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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 33402

FusionGeneSummary for SETD7_NPY5R

check button Fusion gene summary
Fusion gene informationFusion gene name: SETD7_NPY5R
Fusion gene ID: 33402
HgeneTgene
Gene symbol

SETD7

NPY5R

Gene ID

80854

4889

Gene nameSET domain containing lysine methyltransferase 7neuropeptide Y receptor Y5
SynonymsKMT7|SET7|SET7/9|SET9NPY5-R|NPYR5|NPYY5-R
Cytomap

4q31.1

4q32.2

Type of geneprotein-codingprotein-coding
Descriptionhistone-lysine N-methyltransferase SETD7H3-K4-HMTase SETD7SET domain-containing protein 7histone H3-K4 methyltransferase SETD7histone H3-lysine 4-specific methyltransferaselysine N-methyltransferase 7neuropeptide Y receptor type 5NPY-Y5 receptorY5 receptor
Modification date2018051920180523
UniProtAcc

Q8WTS6

Q15761

Ensembl transtripts involved in fusion geneENST00000506866, ENST00000274031, 
ENST00000404104, ENST00000406354, 
ENST00000608958, 
ENST00000338566, 
ENST00000515560, ENST00000506953, 
Fusion gene scores* DoF score5 X 4 X 4=801 X 1 X 1=1
# samples 61
** MAII scorelog2(6/80*10)=-0.415037499278844
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: SETD7 [Title/Abstract] AND NPY5R [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSETD7

GO:0006974

cellular response to DNA damage stimulus

23509280

HgeneSETD7

GO:0018026

peptidyl-lysine monomethylation

17108971

HgeneSETD7

GO:0018027

peptidyl-lysine dimethylation

17108971

HgeneSETD7

GO:0070828

heterochromatin organization

23509280


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSKCMTCGA-W3-A825-06ASETD7chr4

140468074

-NPY5Rchr4

164266866

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000506866ENST00000338566SETD7chr4

140468074

-NPY5Rchr4

164266866

+
5CDS-5UTRENST00000506866ENST00000515560SETD7chr4

140468074

-NPY5Rchr4

164266866

+
5CDS-intronENST00000506866ENST00000506953SETD7chr4

140468074

-NPY5Rchr4

164266866

+
5CDS-5UTRENST00000274031ENST00000338566SETD7chr4

140468074

-NPY5Rchr4

164266866

+
5CDS-5UTRENST00000274031ENST00000515560SETD7chr4

140468074

-NPY5Rchr4

164266866

+
5CDS-intronENST00000274031ENST00000506953SETD7chr4

140468074

-NPY5Rchr4

164266866

+
5CDS-5UTRENST00000404104ENST00000338566SETD7chr4

140468074

-NPY5Rchr4

164266866

+
5CDS-5UTRENST00000404104ENST00000515560SETD7chr4

140468074

-NPY5Rchr4

164266866

+
5CDS-intronENST00000404104ENST00000506953SETD7chr4

140468074

-NPY5Rchr4

164266866

+
5CDS-5UTRENST00000406354ENST00000338566SETD7chr4

140468074

-NPY5Rchr4

164266866

+
5CDS-5UTRENST00000406354ENST00000515560SETD7chr4

140468074

-NPY5Rchr4

164266866

+
5CDS-intronENST00000406354ENST00000506953SETD7chr4

140468074

-NPY5Rchr4

164266866

+
intron-5UTRENST00000608958ENST00000338566SETD7chr4

140468074

-NPY5Rchr4

164266866

+
intron-5UTRENST00000608958ENST00000515560SETD7chr4

140468074

-NPY5Rchr4

164266866

+
intron-intronENST00000608958ENST00000506953SETD7chr4

140468074

-NPY5Rchr4

164266866

+

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FusionProtFeatures for SETD7_NPY5R


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SETD7

Q8WTS6

NPY5R

Q15761

Histone methyltransferase that specificallymonomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylationrepresents a specific tag for epigenetic transcriptionalactivation. Plays a central role in the transcriptional activationof genes such as collagenase or insulin. Recruited by IPF1/PDX-1to the insulin promoter, leading to activate transcription. Hasalso methyltransferase activity toward non-histone proteins suchas p53/TP53, TAF10, and possibly TAF7 by recognizing and bindingthe [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189'of TAF10, leading to increase the affinity of TAF10 for RNApolymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizingp53/TP53 and increasing p53/TP53-mediated transcriptionalactivation. {ECO:0000269|PubMed:12540855,ECO:0000269|PubMed:12588998, ECO:0000269|PubMed:15099517,ECO:0000269|PubMed:15525938, ECO:0000269|PubMed:16141209,ECO:0000269|PubMed:17108971}. Receptor for neuropeptide Y and peptide YY. The activityof this receptor is mediated by G proteins that inhibit adenylatecyclase activity. Seems to be associated with food intake. Couldbe involved in feeding disorders.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SETD7_NPY5R


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SETD7_NPY5R


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SETD7L3MBTL1, DNMT1, RELA, TP53, TAF10, HIST1H3A, ESR1, HIST1H4A, TBP, TAF7, TAF6, E2F1, SIRT1, PPP1R12A, HIST3H3, AR, STAT3, H3F3A, SMARCA4, MYOD1, DPY30, MED1, SERTAD1, A1BG, PRKAR1A, NR2F2, STEAP3, SOX2, KLF4, SETD7, FAM189B, AGTR1, CCR1, ZFP41, CEP170, FOXO1, MDM2, UBXN7, SMAD7, RNF111, SMURF1, SMURF2, PTPN2, ARIH1, TRIM25NPY5RRNF181, NUPR1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SETD7_NPY5R


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SETD7_NPY5R


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneNPY5RC0001973Alcoholic Intoxication, Chronic2PSYGENET
TgeneNPY5RC0028754Obesity1CTD_human
TgeneNPY5RC0085762Alcohol abuse1PSYGENET