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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 33481

FusionGeneSummary for SFMBT1_PTPRG

check button Fusion gene summary
Fusion gene informationFusion gene name: SFMBT1_PTPRG
Fusion gene ID: 33481
HgeneTgene
Gene symbol

SFMBT1

PTPRG

Gene ID

51460

5793

Gene nameScm like with four mbt domains 1protein tyrosine phosphatase, receptor type G
SynonymsRU1|SFMBT|hSFMBTHPTPG|PTPG|R-PTP-GAMMA|RPTPG
Cytomap

3p21.1

3p14.2

Type of geneprotein-codingprotein-coding
Descriptionscm-like with four MBT domains protein 1Scm-related gene containing four mbt domainsScm-related gene product containing four mbt domainsrenal ubiquitous protein 1receptor-type tyrosine-protein phosphatase gammaH_RG317H01.1protein tyrosine phosphatase gammaprotein tyrosine phosphatase, receptor type, gamma polypeptidereceptor type protein tyrosine phosphatase gammareceptor tyrosine phosphatase gammareceptor-t
Modification date2018051920180527
UniProtAcc

Q9UHJ3

P23470

Ensembl transtripts involved in fusion geneENST00000394752, ENST00000394750, 
ENST00000358080, ENST00000296295, 
ENST00000470575, 
ENST00000295874, 
ENST00000474889, ENST00000495879, 
Fusion gene scores* DoF score11 X 8 X 8=7048 X 6 X 5=240
# samples 128
** MAII scorelog2(12/704*10)=-2.55254102302878
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(8/240*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SFMBT1 [Title/Abstract] AND PTPRG [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSFMBT1

GO:0045892

negative regulation of transcription, DNA-templated

23592795


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSKCMTCGA-ER-A19M-06ASFMBT1chr3

53079832

-PTPRGchr3

61975299

+
TCGALDSKCMTCGA-ER-A19M-06ASFMBT1chr3

53080476

-PTPRGchr3

61975299

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000394752ENST00000295874SFMBT1chr3

53079832

-PTPRGchr3

61975299

+
5UTR-3CDSENST00000394752ENST00000474889SFMBT1chr3

53079832

-PTPRGchr3

61975299

+
5UTR-intronENST00000394752ENST00000495879SFMBT1chr3

53079832

-PTPRGchr3

61975299

+
intron-3CDSENST00000394750ENST00000295874SFMBT1chr3

53079832

-PTPRGchr3

61975299

+
intron-3CDSENST00000394750ENST00000474889SFMBT1chr3

53079832

-PTPRGchr3

61975299

+
intron-intronENST00000394750ENST00000495879SFMBT1chr3

53079832

-PTPRGchr3

61975299

+
5UTR-3CDSENST00000358080ENST00000295874SFMBT1chr3

53079832

-PTPRGchr3

61975299

+
5UTR-3CDSENST00000358080ENST00000474889SFMBT1chr3

53079832

-PTPRGchr3

61975299

+
5UTR-intronENST00000358080ENST00000495879SFMBT1chr3

53079832

-PTPRGchr3

61975299

+
5UTR-3CDSENST00000296295ENST00000295874SFMBT1chr3

53079832

-PTPRGchr3

61975299

+
5UTR-3CDSENST00000296295ENST00000474889SFMBT1chr3

53079832

-PTPRGchr3

61975299

+
5UTR-intronENST00000296295ENST00000495879SFMBT1chr3

53079832

-PTPRGchr3

61975299

+
intron-3CDSENST00000470575ENST00000295874SFMBT1chr3

53079832

-PTPRGchr3

61975299

+
intron-3CDSENST00000470575ENST00000474889SFMBT1chr3

53079832

-PTPRGchr3

61975299

+
intron-intronENST00000470575ENST00000495879SFMBT1chr3

53079832

-PTPRGchr3

61975299

+
intron-3CDSENST00000394752ENST00000295874SFMBT1chr3

53080476

-PTPRGchr3

61975299

+
intron-3CDSENST00000394752ENST00000474889SFMBT1chr3

53080476

-PTPRGchr3

61975299

+
intron-intronENST00000394752ENST00000495879SFMBT1chr3

53080476

-PTPRGchr3

61975299

+
intron-3CDSENST00000394750ENST00000295874SFMBT1chr3

53080476

-PTPRGchr3

61975299

+
intron-3CDSENST00000394750ENST00000474889SFMBT1chr3

53080476

-PTPRGchr3

61975299

+
intron-intronENST00000394750ENST00000495879SFMBT1chr3

53080476

-PTPRGchr3

61975299

+
intron-3CDSENST00000358080ENST00000295874SFMBT1chr3

53080476

-PTPRGchr3

61975299

+
intron-3CDSENST00000358080ENST00000474889SFMBT1chr3

53080476

-PTPRGchr3

61975299

+
intron-intronENST00000358080ENST00000495879SFMBT1chr3

53080476

-PTPRGchr3

61975299

+
intron-3CDSENST00000296295ENST00000295874SFMBT1chr3

53080476

-PTPRGchr3

61975299

+
intron-3CDSENST00000296295ENST00000474889SFMBT1chr3

53080476

-PTPRGchr3

61975299

+
intron-intronENST00000296295ENST00000495879SFMBT1chr3

53080476

-PTPRGchr3

61975299

+
intron-3CDSENST00000470575ENST00000295874SFMBT1chr3

53080476

-PTPRGchr3

61975299

+
intron-3CDSENST00000470575ENST00000474889SFMBT1chr3

53080476

-PTPRGchr3

61975299

+
intron-intronENST00000470575ENST00000495879SFMBT1chr3

53080476

-PTPRGchr3

61975299

+

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FusionProtFeatures for SFMBT1_PTPRG


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SFMBT1

Q9UHJ3

PTPRG

P23470

Histone-binding protein, which is part of variouscorepressor complexes. Mediates the recruitment of corepressorcomplexes to target genes, followed by chromatin compaction andrepression of transcription. Plays a role during myogenesis:required for the maintenance of undifferentiated states ofmyogenic progenitor cells via interaction with MYOD1. Interactionwith MYOD1 leads to the recruitment of associated corepressors andsilencing of MYOD1 target genes. Part of the SLC complex in germcells, where it may play a role during spermatogenesis.{ECO:0000269|PubMed:17599839, ECO:0000269|PubMed:23349461,ECO:0000269|PubMed:23592795}. Possesses tyrosine phosphatase activity.{ECO:0000269|PubMed:19167335}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SFMBT1_PTPRG


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SFMBT1_PTPRG


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SFMBT1PHC1, ACP1, PHC2, HIST1H3A, HIST1H4A, PSMA1, SRPK1, ZCCHC10, CLNK, KIF22, RBPJ, HDAC1, HMG20APTPRGDLG4, PTPRG, LGALS8, FYTTD1, FCN1, TMEM185A, CCNL2, DUSP26, PTPRB, SEC24A, FCHO2, CEP89, CDC42BPB, FAM129B, PSD3, PALM, CASKIN2, HSPA12A, GPRIN1, NF2, RPS15, CLNS1A, SLC39A10, ADD2, FARP1, GJB7, SDC1, DUS4L, MED21, PCDHGC3, DUSP22, ISG20, SERPINA12, ZNF517, ACBD7, NCSTN, NPB, SCGB2A2, CLCC1, DUSP23, DEFB104A, IER3IP1, PACS1, PTPRA


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SFMBT1_PTPRG


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SFMBT1_PTPRG


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePTPRGC0038356Stomach Neoplasms1CTD_human