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Fusion gene ID: 33523 |
FusionGeneSummary for SFTPB_NFKBIZ |
Fusion gene summary |
Fusion gene information | Fusion gene name: SFTPB_NFKBIZ | Fusion gene ID: 33523 | Hgene | Tgene | Gene symbol | SFTPB | NFKBIZ | Gene ID | 6439 | 64332 |
Gene name | surfactant protein B | NFKB inhibitor zeta | |
Synonyms | PSP-B|SFTB3|SFTP3|SMDP1|SP-B | IKBZ|INAP|MAIL | |
Cytomap | 2p11.2 | 3q12.3 | |
Type of gene | protein-coding | protein-coding | |
Description | pulmonary surfactant-associated protein B18 kDa pulmonary-surfactant protein6 kDa proteinpulmonary surfactant-associated proteolipid SPL(Phe) | NF-kappa-B inhibitor zetaI-kappa-B-zetaIL-1 inducible nuclear ankyrin-repeat proteinIkappa B-zeta variant 3IkappaB-zetaikB-zetaikappaBzetamolecule possessing ankyrin repeats induced by lipopolysaccharidenuclear factor of kappa light polypeptide ge | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | P07988 | Q9BYH8 | |
Ensembl transtripts involved in fusion gene | ENST00000519937, ENST00000342375, ENST00000393822, ENST00000409383, | ENST00000394054, ENST00000326151, ENST00000326172, | |
Fusion gene scores | * DoF score | 15 X 13 X 2=390 | 5 X 5 X 1=25 |
# samples | 16 | 5 | |
** MAII score | log2(16/390*10)=-1.28540221886225 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/25*10)=1 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: SFTPB [Title/Abstract] AND NFKBIZ [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BF358274 | SFTPB | chr2 | 85887873 | - | NFKBIZ | chr3 | 101575178 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000519937 | ENST00000394054 | SFTPB | chr2 | 85887873 | - | NFKBIZ | chr3 | 101575178 | + |
intron-intron | ENST00000519937 | ENST00000326151 | SFTPB | chr2 | 85887873 | - | NFKBIZ | chr3 | 101575178 | + |
intron-intron | ENST00000519937 | ENST00000326172 | SFTPB | chr2 | 85887873 | - | NFKBIZ | chr3 | 101575178 | + |
intron-intron | ENST00000342375 | ENST00000394054 | SFTPB | chr2 | 85887873 | - | NFKBIZ | chr3 | 101575178 | + |
intron-intron | ENST00000342375 | ENST00000326151 | SFTPB | chr2 | 85887873 | - | NFKBIZ | chr3 | 101575178 | + |
intron-intron | ENST00000342375 | ENST00000326172 | SFTPB | chr2 | 85887873 | - | NFKBIZ | chr3 | 101575178 | + |
intron-intron | ENST00000393822 | ENST00000394054 | SFTPB | chr2 | 85887873 | - | NFKBIZ | chr3 | 101575178 | + |
intron-intron | ENST00000393822 | ENST00000326151 | SFTPB | chr2 | 85887873 | - | NFKBIZ | chr3 | 101575178 | + |
intron-intron | ENST00000393822 | ENST00000326172 | SFTPB | chr2 | 85887873 | - | NFKBIZ | chr3 | 101575178 | + |
intron-intron | ENST00000409383 | ENST00000394054 | SFTPB | chr2 | 85887873 | - | NFKBIZ | chr3 | 101575178 | + |
intron-intron | ENST00000409383 | ENST00000326151 | SFTPB | chr2 | 85887873 | - | NFKBIZ | chr3 | 101575178 | + |
intron-intron | ENST00000409383 | ENST00000326172 | SFTPB | chr2 | 85887873 | - | NFKBIZ | chr3 | 101575178 | + |
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FusionProtFeatures for SFTPB_NFKBIZ |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
SFTPB | NFKBIZ |
Pulmonary surfactant-associated proteins promotealveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. SP-B increases thecollapse pressure of palmitic acid to nearly 70 millinewtons permeter. | Involved in regulation of NF-kappa-B transcriptionfactor complexes. Inhibits NF-kappa-B activity without affectingits nuclear translocation upon stimulation. Inhibits DNA-bindingof RELA and NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimerand the NF-kappa-B p50-p50 homodimer. Seems also to activate NF-kappa-B-mediated transcription. In vitro, upon association withNFKB1/p50 has transcriptional activation activity and, togetherwith NFKB1/p50 and RELA, is recruited to LCN2 promoters. Promotestranscription of LCN2 and DEFB4. Is recruited to IL-6 promotersand activates IL-6 but decreases TNF-alpha production in responseto LPS. Seems to be involved in the induction of inflammatorygenes activated through TLR/IL-1 receptor signaling. May promoteapoptosis (By similarity). Involved in the induction of T helper17 cells (Th17) differentiation upon recognition of antigen by Tcell antigen receptor (TCR) (By similarity). {ECO:0000250,ECO:0000250|UniProtKB:Q9EST8, ECO:0000269|PubMed:16513645,ECO:0000269|PubMed:16622025}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SFTPB_NFKBIZ |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SFTPB_NFKBIZ |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SFTPB_NFKBIZ |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SFTPB_NFKBIZ |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | SFTPB | C0019284 | Diaphragmatic Hernia | 2 | CTD_human |
Hgene | SFTPB | C0024115 | Lung diseases | 1 | CTD_human |
Hgene | SFTPB | C0024121 | Lung Neoplasms | 1 | CTD_human |
Hgene | SFTPB | C1968602 | Surfactant Metabolism Dysfunction, Pulmonary, 1 | 1 | CTD_human;ORPHANET;UNIPROT |
Tgene | NFKBIZ | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |