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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 33514

FusionGeneSummary for SFTA3_SLC25A21

check button Fusion gene summary
Fusion gene informationFusion gene name: SFTA3_SLC25A21
Fusion gene ID: 33514
HgeneTgene
Gene symbol

SFTA3

SLC25A21

Gene ID

253970

89874

Gene namesurfactant associated 3solute carrier family 25 member 21
SynonymsNANCI|SFTPH|SP-H|SPHODC|ODC1
Cytomap

14q13.3

14q13.3

Type of geneprotein-codingprotein-coding
Descriptionsurfactant-associated protein 3NKX2.1 associated non-coding intergenic RNANkx2.1-associated noncoding intergenic RNAputative protein SFTA3surfactant-associated protein Hmitochondrial 2-oxodicarboxylate carrieroxodicarboxylate carriersolute carrier family 25 (mitochondrial oxoadipate carrier), member 21solute carrier family 25 (mitochondrial oxodicarboxylate carrier), member 21
Modification date2018032920180523
UniProtAcc

P0C7M3

Q9BQT8

Ensembl transtripts involved in fusion geneENST00000518529, ENST00000518987, 
ENST00000555449, ENST00000331299, 
ENST00000557611, 
Fusion gene scores* DoF score1 X 1 X 1=18 X 4 X 6=192
# samples 19
** MAII scorelog2(1/1*10)=3.32192809488736log2(9/192*10)=-1.09310940439148
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SFTA3 [Title/Abstract] AND SLC25A21 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUSCTCGA-39-5034-01ASFTA3chr14

36982318

-SLC25A21chr14

37153086

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000518529ENST00000555449SFTA3chr14

36982318

-SLC25A21chr14

37153086

-
Frame-shiftENST00000518529ENST00000331299SFTA3chr14

36982318

-SLC25A21chr14

37153086

-
5CDS-intronENST00000518529ENST00000557611SFTA3chr14

36982318

-SLC25A21chr14

37153086

-
5UTR-3CDSENST00000518987ENST00000555449SFTA3chr14

36982318

-SLC25A21chr14

37153086

-
5UTR-3CDSENST00000518987ENST00000331299SFTA3chr14

36982318

-SLC25A21chr14

37153086

-
5UTR-intronENST00000518987ENST00000557611SFTA3chr14

36982318

-SLC25A21chr14

37153086

-

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FusionProtFeatures for SFTA3_SLC25A21


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SFTA3

P0C7M3

SLC25A21

Q9BQT8

Transports C5-C7 oxodicarboxylates across the innermembranes of mitochondria. Can transport 2-oxoadipate, 2-oxoglutarate, adipate, glutarate, and to a lesser extent,pimelate, 2-oxopimelate, 2-aminoadipate, oxaloacetate, andcitrate.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SFTA3_SLC25A21


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SFTA3_SLC25A21


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SFTA3SLC25A21FBXO6, TBX20, NOSIP, DNASE1L2, PPIE


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SFTA3_SLC25A21


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SFTA3_SLC25A21


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource