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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 33533

FusionGeneSummary for SFTPC_SFTPC

check button Fusion gene summary
Fusion gene informationFusion gene name: SFTPC_SFTPC
Fusion gene ID: 33533
HgeneTgene
Gene symbol

SFTPC

SFTPC

Gene ID

6440

6440

Gene namesurfactant protein Csurfactant protein C
SynonymsBRICD6|PSP-C|SFTP2|SMDP2|SP-CBRICD6|PSP-C|SFTP2|SMDP2|SP-C
Cytomap

8p21.3

8p21.3

Type of geneprotein-codingprotein-coding
Descriptionpulmonary surfactant-associated protein CBRICHOS domain containing 6SP5pulmonary surfactant apoprotein-2 SP-Cpulmonary surfactant-associated proteolipid SPL(Val)pulmonary surfactant-associated protein CBRICHOS domain containing 6SP5pulmonary surfactant apoprotein-2 SP-Cpulmonary surfactant-associated proteolipid SPL(Val)
Modification date2018052020180520
UniProtAcc

P11686

P11686

Ensembl transtripts involved in fusion geneENST00000318561, ENST00000521315, 
ENST00000437090, ENST00000520605, 
ENST00000522109, ENST00000524255, 
ENST00000522880, 
ENST00000318561, 
ENST00000521315, ENST00000437090, 
ENST00000520605, ENST00000522109, 
ENST00000524255, ENST00000522880, 
Fusion gene scores* DoF score5 X 3 X 2=306 X 6 X 4=144
# samples 57
** MAII scorelog2(5/30*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(7/144*10)=-1.04064198449735
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SFTPC [Title/Abstract] AND SFTPC [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BQ016733SFTPCchr8

22021876

-SFTPCchr8

22021792

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000318561ENST00000318561SFTPCchr8

22021876

-SFTPCchr8

22021792

+
3UTR-3UTRENST00000318561ENST00000521315SFTPCchr8

22021876

-SFTPCchr8

22021792

+
3UTR-intronENST00000318561ENST00000437090SFTPCchr8

22021876

-SFTPCchr8

22021792

+
3UTR-intronENST00000318561ENST00000520605SFTPCchr8

22021876

-SFTPCchr8

22021792

+
3UTR-intronENST00000318561ENST00000522109SFTPCchr8

22021876

-SFTPCchr8

22021792

+
3UTR-3UTRENST00000318561ENST00000524255SFTPCchr8

22021876

-SFTPCchr8

22021792

+
3UTR-intronENST00000318561ENST00000522880SFTPCchr8

22021876

-SFTPCchr8

22021792

+
3UTR-3UTRENST00000521315ENST00000318561SFTPCchr8

22021876

-SFTPCchr8

22021792

+
3UTR-3UTRENST00000521315ENST00000521315SFTPCchr8

22021876

-SFTPCchr8

22021792

+
3UTR-intronENST00000521315ENST00000437090SFTPCchr8

22021876

-SFTPCchr8

22021792

+
3UTR-intronENST00000521315ENST00000520605SFTPCchr8

22021876

-SFTPCchr8

22021792

+
3UTR-intronENST00000521315ENST00000522109SFTPCchr8

22021876

-SFTPCchr8

22021792

+
3UTR-3UTRENST00000521315ENST00000524255SFTPCchr8

22021876

-SFTPCchr8

22021792

+
3UTR-intronENST00000521315ENST00000522880SFTPCchr8

22021876

-SFTPCchr8

22021792

+
intron-3UTRENST00000437090ENST00000318561SFTPCchr8

22021876

-SFTPCchr8

22021792

+
intron-3UTRENST00000437090ENST00000521315SFTPCchr8

22021876

-SFTPCchr8

22021792

+
intron-intronENST00000437090ENST00000437090SFTPCchr8

22021876

-SFTPCchr8

22021792

+
intron-intronENST00000437090ENST00000520605SFTPCchr8

22021876

-SFTPCchr8

22021792

+
intron-intronENST00000437090ENST00000522109SFTPCchr8

22021876

-SFTPCchr8

22021792

+
intron-3UTRENST00000437090ENST00000524255SFTPCchr8

22021876

-SFTPCchr8

22021792

+
intron-intronENST00000437090ENST00000522880SFTPCchr8

22021876

-SFTPCchr8

22021792

+
5CDS-3UTRENST00000520605ENST00000318561SFTPCchr8

22021876

-SFTPCchr8

22021792

+
5CDS-3UTRENST00000520605ENST00000521315SFTPCchr8

22021876

-SFTPCchr8

22021792

+
5CDS-intronENST00000520605ENST00000437090SFTPCchr8

22021876

-SFTPCchr8

22021792

+
5CDS-intronENST00000520605ENST00000520605SFTPCchr8

22021876

-SFTPCchr8

22021792

+
5CDS-intronENST00000520605ENST00000522109SFTPCchr8

22021876

-SFTPCchr8

22021792

+
5CDS-3UTRENST00000520605ENST00000524255SFTPCchr8

22021876

-SFTPCchr8

22021792

+
5CDS-intronENST00000520605ENST00000522880SFTPCchr8

22021876

-SFTPCchr8

22021792

+
intron-3UTRENST00000522109ENST00000318561SFTPCchr8

22021876

-SFTPCchr8

22021792

+
intron-3UTRENST00000522109ENST00000521315SFTPCchr8

22021876

-SFTPCchr8

22021792

+
intron-intronENST00000522109ENST00000437090SFTPCchr8

22021876

-SFTPCchr8

22021792

+
intron-intronENST00000522109ENST00000520605SFTPCchr8

22021876

-SFTPCchr8

22021792

+
intron-intronENST00000522109ENST00000522109SFTPCchr8

22021876

-SFTPCchr8

22021792

+
intron-3UTRENST00000522109ENST00000524255SFTPCchr8

22021876

-SFTPCchr8

22021792

+
intron-intronENST00000522109ENST00000522880SFTPCchr8

22021876

-SFTPCchr8

22021792

+
3UTR-3UTRENST00000524255ENST00000318561SFTPCchr8

22021876

-SFTPCchr8

22021792

+
3UTR-3UTRENST00000524255ENST00000521315SFTPCchr8

22021876

-SFTPCchr8

22021792

+
3UTR-intronENST00000524255ENST00000437090SFTPCchr8

22021876

-SFTPCchr8

22021792

+
3UTR-intronENST00000524255ENST00000520605SFTPCchr8

22021876

-SFTPCchr8

22021792

+
3UTR-intronENST00000524255ENST00000522109SFTPCchr8

22021876

-SFTPCchr8

22021792

+
3UTR-3UTRENST00000524255ENST00000524255SFTPCchr8

22021876

-SFTPCchr8

22021792

+
3UTR-intronENST00000524255ENST00000522880SFTPCchr8

22021876

-SFTPCchr8

22021792

+
intron-3UTRENST00000522880ENST00000318561SFTPCchr8

22021876

-SFTPCchr8

22021792

+
intron-3UTRENST00000522880ENST00000521315SFTPCchr8

22021876

-SFTPCchr8

22021792

+
intron-intronENST00000522880ENST00000437090SFTPCchr8

22021876

-SFTPCchr8

22021792

+
intron-intronENST00000522880ENST00000520605SFTPCchr8

22021876

-SFTPCchr8

22021792

+
intron-intronENST00000522880ENST00000522109SFTPCchr8

22021876

-SFTPCchr8

22021792

+
intron-3UTRENST00000522880ENST00000524255SFTPCchr8

22021876

-SFTPCchr8

22021792

+
intron-intronENST00000522880ENST00000522880SFTPCchr8

22021876

-SFTPCchr8

22021792

+

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FusionProtFeatures for SFTPC_SFTPC


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SFTPC

P11686

SFTPC

P11686

Pulmonary surfactant associated proteins promotealveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. Pulmonary surfactant associated proteins promotealveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SFTPC_SFTPC


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SFTPC_SFTPC


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SFTPC_SFTPC


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SFTPC_SFTPC


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSFTPCC1970470SURFACTANT METABOLISM DYSFUNCTION, PULMONARY, 2 (disorder)5CTD_human;ORPHANET;UNIPROT
HgeneSFTPCC0019284Diaphragmatic Hernia1CTD_human
HgeneSFTPCC0032460Polycystic Ovary Syndrome1CTD_human
HgeneSFTPCC0152013Adenocarcinoma of lung (disorder)1CTD_human
TgeneSFTPCC1970470SURFACTANT METABOLISM DYSFUNCTION, PULMONARY, 2 (disorder)5CTD_human;ORPHANET;UNIPROT
TgeneSFTPCC0019284Diaphragmatic Hernia1CTD_human
TgeneSFTPCC0032460Polycystic Ovary Syndrome1CTD_human
TgeneSFTPCC0152013Adenocarcinoma of lung (disorder)1CTD_human