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Fusion gene ID: 33392 |
FusionGeneSummary for SETD5_RAD18 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SETD5_RAD18 | Fusion gene ID: 33392 | Hgene | Tgene | Gene symbol | SETD5 | RAD18 | Gene ID | 55209 | 56852 |
| Gene name | SET domain containing 5 | RAD18, E3 ubiquitin protein ligase | |
| Synonyms | - | RNF73 | |
| Cytomap | 3p25.3 | 3p25.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | SET domain-containing protein 5 | E3 ubiquitin-protein ligase RAD18RAD18 homologRAD18, S. cerevisiae, homologRING finger protein 73RING-type E3 ubiquitin transferase RAD18hHR18hRAD18postreplication repair protein RAD18postreplication repair protein hRAD18p | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q9C0A6 | Q9NS91 | |
| Ensembl transtripts involved in fusion gene | ENST00000402198, ENST00000402466, ENST00000406341, ENST00000407969, ENST00000302463, ENST00000488236, | ENST00000264926, ENST00000495087, | |
| Fusion gene scores | * DoF score | 12 X 12 X 6=864 | 5 X 6 X 4=120 |
| # samples | 16 | 6 | |
| ** MAII score | log2(16/864*10)=-2.43295940727611 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SETD5 [Title/Abstract] AND RAD18 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | RAD18 | GO:0006974 | cellular response to DNA damage stimulus | 22036607|25023518|25931565 |
| Tgene | RAD18 | GO:0051865 | protein autoubiquitination | 25023518 |
| Tgene | RAD18 | GO:0060548 | negative regulation of cell death | 22036607 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BLCA | TCGA-GU-AATP-01A | SETD5 | chr3 | 9490314 | + | RAD18 | chr3 | 9005277 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000402198 | ENST00000264926 | SETD5 | chr3 | 9490314 | + | RAD18 | chr3 | 9005277 | - |
| 5CDS-intron | ENST00000402198 | ENST00000495087 | SETD5 | chr3 | 9490314 | + | RAD18 | chr3 | 9005277 | - |
| 5CDS-intron | ENST00000402466 | ENST00000264926 | SETD5 | chr3 | 9490314 | + | RAD18 | chr3 | 9005277 | - |
| 5CDS-intron | ENST00000402466 | ENST00000495087 | SETD5 | chr3 | 9490314 | + | RAD18 | chr3 | 9005277 | - |
| 5CDS-intron | ENST00000406341 | ENST00000264926 | SETD5 | chr3 | 9490314 | + | RAD18 | chr3 | 9005277 | - |
| 5CDS-intron | ENST00000406341 | ENST00000495087 | SETD5 | chr3 | 9490314 | + | RAD18 | chr3 | 9005277 | - |
| 5CDS-intron | ENST00000407969 | ENST00000264926 | SETD5 | chr3 | 9490314 | + | RAD18 | chr3 | 9005277 | - |
| 5CDS-intron | ENST00000407969 | ENST00000495087 | SETD5 | chr3 | 9490314 | + | RAD18 | chr3 | 9005277 | - |
| 5CDS-intron | ENST00000302463 | ENST00000264926 | SETD5 | chr3 | 9490314 | + | RAD18 | chr3 | 9005277 | - |
| 5CDS-intron | ENST00000302463 | ENST00000495087 | SETD5 | chr3 | 9490314 | + | RAD18 | chr3 | 9005277 | - |
| 3UTR-intron | ENST00000488236 | ENST00000264926 | SETD5 | chr3 | 9490314 | + | RAD18 | chr3 | 9005277 | - |
| 3UTR-intron | ENST00000488236 | ENST00000495087 | SETD5 | chr3 | 9490314 | + | RAD18 | chr3 | 9005277 | - |
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FusionProtFeatures for SETD5_RAD18 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SETD5 | RAD18 |
| Probable transcriptional regulator that acts via theformation of large multiprotein complexes that modify and/orremodel the chromatin. Acts as a regulator of histone acetylationduring gene transcription. {ECO:0000250|UniProtKB:Q5XJV7}. | E3 ubiquitin-protein ligase involved in postreplicationrepair of UV-damaged DNA. Postreplication repair functions in gap-filling of a daughter strand on replication of damaged DNA.Associates to the E2 ubiquitin conjugating enzyme UBE2B to formthe UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164'. Has ssDNAbinding activity. {ECO:0000269|PubMed:17108083,ECO:0000269|PubMed:21659603}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SETD5_RAD18 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SETD5_RAD18 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| SETD5 | DPPA2, CCDC85B, TRAF2, LDOC1, MTUS2, CEP70, KRT40, NXF1, SKAP1, PRMT2, NAGK, PRR20E, SPAG16, RMND5B | RAD18 | UBE2A, UBE2B, HLTF, RAD51, POLH, TP53BP1, POLK, UBE2I, TSG101, SRRM2, FANCD2, FANCI, PCNA, CDC7, POLN, HIST1H2AA, UBC, NBN, ANKRD32, SHPRH, RAD18, SPRTN, ORC2, WRNIP1, MAPK8, RFC2, CPD, ZMYM2, RPL10A, ECT2, DTL, TRIM23, PCGF6, TRIM8, DZIP3, BRCA1, MLKL, DBF4, USP5, SIVA1, USP2, TAX1BP1, RHNO1, MAP3K1, PSME3, ZNF501, RPS2, MAGEA4, ZFP41, LLGL2, XPO1, CREM, HK2, ITSN1, SRGAP3, TNPO3, LIN7C, FAM178A, CERK, SMC6, SRGAP1, ATPAF1, PTRF, USP7, SNW1, CDC5L, JPH4, ZNF692, IRF9, PIP4K2A, JUNB, TXNIP, ZNF263, ARRB2, TCEANC2, ATF2, TULP3, KLHDC3, SRP9, BATF3, UBE2M |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SETD5_RAD18 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SETD5_RAD18 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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