

+NFASCchr1

204889760

+
intron-intronENST00000466407ENST00000495396ATP2B4chr1

203596347

+NFASCchr1

204889760

+

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FusionProtFeatures for ATP2B4_NFASC


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ATP2B4

P23634

NFASC

O94856

Calcium/calmodulin-regulated and magnesium-dependentenzyme that catalyzes the hydrolysis of ATP coupled with thetransport of calcium out of the cell (PubMed:8530416). Byregulating sperm cell calcium homeostasis, may play a role insperm motility (By similarity). {ECO:0000250|UniProtKB:Q6Q477,ECO:0000269|PubMed:8530416}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ATP2B4_NFASC


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ATP2B4_NFASC


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ATP2B4DLG1, CASK, DLG2, DLG3, ERBB2IP, ADRB2, CDK7, LGALS3, BSG, LGALS8, TAS2R7, EDA2R, HSD17B6, LGALS9, AGTR1, LGALS9C, SLC39A4, LYPD3, DLK1, WBP1, PTGER3, TMEM52B, ATP1A1, ATP9A, HM13, ATP5J, CANX, CLGN, TMEM17, EGFR, CDH1, CTDSPL, ATP2B2, TMEM5, LPAR1, LILRB4, FPR2, IPPK, FAM174A, C3AR1, GPC1, CYP2B6, PCDHGB1, APLNR, KCNA5, NMUR2, HTR3A, VAC14, TRIM25NFASC


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for ATP2B4_NFASC


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ATP2B4_NFASC


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneNFASCC0036341Schizophrenia1PSYGENET