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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 3338

FusionGeneSummary for ATP2A3_ZZEF1

check button Fusion gene summary
Fusion gene informationFusion gene name: ATP2A3_ZZEF1
Fusion gene ID: 3338
HgeneTgene
Gene symbol

ATP2A3

ZZEF1

Gene ID

489

23140

Gene nameATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3zinc finger ZZ-type and EF-hand domain containing 1
SynonymsSERCA3ZZZ4
Cytomap

17p13.2

17p13.2

Type of geneprotein-codingprotein-coding
Descriptionsarcoplasmic/endoplasmic reticulum calcium ATPase 3ATPase, Ca(2+)-transporting, ubiquitousATPase, Ca++ transporting, ubiquitousSR Ca(2+)-ATPase 3adenosine triphosphatase, calciumcalcium pump 3calcium-translocating P-type ATPasesarco/endoplasmic retzinc finger ZZ-type and EF-hand domain-containing protein 1zinc finger, ZZ-type with EF hand domain 1
Modification date2018052320180519
UniProtAcc

Q93084

O43149

Ensembl transtripts involved in fusion geneENST00000397035, ENST00000397041, 
ENST00000309890, ENST00000397039, 
ENST00000359983, ENST00000352011, 
ENST00000397043, 
ENST00000381638, 
ENST00000574474, 
Fusion gene scores* DoF score2 X 2 X 2=89 X 11 X 5=495
# samples 214
** MAII scorelog2(2/8*10)=1.32192809488736log2(14/495*10)=-1.82200169802201
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ATP2A3 [Title/Abstract] AND ZZEF1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSTADTCGA-BR-A4PF-01AATP2A3chr17

3867468

-ZZEF1chr17

3999994

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000397035ENST00000381638ATP2A3chr17

3867468

-ZZEF1chr17

3999994

-
5CDS-5UTRENST00000397035ENST00000574474ATP2A3chr17

3867468

-ZZEF1chr17

3999994

-
Frame-shiftENST00000397041ENST00000381638ATP2A3chr17

3867468

-ZZEF1chr17

3999994

-
5CDS-5UTRENST00000397041ENST00000574474ATP2A3chr17

3867468

-ZZEF1chr17

3999994

-
Frame-shiftENST00000309890ENST00000381638ATP2A3chr17

3867468

-ZZEF1chr17

3999994

-
5CDS-5UTRENST00000309890ENST00000574474ATP2A3chr17

3867468

-ZZEF1chr17

3999994

-
5UTR-3CDSENST00000397039ENST00000381638ATP2A3chr17

3867468

-ZZEF1chr17

3999994

-
5UTR-5UTRENST00000397039ENST00000574474ATP2A3chr17

3867468

-ZZEF1chr17

3999994

-
Frame-shiftENST00000359983ENST00000381638ATP2A3chr17

3867468

-ZZEF1chr17

3999994

-
5CDS-5UTRENST00000359983ENST00000574474ATP2A3chr17

3867468

-ZZEF1chr17

3999994

-
Frame-shiftENST00000352011ENST00000381638ATP2A3chr17

3867468

-ZZEF1chr17

3999994

-
5CDS-5UTRENST00000352011ENST00000574474ATP2A3chr17

3867468

-ZZEF1chr17

3999994

-
Frame-shiftENST00000397043ENST00000381638ATP2A3chr17

3867468

-ZZEF1chr17

3999994

-
5CDS-5UTRENST00000397043ENST00000574474ATP2A3chr17

3867468

-ZZEF1chr17

3999994

-

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FusionProtFeatures for ATP2A3_ZZEF1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ATP2A3

Q93084

ZZEF1

O43149


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ATP2A3_ZZEF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ATP2A3_ZZEF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ATP2A3WRAP73, TCF3, CDK2, ATF2, HDAC11, BCL2, BMI1, SPINT2, SRPRB, MCOLN3, TSPAN17, CGRRF1, BTN2A1, GNAI3, TREML2, BCL2L11, HTR3E, EVA1C, IQCF1, ESRRB, VSIG1, PMEL, LRRCC1, IL17RC, LRRTM1, LRRC8B, SLC4A8, CNGA3, KCNA5, FNDC5, PCDHGB4, PCDHB11, KCNS3, TMED6, GABRA6, BTNL3, ENTPD4, IL17RB, PCDHA3, SYT12, ASIC4, IL1R1, PIGO, PCDHB5, CST7, PCDHB16, PCDHGA5, PCDHA12, CYLDZZEF1PHYHIP, PTPN4, HSPB3, SKIL, HECTD3, MYCBP, S100A4, EPS15L1, LMNB1, MAD1L1, NCAPH, GLIPR1L2, GAS2L1, RPS4X, RSPO1, DHRS4L2, MRM1, PARD6B, FOSL2, DLK1, POGLUT1, CCDC130, SCCPDH, TRMT10C, WNT9B, CCNG1, PDGFRB, XRCC5, THOC1, TGS1, GAN, EGFL6, ANGPT2, CHRDL1, RBFA, GAST, CPA6, WFDC10A, PTRF, MRPS24, LYZL1, CLEC3A, SERPINA5, MRPS34, NKAP, FGFRL1, COPS7B, ZBBX, ACSBG2, TTC25, MRPL10, DCAF12, PRSS33, GPR156, LYZL2, CDK5RAP1, GMNN


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ATP2A3_ZZEF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ATP2A3_ZZEF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneATP2A3C0001430Adenoma1CTD_human
HgeneATP2A3C0011853Diabetes Mellitus, Experimental1CTD_human
HgeneATP2A3C0011860Diabetes Mellitus, Non-Insulin-Dependent1CTD_human