|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 33340 |
FusionGeneSummary for SESN1_CENPW |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SESN1_CENPW | Fusion gene ID: 33340 | Hgene | Tgene | Gene symbol | SESN1 | CENPW | Gene ID | 27244 | 387103 |
| Gene name | sestrin 1 | centromere protein W | |
| Synonyms | PA26|SEST1 | C6orf173|CENP-W|CUG2 | |
| Cytomap | 6q21 | 6q22.32 | |
| Type of gene | protein-coding | protein-coding | |
| Description | sestrin-1p53 activated gene 26p53 regulated PA26 nuclear protein | centromere protein Wcancer-up-regulated gene 2 proteincancer-upregulated gene 2 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9Y6P5 | Q5EE01 | |
| Ensembl transtripts involved in fusion gene | ENST00000436639, ENST00000302071, ENST00000356644, ENST00000517548, | ENST00000368326, ENST00000368325, ENST00000368328, | |
| Fusion gene scores | * DoF score | 8 X 3 X 7=168 | 1 X 1 X 1=1 |
| # samples | 8 | 1 | |
| ** MAII score | log2(8/168*10)=-1.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: SESN1 [Title/Abstract] AND CENPW [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | HNSC | TCGA-CR-5250-01A | SESN1 | chr6 | 109414998 | - | CENPW | chr6 | 126667351 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000436639 | ENST00000368326 | SESN1 | chr6 | 109414998 | - | CENPW | chr6 | 126667351 | + |
| 5CDS-intron | ENST00000436639 | ENST00000368325 | SESN1 | chr6 | 109414998 | - | CENPW | chr6 | 126667351 | + |
| 5CDS-intron | ENST00000436639 | ENST00000368328 | SESN1 | chr6 | 109414998 | - | CENPW | chr6 | 126667351 | + |
| intron-intron | ENST00000302071 | ENST00000368326 | SESN1 | chr6 | 109414998 | - | CENPW | chr6 | 126667351 | + |
| intron-intron | ENST00000302071 | ENST00000368325 | SESN1 | chr6 | 109414998 | - | CENPW | chr6 | 126667351 | + |
| intron-intron | ENST00000302071 | ENST00000368328 | SESN1 | chr6 | 109414998 | - | CENPW | chr6 | 126667351 | + |
| intron-intron | ENST00000356644 | ENST00000368326 | SESN1 | chr6 | 109414998 | - | CENPW | chr6 | 126667351 | + |
| intron-intron | ENST00000356644 | ENST00000368325 | SESN1 | chr6 | 109414998 | - | CENPW | chr6 | 126667351 | + |
| intron-intron | ENST00000356644 | ENST00000368328 | SESN1 | chr6 | 109414998 | - | CENPW | chr6 | 126667351 | + |
| 5UTR-intron | ENST00000517548 | ENST00000368326 | SESN1 | chr6 | 109414998 | - | CENPW | chr6 | 126667351 | + |
| 5UTR-intron | ENST00000517548 | ENST00000368325 | SESN1 | chr6 | 109414998 | - | CENPW | chr6 | 126667351 | + |
| 5UTR-intron | ENST00000517548 | ENST00000368328 | SESN1 | chr6 | 109414998 | - | CENPW | chr6 | 126667351 | + |
Top |
FusionProtFeatures for SESN1_CENPW |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SESN1 | CENPW |
| Functions as an intracellular leucine sensor thatnegatively regulates the TORC1 signaling pathway through the GATORcomplex. In absence of leucine, binds the GATOR subcomplex GATOR2and prevents TORC1 signaling. Binding of leucine to SESN2 disruptsits interaction with GATOR2 thereby activating the TORC1 signalingpathway (PubMed:25263562, PubMed:26449471). This stress-induciblemetabolic regulator may also play a role in protection againstoxidative and genotoxic stresses (By similarity). May positivelyregulate the transcription by NFE2L2 of genes involved in theresponse to oxidative stress by facilitating the SQSTM1-mediatedautophagic degradation of KEAP1 (PubMed:23274085). May have analkylhydroperoxide reductase activity born by the N-terminaldomain of the protein (By similarity). Was originally reported tocontribute to oxidative stress resistance by reducing PRDX1(PubMed:15105503). However, this could not be confirmed (Bysimilarity). {ECO:0000250|UniProtKB:P58004,ECO:0000269|PubMed:15105503, ECO:0000269|PubMed:23274085,ECO:0000269|PubMed:25263562, ECO:0000269|PubMed:26449471}. | Component of the CENPA-NAC (nucleosome-associated)complex, a complex that plays a central role in assembly ofkinetochore proteins, mitotic progression and chromosomesegregation (By similarity). The CENPA-NAC complex recruits theCENPA-CAD (nucleosome distal) complex and may be involved inincorporation of newly synthesized CENPA into centromeres (Bysimilarity). Part of a nucleosome-associated complex that bindsspecifically to histone H3-containing nucleosomes at thecentromere, as opposed to nucleosomes containing CENPA. Componentof the heterotetrameric CENP-T-W-S-X complex that binds andsupercoils DNA, and plays an important role in kinetochoreassembly. CENPW has a fundamental role in kinetochore assembly andfunction. It is one of the inner kinetochore proteins, with mostfurther proteins binding downstream. Required for normalchromosome organization and normal progress through mitosis.{ECO:0000250, ECO:0000269|PubMed:19070575,ECO:0000269|PubMed:19533040, ECO:0000269|PubMed:21695110,ECO:0000269|PubMed:22002061, ECO:0000269|PubMed:22304917}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for SESN1_CENPW |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for SESN1_CENPW |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| SESN1 | PRDX1, SQSTM1, RBX1, KEAP1, NXF1 | CENPW | COPS5, CENPT, BTRC, HNRNPU |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for SESN1_CENPW |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for SESN1_CENPW |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|